Detailed information for compound 316231

Basic information

Technical information
  • TDR Targets ID: 316231
  • Name: tert-butyl 2-[[6-cyano-1-[(3-methylimidazol-4 -yl)methyl]-3,4-dihydro-2H-quinolin-3-yl]-pyr idin-2-ylsulfonylamino]acetate
  • MW: 522.619 | Formula: C26H30N6O4S
  • H donors: 0 H acceptors: 6 LogP: 2.5 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: N#Cc1ccc2c(c1)CC(CN2Cc1cncn1C)N(S(=O)(=O)c1ccccn1)CC(=O)OC(C)(C)C
  • InChi: 1S/C26H30N6O4S/c1-26(2,3)36-25(33)17-32(37(34,35)24-7-5-6-10-29-24)21-12-20-11-19(13-27)8-9-23(20)31(15-21)16-22-14-28-18-30(22)4/h5-11,14,18,21H,12,15-17H2,1-4H3
  • InChiKey: ZQIKAKSHLZASKW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • tert-butyl 2-[[6-cyano-1-[(3-methylimidazol-4-yl)methyl]-3,4-dihydro-2H-quinolin-3-yl]-(2-pyridylsulfonyl)amino]acetate
  • 2-[[6-cyano-1-[(3-methyl-4-imidazolyl)methyl]-3,4-dihydro-2H-quinolin-3-yl]-(2-pyridylsulfonyl)amino]acetic acid tert-butyl ester
  • tert-butyl 2-[[6-cyano-1-[(3-methylimidazol-4-yl)methyl]-3,4-dihydro-2H-quinolin-3-yl]-pyridin-2-ylsulfonyl-amino]ethanoate
  • 2-[[6-cyano-1-[(3-methylimidazol-4-yl)methyl]-3,4-dihydro-2H-quinolin-3-yl]-(2-pyridylsulfonyl)amino]acetic acid tert-butyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Protein farnesyltransferase Starlite/ChEMBL References
Homo sapiens farnesyltransferase, CAAX box, alpha Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K05954 farnesyltransferase, CAAX box, alpha [EC:2.5.1.58 2.5.1.59], putative Get druggable targets OG5_128459 All targets in OG5_128459
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein Get druggable targets OG5_128081 All targets in OG5_128081
Cryptosporidium hominis chain B, structure of fpt bound to ggpp Get druggable targets OG5_128081 All targets in OG5_128081
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Plasmodium vivax conserved Plasmodium protein, unknown function Get druggable targets OG5_128081 All targets in OG5_128081
Giardia lamblia Rab geranylgeranyltransferase Get druggable targets OG5_128459 All targets in OG5_128459
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein Get druggable targets OG5_128081 All targets in OG5_128081
Neospora caninum protein farnesyltranstransferase beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Cryptosporidium parvum protein geranyl-geranyltransferase beta subunit Get druggable targets OG5_128081 All targets in OG5_128081
Plasmodium falciparum protein farnesyltransferase subunit beta Get druggable targets OG5_128081 All targets in OG5_128081
Plasmodium falciparum protein farnesyltransferase subunit alpha Get druggable targets OG5_128459 All targets in OG5_128459
Trypanosoma brucei protein farnesyltransferase beta subunit Get druggable targets OG5_128081 All targets in OG5_128081
Toxoplasma gondii hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Candida albicans similar to S. cerevisiae RAM1 (YDL090C) beta subunit of farnesyl transferase (Ram1p+Ram2p), involved in prenylation of RAS prote Get druggable targets OG5_128081 All targets in OG5_128081
Leishmania mexicana farnesyltransferase beta subunit Get druggable targets OG5_128081 All targets in OG5_128081
Plasmodium berghei protein farnesyltransferase subunit beta, putative Get druggable targets OG5_128081 All targets in OG5_128081
Entamoeba histolytica protein farnesyltransferase beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein Get druggable targets OG5_128459 All targets in OG5_128459
Echinococcus granulosus protein farnesyltransferase alpha subunit Get druggable targets OG5_128459 All targets in OG5_128459
Echinococcus multilocularis protein farnesyltransferase subunit beta Get druggable targets OG5_128081 All targets in OG5_128081
Cryptosporidium hominis farnesyltransferase Get druggable targets OG5_128459 All targets in OG5_128459
Echinococcus granulosus protein farnesyltransferase subunit beta Get druggable targets OG5_128081 All targets in OG5_128081
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Plasmodium yoelii Prenyltransferase and squalene oxidase repeat, putative Get druggable targets OG5_128081 All targets in OG5_128081
Neospora caninum hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Trypanosoma brucei gambiense protein farnesyltransferase beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Echinococcus multilocularis protein farnesyltransferase alpha subunit Get druggable targets OG5_128459 All targets in OG5_128459
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein Get druggable targets OG5_128081 All targets in OG5_128081
Candida albicans similar to S. cerevisiae RAM1 (YDL090C) beta subunit of farnesyl transferase (Ram1p+Ram2p), involved in prenylation of RAS prote Get druggable targets OG5_128081 All targets in OG5_128081
Trypanosoma cruzi protein farnesyltransferase, putative Get druggable targets OG5_128081 All targets in OG5_128081
Babesia bovis prenyltransferase and squalene oxidase repeat family protein Get druggable targets OG5_128081 All targets in OG5_128081
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Candida albicans alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p) Get druggable targets OG5_128459 All targets in OG5_128459
Plasmodium vivax farnesyltransferase beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Babesia bovis protein prenyltransferase alpha subunit repeat domain containing protein Get druggable targets OG5_128459 All targets in OG5_128459
Plasmodium berghei protein farnesyltransferase subunit alpha, putative Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Schistosoma mansoni protein farnesyltransferase subunit beta Get druggable targets OG5_128081 All targets in OG5_128081
Leishmania braziliensis farnesyltransferase beta subunit Get druggable targets OG5_128081 All targets in OG5_128081
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Leishmania donovani farnesyltransferase beta subunit Get druggable targets OG5_128081 All targets in OG5_128081
Schistosoma japonicum ko:K05954 farnesyltransferase, CAAX box, beta [EC:2.5.1.58], putative Get druggable targets OG5_128081 All targets in OG5_128081
Plasmodium knowlesi conserved Plasmodium protein, unknown function Get druggable targets OG5_128081 All targets in OG5_128081
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Leishmania major farnesyltransferase beta subunit Get druggable targets OG5_128081 All targets in OG5_128081
Plasmodium vivax prenyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein Get druggable targets OG5_128459 All targets in OG5_128459
Schistosoma mansoni protein farnesyltransferase alpha subunit Get druggable targets OG5_128459 All targets in OG5_128459
Plasmodium knowlesi protein farnesyltransferase subunit alpha, putative Get druggable targets OG5_128459 All targets in OG5_128459
Candida albicans alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p) Get druggable targets OG5_128459 All targets in OG5_128459
Giardia lamblia Prenyltransferase Get druggable targets OG5_128081 All targets in OG5_128081
Trypanosoma cruzi protein farnesyltransferase, putative Get druggable targets OG5_128081 All targets in OG5_128081
Plasmodium knowlesi protein farnesyltransferase subunit beta, putative Get druggable targets OG5_128081 All targets in OG5_128081
Theileria parva farnesyltransferase beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Theileria parva hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Cryptosporidium parvum farnesyltransferase Get druggable targets OG5_128459 All targets in OG5_128459
Leishmania infantum farnesyltransferase beta subunit Get druggable targets OG5_128081 All targets in OG5_128081
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0278 0.0278
Echinococcus granulosus kelch ECH associated protein 1 like 0.0091 0.0253 0.0253
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0143 0.0468 0.0368
Trypanosoma brucei lanosterol synthase 0.0074 0.018 0.0102
Echinococcus granulosus ribonucleoside diphosphate reductase subunit 0.0147 0.0484 0.0484
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0017 0.0017
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.2119 0.8722 1
Schistosoma mansoni hypothetical protein 0.0091 0.0254 0.0254
Echinococcus granulosus caspase 2 0.0058 0.0113 0.0113
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0075 0.0185 0.0033
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.2425 1 1
Schistosoma mansoni ribonucleoside-diphosphate reductase small chain 0.0147 0.0484 0.0484
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0185 0.0033
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0147 0.0484 0.0336
Echinococcus multilocularis kelch ECH associated protein 1 0.0091 0.0253 0.0253
Schistosoma mansoni serine-type protease inhibitor 0.0434 0.1683 0.1683
Toxoplasma gondii hypothetical protein 0.0075 0.0185 0.0033
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0218 0.0781 0.0781
Chlamydia trachomatis transcriptional repressor NrdR 0.0306 0.1149 0.0699
Toxoplasma gondii ribonucleoside-diphosphate reductase small subunit 0.0147 0.0484 0.0336
Toxoplasma gondii hypothetical protein 0.0143 0.0468 0.0321
Brugia malayi hypothetical protein 0.0035 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0066 0.0149 0.0149
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0218 0.0781 0.0711
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.2425 1 1
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.2425 1 1
Echinococcus multilocularis kelch ECH associated protein 1 0.0091 0.0253 0.0253
Mycobacterium ulcerans transcriptional regulator NrdR 0.0306 0.1149 0.1238
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain, putative 0.0147 0.0484 0.0408
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0067 0.0152 0.0152
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0147 0.0484 0.0336
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.065 0.2587 0.2472
Echinococcus granulosus apoptotic protease activating factor 1 0.004 0.004 0.004
Schistosoma mansoni caspase-7 (C14 family) 0.0058 0.0113 0.0113
Echinococcus granulosus kelch ECH associated protein 1 like 0.0091 0.0253 0.0253
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0067 0.0152 0.0152
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0075 0.0185 0.0185
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0147 0.0484 0.0408
Echinococcus multilocularis ribonucleoside diphosphate reductase subunit 0.0147 0.0484 0.0484
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0075 0.0185 0.2198
Brugia malayi Cell death protein 3 precursor 0.0058 0.0113 0.0113
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0218 0.0781 0.0781
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0075 0.0185 0.0033
Echinococcus multilocularis caspase 2 0.0058 0.0113 0.0113
Plasmodium vivax ribonucleotide reductase small subunit, putative 0.005 0.0079 0.0003
Loa Loa (eye worm) hypothetical protein 0.0097 0.0278 0.0278
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0218 0.0781 1
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0067 0.0152 0.0152
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0075 0.0185 0.0185
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0075 0.0185 0.0107
Brugia malayi hypothetical protein 0.004 0.004 0.004
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.2425 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0185 0.0107
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.2119 0.8722 1
Trypanosoma cruzi lanosterol synthase, putative 0.0074 0.018 0.0028
Loa Loa (eye worm) hypothetical protein 0.0218 0.0781 0.0781
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0067 0.0152 0.0074
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0017 0.0017
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0075 0.0185 0.0185
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0218 0.0781 0.0781
Loa Loa (eye worm) hypothetical protein 0.0058 0.0113 0.0113
Echinococcus multilocularis Kelch repeat type 1 0.0091 0.0254 0.0254
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0017 0.0017
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.2119 0.8722 1
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0149 0.0149
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0218 0.0781 0.0734
Echinococcus multilocularis apoptotic protease activating factor 1 0.004 0.004 0.004
Onchocerca volvulus Cell death protein 3 homolog 0.0058 0.0113 0.5013
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0147 0.0484 0.0384
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.2119 0.8722 1
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0067 0.0152 0.0077
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.2425 1 1
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0075 0.0185 0.0185
Schistosoma mansoni hypothetical protein 0.004 0.004 0.004
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) 0.0147 0.0484 0.0356
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.2425 1 1
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.2425 1 1
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.2425 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0278 0.0278
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.2425 1 1
Mycobacterium leprae conserved hypothetical protein 0.0306 0.1149 0.1238
Giardia lamblia Rab geranylgeranyltransferase 0.0218 0.0781 1
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0185 0.0033
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0147 0.0484 0.0384
Giardia lamblia Rab geranylgeranyltransferase 0.0075 0.0185 0.0513
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0067 0.0152 0.1776
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0278 0.0278
Onchocerca volvulus 0.0075 0.0185 1
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0218 0.0781 0.0708
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0075 0.0185 0.0107
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0067 0.0152 0.0074
Echinococcus granulosus kelch ECH associated protein 1 0.0091 0.0253 0.0253
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0218 0.0781 0.0734
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0075 0.0185 0.0107
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0218 0.0781 0.0734
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.2425 1 1
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0147 0.0484 0.0408
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0075 0.0185 0.0082
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0067 0.0152 0.0152
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0762 0.3054 0.3364
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0075 0.0185 0.0033
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0075 0.0185 0.0185
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.2425 1 1
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0218 0.0781 0.0781
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0075 0.0185 0.0185
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0147 0.0484 0.0408
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0075 0.0185 0.0107
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0075 0.0185 0.0185
Schistosoma mansoni serine-type protease inhibitor 0.0434 0.1683 0.1683
Plasmodium vivax ribonucleoside-diphosphate reductase small chain, putative 0.0147 0.0484 0.0411
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) 0.0147 0.0484 0.0356
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.004
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0075 0.0185 0.0038
Loa Loa (eye worm) ribonucleotide reductase M2 B 0.0147 0.0484 0.0484
Schistosoma mansoni hypothetical protein 0.0035 0.0017 0.0017
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0218 0.0781 0.0781
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0075 0.0185 0.0109
Schistosoma mansoni hypothetical protein 0.0066 0.0149 0.0149
Trypanosoma cruzi lanosterol synthase, putative 0.0074 0.018 0.0028
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0147 0.0484 0.0408
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.2119 0.8722 1
Brugia malayi ribonucleotide reductase 2 0.0147 0.0484 0.0484
Leishmania major farnesyltransferase beta subunit 0.0067 0.0152 0.0049
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0067 0.0152 0.0152
Mycobacterium tuberculosis Probable transcriptional regulatory protein NrdR 0.0306 0.1149 0.1135
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.2425 1 1

Activities

Activity type Activity value Assay description Source Reference
Cellular reversion (functional) = 85 % Percentage cellular reversion of H-ras transformed Rat-1 cells at 100 nM ChEMBL. 15780629
Cellular reversion (functional) = 85 % Percentage cellular reversion of H-ras transformed Rat-1 cells at 100 nM ChEMBL. 15780629
IC50 (binding) = 1.5 nM Inhibition of human farnesyltransferase ChEMBL. 15780629
IC50 (binding) = 1.5 nM Inhibition of human farnesyltransferase ChEMBL. 15780629
IC50 (functional) = 10 nM Inhibition of cellular reversion in H-ras transformed Rat-1 cells ChEMBL. 15780629
IC50 (functional) = 10 nM Inhibition of cellular reversion in H-ras transformed Rat-1 cells ChEMBL. 15780629

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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