Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0095 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0065 | 0.3393 | 0.3393 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0089 | 0.875 | 0.8108 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0089 | 0.875 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0065 | 0.3393 | 0.3393 |
Toxoplasma gondii | IMP dehydrogenas | 0.0095 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0065 | 0.3393 | 0.3393 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0065 | 0.3393 | 0.3393 |
Trypanosoma brucei | GMP reductase | 0.0095 | 1 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0065 | 0.3393 | 0.3393 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0095 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0065 | 0.3393 | 0.3393 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0065 | 0.3393 | 0.3393 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0065 | 0.3393 | 0.3393 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 1 | 1 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0089 | 0.875 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0095 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0095 | 1 | 1 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0095 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0065 | 0.3393 | 0.3393 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0065 | 0.3393 | 0.3393 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0095 | 1 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0065 | 0.3393 | 0.3393 |
Trypanosoma cruzi | GMP reductase | 0.0095 | 1 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0065 | 0.3393 | 0.3393 |
Mycobacterium leprae | putative cytochrome p450 | 0.0065 | 0.3393 | 0.3393 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0095 | 1 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0065 | 0.3393 | 0.3393 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 1 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0065 | 0.3393 | 0.3393 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0065 | 0.3393 | 0.3393 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0065 | 0.3393 | 0.3393 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0065 | 0.3393 | 0.3393 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0095 | 1 | 1 |
Leishmania major | guanosine monophosphate reductase | 0.0095 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0065 | 0.3393 | 0.3393 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0065 | 0.3393 | 0.3393 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0065 | 0.3393 | 0.3393 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0095 | 1 | 1 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0095 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0065 | 0.3393 | 0.3393 |
Trypanosoma cruzi | GMP reductase | 0.0095 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.