Detailed information for compound 307905

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 401.504 | Formula: C24H27N5O
  • H donors: 4 H acceptors: 2 LogP: 3.8 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC(C)(C)C)N[C@@H](c1[nH]cc(n1)c1ccccc1)Cc1c[nH]c2c1cccc2
  • InChi: 1S/C24H27N5O/c1-24(2,3)29-23(30)28-20(13-17-14-25-19-12-8-7-11-18(17)19)22-26-15-21(27-22)16-9-5-4-6-10-16/h4-12,14-15,20,25H,13H2,1-3H3,(H,26,27)(H2,28,29,30)/t20-/m1/s1
  • InChiKey: VFJFHKSDNUMTES-HXUWFJFHSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens somatostatin receptor 2 Starlite/ChEMBL References
Homo sapiens somatostatin receptor 1 Starlite/ChEMBL References
Homo sapiens somatostatin receptor 5 Starlite/ChEMBL References
Homo sapiens somatostatin receptor 4 Starlite/ChEMBL References
Homo sapiens somatostatin receptor 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus pyroglutamylated rfamide peptide receptor somatostatin receptor 2 369 aa 411 aa 18.7 %
Echinococcus granulosus pyroglutamylated rfamide peptide receptor somatostatin receptor 4 388 aa 372 aa 20.7 %
Echinococcus granulosus pyroglutamylated rfamide peptide receptor somatostatin receptor 5 364 aa 392 aa 19.4 %
Echinococcus granulosus pyroglutamylated rfamide peptide receptor somatostatin receptor 1 391 aa 368 aa 21.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus thyroid hormone receptor alpha 0.019 0.2318 0.2591
Schistosoma mansoni hypothetical protein 0.0017 0.009 0.0019
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0017 0.009 0.0179
Loa Loa (eye worm) hypothetical protein 0.019 0.2318 0.406
Brugia malayi hypothetical protein 0.0017 0.009 0.0179
Brugia malayi hypothetical protein 0.0017 0.009 0.0179
Loa Loa (eye worm) hypothetical protein 0.0145 0.1742 0.305
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0213 0.261 0.2918
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0257 0.0325
Schistosoma mansoni opsin-like receptor 0.0017 0.009 0.0019
Echinococcus multilocularis muscleblind protein 0.0145 0.1742 0.174
Schistosoma mansoni biogenic amine receptor 0.0017 0.009 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0404 0.5051 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0017 0.009 0.0156
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Brugia malayi neuropeptide F receptor 0.0017 0.009 0.0179
Loa Loa (eye worm) hypothetical protein 0.0145 0.1742 0.305
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0404 0.5051 0.8851
Echinococcus multilocularis GPCR, family 2 0.0015 0.0074 0.0072
Brugia malayi larval opioid receptor 0.0017 0.009 0.0179
Mycobacterium tuberculosis Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) 0.0178 0.2164 0.3711
Brugia malayi ecdysone receptor 0.019 0.2318 0.4588
Schistosoma mansoni amine GPCR 0.0017 0.009 0.0019
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0017 0.009 0.0019
Loa Loa (eye worm) hypothetical protein 0.019 0.2318 0.406
Schistosoma mansoni alpha-1 adrenergic receptor 0.0017 0.009 0.0019
Echinococcus multilocularis g protein coupled receptor 0.0017 0.009 0.0089
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Schistosoma mansoni glutamine synthetase bacteria 0.0178 0.2164 0.2358
Echinococcus multilocularis nuclear receptor nhr 48 0.019 0.2318 0.2316
Brugia malayi sulfakinin receptor protein 0.0017 0.009 0.0179
Brugia malayi nuclear receptor NHR-67 0.019 0.2318 0.4588
Schistosoma mansoni retinoic acid receptor RXR 0.0404 0.5051 0.5613
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.009 0.0019
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0017 0.009 0.01
Brugia malayi Serotonin receptor 0.0017 0.009 0.0179
Loa Loa (eye worm) hypothetical protein 0.0033 0.0302 0.0527
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0257 0.0286
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0404 0.5051 0.5648
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.009 0.0019
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Echinococcus multilocularis serotonin receptor 0.0017 0.009 0.0089
Schistosoma mansoni biogenic amine receptor 0.0017 0.009 0.0019
Loa Loa (eye worm) hypothetical protein 0.019 0.2318 0.406
Echinococcus multilocularis Nuclear hormone receptor HR96 0.019 0.2318 0.2316
Echinococcus granulosus ecdysone induced protein 78C 0.0404 0.5051 0.5648
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.009 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.009 0.01
Loa Loa (eye worm) DR-78 0.019 0.2318 0.406
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0404 0.5051 1
Onchocerca volvulus Glutamine synthetase homolog 0.0455 0.5707 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.019 0.2318 0.253
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.009 0.01
Loa Loa (eye worm) hypothetical protein 0.0049 0.0499 0.0872
Brugia malayi putative neuropeptide receptor NPR1 0.0017 0.009 0.0179
Echinococcus multilocularis fmrfamide receptor 0.0017 0.009 0.0089
Brugia malayi Steroid receptor seven-up type 2 0.0404 0.5051 1
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0313 0.0547
Trichomonas vaginalis glutamine synthetase-bacteria, putative 0.0178 0.2164 0.7321
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0017 0.009 0.0089
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0404 0.5051 0.505
Schistosoma mansoni hypothetical protein 0.0398 0.4983 0.5536
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Echinococcus multilocularis allatostatin A receptor 0.0017 0.009 0.0089
Schistosoma mansoni adenoreceptor 0.0017 0.009 0.0019
Brugia malayi photoreceptor-specific nuclear receptor 0.0404 0.5051 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.019 0.2318 0.2591
Echinococcus granulosus nuclear receptor 2DBD gamma 0.019 0.2318 0.2591
Loa Loa (eye worm) hypothetical protein 0.0213 0.261 0.4573
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.009 0.01
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0404 0.5051 0.5648
Schistosoma mansoni thyroid hormone receptor 0.0404 0.5051 0.5613
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.009 0.0019
Schistosoma mansoni amine GPCR 0.0017 0.009 0.0019
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0017 0.009 0.0179
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Loa Loa (eye worm) hypothetical protein 0.019 0.2318 0.406
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.009 0.0089
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0074 0.0073
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.009 0.0089
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Toxoplasma gondii glutamine synthetase, type I, putative 0.0455 0.5707 1
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.009 0.0156
Brugia malayi steroid hormone receptor 0.0404 0.5051 1
Brugia malayi hypothetical protein 0.0017 0.009 0.0179
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Schistosoma mansoni steroid hormone receptor ad4bp 0.0404 0.5051 0.5613
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0404 0.5051 1
Schistosoma mansoni cpg binding protein 0.003 0.0256 0.0205
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Schistosoma mansoni nuclear hormone receptor 0.019 0.2318 0.253
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0404 0.5051 0.5613
Echinococcus granulosus transcription factor btf3 0.0034 0.0313 0.0349
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0017 0.009 0.01
Loa Loa (eye worm) hypothetical protein 0.019 0.2318 0.406
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0651 0.0651
Brugia malayi Nuclear hormone receptor-like 1 0.0213 0.261 0.5168
Echinococcus multilocularis g protein coupled receptor 0.0017 0.009 0.0089
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0017 0.009 0.0089
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0404 0.5051 0.5648
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.009 0.0089
Brugia malayi Nuclear hormone receptor E75 0.019 0.2318 0.4588
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0404 0.5051 0.505
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0404 0.5051 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.019 0.2318 0.2591
Echinococcus granulosus hypothetical protein 0.0017 0.009 0.01
Loa Loa (eye worm) melatonin receptor type 1A 0.0017 0.009 0.0156
Schistosoma mansoni histamine h1 receptor 0.0017 0.009 0.0019
Loa Loa (eye worm) hypothetical protein 0.019 0.2318 0.406
Onchocerca volvulus 0.0231 0.2842 0.4899
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Brugia malayi putative neuropeptide receptor 0.0017 0.009 0.0179
Brugia malayi ORL1-like opioid receptor 0.0017 0.009 0.0179
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0017 0.009 0.0156
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0017 0.009 0.0179
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.009 0.0089
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Onchocerca volvulus 0.019 0.2318 0.3965
Brugia malayi nuclear receptor NHR-88 0.019 0.2318 0.4588
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.009 0.0019
Brugia malayi hypothetical protein 0.0017 0.009 0.0179
Echinococcus multilocularis G-protein coupled receptor, putative 0.0017 0.009 0.0089
Brugia malayi beta-NAC-like protein 0.0034 0.0313 0.062
Echinococcus granulosus orexin receptor type 2 0.0017 0.009 0.01
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0074 0.0081
Entamoeba histolytica glutamine synthetase, putative 0.0178 0.2164 1
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.009 0.01
Loa Loa (eye worm) hypothetical protein 0.003 0.0257 0.0448
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0017 0.009 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.009 0.01
Brugia malayi hypothetical protein 0.019 0.2318 0.4588
Loa Loa (eye worm) hypothetical protein 0.0404 0.5051 0.8851
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0074 0.0127
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.009 0.0156
Brugia malayi hypothetical protein 0.0213 0.261 0.5168
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0404 0.5051 0.5613
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0257 0.0207
Echinococcus granulosus G protein coupled receptor 139 0.0017 0.009 0.01
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0404 0.5051 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.019 0.2318 0.2591
Brugia malayi GnHR receptor homolog 0.0017 0.009 0.0179
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0404 0.5051 0.5648
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0235 0.041
Brugia malayi hypothetical protein 0.0213 0.261 0.5168
Trypanosoma cruzi glutamine synthetase, putative 0.0707 0.8941 1
Brugia malayi conserved hypotetical protein 0.019 0.2318 0.4588
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.009 0.0019
Echinococcus granulosus peptide allatostatin:somatostatin 0.0017 0.009 0.01
Echinococcus granulosus glutamine synthetase 0.0707 0.8941 1
Echinococcus granulosus sex peptide receptor 0.0017 0.009 0.01
Echinococcus granulosus alpha 1A adrenergic receptor 0.0017 0.009 0.01
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.009 0.0019
Brugia malayi Dopamine receptor protein 2 0.0017 0.009 0.0179
Loa Loa (eye worm) nuclear receptor nhr-7B 0.019 0.2318 0.406
Schistosoma mansoni hypothetical protein 0.0165 0.1992 0.2164
Schistosoma mansoni thyroid hormone receptor 0.0404 0.5051 0.5613
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0404 0.5051 1
Schistosoma mansoni hypothetical protein 0.0017 0.009 0.0019
Brugia malayi ecdysteroid receptor 0.0404 0.5051 1
Onchocerca volvulus 0.003 0.0257 0.0297
Loa Loa (eye worm) hypothetical protein 0.0213 0.261 0.4573
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.009 0.01
Echinococcus multilocularis geminin 0.0165 0.1992 0.1991
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.009 0.0019
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.009 0.0019
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0499 0.0988
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.009 0.0089
Schistosoma mansoni nuclear receptor 0.019 0.2318 0.253
Loa Loa (eye worm) hypothetical protein 0.019 0.2318 0.406
Echinococcus granulosus g protein coupled receptor 0.0017 0.009 0.01
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Schistosoma mansoni neuropeptide receptor 0.0017 0.009 0.0019
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0404 0.5051 0.505
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Schistosoma mansoni neuropeptide receptor 0.0017 0.009 0.0019
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.009 0.0089
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.009 0.0156
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.009 0.0019
Brugia malayi AKH receptor 0.0017 0.009 0.0179
Brugia malayi Tachykinin-like peptides receptor 99D 0.0017 0.009 0.0179
Echinococcus multilocularis neuropeptide receptor 0.0017 0.009 0.0089
Schistosoma mansoni hypothetical protein 0.0165 0.1992 0.2164
Echinococcus granulosus neuropeptide receptor 0.0017 0.009 0.01
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Loa Loa (eye worm) hypothetical protein 0.0404 0.5051 0.8851
Leishmania major glutamine synthetase, putative 0.0707 0.8941 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Onchocerca volvulus 0.0404 0.5051 0.8833
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Schistosoma mansoni amine GPCR 0.0017 0.009 0.0019
Brugia malayi G-protein coupled receptor 0.0017 0.009 0.0179
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0404 0.5051 0.505
Brugia malayi tailless protein 0.019 0.2318 0.4588
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0213 0.261 0.2861
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.009 0.0156
Echinococcus multilocularis orexin receptor type 2 0.0017 0.009 0.0089
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0404 0.5051 0.5613
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0257 0.0256
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0017 0.009 0.0019
Brugia malayi hypothetical protein 0.0017 0.009 0.0179
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0074 0.0147
Brugia malayi hypothetical protein 0.0017 0.009 0.0179
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0017 0.009 0.0179
Echinococcus multilocularis cpg binding protein 0.003 0.0256 0.0254
Brugia malayi nuclear receptor RXR 0.019 0.2318 0.4588
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Schistosoma mansoni amine GPCR 0.0017 0.009 0.0019
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.009 0.0089
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.2483 0.4349
Echinococcus multilocularis neuropeptide s receptor 0.0465 0.5834 0.5833
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Echinococcus multilocularis muscleblind protein 1 0.0145 0.1742 0.174
Loa Loa (eye worm) hypothetical protein 0.019 0.2318 0.406
Loa Loa (eye worm) hypothetical protein 0.019 0.2318 0.406
Onchocerca volvulus 0.019 0.2318 0.3965
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.009 0.01
Brugia malayi hypothetical protein 0.019 0.2318 0.4588
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.019 0.2318 0.3965
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0017 0.009 0.0089
Mycobacterium leprae PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) 0.0455 0.5707 0.5
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0074 0.0073
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0404 0.5051 0.5648
Echinococcus multilocularis sex peptide receptor 0.0017 0.009 0.0089
Schistosoma mansoni amine GPCR 0.0017 0.009 0.0019
Echinococcus multilocularis glutamine synthetase 0.0707 0.8941 0.8941
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0257 0.0256
Brugia malayi hypothetical protein 0.0017 0.009 0.0179
Brugia malayi nuclear hormone receptor 0.0404 0.5051 1
Echinococcus multilocularis somatostatin receptor 0.0017 0.009 0.0089
Loa Loa (eye worm) hypothetical protein 0.0404 0.5051 0.8851
Loa Loa (eye worm) hypothetical protein 0.019 0.2318 0.406
Echinococcus granulosus neuropeptide receptor A26 0.0465 0.5834 0.6524
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.009 0.0019
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0017 0.009 0.0019
Echinococcus multilocularis ecdysone induced protein 78C 0.0404 0.5051 0.505
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0404 0.5051 0.8851
Echinococcus multilocularis neuropeptide receptor 0.0017 0.009 0.0089
Loa Loa (eye worm) steroid hormone receptor 0.0404 0.5051 0.8851
Schistosoma mansoni glutamine synthetase bacteria 0.0178 0.2164 0.2358
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.019 0.2318 0.253
Schistosoma mansoni neuropeptide receptor 0.0017 0.009 0.0019
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.019 0.2318 0.3965
Schistosoma mansoni nuclear receptor 0.019 0.2318 0.253
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.009 0.0019
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Echinococcus multilocularis serotonin receptor 0.0017 0.009 0.0089
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.009 0.01
Schistosoma mansoni cpg binding protein 0.003 0.0256 0.0205
Brugia malayi CXXC zinc finger family protein 0.0028 0.0235 0.0466
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0017 0.009 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0404 0.5051 0.8851
Echinococcus multilocularis FTZ F1 alpha 0.0404 0.5051 0.505
Brugia malayi isocitrate dehydrogenase 0.0015 0.0074 0.0147
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.009 0.01
Schistosoma mansoni transcription factor btf3 0.0034 0.0313 0.027
Brugia malayi orphan nuclear receptor NR2E1 0.019 0.2318 0.4588
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0257 0.0207
Entamoeba histolytica glutamine synthetase, putative 0.0178 0.2164 1
Echinococcus granulosus allatostatin A receptor 0.0017 0.009 0.01
Echinococcus granulosus dro:myosuppressin receptor 0.0017 0.009 0.01
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0404 0.5051 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0236 0.0262
Brugia malayi neuropeptide F receptor 0.0017 0.009 0.0179
Echinococcus granulosus somatostatin receptor 0.0017 0.009 0.01
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Schistosoma mansoni cpg binding protein 0.0028 0.0235 0.0182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0404 0.5051 0.8851
Schistosoma mansoni nuclear hormone receptor 0.0404 0.5051 0.5613
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0499 0.0872
Wolbachia endosymbiont of Brugia malayi glutamine synthetase 0.0178 0.2164 0.5
Brugia malayi nuclear hormone receptor 0.019 0.2318 0.4588
Schistosoma mansoni hypothetical protein 0.0033 0.0302 0.0258
Loa Loa (eye worm) Gln-2 protein 0.0455 0.5707 1
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0313 0.0425
Echinococcus multilocularis g protein coupled receptor 0.0017 0.009 0.0089
Brugia malayi Dopamine receptor protein 1 0.0017 0.009 0.0179
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.009 0.01
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0074 0.0081
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0213 0.261 0.4573
Brugia malayi glutamine synthetase 0.0252 0.3111 0.616
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0017 0.009 0.0019
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.009 0.0019
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0404 0.5051 0.8833
Loa Loa (eye worm) hypothetical protein 0.0404 0.5051 0.8851
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0017 0.009 0.0179
Brugia malayi follicle stimulating hormone receptor 0.0017 0.009 0.0179
Echinococcus multilocularis G protein coupled receptor 139 0.0017 0.009 0.0089
Brugia malayi Nuclear hormone receptor-like 1 0.0404 0.5051 1
Loa Loa (eye worm) hypothetical protein 0.019 0.2318 0.406
Plasmodium falciparum glutamine synthetase, putative 0.0455 0.5707 1
Echinococcus multilocularis g-protein coupled receptor 0.0017 0.009 0.0089
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Brugia malayi G protein-coupled receptor F59B2.13 0.0017 0.009 0.0179
Echinococcus granulosus cpg binding protein 0.003 0.0256 0.0284
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Loa Loa (eye worm) nuclear hormone receptor 0.019 0.2318 0.406
Schistosoma mansoni RAR-like nuclear receptor 0.0404 0.5051 0.5613
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Schistosoma mansoni hypothetical protein 0.0017 0.009 0.0019
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0074 0.0146
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0302 0.0598
Echinococcus granulosus 7TM GPCR rhodopsin 0.0017 0.009 0.01
Schistosoma mansoni opsin-like receptor 0.0017 0.009 0.0019
Brugia malayi Nuclear hormone receptor-like 1 0.0213 0.261 0.5168
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0257 0.0207
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0074 0.0073
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.4983 0.4982
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0017 0.009 0.0156
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0257 0.0207
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.009 0.0019
Brugia malayi Muscleblind-like protein 0.0145 0.1742 0.3448
Echinococcus multilocularis dro:myosuppressin receptor 0.0017 0.009 0.0089
Echinococcus multilocularis fmrfamide receptor 0.0017 0.009 0.0089
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.009 0.0019
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0017 0.009 0.01
Schistosoma mansoni nuclear receptor nhr-48 0.019 0.2318 0.253
Brugia malayi Pre-SET motif family protein 0.003 0.0257 0.0509
Schistosoma mansoni biogenic amine receptor 0.0017 0.009 0.0019
Echinococcus granulosus muscleblind protein 0.0145 0.1742 0.1947
Brugia malayi Pre-SET motif family protein 0.0203 0.2483 0.4915
Plasmodium vivax glutamine synthetase, putative 0.0455 0.5707 1
Schistosoma mansoni myosin xvIII 0.0017 0.009 0.0019
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0313 0.027
Schistosoma mansoni zinc finger protein 0.019 0.2318 0.253
Echinococcus granulosus dnaJ subfamily B 0.0398 0.4983 0.5572
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0213 0.261 0.2609
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0017 0.009 0.0089
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.009 0.01
Brugia malayi nuclear receptor RXR 0.0213 0.261 0.5168
Echinococcus multilocularis Nuclear hormone receptor HR96 0.019 0.2318 0.2316
Brugia malayi G protein-coupled receptor 0.0017 0.009 0.0179
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.009 0.01
Echinococcus granulosus g protein coupled receptor 0.0017 0.009 0.01
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0404 0.5051 1
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0313 0.027
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.019 0.2318 0.2316
Brugia malayi Dopamine receptor 0.0017 0.009 0.0179
Schistosoma mansoni glutamine synthetase 1 2 (glutamate-amonia ligase) (gs) 0.0707 0.8941 1
Plasmodium vivax SET domain protein, putative 0.003 0.0257 0.0325
Loa Loa (eye worm) TYRA-2 protein 0.0017 0.009 0.0156
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.009 0.01
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.009 0.0089
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0127
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0404 0.5051 0.5648
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0404 0.5051 0.8851
Echinococcus multilocularis thyroid hormone receptor alpha 0.0404 0.5051 0.505
Brugia malayi hypothetical protein 0.0017 0.009 0.0179
Mycobacterium ulcerans glutamine synthetase 0.0455 0.5707 1
Loa Loa (eye worm) hypothetical protein 0.0404 0.5051 0.8851
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Onchocerca volvulus Protein ultraspiracle homolog 0.0404 0.5051 0.8833
Brugia malayi nuclear hormone receptor family member odr-7 0.019 0.2318 0.4588
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.009 0.0019
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0074 0.0073
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.009 0.0089
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0017 0.009 0.0089
Echinococcus granulosus g protein coupled receptor 0.0017 0.009 0.01
Brugia malayi hypothetical protein 0.0017 0.009 0.0179
Echinococcus granulosus g-protein coupled receptor 0.0017 0.009 0.01
Brugia malayi RE15519p 0.0017 0.009 0.0179
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.009 0.01
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0017 0.009 0.01
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.009 0.0089
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0404 0.5051 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.009 0.01
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.009 0.0089
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Loa Loa (eye worm) hypothetical protein 0.0213 0.261 0.4573
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.019 0.2318 0.4588
Loa Loa (eye worm) hypothetical protein 0.0213 0.261 0.4573
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0017 0.009 0.0089
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.019 0.2318 0.2316
Schistosoma mansoni growth hormone secretagogue receptor 0.0017 0.009 0.0019
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.057 0.088
Mycobacterium ulcerans glutamine synthetase GlnA1 0.0455 0.5707 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0074 0.0072
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0404 0.5051 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Echinococcus granulosus nuclear receptor nhr 48 0.019 0.2318 0.2591
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.009 0.0089
Echinococcus granulosus tachykinin peptides receptor 99D 0.0017 0.009 0.01
Brugia malayi nuclear receptor NHR-88 0.0404 0.5051 1
Brugia malayi Serotonin receptor 0.0017 0.009 0.0179
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Echinococcus granulosus neuropeptide s receptor 0.0465 0.5834 0.6524
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0017 0.009 0.0156
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0074 0.0127
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0404 0.5051 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0404 0.5051 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0404 0.5051 0.505
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0017 0.009 0.0019
Loa Loa (eye worm) hypothetical protein 0.0404 0.5051 0.8851
Schistosoma mansoni neuropeptide f receptor 76f 0.0017 0.009 0.0019
Brugia malayi Melatonin receptor type 1A 0.0017 0.009 0.0179
Trypanosoma cruzi glutamine synthetase, putative 0.0707 0.8941 1
Echinococcus granulosus fmrfamide receptor 0.0017 0.009 0.01
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0017 0.009 0.0089
Schistosoma mansoni nuclear hormone receptor 0.019 0.2318 0.253
Loa Loa (eye worm) hypothetical protein 0.019 0.2318 0.406
Loa Loa (eye worm) hypothetical protein 0.0213 0.261 0.4573
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Schistosoma mansoni hypothetical protein 0.0017 0.009 0.0019
Brugia malayi G-protein coupled receptor 0.0017 0.009 0.0179
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0074 0.0146
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0017 0.009 0.0019
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0017 0.009 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0404 0.5051 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0499 0.0988
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.009 0.0089
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0404 0.5051 0.5613
Loa Loa (eye worm) hypothetical protein 0.0404 0.5051 0.8851
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.009 0.0019
Loa Loa (eye worm) nuclear receptor NHR-67 0.019 0.2318 0.406
Brugia malayi hypothetical protein 0.0017 0.009 0.0179
Echinococcus granulosus neuropeptide FF receptor 2 0.0017 0.009 0.01
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0074 0.0072
Loa Loa (eye worm) hypothetical protein 0.0404 0.5051 0.8851
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.009 0.01
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Echinococcus multilocularis neuropeptide FF receptor 2 0.0017 0.009 0.0089
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0404 0.5051 0.5648
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0404 0.5051 0.5613
Brugia malayi nuclear hormone receptor family member nhr-6 0.019 0.2318 0.4588
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0313 0.0425
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.009 0.01
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0404 0.5051 0.505
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.009 0.01
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0404 0.5051 0.5613
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.019 0.2318 0.2316
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0313 0.0425
Loa Loa (eye worm) hypothetical protein 0.019 0.2318 0.406
Echinococcus multilocularis transcription factor btf3 0.0034 0.0313 0.0312
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0017 0.009 0.0089
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0017 0.009 0.0156
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0313 0.027
Trypanosoma brucei glutamine synthetase, putative 0.0707 0.8941 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Echinococcus multilocularis neuropeptide receptor A26 0.0465 0.5834 0.5833
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0404 0.5051 0.8851
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.009 0.0019
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0074 0.0081
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.009 0.0089
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.009 0.0089
Trichomonas vaginalis glutamine synthetase, putative 0.0178 0.2164 0.7321
Echinococcus granulosus GPCR family 2 0.0015 0.0074 0.0081
Leishmania major basic transcription factor 3a, putative 0.0034 0.0313 0.027
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0213 0.261 0.2861
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0156
Mycobacterium tuberculosis Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) 0.0455 0.5707 1
Schistosoma mansoni neuropeptide receptor 0.0017 0.009 0.0019
Schistosoma mansoni opsin-like receptor 0.0017 0.009 0.0019
Echinococcus granulosus serotonin receptor 0.0017 0.009 0.01
Echinococcus granulosus 7tm_1 domain containing protein 0.0017 0.009 0.01
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0074 0.0073
Schistosoma mansoni coup transcription factor 0.0404 0.5051 0.5613
Echinococcus granulosus FTZ F1 alpha 0.0404 0.5051 0.5648
Echinococcus granulosus neuropeptide receptor 0.0017 0.009 0.01
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.009 0.0089
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2842 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0404 0.5051 0.8851
Onchocerca volvulus Bile acid receptor homolog 0.0404 0.5051 0.8833
Echinococcus granulosus geminin 0.0165 0.1992 0.2227
Onchocerca volvulus 0.0028 0.0235 0.0258
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.009 0.0089
Brugia malayi Nuclear hormone receptor E75 0.019 0.2318 0.4588

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 400 nM Inhibition of human sst3 receptorexpressed in CHO cells ChEMBL. 11327607
Ki (binding) = 400 nM Inhibition of human sst3 receptorexpressed in CHO cells ChEMBL. 11327607
Ki (binding) > 10000 nM Inhibition of human sst1 receptor expressed in CHO cells ChEMBL. 11327607
Ki (binding) > 10000 nM Inhibition of human sst2 receptor expressed in CHO cells ChEMBL. 11327607
Ki (binding) > 10000 nM Inhibition of human sst4 receptor expressed in CHO cells ChEMBL. 11327607
Ki (binding) > 10000 nM Inhibition of human sst5 receptor expressed in CHO cells ChEMBL. 11327607
Ki (binding) > 10000 nM Inhibition of human sst1 receptor expressed in CHO cells ChEMBL. 11327607
Ki (binding) > 10000 nM Inhibition of human sst2 receptor expressed in CHO cells ChEMBL. 11327607
Ki (binding) > 10000 nM Inhibition of human sst4 receptor expressed in CHO cells ChEMBL. 11327607
Ki (binding) > 10000 nM Inhibition of human sst5 receptor expressed in CHO cells ChEMBL. 11327607

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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