TDR Targets

Basic information

Technical information

TDR Targets ID: 313939
Name: N-cyclohexyl-2-(6,8-dichloro-2-phenylimidazo[ 1,2-a]pyridin-3-yl)acetamide
MW: 402.317 | Formula: C21H21Cl2N3O
H donors: 1 H acceptors: 2 LogP: 5.74 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Cc1c(nc2n1cc(Cl)cc2Cl)c1ccccc1)NC1CCCCC1
InChi: 1S/C21H21Cl2N3O/c22-15-11-17(23)21-25-20(14-7-3-1-4-8-14)18(26(21)13-15)12-19(27)24-16-9-5-2-6-10-16/h1,3-4,7-8,11,13,16H,2,5-6,9-10,12H2,(H,24,27)
InChiKey: AMAZBTQKHYNHBZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-cyclohexyl-2-(6,8-dichloro-2-phenyl-imidazo[1,2-a]pyridin-3-yl)acetamide
N-cyclohexyl-2-(6,8-dichloro-2-phenyl-3-imidazo[1,2-a]pyridinyl)acetamide
N-cyclohexyl-2-(6,8-dichloro-2-phenyl-imidazo[1,2-a]pyridin-3-yl)ethanamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Peripheral-type benzodiazepine receptor	Starlite/ChEMBL	References
Rattus norvegicus	GABA-A receptor; anion channel	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	translocator protein	Get druggable targets OG5_129542	All targets in OG5_129542
Mycobacterium ulcerans	tryptophan-rich sensory protein	Get druggable targets OG5_129542	All targets in OG5_129542
Onchocerca volvulus		Get druggable targets OG5_129542	All targets in OG5_129542
Onchocerca volvulus		Get druggable targets OG5_129542	All targets in OG5_129542
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129542	All targets in OG5_129542
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129542	All targets in OG5_129542
Brugia malayi	TspO/MBR family protein	Get druggable targets OG5_129542	All targets in OG5_129542
Onchocerca volvulus		Get druggable targets OG5_129542	All targets in OG5_129542
Onchocerca volvulus		Get druggable targets OG5_129542	All targets in OG5_129542
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129542	All targets in OG5_129542
Schistosoma mansoni	peripheral-type benzodiazepine receptor	Get druggable targets OG5_129542	All targets in OG5_129542
Echinococcus multilocularis	translocator protein	Get druggable targets OG5_129542	All targets in OG5_129542
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129542	All targets in OG5_129542

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	441 aa	33.8 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	454 aa	30.4 %
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	GABA-A receptor; anion channel	467 aa	454 aa	29.5 %
Echinococcus multilocularis	glycine receptor subunit beta	GABA-A receptor; anion channel	467 aa	478 aa	28.7 %
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	GABA-A receptor; anion channel	467 aa	479 aa	29.2 %
Onchocerca volvulus		Peripheral-type benzodiazepine receptor	169 aa	156 aa	25.6 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	447 aa	25.7 %
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	GABA-A receptor; anion channel	467 aa	379 aa	19.3 %
Onchocerca volvulus	Eukaryotic initiation factor 4A-III homolog	GABA-A receptor; anion channel	467 aa	453 aa	26.9 %
Brugia malayi	Cation transporter family protein	GABA-A receptor; anion channel	467 aa	453 aa	28.5 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	434 aa	26.7 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	446 aa	29.1 %
Onchocerca volvulus	Large subunit GTPase 1 homolog	GABA-A receptor; anion channel	467 aa	496 aa	26.0 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	446 aa	28.0 %
Echinococcus granulosus	vacuolar h atpase	Peripheral-type benzodiazepine receptor	169 aa	137 aa	25.5 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	435 aa	29.7 %
Onchocerca volvulus	Gamma-aminobutyric acid receptor subunit beta homolog	GABA-A receptor; anion channel	467 aa	433 aa	34.6 %
Echinococcus granulosus	glycine receptor subunit beta	GABA-A receptor; anion channel	467 aa	439 aa	29.6 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	468 aa	28.6 %
Echinococcus granulosus	glycine receptor subunit alpha 1	GABA-A receptor; anion channel	467 aa	430 aa	32.3 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	494 aa	25.5 %
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	GABA-A receptor; anion channel	467 aa	375 aa	21.9 %
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	GABA-A receptor; anion channel	467 aa	384 aa	19.5 %
Echinococcus multilocularis	glycine receptor subunit alpha 1	GABA-A receptor; anion channel	467 aa	430 aa	32.3 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	461 aa	27.8 %
Onchocerca volvulus	Acetylcholine receptor subunit alpha-type homolog	GABA-A receptor; anion channel	467 aa	418 aa	19.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0084	0.0098
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0175	0.3649	0.3595
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0033	0.0484	0.0404
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0034	0.0493	0.8107
Onchocerca volvulus		0.0023	0.0248	0.0336
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0023	0.0248	0.0336
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0283	0.0387
Echinococcus multilocularis	lysyl tRNA synthetase	0.0024	0.0283	0.0387
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0023	0.0248	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0248	0.0336
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0248	0.0336
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0484	0.0677
Echinococcus granulosus	GPCR family 2	0.0015	0.0089	0.0106
Schistosoma mansoni	ap endonuclease	0.0018	0.0153	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0484	0.0677
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0023	0.0248	0.0336
Schistosoma mansoni	nAChR subunit	0.0023	0.0248	0.0336
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0834	0.1183
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0023	0.0248	0.0336
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0153	1
Schistosoma mansoni	hypothetical protein	0.0015	0.0089	0.0106
Brugia malayi	Sugar transporter family protein	0.0015	0.0084	0.0098
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0283	0.0387
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0153	0.1364
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0493	0.8107
Entamoeba histolytica	protein kinase, putative	0.0033	0.0484	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0023	0.0248	0.0336
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0021	0.0202	1
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0089	0.0106
Leishmania major	lysyl-tRNA synthetase, putative	0.0024	0.0283	0.395
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0084	0.0098
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0469	0.0655
Echinococcus multilocularis	calcium dependent protein kinase	0.0031	0.0438	0.0611
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0089	0.0106
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0089	0.0106
Brugia malayi	Cam kinase protein 1	0.0033	0.0484	0.0677
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0033	0.0484	0.7919
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0248	0.0336
Chlamydia trachomatis	lysine--tRNA ligase	0.0024	0.0283	1
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0033	0.0484	0.0404
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0033	0.0484	0.0404
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0084	0.0098
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0038	0.0589	0.0779
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0248	0.0336
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0038	0.0589	1
Plasmodium vivax	hexose transporter	0.0108	0.216	0.2094
Echinococcus granulosus	General substrate transporter	0.0093	0.1821	0.2609
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0333	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0283	0.0387
Schistosoma mansoni	nAChR subunit	0.0023	0.0248	0.0336
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0493	0.1973
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0023	0.0248	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0248	0.0336
Mycobacterium ulcerans	integral membrane transport protein	0.0015	0.0084	0.0121
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0153	0.0198
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0023	0.0248	0.0336
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0589	1
Toxoplasma gondii	exonuclease III APE	0.0018	0.0153	0.0106
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0153	0.1364
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0153	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0248	0.0336
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0021	0.0202	1
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0032	0.0469	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0023	0.0248	0.0336
Brugia malayi	hypothetical protein	0.0015	0.0084	0.0098
Onchocerca volvulus		0.0015	0.0084	0.0098
Onchocerca volvulus		0.0015	0.0084	0.0098
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0023	0.0248	0.0336
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0493	0.8107
Onchocerca volvulus		0.0023	0.0248	0.0336
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0108	0.216	0.31
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0023	0.0248	0.0336
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0153	0.1789
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0084	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0098
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0469	0.0655
Schistosoma mansoni	ap endonuclease	0.0018	0.0153	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0469	0.0655
Schistosoma mansoni	sugar transporter	0.0015	0.0084	0.0098
Brugia malayi	excitatory GABA receptor EXP-1A	0.0023	0.0248	0.0336
Leishmania major	glucose transporter, lmgt2	0.0034	0.0493	0.8107
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0493	0.8107
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0489	0.0685
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0023	0.0248	0.0336
Onchocerca volvulus		0.0015	0.0084	0.0098
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0033	0.0484	0.0617
Echinococcus multilocularis	General substrate transporter	0.0093	0.1821	0.2609
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0023	0.0248	0.0336
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0023	0.0248	0.0336
Brugia malayi	hypothetical protein	0.0015	0.0084	0.0098
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0023	0.0248	0.0336
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0033	0.0484	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0098
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0033	0.0484	0.0404
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0034	0.0493	0.8107
Echinococcus granulosus	solute carrier family 22	0.0015	0.0084	0.0098
Brugia malayi	hypothetical protein	0.013	0.2647	0.3803
Echinococcus granulosus	glycine receptor subunit beta	0.0023	0.0248	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0248	0.0336
Brugia malayi	major facilitator superfamily protein	0.0015	0.0084	0.0098
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0283	0.0409
Onchocerca volvulus		0.0015	0.0084	0.0098
Schistosoma mansoni	nAChR subunit	0.0023	0.0248	0.0336
Brugia malayi	Sugar transporter family protein	0.0108	0.216	0.31
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0098
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0493	0.8107
Trichomonas vaginalis	conserved hypothetical protein	0.0108	0.216	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0033	0.0484	0.0617
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0033	0.0484	0.0677
Trichomonas vaginalis	sugar transporter, putative	0.0034	0.0493	0.1973
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0484	0.0677
Schistosoma mansoni	protein kinase	0.0033	0.0484	0.0677
Entamoeba histolytica	protein kinase, putative	0.0033	0.0484	1
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0153	0.0069
Schistosoma mansoni	hypothetical protein	0.0015	0.0089	0.0106
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0484	0.0677
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0322	0.6934	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0834	0.1183
Onchocerca volvulus		0.0015	0.0084	0.0098
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0023	0.0248	0.0336
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0023	0.0248	0.0336
Echinococcus granulosus	nAChR subunit	0.0023	0.0248	0.0336
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0153	0.1364
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0248	0.0336
Mycobacterium ulcerans	sugar transporter	0.0015	0.0084	0.0121
Giardia lamblia	Prolyl-tRNA synthetase	0.0032	0.0469	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0033	0.0484	0.0617
Brugia malayi	Cation transporter family protein	0.0023	0.0248	0.0336
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0038	0.0589	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0033	0.0484	0.0677
Schistosoma mansoni	hypothetical protein	0.0015	0.0089	0.0106
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0084	0.0098
Onchocerca volvulus		0.0148	0.3049	0.4385
Onchocerca volvulus		0.0015	0.0084	0.0098
Onchocerca volvulus		0.0015	0.0084	0.0098
Echinococcus granulosus	synaptic vesicle 2 protein	0.0015	0.0084	0.0098
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0175	0.3649	0.5495
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0248	0.0336
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.0154	0.1383
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0484	0.0677
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0493	0.8107
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0032	0.0469	0.0655
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0248	0.0336
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0034	0.0493	0.8107
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0023	0.0248	0.0336
Brugia malayi	lysyl-tRNA synthetase	0.0024	0.0283	0.0387
Toxoplasma gondii	protein kinase, putative	0.0306	0.6571	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0484	0.0677
Brugia malayi	Cation transporter family protein	0.0023	0.0248	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0248	0.0336
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0023	0.0248	0.0336
Schistosoma mansoni	nAChR subunit	0.0023	0.0248	0.0336
Echinococcus granulosus	lysyl tRNA synthetase	0.0024	0.0283	0.0387
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0015	0.0084	0.0098
Trypanosoma cruzi	hexose transporter, putative	0.0034	0.0493	0.8107
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0089	0.0106
Leishmania major	glucose transporter, lmgt1	0.0034	0.0493	0.8107
Onchocerca volvulus		0.0322	0.6934	1
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0493	0.8107
Plasmodium vivax	proline--tRNA ligase, putative	0.0038	0.0589	0.051
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0089	0.0106
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0834	0.1183
Onchocerca volvulus		0.0322	0.6934	1
Brugia malayi	TspO/MBR family protein	0.0322	0.6934	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0834	0.1183
Echinococcus granulosus	glycine receptor subunit beta	0.0023	0.0248	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0098
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0023	0.0248	0.0336
Echinococcus granulosus	solute carrier family 22	0.0015	0.0084	0.0098
Schistosoma mansoni	glucose transport protein	0.0108	0.216	0.31
Echinococcus multilocularis	glycine receptor subunit beta	0.0023	0.0248	0.0336
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0153	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0098
Trypanosoma brucei	glucose transporter 1E	0.0034	0.0493	0.8107
Plasmodium falciparum	hexose transporter	0.0108	0.216	0.2094
Mycobacterium ulcerans	tryptophan-rich sensory protein	0.0322	0.6934	1
Loa Loa (eye worm)	hypothetical protein	0.0148	0.3049	0.4385
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0153	0.0332
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0015	0.0084	0.0098
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0084	0.0098
Brugia malayi	Cation transporter family protein	0.0023	0.0248	0.0336
Onchocerca volvulus		0.0015	0.0084	0.0098
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0024	0.0283	0.395
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0108	0.216	0.31
Echinococcus granulosus	solute carrier family 22	0.0015	0.0084	0.0098
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0153	0.5825
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0248	0.0336
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0033	0.0484	0.0404
Schistosoma mansoni	peripheral-type benzodiazepine receptor	0.0322	0.6934	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0098
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0493	0.8107
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0021	0.0217	0.0641
Onchocerca volvulus		0.0015	0.0084	0.0098
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0484	0.0677
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0033	0.0484	0.0404
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0493	0.8107
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0469	0.0655
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0023	0.0248	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0248	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0248	0.0336
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0589	1
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0589	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0248	0.0336
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0015	0.0084	0.0098
Onchocerca volvulus		0.0015	0.0084	0.0098
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0023	0.0248	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0248	0.0336
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0034	0.0493	0.8107
Plasmodium vivax	lysine--tRNA ligase, putative	0.0024	0.0283	0.0201
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0023	0.0248	0.0336
Trichomonas vaginalis	CAMK family protein kinase	0.0033	0.0484	0.1927
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0098
Onchocerca volvulus	Putative nachr subunit	0.0023	0.0248	0.0336
Schistosoma mansoni	sugar transporter	0.0015	0.0084	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0098
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0283	0.0409
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0023	0.0248	0.0336
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0153	1
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0023	0.0248	0.0336
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0493	0.1973
Echinococcus multilocularis	nAChR subunit	0.0023	0.0248	0.0336
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0033	0.0484	0.0404
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0023	0.0248	0.0336
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0023	0.0248	0.0336
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0108	0.216	0.31
Onchocerca volvulus		0.0015	0.0084	0.0098
Giardia lamblia	Lysyl-tRNA synthetase	0.0024	0.0283	0.5182
Schistosoma mansoni	glucose transport protein	0.0108	0.216	0.31
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0023	0.0248	0.0336
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0484	0.0677
Schistosoma mansoni	protein kinase	0.0033	0.0484	0.0677
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0484	0.0677
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0033	0.0484	0.0677
Loa Loa (eye worm)	ACC-1 protein	0.0023	0.0248	0.0336
Onchocerca volvulus		0.0015	0.0084	0.0098
Brugia malayi	Sugar transporter family protein	0.0015	0.0084	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0098
Trypanosoma cruzi	hexose transporter	0.0034	0.0493	0.8107
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0248	0.0336
Trichomonas vaginalis	sugar transporter, putative	0.0034	0.0493	0.1973
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0023	0.0248	0.0336
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0033	0.0484	0.0404
Onchocerca volvulus		0.0015	0.0084	0.0098
Trichomonas vaginalis	sugar transporter, putative	0.0034	0.0493	0.1973
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0098
Plasmodium falciparum	protein kinase 7	0.0306	0.6571	0.6542
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0015	0.0084	0.0098
Schistosoma mansoni	hypothetical protein	0.0015	0.0089	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0248	0.0336
Schistosoma mansoni	nAChR subunit	0.0023	0.0248	0.0336
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0023	0.0248	0.0336
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0089	0.0106
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0023	0.0248	0.0336
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0023	0.0248	0.0336
Echinococcus granulosus	solute carrier family 22	0.0015	0.0084	0.0098
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0023	0.0248	0.0336
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0248	0.0336
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0023	0.0248	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0322	0.6934	1
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0024	0.0283	0.3046
Echinococcus multilocularis	translocator protein	0.0322	0.6934	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0098
Onchocerca volvulus		0.0023	0.0248	0.0336
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0153	0.0198
Onchocerca volvulus		0.0023	0.0248	0.0336
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0023	0.0248	0.0336
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0089	0.0106
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0153	0.0198
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0033	0.0484	0.0677
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0032	0.0469	0.968
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0023	0.0248	0.0336
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0023	0.0248	0.0336
Onchocerca volvulus		0.0322	0.6934	1
Onchocerca volvulus	Putative transporter	0.0015	0.0084	0.0098
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0023	0.0248	0.0336
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0459	1	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0108	0.216	0.31
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0023	0.0248	0.0336
Schistosoma mansoni	nAChR subunit	0.0023	0.0248	0.0336
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0248	0.0336
Trichomonas vaginalis	glucose transporter, putative	0.0034	0.0493	0.1973
Schistosoma mansoni	hypothetical protein	0.0108	0.216	0.31
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0023	0.0248	0.0336
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0023	0.0248	0.0336
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0023	0.0248	0.0336
Toxoplasma gondii	facilitative glucose transporter GT1	0.0108	0.216	0.3201
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0084	0.0098
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.0153	0.2925
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.0042	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0489	0.0685
Loa Loa (eye worm)	sugar transporter	0.0015	0.0084	0.0098
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0469	0.0655
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0032	0.0469	0.1855
Echinococcus granulosus	calcium dependent protein kinase	0.0031	0.0438	0.0611
Schistosoma mansoni	glucose transport protein	0.0108	0.216	0.31
Onchocerca volvulus		0.0015	0.0084	0.0098
Loa Loa (eye worm)	sugar transporter	0.0108	0.216	0.31
Trypanosoma brucei	glucose transporter 2A	0.0034	0.0493	0.8107
Brugia malayi	major facilitator superfamily protein	0.0015	0.0084	0.0098
Plasmodium falciparum	lysine--tRNA ligase	0.0024	0.0283	0.0201
Onchocerca volvulus		0.0015	0.0084	0.0098
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0175	0.3649	0.3595
Trypanosoma cruzi	hexose transporter, putative	0.0034	0.0493	0.8107
Schistosoma mansoni	nAChR subunit	0.0023	0.0248	0.0336
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0084	0.0098
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0015	0.0084	0.0121
Onchocerca volvulus		0.0015	0.0084	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0248	0.0336
Trichomonas vaginalis	glucose transporter, putative	0.0034	0.0493	0.1973
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.0153	0.022
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0024	0.0283	0.0961
Schistosoma mansoni	hypothetical protein	0.0033	0.0489	0.0685
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0108	0.216	0.31
Plasmodium falciparum	proline--tRNA ligase	0.0038	0.0589	0.051
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0023	0.0248	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0322	0.6934	1
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0015	0.0084	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0098
Schistosoma mansoni	sugar transporter	0.0015	0.0084	0.0098
Trypanosoma cruzi	hexose transporter, putative	0.0034	0.0493	0.8107
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0089	0.0106
Echinococcus multilocularis	glycine receptor subunit beta	0.0023	0.0248	0.0336
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0153	0.1364
Loa Loa (eye worm)	ACC-1 protein	0.0023	0.0248	0.0336
Toxoplasma gondii	lysine-tRNA ligase	0.0024	0.0283	0.0308
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0023	0.0248	0.0336
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0108	0.216	0.31
Brugia malayi	hypothetical protein	0.0015	0.0084	0.0098
Schistosoma mansoni	protein kinase	0.0033	0.0484	0.0677
Onchocerca volvulus		0.0322	0.6934	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0098
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0153	0.0069
Onchocerca volvulus		0.0023	0.0248	0.0336
Leishmania major	protein kinase, putative	0.0033	0.0484	0.7919
Leishmania major	glucose transporter, lmgt3	0.0034	0.0493	0.8107
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0108	0.216	0.31
Echinococcus granulosus	translocator protein	0.0322	0.6934	1
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0084	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0248	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0322	0.6934	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0108	0.216	0.31
Entamoeba histolytica	hypothetical protein	0.0024	0.0283	0.5716
Schistosoma mansoni	sugar transporter	0.0015	0.0084	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0248	0.0336
Loa Loa (eye worm)	LGC-31 protein	0.0023	0.0248	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0469	0.0655
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0089	0.0106
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0248	0.0336
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0032	0.0469	0.0655
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0248	0.0336
Schistosoma mansoni	glucose transporter	0.0015	0.0084	0.0098
Onchocerca volvulus		0.0023	0.0248	0.0336
Brugia malayi	hypothetical protein	0.0148	0.3049	0.4385
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0024	0.0283	0.395

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5	Inhibitory concentration of central benzodiazepine GABA-A receptor of rat cerebral cortex	ChEMBL.	15634024
IC50 (binding)	= 5.878	Inhibitory concentration against peripheral benzodiazepine receptor of rat cerebral cortex	ChEMBL.	15634024
IC50 (binding)	= 5.884	Inhibitory concentration against peripheral benzodiazepine receptor of rat ovary	ChEMBL.	15634024
Ki (binding)	= 771.429 nM	Displacement of [3H]-PK11195 from peripheral benzodiazepine receptor of rat cerebral cortex	ChEMBL.	15634024
Ki (binding)	= 771.429 nM	Displacement of [3H]-PK11195 from peripheral benzodiazepine receptor of rat cerebral cortex	ChEMBL.	15634024
Ki (binding)	= 941.535 nM	Displacement of [3H]-PK11195 from peripheral benzodiazepine receptor of rat ovary	ChEMBL.	15634024
Ki (binding)	= 941.54 nM	Displacement of [3H]-PK11195 from peripheral benzodiazepine receptor of rat ovary	ChEMBL.	15634024
Ki (binding)	= 7010 nM	Displacement of [3H]-flunitrazepam from central benzodiazepine GABA-A receptor of rat cerebral cortex	ChEMBL.	15634024
Ki (binding)	= 7010 nM	Displacement of [3H]-flunitrazepam from central benzodiazepine GABA-A receptor of rat cerebral cortex	ChEMBL.	15634024
Log IC50 (binding)	= 5	Inhibitory concentration of central benzodiazepine GABA-A receptor of rat cerebral cortex	ChEMBL.	15634024
Log IC50 (binding)	= 5.878	Inhibitory concentration against peripheral benzodiazepine receptor of rat cerebral cortex	ChEMBL.	15634024
Log IC50 (binding)	= 5.884	Inhibitory concentration against peripheral benzodiazepine receptor of rat ovary	ChEMBL.	15634024
Selectivity index (binding)	= 0.878	Ratio of inhibition of peripheral benzodiazepine receptor of rat cortex and central benzodiazepine GABA-A receptor	ChEMBL.	15634024
Selectivity index (binding)	= 0.884	Ratio of inhibition for peripheral benzodiazepine receptor of rat ovary and central benzodiazepine GABA-A receptor	ChEMBL.	15634024

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL361857
PubChem: 11188834

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 313939