Detailed information for compound 30777

Basic information

Technical information
  • TDR Targets ID: 30777
  • Name: methyl 2-[[3-[2-[[(2R)-2-(3-chlorophenyl)-2-h ydroxyethyl]amino]propyl]-1H-indol-7-yl]oxy]a cetate
  • MW: 416.898 | Formula: C22H25ClN2O4
  • H donors: 3 H acceptors: 2 LogP: 3.68 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)COc1cccc2c1[nH]cc2CC(NC[C@@H](c1cccc(c1)Cl)O)C
  • InChi: 1S/C22H25ClN2O4/c1-14(24-12-19(26)15-5-3-6-17(23)10-15)9-16-11-25-22-18(16)7-4-8-20(22)29-13-21(27)28-2/h3-8,10-11,14,19,24-26H,9,12-13H2,1-2H3/t14?,19-/m0/s1
  • InChiKey: GBDSYNHPPHBHMR-PKDNWHCCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 2-[[3-[2-[[(2R)-2-(3-chlorophenyl)-2-hydroxy-ethyl]amino]propyl]-1H-indol-7-yl]oxy]acetate
  • 2-[[3-[2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1H-indol-7-yl]oxy]acetic acid methyl ester
  • methyl 2-[[3-[2-[[(2R)-2-(3-chlorophenyl)-2-hydroxy-ethyl]amino]propyl]-1H-indol-7-yl]oxy]ethanoate
  • 2-[[3-[2-[[(2R)-2-(3-chlorophenyl)-2-hydroxy-ethyl]amino]propyl]-1H-indol-7-yl]oxy]acetic acid methyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adrenoceptor beta 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.004 0.1245 0.1377
Onchocerca volvulus 0.004 0.1245 0.3483
Echinococcus granulosus hyperpolarization activated cyclic 0.0031 0.0686 0.0758
Schistosoma mansoni histamine h1 receptor 0.004 0.1245 0.1245
Echinococcus granulosus neuropeptide Y receptor 0.004 0.1245 0.1377
Onchocerca volvulus 0.004 0.1245 0.3483
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.004 0.1245 0.1377
Echinococcus multilocularis allatostatin A receptor 0.004 0.1245 0.1377
Leishmania major hypothetical protein, conserved 0.0021 0 0.5
Leishmania major protein kinase, putative 0.0021 0 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.004 0.1245 0.1245
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0021 0 0.5
Plasmodium falciparum cGMP-dependent protein kinase 0.0021 0 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0031 0.0686 0.0686
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Echinococcus granulosus dro:myosuppressin receptor 0.004 0.1245 0.1377
Echinococcus multilocularis fmrfamide receptor 0.004 0.1245 0.1377
Mycobacterium ulcerans transmembrane transport protein 0.0021 0 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.004 0.1245 0.1377
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.004 0.1245 0.1377
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.004 0.1245 0.1245
Leishmania major protein kinase A regulatory subunit, putative 0.0021 0 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Trypanosoma brucei cAMP response protein 1, putative 0.0021 0 0.5
Schistosoma mansoni amine GPCR 0.004 0.1245 0.1245
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.1245 0.1377
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0021 0 0.5
Mycobacterium ulcerans hypothetical protein 0.0021 0 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.004 0.1245 0.1377
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.004 0.1245 0.1245
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.1643 0.1643
Mycobacterium ulcerans hypothetical protein 0.0021 0 0.5
Mycobacterium ulcerans regulatory protein 0.0021 0 0.5
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0046 0.1643 0.1816
Onchocerca volvulus 0.004 0.1245 0.3483
Echinococcus multilocularis biogenic amine (5HT) receptor 0.004 0.1245 0.1377
Brugia malayi Cyclic-nucleotide gated cation channel 0.0031 0.0686 0.0758
Mycobacterium tuberculosis Conserved protein 0.0021 0 0.5
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0021 0 0.5
Echinococcus multilocularis neuropeptide s receptor 0.004 0.1245 0.1377
Trypanosoma brucei Flagellar Member 6 0.0021 0 0.5
Brugia malayi Tachykinin-like peptides receptor 99D 0.004 0.1245 0.1377
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0046 0.1643 0.1816
Onchocerca volvulus 0.004 0.1245 0.3483
Echinococcus granulosus tachykinin peptides receptor 99D 0.004 0.1245 0.1377
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Echinococcus granulosus g-protein coupled receptor 0.004 0.1245 0.1377
Schistosoma mansoni biogenic amine receptor 0.004 0.1245 0.1245
Trypanosoma cruzi cAMP response protein 1, putative 0.0021 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.1245 0.1245
Leishmania major hypothetical protein, conserved 0.0021 0 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.004 0.1245 0.1377
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0148 0.8357 1
Treponema pallidum catabolite gene activator (Crp) 0.0021 0 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.1245 0.1377
Echinococcus granulosus thyrotropin releasing hormone receptor 0.004 0.1245 0.1377
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.1245 0.1377
Echinococcus granulosus neuropeptide s receptor 0.004 0.1245 0.1377
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0096 0.493 0.5452
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.1245 0.1377
Echinococcus multilocularis g protein coupled receptor 0.004 0.1245 0.1377
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.004 0.1245 0.1245
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0021 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.1245 0.1245
Loa Loa (eye worm) neuropeptide F receptor 0.004 0.1245 0.1377
Brugia malayi hypothetical protein 0.004 0.1245 0.1377
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0031 0.0686 0.082
Trypanosoma brucei cAMP binding protein, putative 0.0021 0 0.5
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0031 0.0686 0.0758
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0031 0.0686 0.0758
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0031 0.0686 0.0758
Echinococcus granulosus g protein coupled receptor 0.004 0.1245 0.1377
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0021 0 0.5
Echinococcus granulosus alpha 1A adrenergic receptor 0.004 0.1245 0.1377
Onchocerca volvulus 0.004 0.1245 0.3483
Echinococcus multilocularis neuropeptide receptor 0.004 0.1245 0.1377
Brugia malayi ORL1-like opioid receptor 0.004 0.1245 0.1377
Brugia malayi Melatonin receptor type 1A 0.004 0.1245 0.1377
Echinococcus granulosus neuropeptide Y receptor 0.004 0.1245 0.1377
Loa Loa (eye worm) G-protein coupled receptor 0.004 0.1245 0.1377
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Onchocerca volvulus 0.004 0.1245 0.3483
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.1245 0.1245
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.1245 0.1245
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.1245 0.1377
Trypanosoma cruzi cAMP binding protein, putative 0.0021 0 0.5
Brugia malayi AKH receptor 0.004 0.1245 0.1377
Echinococcus granulosus neuropeptide receptor 0.004 0.1245 0.1377
Echinococcus multilocularis G-protein coupled receptor, putative 0.004 0.1245 0.1377
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.1245 0.1377
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0021 0 0.5
Mycobacterium ulcerans transcriptional regulatory protein 0.0021 0 0.5
Schistosoma mansoni hypothetical protein 0.004 0.1245 0.1245
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.1245 0.1377
Onchocerca volvulus Neuropeptide F receptor homolog 0.004 0.1245 0.3483
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.1245 0.1245
Brugia malayi Dopamine receptor protein 1 0.004 0.1245 0.1377
Echinococcus multilocularis somatostatin receptor 0.004 0.1245 0.1377
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Echinococcus multilocularis g protein coupled receptor 0.004 0.1245 0.1377
Echinococcus granulosus fmrfamide receptor 0.004 0.1245 0.1377
Brugia malayi Serotonin receptor 0.004 0.1245 0.1377
Echinococcus granulosus allatostatin A receptor 0.004 0.1245 0.1377
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Brugia malayi neuropeptide F receptor 0.004 0.1245 0.1377
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Loa Loa (eye worm) hypothetical protein 0.0031 0.0686 0.0758
Echinococcus multilocularis sex peptide receptor 0.004 0.1245 0.1377
Brugia malayi RE15519p 0.004 0.1245 0.1377
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Brugia malayi Dopamine receptor 0.004 0.1245 0.1377
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.004 0.1245 0.1377
Brugia malayi hypothetical protein 0.004 0.1245 0.1377
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0021 0 0.5
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0159 0.9043 1
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0021 0 0.5
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.004 0.1245 0.1245
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Echinococcus multilocularis g protein coupled receptor 0.004 0.1245 0.1377
Schistosoma mansoni neuropeptide F-like receptor 0.004 0.1245 0.1245
Echinococcus granulosus 7TM GPCR rhodopsin 0.004 0.1245 0.1377
Schistosoma mansoni neuropeptide f receptor 76f 0.004 0.1245 0.1245
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0031 0.0686 0.082
Schistosoma mansoni peptide (allatostatin)-like receptor 0.004 0.1245 0.1245
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0021 0 0.5
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0031 0.0686 0.0686
Echinococcus multilocularis voltage gated potassium channel 0.0046 0.1643 0.1816
Loa Loa (eye worm) follicle stimulating hormone receptor 0.004 0.1245 0.1377
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.004 0.1245 0.1377
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.1245 0.1377
Echinococcus granulosus G protein coupled receptor 139 0.004 0.1245 0.1377
Schistosoma mansoni voltage-gated potassium channel 0.0025 0.0267 0.0267
Schistosoma mansoni adenoreceptor 0.004 0.1245 0.1245
Schistosoma mansoni biogenic amine (5HT) receptor 0.004 0.1245 0.1245
Schistosoma mansoni alpha-1 adrenergic receptor 0.004 0.1245 0.1245
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Onchocerca volvulus 0.004 0.1245 0.3483
Echinococcus multilocularis serotonin receptor 0.004 0.1245 0.1377
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.1245 0.1245
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.004 0.1245 0.1245
Brugia malayi G protein-coupled receptor F59B2.13 0.004 0.1245 0.1377
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Echinococcus multilocularis neuropeptides capa receptor 0.004 0.1245 0.1377
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.1245 0.1377
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.004 0.1245 0.1245
Onchocerca volvulus 0.004 0.1245 0.3483
Schistosoma mansoni amine GPCR 0.004 0.1245 0.1245
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0021 0 0.5
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0031 0.0686 0.0686
Schistosoma mansoni opsin-like receptor 0.004 0.1245 0.1245
Echinococcus granulosus 7tm_1 domain containing protein 0.004 0.1245 0.1377
Brugia malayi Serotonin/octopamine receptor family protein 7 0.004 0.1245 0.1377
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0021 0 0.5
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.004 0.1245 0.1377
Brugia malayi hypothetical protein 0.004 0.1245 0.1377
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.1245 0.1377
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Brugia malayi Dopamine receptor protein 2 0.004 0.1245 0.1377
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0159 0.9043 1
Schistosoma mansoni jun-related protein 0.0078 0.3749 0.3749
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Echinococcus granulosus biogenic amine 5HT receptor 0.004 0.1245 0.1377
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Brugia malayi sulfakinin receptor protein 0.004 0.1245 0.1377
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.004 0.1245 0.1377
Brugia malayi hypothetical protein 0.004 0.1245 0.1377
Echinococcus granulosus g protein coupled receptor 0.004 0.1245 0.1377
Mycobacterium ulcerans hypothetical protein 0.0021 0 0.5
Brugia malayi GnHR receptor homolog 0.004 0.1245 0.1377
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.1245 0.1377
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.1245 0.1377
Mycobacterium ulcerans hypothetical protein 0.0021 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.1643 0.1816
Brugia malayi hypothetical protein 0.004 0.1245 0.1377
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.1245 0.1245
Schistosoma mansoni amine GPCR 0.004 0.1245 0.1245
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0021 0 0.5
Brugia malayi hypothetical protein 0.0076 0.3576 0.3955
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0148 0.8357 1
Schistosoma mansoni opsin-like receptor 0.004 0.1245 0.1245
Leishmania major protein kinase, putative 0.0021 0 0.5
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0031 0.0686 0.0686
Echinococcus multilocularis hyperpolarization activated cyclic 0.0031 0.0686 0.0758
Brugia malayi G-protein coupled receptor 0.004 0.1245 0.1377
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.1245 0.1245
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Brugia malayi G-protein coupled receptor 0.004 0.1245 0.1377
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0031 0.0686 0.0758
Schistosoma mansoni biogenic amine receptor 0.004 0.1245 0.1245
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Echinococcus granulosus peptide allatostatin:somatostatin 0.004 0.1245 0.1377
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Trypanosoma brucei protein kinase A regulatory subunit 0.0021 0 0.5
Onchocerca volvulus 0.004 0.1245 0.3483
Brugia malayi putative neuropeptide receptor 0.004 0.1245 0.1377
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.1245 0.1377
Trypanosoma cruzi cAMP response protein 1 0.0021 0 0.5
Echinococcus multilocularis serotonin receptor 0.004 0.1245 0.1377
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.004 0.1245 0.1377
Brugia malayi putative neuropeptide receptor NPR1 0.004 0.1245 0.1377
Echinococcus multilocularis neuropeptide Y receptor 0.004 0.1245 0.1377
Schistosoma mansoni hypothetical protein 0.0078 0.3749 0.3749
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Echinococcus granulosus serotonin receptor 0.004 0.1245 0.1377
Echinococcus granulosus sex peptide receptor 0.004 0.1245 0.1377
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0021 0 0.5
Echinococcus multilocularis dro:myosuppressin receptor 0.004 0.1245 0.1377
Echinococcus multilocularis fmrfamide receptor 0.004 0.1245 0.1377
Loa Loa (eye worm) TYRA-2 protein 0.004 0.1245 0.1377
Trypanosoma cruzi protein kinase A regulatory subunit 0.0021 0 0.5
Echinococcus granulosus hypothetical protein 0.004 0.1245 0.1377
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.004 0.1245 0.1377
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.1245 0.1245
Brugia malayi hypothetical protein 0.004 0.1245 0.1377
Echinococcus multilocularis orexin receptor type 2 0.004 0.1245 0.1377
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Echinococcus granulosus neuropeptide FF receptor 2 0.004 0.1245 0.1377
Echinococcus multilocularis tachykinin peptides receptor 99D 0.004 0.1245 0.1377
Echinococcus multilocularis neuropeptide receptor A26 0.004 0.1245 0.1377
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0046 0.1643 0.1816
Mycobacterium leprae Conserved hypothetical protein 0.0021 0 0.5
Echinococcus granulosus jun protein 0.0096 0.493 0.5452
Schistosoma mansoni hypothetical protein 0.004 0.1245 0.1245
Schistosoma mansoni hypothetical protein 0.004 0.1245 0.1245
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.004 0.1245 0.1377
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.004 0.1245 0.1377
Echinococcus multilocularis hyperpolarization activated cyclic 0.0031 0.0686 0.0758
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.1245 0.1377
Onchocerca volvulus 0.004 0.1245 0.3483
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.004 0.1245 0.1377
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.1245 0.1245
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Loa Loa (eye worm) hypothetical protein 0.0138 0.7667 0.8478
Brugia malayi hypothetical protein 0.004 0.1245 0.1377
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0 0.5
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0021 0 0.5
Brugia malayi G protein-coupled receptor 0.004 0.1245 0.1377
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.1245 0.1245
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.1245 0.1377
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.0686 0.0686
Schistosoma mansoni 60S ribosomal protein L21 0.0025 0.0267 0.0267
Schistosoma mansoni biogenic amine receptor 0.004 0.1245 0.1245
Schistosoma mansoni neuropeptide receptor 0.004 0.1245 0.1245
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0159 0.9043 1
Leishmania major hypothetical protein, conserved 0.0021 0 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.1245 0.1377
Schistosoma mansoni amine GPCR 0.004 0.1245 0.1245
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.004 0.1245 0.1377
Echinococcus multilocularis G protein coupled receptor 139 0.004 0.1245 0.1377
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.004 0.1245 0.1377
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0096 0.493 0.5452
Echinococcus multilocularis neuropeptide Y receptor 0.004 0.1245 0.1377
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0021 0 0.5
Schistosoma mansoni growth hormone secretagogue receptor 0.004 0.1245 0.1245
Schistosoma mansoni myosin xvIII 0.004 0.1245 0.1245
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.004 0.1245 0.1377
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.004 0.1245 0.1377
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0031 0.0686 0.0758
Schistosoma mansoni neuropeptide F-like receptor 0.004 0.1245 0.1245
Onchocerca volvulus 0.0076 0.3576 1
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.1643 0.1643
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.1245 0.1245
Loa Loa (eye worm) melatonin receptor type 1A 0.004 0.1245 0.1377
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.004 0.1245 0.1377
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.004 0.1245 0.1377
Echinococcus multilocularis neuropeptide receptor 0.004 0.1245 0.1377
Brugia malayi hypothetical protein 0.004 0.1245 0.1377
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0021 0 0.5
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0021 0 0.5
Echinococcus granulosus neuropeptide receptor A26 0.004 0.1245 0.1377
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.004 0.1245 0.1377
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Brugia malayi larval opioid receptor 0.004 0.1245 0.1377
Loa Loa (eye worm) hypothetical protein 0.0094 0.4757 0.5261
Brugia malayi hypothetical protein 0.004 0.1245 0.1377
Schistosoma mansoni neuropeptide receptor 0.004 0.1245 0.1245
Treponema pallidum cyclic nucleotide binding protein 0.0021 0 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Treponema pallidum cyclic nucleotide binding protein 0.0021 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.1245 0.1377
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.004 0.1245 0.1245
Echinococcus granulosus voltage gated potassium channel 0.0046 0.1643 0.1816
Onchocerca volvulus 0.004 0.1245 0.3483
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0021 0 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Onchocerca volvulus 0.004 0.1245 0.3483
Brugia malayi gonadotropin-releasing hormone receptor 2 0.004 0.1245 0.1377
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.004 0.1245 0.3483
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.1245 0.1377
Schistosoma mansoni amine GPCR 0.004 0.1245 0.1245
Schistosoma mansoni voltage-gated potassium channel 0.0174 1 1
Onchocerca volvulus 0.004 0.1245 0.3483
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.1245 0.1377
Echinococcus granulosus orexin receptor type 2 0.004 0.1245 0.1377
Echinococcus granulosus neuropeptide receptor 0.004 0.1245 0.1377
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.004 0.1245 0.1245
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0021 0 0.5
Onchocerca volvulus 0.004 0.1245 0.3483
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0031 0.0686 0.0758
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.004 0.1245 0.1377
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.004 0.1245 0.1377
Leishmania major regulatory subunit of protein kinase a-like protein 0.0021 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.1245 0.1377
Brugia malayi Serotonin receptor 0.004 0.1245 0.1377
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0031 0.0686 0.0686
Onchocerca volvulus 0.004 0.1245 0.3483
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Treponema pallidum catabolite gene activator 0.0021 0 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Leishmania major hypothetical protein, unknown function 0.0021 0 0.5
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0021 0 0.5
Echinococcus multilocularis g-protein coupled receptor 0.004 0.1245 0.1377
Echinococcus multilocularis neuropeptides capa receptor 0.004 0.1245 0.1377
Schistosoma mansoni biogenic amine (5HT) receptor 0.004 0.1245 0.1245
Echinococcus granulosus g protein coupled receptor 0.004 0.1245 0.1377
Echinococcus granulosus hyperpolarization activated cyclic 0.0031 0.0686 0.0758
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0031 0.0686 0.0758
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Brugia malayi neuropeptide F receptor 0.004 0.1245 0.1377
Echinococcus granulosus neuropeptides capa receptor 0.004 0.1245 0.1377
Brugia malayi bZIP transcription factor family protein 0.0096 0.493 0.5452
Schistosoma mansoni opsin-like receptor 0.004 0.1245 0.1245
Trypanosoma cruzi Flagellar Member 6 0.0021 0 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Schistosoma mansoni neuropeptide receptor 0.004 0.1245 0.1245
Leishmania major cyclic nucleotide-binding protein-like protein 0.0021 0 0.5
Brugia malayi hypothetical protein 0.004 0.1245 0.1377
Brugia malayi follicle stimulating hormone receptor 0.004 0.1245 0.1377
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Echinococcus multilocularis alpha 1A adrenergic receptor 0.004 0.1245 0.1377
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.1245 0.1377
Loa Loa (eye worm) hypothetical protein 0.004 0.1245 0.1377
Schistosoma mansoni neuropeptide receptor 0.004 0.1245 0.1245
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0031 0.0686 0.0758
Echinococcus granulosus somatostatin receptor 0.004 0.1245 0.1377
Onchocerca volvulus 0.004 0.1245 0.3483
Onchocerca volvulus 0.004 0.1245 0.3483
Echinococcus multilocularis jun protein 0.0096 0.493 0.5452
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0159 0.9043 1
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0031 0.0686 0.0758
Schistosoma mansoni hypothetical protein 0.004 0.1245 0.1245
Echinococcus granulosus neuropeptides capa receptor 0.004 0.1245 0.1377

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.92 nM Agonism of recombinant human beta-3 adrenergic receptor assayed by measuring cAMP accumulation in CHO cells expressing beta3-AR ChEMBL. 12657269
EC50 (functional) = 0.92 nM Agonism of recombinant human beta-3 adrenergic receptor assayed by measuring cAMP accumulation in CHO cells expressing beta3-AR ChEMBL. 12657269
Intrinsic activity (functional) = 102 % Agonistic activity to recombinant human beta-3 adrenergic receptor expressed in CHO cells by measuring cAMP accumulation ChEMBL. 12657269
Intrinsic activity (functional) = 102 % Agonistic activity to recombinant human beta-3 adrenergic receptor expressed in CHO cells by measuring cAMP accumulation ChEMBL. 12657269

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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