TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 261.704 | Formula: C14H12ClNO2
H donors: 2 H acceptors: 2 LogP: 4.16 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: O/N=C(/c1cc(C)ccc1O)\c1ccc(cc1)Cl
InChi: 1S/C14H12ClNO2/c1-9-2-7-13(17)12(8-9)14(16-18)10-3-5-11(15)6-4-10/h2-8,17-18H,1H3/b16-14+
InChiKey: LCTYUYIQNJOJKI-JQIJEIRASA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative	0.0032	0.0104	0.0045
Mycobacterium tuberculosis	Possible maturase	0.0032	0.0104	0.027
Mycobacterium leprae	Probable lipase LipE	0.0039	0.0157	0.8833
Brugia malayi	Zinc knuckle family protein	0.0032	0.0104	0.0105
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.0157	0.0227
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0597	0.4177	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0157	0.0227
Mycobacterium tuberculosis	Possible oxidoreductase	0.0042	0.0178	0.046
Trichomonas vaginalis	reverse transcriptases, putative	0.0032	0.0104	0.0406
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0157	0.0611
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0042	0.0178	0.0353
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0042	0.0178	1
Mycobacterium ulcerans	beta-lactamase	0.0039	0.0157	0.0377
Plasmodium falciparum	protoporphyrinogen oxidase	0.0042	0.0178	0.1093
Onchocerca volvulus		0.0039	0.0157	0.0214
Echinococcus granulosus	importin subunit beta 1	0.003	0.0089	0.0177
Leishmania major	hypothetical protein, conserved	0.0039	0.0157	0.043
Trichomonas vaginalis	conserved hypothetical protein	0.0176	0.1146	0.4449
Brugia malayi	reverse transcriptase	0.0032	0.0104	0.0105
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0042	0.0178	0.1093
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0.0157	0.0377
Echinococcus granulosus	KRAB A domain containing protein	0.0032	0.0104	0.0207
Onchocerca volvulus		0.0042	0.0178	0.0298
Giardia lamblia	Macrophage migration inhibitory factor	0.0176	0.1146	0.4214
Brugia malayi	Pao retrotransposon peptidase family protein	0.0032	0.0104	0.0105
Schistosoma mansoni	hypothetical protein	0.0032	0.0104	0.0104
Mycobacterium ulcerans	lipase LipD	0.0039	0.0157	0.0377
Mycobacterium ulcerans	monoamine oxidase	0.0042	0.0178	0.0426
Schistosoma mansoni	phosphoglucomutase	0.0374	0.2575	0.2575
Toxoplasma gondii	macrophage migration inhibitory factor, putative	0.0176	0.1146	0.4318
Trichomonas vaginalis	macrophage migration inhibitory factor, mif, putative	0.0176	0.1146	0.4449
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0157	0.0227
Schistosoma mansoni	phosphoglucomutase	0.0374	0.2575	0.2575
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0104	0.0104
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.0157	0.0312
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0157	0.0406
Schistosoma mansoni	jumonji/arid domain-containing protein	0.006	0.0305	0.0305
Schistosoma mansoni	phosphoglucomutase	0.0374	0.2575	0.2575
Trypanosoma brucei	ingi protein (ORF1)	0.0406	0.2804	0.2761
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0178	0.0276
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0317	0.2159	0.4877
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0032	0.0104	0.0207
Schistosoma mansoni	importin beta-1	0.003	0.0089	0.0089
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0032	0.0104	0.0207
Trypanosoma brucei	retrotransposon hot spot protein 4 (RHS4), interrupted	0.0406	0.2804	0.2761
Schistosoma mansoni	hypothetical protein	0.0032	0.0104	0.0104
Brugia malayi	Pao retrotransposon peptidase family protein	0.0032	0.0104	0.0105
Trypanosoma brucei	SLACS retrotransposable element (part), putative	0.0032	0.0104	0.0045
Mycobacterium ulcerans	dehydrogenase	0.0042	0.0178	0.0426
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0042	0.0178	0.1093
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.006	0.0305	0.0605
Brugia malayi	amine oxidase, flavin-containing family protein	0.0042	0.0178	0.0276
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0042	0.0178	0.0353
Toxoplasma gondii	ribonuclease HI protein	0.0374	0.2575	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0039	0.0157	0.0406
Echinococcus multilocularis		0.0042	0.0178	0.0353
Trypanosoma cruzi	ribonuclease H1, putative	0.0374	0.2575	1
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0042	0.0178	0.0512
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.0157	0.8833
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0089	0.0118
Loa Loa (eye worm)	macrophage migration inhibitory factor 2	0.0075	0.0417	0.0831
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0032	0.0104	0.0207
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.0157	0.0312
Brugia malayi	Pao retrotransposon peptidase family protein	0.0032	0.0104	0.0105
Leishmania major	macrophage migration inhibitory factor-like protein	0.0176	0.1146	0.4342
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0059	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0157	0.0227
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.0049	0.0189
Echinococcus multilocularis	lysine specific demethylase 5A	0.006	0.0305	0.0605
Trypanosoma brucei	unspecified product	0.0406	0.2804	0.2761
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.006	0.0305	0.0605
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0157	0.0227
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0157	0.0406
Schistosoma mansoni	hypothetical protein	0.036	0.2473	0.2473
Brugia malayi	Pao retrotransposon peptidase family protein	0.0032	0.0104	0.0105
Brugia malayi	RNA, U transporter 1	0.0084	0.0484	0.0985
Brugia malayi	hypothetical protein	0.0032	0.0104	0.0105
Brugia malayi	Pao retrotransposon peptidase family protein	0.0032	0.0104	0.0105
Brugia malayi	RNase H family protein	0.0374	0.2575	0.5842
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0032	0.0104	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0157	0.0227
Brugia malayi	hypothetical protein	0.0032	0.0104	0.0105
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0059	0.0043
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0032	0.0104	0.0207
Mycobacterium tuberculosis	Probable oxidoreductase	0.027	0.1825	0.4711
Onchocerca volvulus		0.0039	0.0157	0.0214
Toxoplasma gondii	histone lysine-specific demethylase	0.0042	0.0178	0.0472
Brugia malayi	RNase H family protein	0.0374	0.2575	0.5842
Schistosoma mansoni	protein kinase	0.0032	0.0104	0.0104
Trichomonas vaginalis	reverse transcriptase [C. elegans], putative	0.0032	0.0104	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0178	0.0276
Brugia malayi	jmjC domain containing protein	0.006	0.0305	0.0571
Echinococcus granulosus	geminin	0.036	0.2473	0.4901
Giardia lamblia	Ribonuclease H	0.0374	0.2575	1
Brugia malayi	Pao retrotransposon peptidase family protein	0.0032	0.0104	0.0105
Schistosoma mansoni	hypothetical protein	0.0317	0.2159	0.2159
Loa Loa (eye worm)	beta-lactamase	0.0039	0.0157	0.0227
Brugia malayi	hypothetical protein	0.0032	0.0104	0.0105
Brugia malayi	Pao retrotransposon peptidase family protein	0.0032	0.0104	0.0105
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0157	0.0611
Mycobacterium tuberculosis	Probable lipase LipE	0.0039	0.0157	0.0406
Mycobacterium tuberculosis	Probable lipase LipD	0.0039	0.0157	0.0406
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0157	0.0157
Plasmodium vivax	macrophage migration inhibitory factor, putative	0.0176	0.1146	1
Trypanosoma brucei	ingi protein (ORF1)	0.0406	0.2804	0.2761
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0039	0.0157	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0623	0.4366	1
Plasmodium falciparum	importin beta, putative	0.003	0.0089	0.0274
Brugia malayi	reverse transcriptase	0.0032	0.0104	0.0105
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0042	0.0178	0.1093
Trypanosoma brucei	SLACS reverse transcriptase, putative	0.0032	0.0104	0.0045
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0042	0.0178	0.0353
Loa Loa (eye worm)	hypothetical protein	0.003	0.0089	0.0069
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.0157	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0178	0.0276
Brugia malayi	Muscleblind-like protein	0.0623	0.4366	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0157	0.043
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0597	0.4177	1
Plasmodium falciparum	macrophage migration inhibitory factor	0.0176	0.1146	1
Brugia malayi	hypothetical protein	0.0032	0.0104	0.0105
Loa Loa (eye worm)	macrophage migration inhibitory factor 2	0.0075	0.0417	0.0831
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0039	0.0157	0.0406
Brugia malayi	beta-lactamase family protein	0.0039	0.0157	0.0227
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.0157	0.0098
Echinococcus multilocularis	ribonuclease H1	0.0374	0.2575	0.5104
Leishmania major	UDP-galactopyranose mutase	0.0042	0.0178	0.0512
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0157	0.0611
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0042	0.0178	0.0426
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0049	0.0189
Brugia malayi	Pao retrotransposon peptidase family protein	0.0032	0.0104	0.0105
Mycobacterium tuberculosis	Probable esterase LipL	0.0039	0.0157	0.0406
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0157	0.0406
Trichomonas vaginalis	ribonuclease H1, putative	0.0374	0.2575	1
Echinococcus granulosus	muscleblind protein	0.0623	0.4366	0.8652
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0032	0.0104	0.0207
Plasmodium vivax	importin-beta 2, putative	0.003	0.0089	0.0274
Brugia malayi	Pao retrotransposon peptidase family protein	0.0032	0.0104	0.0105
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0042	0.0178	0.0472
Trichomonas vaginalis	reverse transcriptases, putative	0.0032	0.0104	0.0406
Trypanosoma cruzi	ribonuclease H1, putative	0.0374	0.2575	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.025	0.1678	0.4331
Mycobacterium tuberculosis	Probable hydrolase	0.0039	0.0157	0.0406
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0032	0.0104	0.0207
Brugia malayi	Zinc knuckle family protein	0.0032	0.0104	0.0105
Schistosoma mansoni	jumonji/arid domain-containing protein	0.006	0.0305	0.0305
Wolbachia endosymbiont of Brugia malayi	ribonuclease HI	0.0374	0.2575	1
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.0178	0.1093
Echinococcus granulosus	lysine specific demethylase 5A	0.006	0.0305	0.0605
Trypanosoma brucei	RNA helicase, putative	0.1404	1	1
Brugia malayi	reverse transcriptase	0.0032	0.0104	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0178	0.0276
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0157	0.043
Loa Loa (eye worm)	macrophage migration inhibitory factor	0.0176	0.1146	0.2522
Echinococcus granulosus	RNA directed DNA polymerase	0.0032	0.0104	0.0207
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0157	0.0611
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0042	0.0178	0.0512
Brugia malayi	beta-lactamase	0.0039	0.0157	0.0227
Trichomonas vaginalis	NeSL-1_NeSL reverse transcriptases, putative	0.0032	0.0104	0.0406
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0089	0.003
Loa Loa (eye worm)	hypothetical protein	0.0623	0.4366	1
Leishmania major	macrophage migration inhibitory factor-like protein	0.0176	0.1146	0.4342
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0042	0.0178	0.0178
Schistosoma mansoni	scy1(yeast) protein kinase-like	0.0032	0.0104	0.0104
Schistosoma mansoni	amine oxidase	0.0042	0.0178	0.0178
Mycobacterium ulcerans	short chain dehydrogenase	0.027	0.1825	0.4369
Leishmania major	ribonuclease H1, putative	0.0374	0.2575	1
Onchocerca volvulus		0.0039	0.0157	0.0214
Echinococcus granulosus	ribonuclease H1	0.0374	0.2575	0.5104
Schistosoma mansoni	hypothetical protein	0.036	0.2473	0.2473
Echinococcus multilocularis	snurportin 1	0.0317	0.2159	0.428
Brugia malayi	Pao retrotransposon peptidase family protein	0.0032	0.0104	0.0105
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0157	0.0611
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0042	0.0178	0.5
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0178	0.0276
Brugia malayi	SWIRM domain containing protein	0.0042	0.0178	0.0276
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0042	0.0178	0.0353
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0089	0.0177
Brugia malayi	jmjC domain containing protein	0.006	0.0305	0.0571
Schistosoma mansoni	microtubule-associated protein tau	0.0717	0.5046	0.5046
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0032	0.0104	0.0207
Brugia malayi	hypothetical protein	0.0042	0.0178	0.0276
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.0157	0.0901
Brugia malayi	Pao retrotransposon peptidase family protein	0.0032	0.0104	0.0105
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0042	0.0178	0.0178
Brugia malayi	Pao retrotransposon peptidase family protein	0.0032	0.0104	0.0105
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0032	0.0104	0.0207
Mycobacterium ulcerans	esterase/lipase LipP	0.0039	0.0157	0.0377
Leishmania major	hypothetical protein, conserved	0.0026	0.0059	0.0043
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0032	0.0104	0.0207
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0042	0.0178	0.1093
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0157	0.0227
Trypanosoma brucei	hypothetical protein, conserved	0.0406	0.2804	0.2761
Brugia malayi	Pao retrotransposon peptidase family protein	0.0032	0.0104	0.0105
Trichomonas vaginalis	esterase, putative	0.0039	0.0157	0.0611
Schistosoma mansoni	amine oxidase	0.0042	0.0178	0.0178
Toxoplasma gondii	ABC1 family protein	0.0039	0.0157	0.0389
Loa Loa (eye worm)	jmjC domain-containing protein	0.006	0.0305	0.0571
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.0178	0.1093
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0157	0.0377
Entamoeba histolytica	macrophage migration inhibitory factor-like protein	0.0176	0.1146	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0049	0.0189
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0032	0.0104	0.0207
Echinococcus multilocularis	microtubule associated protein 2	0.0717	0.5046	1
Echinococcus granulosus	microtubule associated protein 2	0.0717	0.5046	1
Schistosoma mansoni	jumonji domain containing protein	0.006	0.0305	0.0305
Echinococcus multilocularis	muscleblind protein 1	0.0623	0.4366	0.8652
Echinococcus multilocularis	RNA directed DNA polymerase	0.0032	0.0104	0.0207
Brugia malayi	RNase H family protein	0.0374	0.2575	0.5842
Echinococcus multilocularis	geminin	0.036	0.2473	0.4901
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0042	0.0178	0.046
Echinococcus granulosus	snurportin 1	0.0317	0.2159	0.428
Trypanosoma cruzi	hypothetical protein, conserved	0.0032	0.0104	0.0221
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0157	0.0157
Onchocerca volvulus	Ribonuclease H1 homolog	0.0374	0.2575	1
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0032	0.0104	0.0207
Echinococcus multilocularis	muscleblind protein	0.0623	0.4366	0.8652
Brugia malayi	beta-lactamase family protein	0.0039	0.0157	0.0227
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0089	0.003
Treponema pallidum	ribonuclease H (rnhA)	0.0374	0.2575	1
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0032	0.0104	0.0207
Brugia malayi	Bm-MIF-1, identical	0.0176	0.1146	0.2522
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0178	0.0276
Trypanosoma brucei	ribonuclease H1	0.0374	0.2575	0.2531
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0555	0.3874	1
Mycobacterium ulcerans	oxidoreductase	0.0042	0.0178	0.0426
Brugia malayi	Importin beta-1 subunit	0.003	0.0089	0.0069
Brugia malayi	Pao retrotransposon peptidase family protein	0.0032	0.0104	0.0105
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0032	0.0104	0.0207

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 25 %	Inhibition of histamine release from sensitized guinea pig chopped lung upon antigen challenge at 10 ug/mL.	ChEMBL.	3612683
Inhibition (functional)	= 32 %	Inhibition of slow reacting substance of anaphylaxis (SRS-A) release from sensitized guinea pig chopped lung upon antigen challenge at 10 ug/mL	ChEMBL.	3612683
Inhibition (functional)	= 40 %	Inhibition of slow reacting substance of anaphylaxis (SRS-A) release from sensitized guinea pig chopped lung upon antigen challenge at 10 ug/mL	ChEMBL.	3612683
Inhibition (functional)	= 59 %	Inhibition of histamine release from sensitized guinea pig chopped lung upon antigen challenge at 10 ug/mL.	ChEMBL.	3612683

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL441509

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 32629