Detailed information for compound 328818

Basic information

Technical information
  • TDR Targets ID: 328818
  • Name: 2-[(2R)-1-(3,4-dichlorophenyl)sulfonyl-3-oxo- 2,4-dihydroquinoxalin-2-yl]-N-[2-(4-imidazol- 1-ylphenyl)ethyl]acetamide
  • MW: 584.474 | Formula: C27H23Cl2N5O4S
  • H donors: 2 H acceptors: 5 LogP: 3.85 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(C[C@@H]1C(=O)Nc2c(N1S(=O)(=O)c1ccc(c(c1)Cl)Cl)cccc2)NCCc1ccc(cc1)n1ccnc1
  • InChi: 1S/C27H23Cl2N5O4S/c28-21-10-9-20(15-22(21)29)39(37,38)34-24-4-2-1-3-23(24)32-27(36)25(34)16-26(35)31-12-11-18-5-7-19(8-6-18)33-14-13-30-17-33/h1-10,13-15,17,25H,11-12,16H2,(H,31,35)(H,32,36)/t25-/m1/s1
  • InChiKey: IHBZNHPRUWQCCD-RUZDIDTESA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(2R)-1-(3,4-dichlorophenyl)sulfonyl-3-oxo-2,4-dihydroquinoxalin-2-yl]-N-[2-[4-(1-imidazolyl)phenyl]ethyl]acetamide
  • 2-[(2R)-1-(3,4-dichlorophenyl)sulfonyl-3-oxo-2,4-dihydroquinoxalin-2-yl]-N-[2-(4-imidazol-1-ylphenyl)ethyl]ethanamide
  • 2-[(2R)-1-(3,4-dichlorophenyl)sulfonyl-3-keto-2,4-dihydroquinoxalin-2-yl]-N-[2-(4-imidazol-1-ylphenyl)ethyl]acetamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens bradykinin receptor B1 Starlite/ChEMBL References
Homo sapiens bradykinin receptor B2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus pyroglutamylated rfamide peptide receptor bradykinin receptor B2 391 aa 354 aa 19.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0562 0.213
Brugia malayi Papain family cysteine protease containing protein 0.0101 0.0678 0.0664
Loa Loa (eye worm) hypothetical protein 0.0071 0.0392 0.0392
Plasmodium vivax vivapain-1 0.0056 0.0259 0.3639
Echinococcus granulosus cathepsin b 0.0304 0.2565 0.8451
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Echinococcus multilocularis g protein coupled receptor 0.0054 0.0237 0.0355
Schistosoma mansoni opsin-like receptor 0.0054 0.0237 0.0851
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0678 0.8336
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0237 0.0851
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0678 0.8336
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Loa Loa (eye worm) calpain family protein 1 0.0084 0.0515 0.0515
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0119 0.0842 0.2461
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0054 0.0237 0.0355
Echinococcus multilocularis neuropeptide s receptor 0.0054 0.0237 0.0355
Echinococcus granulosus cathepsin L cysteine proteinase 0.0101 0.0678 0.1888
Trypanosoma cruzi cysteine peptidase, putative 0.0031 0.002 0.0022
Echinococcus multilocularis G-protein coupled receptor, putative 0.0054 0.0237 0.0355
Brugia malayi cathepsin B-like cysteine proteinase 0.0304 0.2565 0.2554
Trypanosoma cruzi cysteine protease, putative 0.0056 0.0259 0.096
Schistosoma mansoni histamine h1 receptor 0.0054 0.0237 0.0851
Echinococcus multilocularis neuropeptide Y receptor 0.0054 0.0237 0.0355
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.031 0.031
Entamoeba histolytica cysteine protease, putative 0.0056 0.0259 0.3693
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0054 0.0237 0.0851
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.0678 0.8714
Echinococcus granulosus neuropeptide Y receptor 0.0054 0.0237 0.0355
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0562 0.1486
Echinococcus multilocularis cathepsin b 0.0304 0.2565 0.8451
Onchocerca volvulus 0.0071 0.0395 0.3584
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0054 0.0237 0.0355
Schistosoma mansoni hypothetical protein 0.0054 0.0237 0.0851
Echinococcus multilocularis g protein coupled receptor 0.0054 0.0237 0.0355
Leishmania major cathepsin L-like protease 0.0101 0.0678 0.8714
Brugia malayi Dopamine receptor protein 1 0.0054 0.0237 0.0223
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0678 0.8336
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0678 0.8336
Brugia malayi RNA binding protein 0.0062 0.031 0.0296
Loa Loa (eye worm) hypothetical protein 0.0049 0.0188 0.0188
Schistosoma mansoni biogenic amine receptor 0.0054 0.0237 0.0851
Loa Loa (eye worm) hypothetical protein 0.0031 0.002 0.002
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0562 0.0548
Schistosoma mansoni amine GPCR 0.0054 0.0237 0.0851
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0054 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0678 0.8336
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Trypanosoma cruzi cysteine proteinase, putative 0.0056 0.0259 0.096
Schistosoma mansoni cathepsin D (A01 family) 0.0143 0.107 0.4125
Echinococcus granulosus cathepsin L cysteine protease 0.0056 0.0259 0.0434
Brugia malayi hypothetical protein 0.0054 0.0237 0.0223
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0237 0.0355
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.0678 0.8336
Brugia malayi hypothetical protein 0.0054 0.0237 0.0223
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0043 0.0135 0.0471
Loa Loa (eye worm) neuropeptide F receptor 0.0054 0.0237 0.0237
Echinococcus granulosus 7tm_1 domain containing protein 0.0054 0.0237 0.0355
Echinococcus granulosus cathepsin b 0.0304 0.2565 0.8451
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Echinococcus granulosus neuropeptides capa receptor 0.0054 0.0237 0.0355
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0054 0.0237 0.0355
Schistosoma mansoni neuropeptide receptor 0.0054 0.0237 0.0851
Onchocerca volvulus Cathepsin L homolog 0.0101 0.0678 1
Onchocerca volvulus 0.0101 0.0678 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0112 0.0775 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0392 0.3484
Brugia malayi Tachykinin-like peptides receptor 99D 0.0054 0.0237 0.0223
Plasmodium vivax vivapain-3 0.0056 0.0259 0.3639
Echinococcus granulosus sex peptide receptor 0.0054 0.0237 0.0355
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0054 0.0237 0.0355
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0054 0.0237 0.0851
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.0678 0.8714
Echinococcus granulosus tar DNA binding protein 0.0062 0.031 0.061
Echinococcus multilocularis cathepsin b 0.0304 0.2565 0.8451
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.0678 0.8714
Plasmodium falciparum cysteine proteinase falcipain 1 0.0056 0.0259 0.1464
Leishmania major cathepsin L-like protease 0.0101 0.0678 0.8714
Echinococcus granulosus calpain A 0.0119 0.0842 0.2461
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0054 0.0237 0.0355
Echinococcus multilocularis Tolloid protein 1 0.0046 0.0159 0.0085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0259 0.3219
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.0678 0.8336
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0054 0.0237 0.0851
Brugia malayi Cathepsin L-like precursor 0.0101 0.0678 0.0664
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0049 0.0188 0.0185
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0562 0.213
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0054 0.0237 0.0851
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Entamoeba histolytica cysteine protease, putative 0.0056 0.0259 0.3693
Echinococcus granulosus biogenic amine 5HT receptor 0.0054 0.0237 0.0355
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.0678 0.8336
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0054 0.0237 0.0355
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.0678 0.8336
Schistosoma mansoni neuropeptide receptor 0.0054 0.0237 0.0851
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Brugia malayi Cathepsin L-like precursor 0.0101 0.0678 0.0664
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0259 0.3219
Brugia malayi G-protein coupled receptor 0.0054 0.0237 0.0223
Echinococcus multilocularis g-protein coupled receptor 0.0054 0.0237 0.0355
Loa Loa (eye worm) hypothetical protein 0.0071 0.0392 0.0392
Schistosoma mansoni cathepsin D (A01 family) 0.0143 0.107 0.4125
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0101 0.0678 1
Echinococcus granulosus cathepsin l1 0.0101 0.0678 0.1888
Schistosoma mansoni opsin-like receptor 0.0054 0.0237 0.0851
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0031 0.002 0.002
Echinococcus multilocularis cathepsin L 0.0056 0.0259 0.0434
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0043 0.0135 0.0471
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0101 0.0678 0.0678
Echinococcus multilocularis fmrfamide receptor 0.0054 0.0237 0.0355
Echinococcus multilocularis orexin receptor type 2 0.0054 0.0237 0.0355
Schistosoma mansoni cathepsin F (C01 family) 0.0071 0.0392 0.1463
Leishmania major cysteine peptidase A (CPA) 0.0101 0.0678 0.8714
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0678 0.8336
Echinococcus granulosus dro:myosuppressin receptor 0.0054 0.0237 0.0355
Schistosoma mansoni tar DNA-binding protein 0.0062 0.031 0.1139
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0237 0.0355
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.0678 0.8714
Echinococcus granulosus cathepsin l cysteine peptidase 0.0101 0.0678 0.1888
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Brugia malayi putative neuropeptide receptor NPR1 0.0054 0.0237 0.0223
Loa Loa (eye worm) hypothetical protein 0.0031 0.002 0.002
Trypanosoma cruzi cysteine peptidase, putative 0.0056 0.0259 0.096
Loa Loa (eye worm) calpain 0.0043 0.0135 0.0135
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.0678 0.8714
Giardia lamblia Cathepsin B precursor 0.0112 0.0775 0.5
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0112 0.0775 1
Echinococcus multilocularis fmrfamide receptor 0.0054 0.0237 0.0355
Echinococcus granulosus neuropeptide FF receptor 2 0.0054 0.0237 0.0355
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0304 0.2565 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0054 0.0237 0.0355
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0054 0.0237 0.0355
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0237 0.0355
Onchocerca volvulus 0.0101 0.0678 1
Leishmania major cathepsin L-like protease 0.0101 0.0678 0.8714
Brugia malayi sulfakinin receptor protein 0.1103 1 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0054 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.1103 1 1
Schistosoma mansoni amine GPCR 0.0054 0.0237 0.0851
Schistosoma mansoni neuropeptide receptor 0.0054 0.0237 0.0851
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0237 0.0355
Brugia malayi neuropeptide F receptor 0.0054 0.0237 0.0223
Schistosoma mansoni tar DNA-binding protein 0.0062 0.031 0.1139
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0135 0.1579
Echinococcus granulosus cathepsin L 0.0056 0.0259 0.0434
Brugia malayi Cathepsin L-like precursor 0.0071 0.0392 0.0379
Loa Loa (eye worm) fibroinase 0.0101 0.0678 0.0678
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0237 0.0851
Brugia malayi G protein-coupled receptor 0.0054 0.0237 0.0223
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0135 0.0471
Echinococcus multilocularis allatostatin A receptor 0.0054 0.0237 0.0355
Echinococcus granulosus allatostatin A receptor 0.0054 0.0237 0.0355
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0237 0.0355
Entamoeba histolytica cysteine proteinase, putative 0.0071 0.0392 0.57
Brugia malayi TAR-binding protein 0.0062 0.031 0.0296
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0043 0.0135 0.0471
Schistosoma mansoni biogenic amine (5HT) receptor 0.0054 0.0237 0.0851
Schistosoma mansoni amine GPCR 0.0054 0.0237 0.0851
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0562 0.213
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0049 0.0188 0.0188
Echinococcus multilocularis sex peptide receptor 0.0054 0.0237 0.0355
Echinococcus multilocularis calpain family protein 1, d 0.0084 0.0515 0.1323
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0071 0.0392 0.1482
Entamoeba histolytica cysteine proteinase, putative 0.0056 0.0259 0.3693
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0119 0.0842 0.3231
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0135 0.1579
Brugia malayi hypothetical protein 0.0054 0.0237 0.0223
Loa Loa (eye worm) ctsf protein 0.0101 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0114 0.0794 0.0794
Echinococcus multilocularis somatostatin receptor 0.0054 0.0237 0.0355
Schistosoma mansoni calpain-7 (C02 family) 0.0043 0.0135 0.045
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0056 0.0259 0.094
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0054 0.0237 0.0851
Onchocerca volvulus 0.0101 0.0678 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0237 0.0355
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0678 0.8336
Schistosoma mansoni neuropeptide F-like receptor 0.0054 0.0237 0.0851
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.0678 0.8714
Echinococcus granulosus g protein coupled receptor 0.0054 0.0237 0.0355
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Echinococcus multilocularis G protein coupled receptor 139 0.0054 0.0237 0.0355
Leishmania major cathepsin L-like protease 0.0101 0.0678 0.8714
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0135 0.0471
Brugia malayi GnHR receptor homolog 0.0054 0.0237 0.0223
Echinococcus multilocularis cysteine protease 0.0101 0.0678 0.1888
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Trypanosoma cruzi cruzipain precursor, putative 0.0101 0.0678 0.26
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0054 0.0237 0.0223
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0054 0.0237 0.0851
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Echinococcus multilocularis g protein coupled receptor 0.0054 0.0237 0.0355
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0054 0.0237 0.0355
Echinococcus granulosus neuropeptide s receptor 0.0054 0.0237 0.0355
Loa Loa (eye worm) hypothetical protein 0.0044 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0054 0.0237 0.0355
Giardia lamblia Cathepsin B precursor 0.0112 0.0775 0.5
Plasmodium vivax unspecified product 0.0056 0.0259 0.3639
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0237 0.0355
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.0678 0.8336
Echinococcus multilocularis neuropeptide receptor A26 0.0054 0.0237 0.0355
Loa Loa (eye worm) G-protein coupled receptor 0.0054 0.0237 0.0237
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0101 0.0678 0.8336
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.0678 0.8336
Entamoeba histolytica cysteine protease, putative 0.0056 0.0259 0.3693
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Plasmodium vivax vivapain-2 0.0101 0.0678 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0101 0.0678 1
Entamoeba histolytica cysteine protease, putative 0.0056 0.0259 0.3693
Brugia malayi Cathepsin L-like precursor 0.0101 0.0678 0.0664
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Trypanosoma cruzi cysteine proteinase, putative 0.0056 0.0259 0.096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.0678 0.8714
Plasmodium falciparum cysteine proteinase falcipain 3 0.0101 0.0678 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.0678 0.8714
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.0678 0.8336
Brugia malayi Cathepsin L-like precursor 0.0101 0.0678 0.0664
Schistosoma mansoni neuropeptide receptor 0.0054 0.0237 0.0851
Onchocerca volvulus 0.0101 0.0678 1
Schistosoma mansoni calpain (C02 family) 0.0043 0.0135 0.045
Schistosoma mansoni biogenic amine (5HT) receptor 0.0054 0.0237 0.0851
Loa Loa (eye worm) TAR-binding protein 0.0062 0.031 0.031
Loa Loa (eye worm) RNA binding protein 0.0062 0.031 0.031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0237 0.0355
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0054 0.0237 0.0355
Trypanosoma brucei antigen, putative 0.0043 0.0135 0.1579
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0054 0.0237 0.0237
Brugia malayi putative neuropeptide receptor 0.0054 0.0237 0.0223
Entamoeba histolytica cysteine proteinase, putative 0.0056 0.0259 0.3693
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0054 0.0237 0.0355
Loa Loa (eye worm) cysteine protease 0.0101 0.0678 0.0678
Schistosoma mansoni cathepsin F (C01 family) 0.0101 0.0678 0.2584
Schistosoma mansoni hypothetical protein 0.0054 0.0237 0.0851
Echinococcus granulosus cysteine protease 0.0056 0.0259 0.0434
Brugia malayi RE15519p 0.0054 0.0237 0.0223
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0054 0.0237 0.0355
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0237 0.0355
Echinococcus multilocularis cysteine protease 0.0101 0.0678 0.1888
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0101 0.0678 0.1888
Brugia malayi calpain 7 0.0043 0.0135 0.012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.0678 0.8336
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0112 0.0775 0.2984
Loa Loa (eye worm) hypothetical protein 0.0304 0.2565 0.2565
Schistosoma mansoni Mername-AA248 (C02 family) 0.0043 0.0135 0.045
Entamoeba histolytica cysteine proteinase, putative 0.0101 0.0678 1
Trypanosoma cruzi cysteine peptidase, putative 0.0101 0.0678 0.26
Echinococcus granulosus serotonin receptor 0.0054 0.0237 0.0355
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0054 0.0237 0.0851
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0054 0.0237 0.0223
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0237 0.0355
Giardia lamblia Cathepsin B precursor 0.0112 0.0775 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0392 0.3484
Echinococcus granulosus G protein coupled receptor 139 0.0054 0.0237 0.0355
Brugia malayi hypothetical protein 0.0054 0.0237 0.0223
Schistosoma mansoni amine GPCR 0.0054 0.0237 0.0851
Schistosoma mansoni opsin-like receptor 0.0054 0.0237 0.0851
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.0678 0.8714
Echinococcus granulosus tachykinin peptides receptor 99D 0.0352 0.301 1
Schistosoma mansoni neuropeptide F-like receptor 0.0054 0.0237 0.0851
Echinococcus granulosus fmrfamide receptor 0.0054 0.0237 0.0355
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0054 0.0237 0.0223
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0054 0.0237 0.0851
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0054 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Brugia malayi AKH receptor 0.0054 0.0237 0.0223
Echinococcus multilocularis neuropeptides capa receptor 0.0054 0.0237 0.0355
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.0678 0.8336
Loa Loa (eye worm) TYRA-2 protein 0.0054 0.0237 0.0237
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0135 0.1579
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Trypanosoma brucei calpain-like protein, putative 0.0043 0.0135 0.1579
Entamoeba histolytica cysteine protease, putative 0.0056 0.0259 0.3693
Entamoeba histolytica cysteine protease, putative 0.0056 0.0259 0.3693
Schistosoma mansoni cathepsin F (C01 family) 0.0101 0.0678 0.2584
Brugia malayi neuropeptide F receptor 0.0054 0.0237 0.0223
Brugia malayi follicle stimulating hormone receptor 0.0054 0.0237 0.0223
Loa Loa (eye worm) hypothetical protein 0.0101 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0101 0.0674 0.0674
Schistosoma mansoni amine GPCR 0.0054 0.0237 0.0851
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Toxoplasma gondii cathepsin CPL 0.0101 0.0678 0.8336
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0562 0.1486
Brugia malayi Dopamine receptor 0.0054 0.0237 0.0223
Loa Loa (eye worm) calpain 5 0.003 0.0014 0.0014
Entamoeba histolytica cysteine proteinase 2 0.0056 0.0259 0.3693
Schistosoma mansoni alpha-1 adrenergic receptor 0.0054 0.0237 0.0851
Plasmodium vivax aspartyl proteinase, putative 0.0049 0.0188 0.2549
Echinococcus multilocularis neuropeptide receptor 0.0054 0.0237 0.0355
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Entamoeba histolytica cysteine protease, putative 0.0056 0.0259 0.3693
Echinococcus multilocularis neuropeptides capa receptor 0.0054 0.0237 0.0355
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Echinococcus granulosus neuropeptide receptor A26 0.0054 0.0237 0.0355
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0237 0.0851
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0043 0.0135 0.0471
Brugia malayi Papain family cysteine protease containing protein 0.0056 0.0259 0.0245
Echinococcus granulosus tm gpcr rhodopsin 0.0054 0.0237 0.0355
Loa Loa (eye worm) melatonin receptor type 1A 0.0054 0.0237 0.0237
Entamoeba histolytica cysteine protease, putative 0.0056 0.0259 0.3693
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0135 0.0471
Entamoeba histolytica cysteine proteinase, putative 0.0056 0.0259 0.3693
Brugia malayi Cathepsin L-like precursor 0.0071 0.0392 0.0379
Schistosoma mansoni tar DNA-binding protein 0.0062 0.031 0.1139
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0054 0.0237 0.0355
Brugia malayi ORL1-like opioid receptor 0.0054 0.0237 0.0223
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0678 0.8336
Schistosoma mansoni tar DNA-binding protein 0.0062 0.031 0.1139
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0562 0.0562
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0304 0.2565 1
Echinococcus granulosus g protein coupled receptor 0.0054 0.0237 0.0355
Onchocerca volvulus 0.0101 0.0678 1
Onchocerca volvulus 0.0101 0.0678 1
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0046 0.0159 0.0159
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0054 0.0237 0.0355
Trypanosoma cruzi cysteine peptidase, putative 0.0101 0.0678 0.26
Echinococcus granulosus biogenic amine 5HT receptor 0.0054 0.0237 0.0355
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0043 0.0135 0.0471
Brugia malayi hypothetical protein 0.0054 0.0237 0.0223
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0054 0.0237 0.0851
Echinococcus granulosus Tolloid protein 1 0.0046 0.0159 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0259 0.122
Trypanosoma brucei calpain-like protein, putative 0.0043 0.0135 0.1579
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0119 0.0842 0.3231
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Schistosoma mansoni biogenic amine receptor 0.0054 0.0237 0.0851
Brugia malayi Serotonin receptor 0.0054 0.0237 0.0223
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0054 0.0237 0.0851
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0054 0.0237 0.0223
Brugia malayi hypothetical protein 0.0054 0.0237 0.0223
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Schistosoma mansoni adenoreceptor 0.0054 0.0237 0.0851
Brugia malayi cathepsin L-like precursor 0.0071 0.0392 0.0379
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Echinococcus granulosus tm gpcr rhodopsin 0.0054 0.0237 0.0355
Leishmania major cathepsin L-like protease 0.0101 0.0678 0.8714
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0304 0.2565 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0054 0.0237 0.0851
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0237 0.0355
Echinococcus granulosus alpha 1A adrenergic receptor 0.0054 0.0237 0.0355
Loa Loa (eye worm) G-protein coupled receptor 0.0054 0.0237 0.0237
Echinococcus multilocularis cathepsin L cysteine protease 0.0101 0.0678 0.1888
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0114 0.0794 0.3043
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0054 0.0237 0.0237
Plasmodium vivax vivapain-2 0.0101 0.0678 1
Entamoeba histolytica cysteine proteinase, putative 0.0101 0.0678 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0101 0.0678 0.0678
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0237 0.0851
Leishmania major cathepsin L-like protease 0.0101 0.0678 0.8714
Brugia malayi hypothetical protein 0.0054 0.0237 0.0223
Schistosoma mansoni growth hormone secretagogue receptor 0.0054 0.0237 0.0851
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0054 0.0237 0.0851
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0678 0.8336
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0056 0.0259 0.096
Echinococcus granulosus hypothetical protein 0.0054 0.0237 0.0355
Schistosoma mansoni neuropeptide f receptor 76f 0.0054 0.0237 0.0851
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0562 0.1486
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0237 0.0851
Echinococcus granulosus cathepsin l1 0.0071 0.0392 0.0897
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0237 0.0851
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0054 0.0237 0.0355
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0084 0.0515 0.0515
Entamoeba histolytica cysteine proteinase 1, putative 0.0056 0.0259 0.3693
Loa Loa (eye worm) calpain family protein 1 0.0114 0.0794 0.0794
Echinococcus granulosus tm gpcr rhodopsin 0.0054 0.0237 0.0355
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0056 0.0259 0.094
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0304 0.2565 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0056 0.0259 0.094
Echinococcus granulosus neuropeptide receptor 0.0054 0.0237 0.0355
Echinococcus granulosus neuropeptide receptor 0.0054 0.0237 0.0355
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0101 0.0678 0.1888
Brugia malayi calpain family protein 1 0.0114 0.0794 0.0781
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0678 0.8336
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.0678 0.8714
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0112 0.0775 0.2968
Entamoeba histolytica cysteine protease, putative 0.0056 0.0259 0.3693
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0678 0.8336
Echinococcus multilocularis neuropeptide receptor 0.0054 0.0237 0.0355
Echinococcus multilocularis calpain A 0.0119 0.0842 0.2461
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0054 0.0237 0.0851
Onchocerca volvulus 0.0101 0.0678 1
Plasmodium vivax plasmepsin IV, putative 0.0049 0.0188 0.2549
Loa Loa (eye worm) neuropeptide F receptor 0.0054 0.0237 0.0237
Echinococcus granulosus orexin receptor type 2 0.0054 0.0237 0.0355
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0562 0.1486
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0352 0.301 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Brugia malayi G protein-coupled receptor F59B2.13 0.0054 0.0237 0.0223
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0054 0.0237 0.0223
Schistosoma mansoni hypothetical protein 0.0054 0.0237 0.0851
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0304 0.2565 1
Leishmania major cathepsin L-like protease 0.0101 0.0678 0.8714
Brugia malayi Cathepsin L-like cysteine proteinase 0.0071 0.0392 0.0379
Echinococcus multilocularis neuropeptide Y receptor 0.0054 0.0237 0.0355
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0678 0.8336
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Brugia malayi Cathepsin L-like precursor 0.0031 0.002 0.0006
Echinococcus granulosus neuropeptides capa receptor 0.0054 0.0237 0.0355
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Onchocerca volvulus Cathepsin F homolog 0.0101 0.0678 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0678 0.8336
Loa Loa (eye worm) hypothetical protein 0.0031 0.002 0.002
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0046 0.0159 0.0546
Entamoeba histolytica cysteine proteinase, putative 0.0056 0.0259 0.3693
Brugia malayi Cathepsin L-like precursor 0.0101 0.0678 0.0664
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0259 0.122
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0043 0.0135 0.0471
Echinococcus granulosus neuropeptide Y receptor 0.0054 0.0237 0.0355
Loa Loa (eye worm) hypothetical protein 0.0071 0.0392 0.0392
Echinococcus multilocularis tar DNA binding protein 0.0062 0.031 0.061
Toxoplasma gondii cathepsin B 0.0112 0.0775 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0054 0.0237 0.0355
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.031 0.0296
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0135 0.1579
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Plasmodium vivax calpain, putative 0.0043 0.0135 0.1741
Brugia malayi Cathepsin L-like precursor 0.0101 0.0678 0.0664
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Echinococcus granulosus peptide allatostatin:somatostatin 0.0054 0.0237 0.0355
Echinococcus multilocularis neuropeptide FF receptor 2 0.0054 0.0237 0.0355
Leishmania major cathepsin L-like protease 0.0101 0.0678 0.8714
Trypanosoma cruzi cruzipain precursor, putative 0.0031 0.002 0.0022
Echinococcus granulosus g protein coupled receptor 0.0054 0.0237 0.0355
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0112 0.0775 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0237 0.0851
Schistosoma mansoni biogenic amine receptor 0.0054 0.0237 0.0851
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Brugia malayi larval opioid receptor 0.0054 0.0237 0.0223
Echinococcus multilocularis serotonin receptor 0.0054 0.0237 0.0355
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0054 0.0237 0.0355
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0237 0.0355
Brugia malayi Papain family cysteine protease containing protein 0.0056 0.0259 0.0245
Echinococcus multilocularis dro:myosuppressin receptor 0.0054 0.0237 0.0355
Trypanosoma brucei calpain-like protein, putative 0.0043 0.0135 0.1579
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0237 0.0851
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0135 0.0471
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0031 0.002 0.0006
Echinococcus multilocularis cathepsin L cysteine protease 0.0101 0.0678 0.1888
Brugia malayi calpain family protein 1 0.0114 0.0794 0.0781
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0043 0.0135 0.1579
Brugia malayi Dopamine receptor protein 2 0.0054 0.0237 0.0223
Brugia malayi cathepsin F-like cysteine proteinase 0.0031 0.002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Echinococcus granulosus somatostatin receptor 0.0054 0.0237 0.0355
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0054 0.0237 0.0355
Brugia malayi hypothetical protein 0.0054 0.0237 0.0223
Entamoeba histolytica cysteine protease, putative 0.0056 0.0259 0.3693
Trypanosoma cruzi cysteine peptidase, putative 0.0101 0.0678 0.26
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0049 0.0188 0.0659
Onchocerca volvulus 0.0071 0.0392 0.3532
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0237 0.0851
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.0678 0.8714
Brugia malayi Serotonin receptor 0.0054 0.0237 0.0223
Schistosoma mansoni hypothetical protein 0.0054 0.0237 0.0851
Brugia malayi hypothetical protein 0.0054 0.0237 0.0223
Loa Loa (eye worm) hypothetical protein 0.0071 0.0395 0.0395
Schistosoma mansoni myosin xvIII 0.0054 0.0237 0.0851
Schistosoma mansoni calpain-7 (C02 family) 0.0043 0.0135 0.045
Entamoeba histolytica cysteine protease, putative 0.0056 0.0259 0.3693
Entamoeba histolytica cysteine protease, putative 0.0056 0.0259 0.3693
Schistosoma mansoni calpain C (C02 family) 0.0043 0.0135 0.045
Trypanosoma cruzi cysteine peptidase, putative 0.0101 0.0678 0.26
Brugia malayi G-protein coupled receptor 0.0054 0.0237 0.0223
Echinococcus multilocularis serotonin receptor 0.0054 0.0237 0.0355
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0101 0.0678 0.8336
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0119 0.0842 0.2461
Entamoeba histolytica cysteine protease, putative 0.0056 0.0259 0.3693
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0237 0.0355
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0054 0.0237 0.0355
Schistosoma mansoni tar DNA-binding protein 0.0062 0.031 0.1139
Entamoeba histolytica cysteine protease, putative 0.0101 0.0678 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0237 0.0355
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0049 0.0188 0.0185
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0237 0.0355
Echinococcus granulosus g-protein coupled receptor 0.0054 0.0237 0.0355
Brugia malayi Melatonin receptor type 1A 0.0054 0.0237 0.0223
Onchocerca volvulus Cathepsin L homolog 0.0101 0.0678 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Trypanosoma brucei calpain-like protein, putative 0.0043 0.0135 0.1579
Loa Loa (eye worm) cathepsin B 0.0112 0.0775 0.0775
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0678 0.8336

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.09 nM Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assay ChEMBL. 15546726
Ki (binding) = 1.09 nM Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assay ChEMBL. 15546726
Ki (binding) > 10000 nM Binding affinity to human Bradykinin receptor B2 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assay ChEMBL. 15546726
Ki (binding) > 10000 nM Binding affinity to human Bradykinin receptor B2 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assay ChEMBL. 15546726
logP (ADMET) = 3.35 Partition coefficient (logP) ChEMBL. 15546726
Protein binding (binding) 0 Binding affinity to human plasma protein; ND denotes not done ChEMBL. 15546726

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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