Detailed information for compound 31699

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 520.683 | Formula: C30H36N2O4S
  • H donors: 0 H acceptors: 0 LogP: 3.48 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC1(OC)CC=C(C=C1)C1(Sc2ccccc2n2c1ccc2CN(C)C)C1=CC=CC(C1)(OC)OC
  • InChi: 1S/C30H36N2O4S/c1-31(2)21-24-13-14-27-30(22-15-18-28(33-3,34-4)19-16-22,23-10-9-17-29(20-23,35-5)36-6)37-26-12-8-7-11-25(26)32(24)27/h7-18H,19-21H2,1-6H3
  • InChiKey: ZIYSWDIYEMXYQO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1D subunit Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent L type calcium channel subunit Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Probable voltage-dependent R-type calcium channel subunit alpha-1E, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Muscle calcium channel subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Toxoplasma gondii transporter, cation channel family protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04853 calcium channel, voltage-dependent, L type, alpha 1F subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent N-type calcium channel subunit alpha-1B, putative Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum expressed protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type A subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04850 calcium channel, voltage-dependent, L type, alpha 1C subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum expressed protein Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma congolense Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel type d subunit Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) voltage-dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Neospora caninum hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma brucei gambiense calcium channel protein, putative Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04344 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent L type calcium channel subunit Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type D subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Toxoplasma gondii hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel type d subunit Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni high voltage-activated calcium channel Cav2A Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni voltage-gated cation channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type A subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type D subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni high voltage-activated calcium channel Cav1 Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04849 calcium channel, voltage-dependent, N type, alpha 1B subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Thioredoxin reductase 0.0042 0.0137 0.0378
Loa Loa (eye worm) hypothetical protein 0.0069 0.0501 0.1429
Brugia malayi Pre-SET motif family protein 0.0033 0.0017 0.0029
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0093 0.0829 0.0823
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0093 0.0829 0.0823
Loa Loa (eye worm) hypothetical protein 0.0182 0.2033 0.5852
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0181 0.0425
Loa Loa (eye worm) hypothetical protein 0.0032 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0093 0.0829 0.2378
Schistosoma mansoni retinoic acid receptor RXR 0.0069 0.0501 0.0494
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0159 0.1727 0.3978
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0069 0.0501 0.1429
Loa Loa (eye worm) hypothetical protein 0.0032 0.0006 0.0003
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0093 0.0829 0.0829
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0093 0.0829 0.0823
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0325 0.3985 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0159 0.1724 0.8675
Brugia malayi DNA topoisomerase I 0.0207 0.2372 0.6831
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0069 0.0501 0.1427
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0093 0.0829 0.0823
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0069 0.0501 0.1427
Trichomonas vaginalis rap1 and, putative 0.0287 0.347 0.8647
Loa Loa (eye worm) hypothetical protein 0.0069 0.0501 0.1429
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0017 0.0017
Plasmodium vivax topoisomerase I, putative 0.0207 0.2372 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0069 0.0501 0.0501
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0093 0.0829 0.0829
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0069 0.0501 0.1427
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0069 0.0501 0.0494
Echinococcus granulosus thioredoxin glutathione reductase 0.0043 0.0145 0.0145
Loa Loa (eye worm) steroid hormone receptor 0.0069 0.0501 0.1429
Loa Loa (eye worm) hypothetical protein 0.0032 0.0006 0.0003
Toxoplasma gondii hypothetical protein 0.0054 0.0302 0.1252
Trypanosoma brucei trypanothione reductase 0.0042 0.0137 0.0319
Loa Loa (eye worm) nuclear receptor NHR-67 0.0032 0.0006 0.0003
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0181 0.0425
Echinococcus multilocularis voltage dependent calcium channel 0.0093 0.0829 0.0823
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0181 0.0425
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0181 0.0383
Schistosoma mansoni single-minded 0.0054 0.0301 0.0295
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0017 0.0047
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0017 0.001
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0059 0.0153
Loa Loa (eye worm) hypothetical protein 0.0032 0.0006 0.0003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.3985 1
Brugia malayi steroid hormone receptor 0.0069 0.0501 0.1427
Trichomonas vaginalis set domain proteins, putative 0.0264 0.3147 0.7798
Leishmania major DNA topoisomerase type IB small subunit 0.0052 0.0271 0.0334
Trypanosoma cruzi DNA topoisomerase type IB small subunit, putative 0.0052 0.0271 0.0642
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0017 0.001
Loa Loa (eye worm) glutathione reductase 0.0042 0.0137 0.038
Echinococcus granulosus thyroid hormone receptor alpha 0.0032 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0069 0.0501 0.1429
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0181 0.0425
Loa Loa (eye worm) calcium channel 0.0093 0.0829 0.2378
Leishmania major mitochondrial DNA polymerase beta 0.0336 0.4132 1
Trypanosoma cruzi trypanothione reductase, putative 0.0042 0.0137 0.0319
Echinococcus granulosus ecdysone induced protein 78C 0.0069 0.0501 0.0501
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0058 0.0348 0.0829
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0069 0.0501 0.1427
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0069 0.0501 0.0501
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0207 0.0489
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0207 0.0489
Echinococcus multilocularis ras gtpase 0.0287 0.347 0.3466
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0207 0.0489
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 0.0155 0.1667 0.4027
Brugia malayi Nuclear hormone receptor-like 1 0.0069 0.0501 0.1427
Onchocerca volvulus 0.0069 0.0501 0.1573
Mycobacterium tuberculosis Probable oxidoreductase 0.0107 0.1016 0.4791
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0232 0.2712 0.7813
Onchocerca volvulus Bile acid receptor homolog 0.0069 0.0501 0.1573
Leishmania major DNA topoisomerase IB, large subunit 0.0155 0.1667 0.383
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0069 0.0501 0.0501
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.3985 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0069 0.0501 0.1427
Brugia malayi ecdysteroid receptor 0.0069 0.0501 0.1427
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0336 0.4132 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0031 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0031 0.0062
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0336 0.4132 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0032 0.0006 0.0006
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0069 0.0501 0.0494
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0181 0.0425
Loa Loa (eye worm) DNA topoisomerase I 0.0207 0.2372 0.6832
Trypanosoma brucei DNA topoisomerase IB, large subunit 0.0155 0.1667 0.4027
Echinococcus granulosus Nuclear hormone receptor HR96 0.0032 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0287 0.347 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0069 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0069 0.0501 0.1429
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0069 0.0501 0.1429
Trichomonas vaginalis dexras1, putative 0.0287 0.347 0.8647
Loa Loa (eye worm) hypothetical protein 0.0036 0.0059 0.0155
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0096 0.087 0.3997
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0181 0.0425
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0069 0.0501 0.1427
Brugia malayi Ras protein let-60 0.0287 0.347 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0036 0.0059 0.0053
Echinococcus granulosus voltage dependent calcium channel 0.0032 0.0006 0.0006
Brugia malayi Ras-related protein R-Ras2 0.0287 0.347 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0093 0.0829 0.0829
Trichomonas vaginalis ral, putative 0.0287 0.347 0.8647
Mycobacterium tuberculosis Probable dehydrogenase 0.0096 0.087 0.3997
Schistosoma mansoni thyroid hormone receptor 0.0069 0.0501 0.0494
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0069 0.0501 0.1427
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0093 0.0829 0.2376
Loa Loa (eye worm) hypothetical protein 0.0036 0.0059 0.0155
Loa Loa (eye worm) hypothetical protein 0.0032 0.0006 0.0003
Treponema pallidum fructose-bisphosphate aldolase 0.0325 0.3985 0.5
Schistosoma mansoni thyroid hormone receptor 0.0069 0.0501 0.0494
Brugia malayi glutathione reductase 0.0042 0.0137 0.0378
Loa Loa (eye worm) hypothetical protein 0.0036 0.0059 0.0155
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0096 0.087 0.3997
Brugia malayi photoreceptor-specific nuclear receptor 0.0069 0.0501 0.1427
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0017 0.001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0069 0.0501 0.0494
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0069 0.0501 0.0494
Brugia malayi hypothetical protein 0.0036 0.0059 0.0153
Brugia malayi PAS domain containing protein 0.0054 0.0301 0.085
Brugia malayi nuclear hormone receptor 0.0069 0.0501 0.1427
Echinococcus granulosus ras gtpase 0.0287 0.347 0.347
Mycobacterium tuberculosis Conserved hypothetical protein 0.0177 0.1971 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0032 0.0006 0.0003
Schistosoma mansoni DNA topoisomerase type I 0.0155 0.1667 0.1662
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0069 0.0501 0.0494
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0159 0.1724 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0069 0.0501 0.0494
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0017 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.3985 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0325 0.3985 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0017 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0181 0.0425
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0181 0.0425
Brugia malayi polk-prov protein 0.0034 0.0031 0.0072
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0093 0.0829 0.0823
Loa Loa (eye worm) nuclear hormone receptor 0.0032 0.0006 0.0003
Schistosoma mansoni microtubule-associated protein tau 0.0768 1 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0159 0.1724 0.8655
Echinococcus multilocularis transfer RNA-Lys 0.004 0.011 0.0103
Echinococcus multilocularis thioredoxin glutathione reductase 0.0043 0.0145 0.0139
Echinococcus granulosus voltage dependent calcium channel 0.0093 0.0829 0.0829
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0069 0.0501 0.0494
Loa Loa (eye worm) hypothetical protein 0.0069 0.0501 0.1429
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0069 0.0501 0.0494
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0107 0.1016 0.4791
Trypanosoma brucei DNA topoisomerase type IB small subunit 0.0052 0.0271 0.0642
Loa Loa (eye worm) thioredoxin reductase 0.0042 0.0137 0.038
Schistosoma mansoni DNA topoisomerase type I 0.0155 0.1667 0.1662
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0159 0.1727 0.4171
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0069 0.0501 0.1429
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.3985 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0069 0.0501 0.0494
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0069 0.0501 0.0501
Mycobacterium ulcerans hypothetical protein 0.0177 0.1971 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0006 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0069 0.0501 0.1427
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.3985 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0017 0.001
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0159 0.1727 0.4171
Echinococcus multilocularis DNA topoisomerase 1 0.0207 0.2372 0.2368
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0107 0.1016 0.1705
Brugia malayi Pre-SET motif family protein 0.0232 0.2712 0.7812
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0336 0.4132 1
Trypanosoma brucei unspecified product 0.0038 0.0082 0.0185
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0069 0.0501 0.1573
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0069 0.0501 0.0494
Loa Loa (eye worm) hypothetical protein 0.0034 0.0031 0.0074
Brugia malayi bHLH-PAS transcription factor 0.004 0.011 0.0298
Loa Loa (eye worm) hypothetical protein 0.0036 0.0059 0.0155
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0082 0.0185
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0069 0.0501 0.0501
Mycobacterium tuberculosis Probable reductase 0.0096 0.087 0.3997
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0069 0.0501 0.1427
Echinococcus multilocularis FTZ F1 alpha 0.0069 0.0501 0.0494
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0069 0.0501 0.0494
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0069 0.0501 0.0494
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0069 0.0501 0.0501
Brugia malayi hypothetical protein 0.0182 0.2033 0.5851
Onchocerca volvulus 0.0264 0.3147 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0325 0.3985 0.5
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0036 0.0059 0.0059
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0096 0.087 0.3997
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0069 0.0501 0.1429
Loa Loa (eye worm) DR-78 0.0032 0.0006 0.0003
Schistosoma mansoni steroid hormone receptor ad4bp 0.0069 0.0501 0.0494
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0032 0.0006 0.0006
Loa Loa (eye worm) Ras protein let-60 0.0287 0.347 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0069 0.0501 0.1429
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0069 0.0501 0.1427
Loa Loa (eye worm) hypothetical protein 0.0032 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0033 0.0017 0.0032
Loa Loa (eye worm) hypothetical protein 0.0032 0.0006 0.0003
Schistosoma mansoni RAR-like nuclear receptor 0.0069 0.0501 0.0494
Onchocerca volvulus 0.004 0.011 0.0329
Schistosoma mansoni aryl hydrocarbon receptor 0.0054 0.0301 0.0295
Loa Loa (eye worm) hypothetical protein 0.0036 0.0059 0.0155
Echinococcus multilocularis microtubule associated protein 2 0.0768 1 1
Brugia malayi hypoxia-induced factor 1 0.0168 0.1842 0.5299
Plasmodium vivax glutathione reductase, putative 0.0042 0.0137 0.0512
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0069 0.0501 0.1427
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0181 0.0383
Schistosoma mansoni nuclear hormone receptor 0.0069 0.0501 0.0494
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0093 0.0829 0.0823
Loa Loa (eye worm) hypoxia-induced factor 1 0.0168 0.1842 0.53
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0059 0.0053
Brugia malayi nuclear receptor RXR 0.0036 0.0059 0.0153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0069 0.0501 0.1429
Echinococcus granulosus DNA topoisomerase 1 0.0207 0.2372 0.2372
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.3985 1
Trichomonas vaginalis ras-dva small GTPase, putative 0.0287 0.347 0.8647
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0069 0.0501 0.1427
Brugia malayi Steroid receptor seven-up type 2 0.0069 0.0501 0.1427
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0036 0.0059 0.0155
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0006 0.0006
Plasmodium vivax thioredoxin reductase, putative 0.0042 0.0137 0.0512
Toxoplasma gondii thioredoxin reductase 0.0042 0.0137 0.0556
Loa Loa (eye worm) hypothetical protein 0.0069 0.0501 0.1429
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0096 0.087 0.3997
Plasmodium falciparum topoisomerase I 0.0207 0.2372 1
Brugia malayi nuclear receptor NHR-88 0.0069 0.0501 0.1427
Loa Loa (eye worm) hypothetical protein 0.0032 0.0006 0.0003
Schistosoma mansoni voltage-gated cation channel 0.0093 0.0829 0.0823
Echinococcus granulosus FTZ F1 alpha 0.0069 0.0501 0.0501
Schistosoma mansoni coup transcription factor 0.0069 0.0501 0.0494
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0059 0.0153
Loa Loa (eye worm) hypothetical protein 0.0032 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0032 0.0006 0.0003
Echinococcus granulosus dna polymerase kappa 0.0045 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0032 0.0006 0.0003
Brugia malayi hypothetical protein 0.0036 0.0059 0.0153
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0107 0.1016 0.4791
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0181 0.0425
Trichomonas vaginalis rheb, putative 0.0287 0.347 0.8647
Echinococcus granulosus nuclear receptor nhr 48 0.0032 0.0006 0.0006
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.0207 0.0489
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0181 0.0425
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0181 0.0425
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0069 0.0501 0.1429
Onchocerca volvulus 0.0033 0.0017 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0181 0.0425
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0181 0.0425
Loa Loa (eye worm) hypothetical protein 0.0069 0.0501 0.1429
Echinococcus multilocularis dna polymerase kappa 0.0045 0.0181 0.0175
Toxoplasma gondii DNA topoisomerase I, putative 0.0207 0.2372 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0036 0.0059 0.0053
Loa Loa (eye worm) hypothetical protein 0.0032 0.0006 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0069 0.0501 0.1427
Trichomonas vaginalis GTP-binding protein rit, putative 0.0287 0.347 0.8647
Loa Loa (eye worm) hypothetical protein 0.0069 0.0501 0.1429
Schistosoma mansoni DNA topoisomerase type I 0.0207 0.2372 0.2368
Echinococcus granulosus single minded 2 0.004 0.011 0.011
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0181 0.0425
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0069 0.0501 0.0494
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.3985 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.3985 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0069 0.0501 0.0494
Onchocerca volvulus Protein ultraspiracle homolog 0.0069 0.0501 0.1573
Echinococcus multilocularis voltage dependent calcium channel 0.0093 0.0829 0.0823
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0181 0.0425

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = -5.66 Inhibition of [3H]-nitrendipine binding to L-type [Ca2+] channel in rat cortex homogenate, activity expressed as pIC50 ChEMBL. 9016337
Log IC50 (binding) = 5.66 Inhibition of [3H]-nitrendipine binding to L-type [Ca2+] channel in rat cortex homogenate, activity expressed as pIC50 ChEMBL. 9016337

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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