Detailed information for compound 321436

Basic information

Technical information
  • TDR Targets ID: 321436
  • Name: N-(6-pyridin-3-ylfuro[2,3-d]pyrimidin-4-yl)cy clopropanecarboxamide
  • MW: 280.281 | Formula: C15H12N4O2
  • H donors: 1 H acceptors: 4 LogP: 1.5 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CC1)Nc1ncnc2c1cc(o2)c1cccnc1
  • InChi: 1S/C15H12N4O2/c20-14(9-3-4-9)19-13-11-6-12(10-2-1-5-16-7-10)21-15(11)18-8-17-13/h1-2,5-9H,3-4H2,(H,17,18,19,20)
  • InChiKey: WMJDKJPJZVMOIF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[6-(3-pyridyl)furo[2,3-d]pyrimidin-4-yl]cyclopropanecarboxamide
  • N-[6-(3-pyridyl)-4-furo[2,3-d]pyrimidinyl]cyclopropanecarboxamide
  • N-(6-pyridin-3-ylfuro[3,2-e]pyrimidin-4-yl)cyclopropanecarboxamide
  • N-[6-(3-pyridyl)furo[3,2-e]pyrimidin-4-yl]cyclopropanecarboxamide
  • N-[6-(3-pyridyl)-4-furo[3,2-e]pyrimidinyl]cyclopropanecarboxamide
  • 4-Acylamino-6-arylfuro[2,3-d]pyrimidine 19

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin-dependent kinase 3 Starlite/ChEMBL References
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cyclin dependent kinase 0.0053 0.1357 0.1357
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.1357 0.1357
Brugia malayi Protein kinase domain containing protein 0.0053 0.1357 0.1357
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0344 1 1
Leishmania major eukaryotic initiation factor 4a, putative 0.0344 1 1
Echinococcus multilocularis roundabout 2 0.0018 0.0321 0.0321
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0344 1 1
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0059 0.1533 0.0203
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0344 1 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0183 0.5213 0.5213
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0059 0.1533 0.1533
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0344 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0127 0.0127
Onchocerca volvulus 0.0059 0.1533 0.1533
Echinococcus granulosus protein kinase shaggy 0.0059 0.1533 0.1533
Echinococcus multilocularis Immunoglobulin 0.0011 0.0127 0.0127
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0053 0.1357 0.1357
Loa Loa (eye worm) hypothetical protein 0.0015 0.0236 0.0236
Echinococcus multilocularis Immunoglobulin 0.0011 0.0127 0.0127
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.1533 0.1533
Echinococcus granulosus neuroglian 0.0014 0.0212 0.0212
Plasmodium falciparum eukaryotic initiation factor 4A 0.0344 1 1
Schistosoma mansoni nephrin 0.0014 0.0212 0.0212
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.1533 0.0203
Echinococcus granulosus eukaryotic initiation factor 4A 0.0344 1 1
Brugia malayi cell division control protein 2 homolog 0.0053 0.1357 0.1357
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0344 1 1
Trypanosoma brucei protein kinase, putative 0.0059 0.1533 0.0203
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0053 0.1357 0.1357
Brugia malayi hypothetical protein 0.0011 0.0127 0.0127
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0344 1 1
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0344 1 1
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0344 1 1
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.0236 0.0236
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0059 0.1533 0.1533
Plasmodium vivax RNA helicase-1, putative 0.0344 1 1
Echinococcus multilocularis neuroglian 0.0014 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0011 0.0127 0.0127
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.1533 0.1533
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0344 1 1
Schistosoma mansoni vesicular amine transporter 0.0011 0.0127 0.0127
Loa Loa (eye worm) hypothetical protein 0.0011 0.0127 0.0127
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0059 0.1533 0.0203
Brugia malayi Immunoglobulin I-set domain containing protein 0.0183 0.5213 0.5213
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.1357 0.1357
Echinococcus granulosus defective proboscis extension response 0.0011 0.0127 0.0127
Loa Loa (eye worm) hypothetical protein 0.0344 1 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.1357 0.1357
Plasmodium vivax glycogen synthase kinase 3, putative 0.0059 0.1533 0.0203
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.1533 0.0203
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0011 0.0127 0.0127
Loa Loa (eye worm) hypothetical protein 0.0011 0.0127 0.0127
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.1357 0.1357
Loa Loa (eye worm) hypothetical protein 0.0011 0.0127 0.0127
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0344 1 1
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0344 1 1
Echinococcus multilocularis cyclin dependent kinase 0.0053 0.1357 0.1357
Loa Loa (eye worm) hypothetical protein 0.0011 0.0127 0.0127
Giardia lamblia Kinase, CMGC GSK 0.0059 0.1533 0.0203
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0011 0.0127 0.0127
Treponema pallidum ATP-dependent RNA helicase 0.0344 1 0.5
Echinococcus multilocularis cyclin dependent kinase 5 0.0053 0.1357 0.1357
Brugia malayi intracellular kinase 0.0059 0.1533 0.1533
Loa Loa (eye worm) hypothetical protein 0.0052 0.1324 0.1324
Echinococcus granulosus cyclin dependent kinase 5 0.0053 0.1357 0.1357
Mycobacterium ulcerans hypothetical protein 0.0007 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0018 0.0321 0.0321
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0059 0.1533 0.1533
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.1357 0.1357
Leishmania major eukaryotic initiation factor 4a, putative 0.0344 1 1
Echinococcus multilocularis protein kinase shaggy 0.0059 0.1533 0.1533
Brugia malayi Fibronectin type III domain containing protein 0.0011 0.0127 0.0127
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.1533 0.0203
Entamoeba histolytica protein kinase, putative 0.0059 0.1533 0.0203
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0127 0.0127
Schistosoma mansoni tyrosine kinase 0.0008 0.0018 0.0018
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0011 0.0127 0.0127
Echinococcus granulosus Immunoglobulin 0.0011 0.0127 0.0127
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0344 1 1
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0344 1 1
Schistosoma mansoni cell adhesion molecule 0.0015 0.0236 0.0236
Echinococcus granulosus roundabout 2 0.0018 0.0321 0.0321
Onchocerca volvulus 0.0167 0.4741 0.4741
Plasmodium falciparum glycogen synthase kinase 3 0.0059 0.1533 0.0203
Onchocerca volvulus Tyrosine kinase homolog 0.0171 0.4856 0.4856
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0059 0.1533 0.0203
Echinococcus granulosus twitchin 0.0015 0.0245 0.0245
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.1533 0.0203
Loa Loa (eye worm) hypothetical protein 0.0018 0.0321 0.0321
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.1357 0.1357
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0008 0.0021 0.0021
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0344 1 1
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0344 1 0.5
Echinococcus granulosus cyclin dependent kinase 1 0.0053 0.1357 0.1357
Giardia lamblia Kinase, CMGC GSK 0.0059 0.1533 0.0203
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0344 1 1

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.74 uM Potency of compound in glycogen accumulation in L6 cells ChEMBL. 15225695
IC50 (binding) = 0.005 uM Inhibition of human Glycogen synthase kinase-3 beta ChEMBL. 15225695
IC50 (binding) = 0.005 uM Inhibition of human Glycogen synthase kinase-3 beta ChEMBL. 15225695
IC50 (binding) = 0.44 uM Inhibition of cyclin-dependent kinase 2 ChEMBL. 15225695
IC50 (binding) = 0.44 uM Inhibition of cyclin-dependent kinase 2 ChEMBL. 15225695
IC50 (binding) = 3.24 uM Inhibiion of Vascular endothelial growth factor receptor 2 kinase ChEMBL. 15225695
IC50 (binding) = 3.24 uM Inhibiion of Vascular endothelial growth factor receptor 2 kinase ChEMBL. 15225695

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.