TDR Targets

Basic information

Technical information

TDR Targets ID: 333433
Name: [(3S,6S,7R,8R)-8-benzyl-6-methyl-4,9-dioxo-3- [(2-oxo-1H-pyridine-3-carbonyl)amino]-1,5-dio xonan-7-yl] 2-methylpropanoate
MW: 484.498 | Formula: C25H28N2O8
H donors: 2 H acceptors: 6 LogP: 3.63 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CC(C(=O)O[C@H]1[C@H](C)OC(=O)[C@H](COC(=O)[C@@H]1Cc1ccccc1)NC(=O)c1cccnc1O)C
InChi: 1S/C25H28N2O8/c1-14(2)23(30)35-20-15(3)34-25(32)19(27-22(29)17-10-7-11-26-21(17)28)13-33-24(31)18(20)12-16-8-5-4-6-9-16/h4-11,14-15,18-20H,12-13H2,1-3H3,(H,26,28)(H,27,29)/t15-,18+,19-,20-/m0/s1
InChiKey: FFDHFHWFEQBSQA-LDTOTXGLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-methylpropanoic acid [(3S,6S,7R,8R)-8-benzyl-6-methyl-4,9-dioxo-3-[[oxo-(2-oxo-1H-pyridin-3-yl)methyl]amino]-1,5-dioxonan-7-yl] ester
[(3S,6S,7R,8R)-6-methyl-4,9-dioxo-3-[(2-oxo-1H-pyridin-3-yl)carbonylamino]-8-(phenylmethyl)-1,5-dioxonan-7-yl] 2-methylpropanoate
2-methylpropionic acid [(3S,6S,7R,8R)-8-benzyl-4,9-diketo-3-[(2-keto-1H-pyridine-3-carbonyl)amino]-6-methyl-1,5-dioxonan-7-yl] ester
[(3S,6S,7R,8R)-6-methyl-4,9-dioxo-3-[(2-oxo1H-pyridine-3-carbonyl)amino]-8-(phenylmethyl)-1,5-dioxonan-7-yl] 2-methylpropanoate
2-methylpropanoic acid [(3S,6S,7R,8R)-6-methyl-4,9-dioxo-3-[[oxo-(2-oxo-1H-pyridin-3-yl)methyl]amino]-8-(phenylmethyl)-1,5-dioxonan-7-yl] ester
2-methylpropionic acid [(3S,6S,7R,8R)-8-(benzyl)-4,9-diketo-3-[(2-keto1H-pyridine-3-carbonyl)amino]-6-methyl-1,5-dioxonan-7-yl] ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Possible transmembrane cation transporter	0.0102	0.0347	1
Loa Loa (eye worm)	hypothetical protein	0.0417	0.167	0.167
Echinococcus granulosus	BC026374 protein S09 family	0.007	0.0213	0.0213
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.007	0.0213	0.614
Trypanosoma cruzi	ion transport protein, putative	0.0102	0.0347	1
Echinococcus multilocularis	BC026374 protein (S09 family)	0.007	0.0213	0.0213
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.007	0.0213	0.614
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0102	0.0347	1
Entamoeba histolytica	calcium-gated potassium channel protein, putative	0.0102	0.0347	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 12	0.0102	0.0347	0.2078
Loa Loa (eye worm)	carboxylesterase	0.0417	0.167	0.167
Onchocerca volvulus		0.0102	0.0347	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0	0.5
Schistosoma mansoni	lipoxygenase	0.0021	0.0004	0.0004
Echinococcus granulosus	Polycystic kidney disease protein	0.0021	0.0004	0.0004
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 7	0.0102	0.0347	0.2078
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 5	0.0102	0.0347	0.2078
Brugia malayi	hypothetical protein	0.0102	0.0347	0.2078
Onchocerca volvulus		0.0102	0.0347	1
Mycobacterium ulcerans	ion transport protein	0.0102	0.0347	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0102	0.0347	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.007	0.0213	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0004	0.0004
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0102	0.0347	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.0213	0.0213
Echinococcus granulosus	para nitrobenzyl esterase	0.007	0.0213	0.0213
Trypanosoma brucei	calcium-activated potassium channel, putative	0.0102	0.0347	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.0199	0.5732
Brugia malayi	hypothetical protein	0.0021	0.0004	0.0024
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.007	0.0213	0.0213
Brugia malayi	Carboxylesterase family protein	0.0417	0.167	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 28	0.0102	0.0347	0.2078
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0	0.5
Echinococcus granulosus	potassium channel subfamily K 8	0.0102	0.0347	0.0347
Echinococcus granulosus	TWiK family of potassium channels protein 7	0.0102	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0199	0.5732
Loa Loa (eye worm)	hypothetical protein	0.007	0.0213	0.0213
Schistosoma mansoni	lipoxygenase	0.0058	0.0161	0.0161
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog	0.0102	0.0347	0.2078
Echinococcus granulosus	twik family of potassium channels	0.0102	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Echinococcus granulosus	potassium channel subfamily K	0.0102	0.0347	0.0347
Plasmodium falciparum	potassium channel	0.0102	0.0347	1
Echinococcus multilocularis	small conductance calcium activated potassium	0.2396	1	1
Leishmania major	hypothetical protein, conserved	0.0102	0.0347	1
Brugia malayi	Carboxylesterase family protein	0.0417	0.167	1
Loa Loa (eye worm)	large conductance calcium-activated potassium channel alpha subunit ai	0.0102	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Echinococcus granulosus	RUN	0.0021	0.0004	0.0004
Leishmania major	hypothetical protein, conserved	0.0102	0.0347	1
Loa Loa (eye worm)	hypothetical protein	0.0943	0.3887	0.3887
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Leishmania major	calcium/potassium channel (CAKC), putative	0.0102	0.0347	1
Mycobacterium tuberculosis	Carboxylesterase LipT	0.007	0.0213	0.614
Trypanosoma cruzi	ion transport protein, putative	0.0102	0.0347	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Trypanosoma cruzi	major cysteine proteinase, putative	0.0053	0.0139	0.3992
Echinococcus granulosus	Two pore potassium channel protein sup 9	0.0102	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Schistosoma mansoni	rab6-interacting	0.0021	0.0004	0.0004
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0417	0.167	0.167
Brugia malayi	Carboxylesterase family protein	0.007	0.0213	0.1276
Loa Loa (eye worm)	cytochrome P450 family protein	0.0048	0.0117	0.0117
Echinococcus multilocularis	Polycystic kidney disease protein	0.0021	0.0004	0.0004
Brugia malayi	Carboxylesterase family protein	0.007	0.0213	0.1276
Schistosoma mansoni	jumonji domain containing protein	0.0062	0.0177	0.0177
Loa Loa (eye worm)	potassium voltage-gated channel subfamily Q member 5	0.0102	0.0347	0.0347
Loa Loa (eye worm)	carboxylesterase	0.007	0.0213	0.0213
Leishmania major	potassium channel subunit-like protein	0.0102	0.0347	1
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0102	0.0347	1
Echinococcus multilocularis	potassium channel subfamily K 8	0.0102	0.0347	0.0347
Echinococcus multilocularis	choline:ethanolamine kinase	0.0086	0.0279	0.0279
Echinococcus multilocularis	twik family of potassium channels	0.0102	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Schistosoma mansoni	neuroligin 3 (S09 family)	0.007	0.0213	0.0213
Echinococcus granulosus	calcium activated potassium channel variant	0.0102	0.0347	0.0347
Onchocerca volvulus		0.0102	0.0347	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0062	0.0177	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Schistosoma mansoni	hypothetical protein	0.0102	0.0347	0.0347
Schistosoma mansoni	calcium-activated potassium channel	0.0102	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0417	0.167	0.167
Loa Loa (eye worm)	hypothetical protein	0.007	0.0213	0.0213
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 45	0.0102	0.0347	0.2078
Trypanosoma cruzi	cruzipain precursor, putative	0.0067	0.0199	0.5732
Mycobacterium ulcerans	transmembrane cation transporter	0.0102	0.0347	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0199	0.5732
Echinococcus multilocularis	potassium channel subfamily K	0.0102	0.0347	0.0347
Schistosoma mansoni	twik family of potassium channels-related	0.0102	0.0347	0.0347
Toxoplasma gondii	phosphotransferase enzyme family protein	0.0086	0.0279	0.8034
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.007	0.0213	0.0213
Brugia malayi	Carboxylesterase family protein	0.007	0.0213	0.1276
Loa Loa (eye worm)	TWK-7 protein	0.0102	0.0347	0.0347
Schistosoma mansoni	gliotactin	0.007	0.0213	0.0213
Schistosoma mansoni	acetylcholinesterase	0.007	0.0213	0.0213
Brugia malayi	Cytochrome P450 family protein	0.0048	0.0117	0.07
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0102	0.0347	1
Schistosoma mansoni	twik family of potassium channels-related	0.0102	0.0347	0.0347
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0199	0.5732
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0102	0.0347	0.2078
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.007	0.0213	0.0213
Plasmodium vivax	potassium channel, putative	0.0102	0.0347	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0062	0.0177	0.0177
Schistosoma mansoni	calcium-activated potassium channel	0.1995	0.8311	0.8311
Trypanosoma cruzi	hypothetical protein, conserved	0.0102	0.0347	1
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.007	0.0213	0.614
Echinococcus granulosus	lysine specific demethylase 5A	0.0062	0.0177	0.0177
Brugia malayi	Doublecortin family protein	0.0021	0.0004	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0199	0.5732
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0058	0.0161	0.0161
Plasmodium vivax	potassium channel, putative	0.0102	0.0347	1
Loa Loa (eye worm)	hypothetical protein	0.2396	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.0199	0.5732
Echinococcus granulosus	acetylcholinesterase	0.0417	0.167	0.167
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39A	0.0102	0.0347	0.2078
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0102	0.0347	1
Brugia malayi	jmjC domain containing protein	0.0062	0.0177	0.1059
Echinococcus granulosus	carboxylesterase 5A	0.0417	0.167	0.167
Plasmodium falciparum	potassium channel	0.0102	0.0347	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Schistosoma mansoni	polycystin 1-related	0.0021	0.0004	0.0004
Brugia malayi	Twik (KCNK-like) family of potasium channels, alpha subunit 40	0.0102	0.0347	0.2078
Onchocerca volvulus		0.007	0.0213	0.6095
Echinococcus granulosus	neuroligin	0.007	0.0213	0.0213
Onchocerca volvulus		0.0102	0.0347	1
Schistosoma mansoni	calcium-activated potassium channel	0.0102	0.0347	0.0347
Leishmania major	cathepsin L-like protease	0.0067	0.0199	0.5732
Echinococcus multilocularis	RUN	0.0021	0.0004	0.0004
Echinococcus multilocularis	calcium activated potassium channel variant	0.0102	0.0347	0.0347
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.007	0.0213	0.0213
Echinococcus granulosus	acetylcholinesterase	0.0417	0.167	0.167
Onchocerca volvulus		0.0102	0.0347	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0199	0.5732
Loa Loa (eye worm)	TWK-28 protein	0.0102	0.0347	0.0347
Echinococcus multilocularis	lysine specific demethylase 5A	0.0062	0.0177	0.0177
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0102	0.0347	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Schistosoma mansoni	microtubule-associated protein tau	0.0725	0.2968	0.2968
Brugia malayi	Choline/ethanolamine kinase family protein	0.0086	0.0279	0.167
Trichomonas vaginalis	spcc417.12 protein, putative	0.007	0.0213	0.614
Schistosoma mansoni	twik family of potassium channels-related	0.0102	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Schistosoma mansoni	twik family of potassium channels-related	0.0102	0.0347	0.0347
Onchocerca volvulus		0.007	0.0213	0.6095
Onchocerca volvulus		0.007	0.0213	0.6095
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 24	0.0102	0.0347	0.2078
Echinococcus granulosus	microtubule associated protein 2	0.0725	0.2968	0.2968
Brugia malayi	hypothetical protein	0.0102	0.0347	0.2078
Toxoplasma gondii	ion channel protein	0.0102	0.0347	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Toxoplasma gondii	ion channel protein	0.0102	0.0347	1
Schistosoma mansoni	BC026374 protein (S09 family)	0.007	0.0213	0.0213
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0062	0.0177	0.0177
Schistosoma mansoni	calcium-activated potassium channel	0.2396	1	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Brugia malayi	jmjC domain containing protein	0.0062	0.0177	0.1059
Schistosoma mansoni	hypothetical protein	0.2396	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0199	0.5732
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0062	0.0177	0.0177
Loa Loa (eye worm)	hypothetical protein	0.1051	0.4341	0.4341
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0299	0.1176	0.1176
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Onchocerca volvulus		0.0102	0.0347	1
Echinococcus multilocularis	Two pore potassium channel protein sup 9	0.0102	0.0347	0.0347
Schistosoma mansoni	loxhd1	0.0021	0.0004	0.0004
Schistosoma mansoni	twik family of potassium channels-related	0.0102	0.0347	0.0347
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0199	0.5732
Plasmodium falciparum	choline kinase	0.0086	0.0279	0.8034
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 35	0.0102	0.0347	0.2078
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0021	0.0004	0.0004
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0058	0.0161	0.0161
Echinococcus granulosus	lipoxygenase domain containing protein	0.0021	0.0004	0.0004
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0102	0.0347	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 21	0.0102	0.0347	0.2078
Echinococcus multilocularis	acetylcholinesterase	0.0417	0.167	0.167
Echinococcus multilocularis	microtubule associated protein 2	0.0725	0.2968	0.2968
Giardia lamblia	Hypothetical protein	0.0102	0.0347	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0102	0.0347	1
Echinococcus granulosus	choline:ethanolamine kinase	0.0086	0.0279	0.0279
Echinococcus multilocularis	potassium channel subfamily K 8	0.0102	0.0347	0.0347
Echinococcus granulosus	twik family of potassium channels	0.0102	0.0347	0.0347
Loa Loa (eye worm)	S-phase kinase-associated protein 1A	0.0102	0.0347	0.0347
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39B	0.0102	0.0347	0.2078
Leishmania major	cathepsin L-like protease	0.0067	0.0199	0.5732
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Leishmania major	ion transport protein-like protein	0.0102	0.0347	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.0213	0.0213
Brugia malayi	hypothetical protein	0.007	0.0213	0.1276
Echinococcus granulosus	potassium channel subfamily K 8	0.0102	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.007	0.0213	0.0213
Schistosoma mansoni	twik family of potassium channels-related	0.0102	0.0347	0.0347
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 17	0.0102	0.0347	0.2078
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.0199	0.5732
Schistosoma mansoni	hypothetical protein	0.0021	0.0004	0.0004
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0061	0.0174	0.5027
Loa Loa (eye worm)	hypothetical protein	0.007	0.0213	0.0213
Loa Loa (eye worm)	jmjC domain-containing protein	0.0062	0.0177	0.0177
Onchocerca volvulus		0.007	0.0213	0.6095
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0199	0.5732
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 13	0.0102	0.0347	0.2078
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0199	0.5732
Loa Loa (eye worm)	carboxylesterase	0.007	0.0213	0.0213
Loa Loa (eye worm)	uncoordinated protein 58	0.0102	0.0347	0.0347
Echinococcus multilocularis	twik family of potassium channels	0.0102	0.0347	0.0347
Onchocerca volvulus		0.0102	0.0347	1
Echinococcus multilocularis	carboxylesterase 5A	0.0417	0.167	0.167
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog	0.0102	0.0347	0.2078
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Mycobacterium ulcerans	carboxylesterase, LipT	0.007	0.0213	0.614
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0102	0.0347	1
Loa Loa (eye worm)	doublecortin family protein	0.0021	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.007	0.0213	0.0213
Plasmodium falciparum	LCCL domain-containing protein	0.0021	0.0004	0.0116
Loa Loa (eye worm)	acetylcholinesterase 1	0.0417	0.167	0.167
Brugia malayi	Carboxylesterase family protein	0.007	0.0213	0.1276
Echinococcus multilocularis	neuroligin	0.007	0.0213	0.0213
Trypanosoma brucei	calcium/potassium channel (CAKC), putative	0.0102	0.0347	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0021	0.0004	0.0004
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0199	0.5732
Brugia malayi	hypothetical protein	0.0021	0.0004	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Onchocerca volvulus		0.0102	0.0347	1
Plasmodium vivax	multidomain scavenger receptor, putative	0.0021	0.0004	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Schistosoma mansoni	twik family of potassium channels-related	0.0102	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0004	0.0004
Onchocerca volvulus		0.007	0.0213	0.6095
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0199	0.5732
Echinococcus multilocularis	acetylcholinesterase	0.0417	0.167	0.167
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0347	0.0347
Echinococcus multilocularis	para nitrobenzyl esterase	0.007	0.0213	0.0213
Loa Loa (eye worm)	choline/ethanolamine kinase	0.0086	0.0279	0.0279
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0102	0.0347	0.2078
Echinococcus multilocularis	TWiK family of potassium channels protein 7	0.0102	0.0347	0.0347
Plasmodium vivax	choline kinase, putative	0.0086	0.0279	0.8034
Leishmania major	cathepsin L-like protease	0.0067	0.0199	0.5732
Echinococcus granulosus	lipoxygenase domain containing protein	0.0021	0.0004	0.0004
Schistosoma mansoni	rab6-interacting	0.0021	0.0004	0.0004
Schistosoma mansoni	twik family of potassium channels-related	0.0102	0.0347	0.0347

Activities

Activity type	Activity value	Assay description	Source	Reference
IZ (functional)	= 0 mm	Zone of inhibition for Saccharomyces cerevisiae IFO 0203 at 0.025 ug/disc by conventional paper disk method	ChEMBL.	15808458
IZ (functional)	= 12 mm	Zone of inhibition for Saccharomyces cerevisiae IFO 0203 at 0.05 ug/disc by conventional paper disk method	ChEMBL.	15808458
IZ (functional)	= 16 mm	Zone of inhibition for Saccharomyces cerevisiae IFO 0203 at 0.125 ug/disc by conventional paper disk method	ChEMBL.	15808458
IZ (functional)	= 17 mm	Zone of inhibition for Saccharomyces cerevisiae IFO 0203 at 0.25 ug/disc by conventional paper disk method	ChEMBL.	15808458
Zone of inhibition (functional)	= 0 mm	Zone of inhibition for Saccharomyces cerevisiae IFO 0203 at 0.025 ug/disc by conventional paper disk method	ChEMBL.	15808458
Zone of inhibition (functional)	= 12 mm	Zone of inhibition for Saccharomyces cerevisiae IFO 0203 at 0.05 ug/disc by conventional paper disk method	ChEMBL.	15808458
Zone of inhibition (functional)	= 16 mm	Zone of inhibition for Saccharomyces cerevisiae IFO 0203 at 0.125 ug/disc by conventional paper disk method	ChEMBL.	15808458
Zone of inhibition (functional)	= 17 mm	Zone of inhibition for Saccharomyces cerevisiae IFO 0203 at 0.25 ug/disc by conventional paper disk method	ChEMBL.	15808458

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL189926
PubChem: 9869946

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 333433