Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 13 (collagenase 3) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | References |
Homo sapiens | ADAM metallopeptidase domain 17 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus granulosus | adam 17 protease | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus multilocularis | adam 17 protease | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Schistosoma japonicum | ko:K06059 a disintegrin and metalloproteinase domain 17, putative | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Disintegrin family protein | ADAM metallopeptidase domain 17 | 824 aa | 724 aa | 27.4 % |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 13 (collagenase 3) | 471 aa | 448 aa | 34.1 % |
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Dual oxidase homolog | 0.0522 | 1 | 1 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0169 | 0.1282 | 0.1049 |
Brugia malayi | Blistered cuticle protein 3 | 0.0522 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1282 | 0.1282 |
Onchocerca volvulus | 0.0522 | 1 | 1 | |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0223 | 0.2619 | 0.1534 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0522 | 1 | 1 |
Onchocerca volvulus | 0.0522 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1282 | 0.1282 |
Echinococcus granulosus | protein jagged 2 | 0.0169 | 0.1282 | 0.0754 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1282 | 0.1282 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 1 | 1 |
Echinococcus granulosus | protein jagged 2 | 0.0169 | 0.1282 | 0.0754 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0169 | 0.1282 | 0.5 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0169 | 0.1282 | 0.0754 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0169 | 0.1282 | 0.0754 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1282 | 0.1282 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1282 | 0.1282 |
Echinococcus granulosus | adam 17 protease | 0.0245 | 0.3167 | 0.2754 |
Echinococcus granulosus | slit 2 protein | 0.0169 | 0.1282 | 0.0754 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1282 | 0.1282 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0522 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0522 | 1 | 1 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0169 | 0.1282 | 0.0754 |
Onchocerca volvulus | 0.0169 | 0.1282 | 0.1282 | |
Echinococcus multilocularis | slit 2 protein | 0.0169 | 0.1282 | 0.0754 |
Onchocerca volvulus | 0.0169 | 0.1282 | 0.1282 | |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1282 | 0.1282 |
Brugia malayi | EGF-like domain containing protein | 0.0169 | 0.1282 | 0.1049 |
Onchocerca volvulus | Slit protein homolog | 0.0169 | 0.1282 | 0.1282 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0169 | 0.1282 | 0.0754 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0522 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0522 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0522 | 1 | 1 |
Echinococcus multilocularis | notch | 0.0169 | 0.1282 | 0.0754 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0522 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1282 | 0.1282 |
Brugia malayi | Peroxidasin | 0.0522 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1282 | 0.1282 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1282 | 0.1282 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1282 | 0.1282 |
Onchocerca volvulus | 0.0169 | 0.1282 | 0.1282 | |
Onchocerca volvulus | 0.0169 | 0.1282 | 0.1282 | |
Echinococcus granulosus | notch | 0.0169 | 0.1282 | 0.0754 |
Echinococcus granulosus | peroxidasin | 0.0522 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0169 | 0.1282 | 0.1049 |
Onchocerca volvulus | Putative cubilin | 0.0169 | 0.1282 | 0.1282 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0169 | 0.1282 | 0.1049 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0522 | 1 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0169 | 0.1282 | 0.1049 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1282 | 0.1282 |
Echinococcus multilocularis | neural cadherin | 0.0169 | 0.1282 | 0.0754 |
Onchocerca volvulus | 0.0169 | 0.1282 | 0.1282 | |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0169 | 0.1282 | 0.1049 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0169 | 0.1282 | 0.1049 |
Brugia malayi | Animal haem peroxidase family protein | 0.0522 | 1 | 1 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0169 | 0.1282 | 0.1049 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0522 | 1 | 1 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0169 | 0.1282 | 0.0754 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 1 | 1 |
Brugia malayi | Muscle positioning protein 4 | 0.0169 | 0.1282 | 0.1049 |
Brugia malayi | EGF-like domain containing protein | 0.0169 | 0.1282 | 0.1049 |
Onchocerca volvulus | Peroxidase homolog | 0.0522 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0522 | 1 | 1 |
Loa Loa (eye worm) | Notch2 | 0.0169 | 0.1282 | 0.1282 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1282 | 0.1282 |
Giardia lamblia | High cysteine protein | 0.0169 | 0.1282 | 0.5 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0169 | 0.1282 | 0.0754 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0169 | 0.1282 | 0.0754 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1282 | 0.1282 |
Onchocerca volvulus | Peroxidasin homolog | 0.0522 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1282 | 0.1282 |
Brugia malayi | notch-like transmembrane receptor | 0.0169 | 0.1282 | 0.1049 |
Brugia malayi | EGF-like domain containing protein | 0.0169 | 0.1282 | 0.1049 |
Echinococcus granulosus | neural cadherin | 0.0169 | 0.1282 | 0.0754 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1282 | 0.1282 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1282 | 0.1282 |
Loa Loa (eye worm) | hypothetical protein | 0.0468 | 0.8675 | 0.8675 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1282 | 0.1282 |
Onchocerca volvulus | Peroxidasin homolog | 0.0522 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1282 | 0.1282 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1282 | 0.1282 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0169 | 0.1282 | 0.0754 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 1 | 1 |
Echinococcus granulosus | fibropellin Ia | 0.0169 | 0.1282 | 0.0754 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1282 | 0.1282 |
Brugia malayi | Animal haem peroxidase family protein | 0.0522 | 1 | 1 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0169 | 0.1282 | 0.1282 |
Echinococcus multilocularis | adam 17 protease | 0.0223 | 0.2619 | 0.2172 |
Echinococcus granulosus | delta-like protein 1 | 0.0169 | 0.1282 | 0.0754 |
Brugia malayi | Cadherin domain containing protein | 0.0169 | 0.1282 | 0.1049 |
Brugia malayi | EGF-like domain containing protein | 0.0169 | 0.1282 | 0.1049 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0191 | 0.1841 | 0.1347 |
Echinococcus multilocularis | protein jagged 1 | 0.0169 | 0.1282 | 0.0754 |
Echinococcus multilocularis | fibropellin Ia | 0.0169 | 0.1282 | 0.0754 |
Echinococcus multilocularis | protein jagged 2 | 0.0169 | 0.1282 | 0.0754 |
Echinococcus granulosus | protein jagged 1 | 0.0169 | 0.1282 | 0.0754 |
Brugia malayi | EGF-like domain containing protein | 0.0169 | 0.1282 | 0.1049 |
Brugia malayi | Cadherin domain containing protein | 0.0169 | 0.1282 | 0.1049 |
Onchocerca volvulus | Peroxidase homolog | 0.0522 | 1 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0191 | 0.1841 | 0.1347 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0522 | 1 | 1 |
Echinococcus granulosus | protein jagged 1 | 0.0169 | 0.1282 | 0.0754 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1282 | 0.1282 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0169 | 0.1282 | 0.0754 |
Onchocerca volvulus | 0.0522 | 1 | 1 | |
Loa Loa (eye worm) | matrixin family protein | 0.0127 | 0.026 | 0.026 |
Loa Loa (eye worm) | notch protein | 0.0169 | 0.1282 | 0.1282 |
Echinococcus multilocularis | peroxidasin | 0.0522 | 1 | 1 |
Brugia malayi | Delta serrate ligand family protein | 0.0169 | 0.1282 | 0.1049 |
Echinococcus multilocularis | protein jagged 1 | 0.0169 | 0.1282 | 0.0754 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0169 | 0.1282 | 0.0754 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0169 | 0.1282 | 0.1282 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 41 nM | Inhibitory activity against Tumor necrosis factor alpha converting enzyme | ChEMBL. | 15261259 |
IC50 (binding) | = 41 nM | Inhibitory activity against Tumor necrosis factor alpha converting enzyme | ChEMBL. | 15261259 |
IC50 (binding) | = 42 nM | In vitro inhibitory activity against matrix metalloproteinase-13 | ChEMBL. | 15261259 |
IC50 (binding) | = 42 nM | In vitro inhibitory activity against matrix metalloproteinase-13 | ChEMBL. | 15261259 |
IC50 (binding) | = 813 nM | In vitro inhibitory activity against matrix metalloproteinase-1 | ChEMBL. | 15261259 |
IC50 (binding) | = 813 nM | In vitro inhibitory activity against matrix metalloproteinase-1 | ChEMBL. | 15261259 |
Inhibition (functional) | = 64 % | Ability of the compound to inhibit LPS-stimulated TNF production in THP-1 cells at 3 uM concentration | ChEMBL. | 15261259 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.