Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0066 | 0.1125 |
Echinococcus multilocularis | expressed protein | 0.0017 | 0.0171 | 0.0109 |
Toxoplasma gondii | hypothetical protein | 0.0017 | 0.0171 | 0.2921 |
Echinococcus granulosus | expressed protein | 0.0017 | 0.0171 | 0.2024 |
Brugia malayi | Peptidase family M28 containing protein | 0.0047 | 0.0586 | 1 |
Schistosoma mansoni | nicalin (M28 family) | 0.0047 | 0.0586 | 0.0825 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0712 | 0.976 | 1 |
Trypanosoma brucei | PA domain containing protein, putative | 0.0017 | 0.0171 | 0.1367 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0047 | 0.0586 | 1 |
Schistosoma mansoni | mannosyl-oligosaccharidealpha-12-mannosidase-r el ated | 0.0017 | 0.0171 | 0.0167 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0065 | 0.0826 | 1 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0047 | 0.0586 | 0.0537 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0047 | 0.0586 | 1 |
Brugia malayi | leucyl aminopeptidase | 0.0047 | 0.0586 | 1 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0065 | 0.0826 | 1 |
Loa Loa (eye worm) | PA domain-containing protein | 0.0017 | 0.0171 | 0.0106 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0024 | 0.0257 | 0.3677 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0466 | 0.6372 | 1 |
Onchocerca volvulus | 0.0047 | 0.0586 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.0586 | 1 |
Leishmania major | glutaminyl cyclase, putative | 0.0047 | 0.0586 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0024 | 0.0257 | 0.3156 |
Schistosoma mansoni | zinc finger protein | 0.0017 | 0.0171 | 0.0167 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0047 | 0.0586 | 0.0537 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0047 | 0.0586 | 0.0524 |
Loa Loa (eye worm) | RecQ helicase | 0.0024 | 0.0257 | 0.0193 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.001 | 0.0066 | 0.5 |
Echinococcus granulosus | bloom syndrome protein | 0.0024 | 0.0257 | 0.3677 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1572 | 0.1516 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0066 | 0.1125 |
Brugia malayi | FXNA | 0.0047 | 0.0586 | 1 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0047 | 0.0586 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0017 | 0.0171 | 0.0167 |
Brugia malayi | PA domain containing protein | 0.0017 | 0.0171 | 0.2024 |
Echinococcus granulosus | e3 ubiquitin protein ligase RNF13 | 0.0017 | 0.0171 | 0.2024 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0016 | 0.0149 | 0.2544 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0047 | 0.0586 | 0.0825 |
Leishmania major | hypothetical protein, conserved | 0.0047 | 0.0586 | 1 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0019 | 0.0189 | 0.0195 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0047 | 0.0586 | 0.0825 |
Echinococcus granulosus | er degradation enhancing alpha mannosidase | 0.0017 | 0.0171 | 0.2024 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0047 | 0.0586 | 1 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0047 | 0.0586 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.0586 | 1 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0047 | 0.0586 | 0.0825 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0047 | 0.0586 | 1 |
Echinococcus multilocularis | bloom syndrome protein | 0.0024 | 0.0257 | 0.0197 |
Loa Loa (eye worm) | hypothetical protein | 0.0664 | 0.9105 | 0.9099 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0047 | 0.0586 | 1 |
Echinococcus multilocularis | e3 ubiquitin protein ligase RNF13 | 0.0017 | 0.0171 | 0.0109 |
Entamoeba histolytica | recQ family helicase, putative | 0.0013 | 0.0106 | 1 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0047 | 0.0586 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0047 | 0.0586 | 1 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0047 | 0.0586 | 1 |
Echinococcus multilocularis | er degradation enhancing alpha mannosidase er degradation enhancer mannosidase alpha | 0.0017 | 0.0171 | 0.0109 |
Loa Loa (eye worm) | hypothetical protein | 0.0484 | 0.6612 | 0.659 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.0586 | 1 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0047 | 0.0586 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0586 | 0.0524 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0024 | 0.0257 | 0.3156 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0047 | 0.0586 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0586 | 0.0524 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0047 | 0.0586 | 0.0537 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0016 | 0.0152 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0047 | 0.0586 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0586 | 0.0524 |
Schistosoma mansoni | protease | 0.0017 | 0.0171 | 0.0167 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0021 | 0.0218 | 1 |
Brugia malayi | nicalin | 0.0047 | 0.0586 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 25 % | Inhibition of CXCL8-induced chemotaxis of human polymorphonuclear cells at 10e-8 M | ChEMBL. | 15974585 |
Inhibition (functional) | = 25 % | Inhibition of CXCL8-induced chemotaxis of human polymorphonuclear cells at 10e-8 M | ChEMBL. | 15974585 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.