Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Butyrylcholinesterase | Starlite/ChEMBL | References |
Bos taurus | Acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Putative nuclear protein | Acetylcholinesterase | 613 aa | 572 aa | 41.6 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 613 aa | 627 aa | 34.0 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 613 aa | 564 aa | 30.3 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 565 aa | 26.0 % | |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Acetylcholinesterase | 613 aa | 511 aa | 39.9 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 613 aa | 573 aa | 26.5 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 613 aa | 569 aa | 31.3 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 613 aa | 534 aa | 23.2 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 613 aa | 561 aa | 24.6 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 613 aa | 26.8 % | |
Schistosoma mansoni | gliotactin | Butyrylcholinesterase | 602 aa | 587 aa | 28.1 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 613 aa | 491 aa | 26.7 % |
Echinococcus granulosus | neuroligin | Butyrylcholinesterase | 602 aa | 492 aa | 24.2 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 613 aa | 527 aa | 32.3 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 552 aa | 31.3 % | |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 613 aa | 627 aa | 33.8 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 613 aa | 601 aa | 23.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.1012 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1012 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1012 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1012 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1012 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1012 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1012 | 1 | 1 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.1012 | 1 | 0.5 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.1012 | 1 | 0.5 |
Loa Loa (eye worm) | hyaluronidase | 0.0884 | 0.8316 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0759 | 0.6669 | 0.6669 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1012 | 1 | 1 |
Entamoeba histolytica | modulator of drug activity B homolog, putative | 0.0253 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1012 | 1 | 1 |
Schistosoma mansoni | Hyaluronidase | 0.0884 | 0.8316 | 0.5 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.0884 | 0.8316 | 0.5 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.1012 | 1 | 1 |
Entamoeba histolytica | iron-sulfur flavoprotein, putative | 0.0253 | 0 | 0.5 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.1012 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1012 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1012 | 1 | 1 |
Brugia malayi | Hyaluronidase family protein | 0.0884 | 0.8316 | 0.5 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.1012 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1012 | 1 | 1 |
Echinococcus multilocularis | bifunctional protein NCOAT | 0.0884 | 0.8316 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1012 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0253 | 0 | 0.5 |
Echinococcus granulosus | bifunctional protein NCOAT | 0.0884 | 0.8316 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.336 uM | Inhibition of bovine AChE after 20 mins using acetylthiocholine iodide as a substrate by Ellman's assay | ChEMBL. | 21417225 |
IC50 (binding) | = 1.3 uM | Inhibition of equine BChE after 20 mins using butyrylthiocholine iodide as a substrate by Ellman's assay | ChEMBL. | 21417225 |
IC50 (binding) | = 24 uM | Inhibitory activity against human choline kinase enzyme | ChEMBL. | 15481981 |
IC50 (binding) | = 24 uM | Inhibitory activity against human choline kinase enzyme | ChEMBL. | 15481981 |
IC50 (functional) | > 100 uM | Antiproliferative activity was determined using HT-29 human colon cancer cell line | ChEMBL. | 15481981 |
IC50 (functional) | > 100 uM | Antiproliferative activity was determined using HT-29 human colon cancer cell line | ChEMBL. | 15481981 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.