TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 551.512 | Formula: C25H36Cl2N8O2
H donors: 3 H acceptors: 3 LogP: 2.33 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: CCN(C(=O)[C@@H](N=C(N)N)CCNC(=O)N1CCC(CC1)c1cc(nn1C)c1cccc(c1Cl)Cl)CC
InChi: 1S/C25H36Cl2N8O2/c1-4-34(5-2)23(36)19(31-24(28)29)9-12-30-25(37)35-13-10-16(11-14-35)21-15-20(32-33(21)3)17-7-6-8-18(26)22(17)27/h6-8,15-16,19H,4-5,9-14H2,1-3H3,(H,30,37)(H4,28,29,31)/t19-/m0/s1
InChiKey: ATDBDKQGCGVKBJ-IBGZPJMESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 14	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 14	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	ubiquitin specific protease, putative	0.0003	0	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0003	0	0.5
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Plasmodium falciparum	peptide deformylase	0.0238	0.2991	1
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0003	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0091	0.1116	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Harbinger-1_Harbinger/PIFA2 transposable element protein	0.0003	0	0.5
Giardia lamblia	Hypothetical protein	0.0003	0	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0162	0.202	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0003	0	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 46 (C19 family)	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Brugia malayi	hypothetical protein	0.0003	0	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Schistosoma mansoni	hypothetical protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 24 (C19 family)	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0003	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0003	0	0.5
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 30 (C19 family)	0.0003	0	0.5
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0	0.5
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0091	0.1116	1
Onchocerca volvulus		0.0003	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0003	0	0.5
Trichomonas vaginalis	Harbinger-1_Harbinger/PIFA2 transposable element protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0	0.5
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0	0.5
Trypanosoma brucei	Peptide deformylase 2	0.0091	0.1116	1
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0	0.5
Schistosoma mansoni	calpain-7 (C02 family)	0.0003	0	0.5
Trichomonas vaginalis	ubiquitin specific protease, putative	0.0003	0	0.5
Schistosoma mansoni	peptidase	0.0003	0	0.5
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0	0.5
Trypanosoma brucei	Polypeptide deformylase 1	0.0091	0.1116	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0162	0.202	0.202
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0003	0	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 4 (C19 family)	0.0003	0	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Schistosoma mansoni	ubiquitin carboxyl-terminal hydrolase of the cysteine proteinase fold	0.0003	0	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 44 (C19 family)	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0003	0	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 9X (C19 family)	0.0003	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0003	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0	0.5
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase 46	0.0003	0	0.5
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0003	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 42 (C19 family)	0.0003	0	0.5
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	ubiquitin specific protease, putative	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase 5, putative	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0003	0	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0003	0	0.5
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0003	0	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0003	0	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 45 (C19 family)	0.0003	0	0.5
Mycobacterium ulcerans	peptide deformylase	0.0238	0.2991	0.5
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Harbinger-1_Harbinger/PIFA2 transposable element protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase 5, putative	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 48 (C19 family)	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 5 (C19 family)	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Onchocerca volvulus		0.0003	0	0.5
Trichomonas vaginalis	Harbinger-1_Harbinger/PIFA2 transposable element protein	0.0003	0	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0003	0	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0003	0	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0003	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 10 (C19 family)	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Mycobacterium leprae	PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE)	0.0238	0.2991	0.5
Treponema pallidum	polypeptide deformylase (def)	0.0238	0.2991	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Plasmodium vivax	peptide deformylase, putative	0.0238	0.2991	1
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0091	0.1116	1
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Mycobacterium tuberculosis	Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase)	0.0238	0.2991	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Chlamydia trachomatis	peptide deformylase	0.0238	0.2991	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Toxoplasma gondii	hypothetical protein	0.0238	0.2991	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0003	0	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0003	0	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 14 (C19 family)	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 22 (C19 family)	0.0003	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0003	0	0.5
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0003	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0003	0	0.5
Onchocerca volvulus		0.0003	0	0.5
Giardia lamblia	DUB-1	0.0003	0	0.5
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0003	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0	0.5
Brugia malayi	ubiquitin specific protease 14	0.0003	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Schistosoma mansoni	family C19 non-peptidase homologue (C19 family)	0.0003	0	0.5
Schistosoma mansoni	family C19 unassigned peptidase (C19 family)	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0003	0	0.5
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0003	0	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 9X (C19 family)	0.0003	0	0.5
Loa Loa (eye worm)	ubiquitin specific peptidase 39	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Brugia malayi	ubiquitin carboxyl-terminal hydrolase 46	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0091	0.1116	1
Wolbachia endosymbiont of Brugia malayi	peptide deformylase	0.0238	0.2991	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase, putative	0.0003	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0	0.5
Entamoeba histolytica	hypothetical protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0003	0	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0003	0	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 7 (C19 family)	0.0003	0	0.5
Leishmania major	polypeptide deformylase-like protein, putative	0.0091	0.1116	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Schistosoma mansoni	ubiquitin-specific peptidase 16 (C19 family)	0.0003	0	0.5
Schistosoma mansoni	calpain-7 (C02 family)	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0003	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 11 uM	Inhibitory concentration against interleukin-2 binding	ChEMBL.	15686897

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 316927