Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Angiotensin II type 1a (AT-1a) receptor | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Putative organic anion transporter | 0.043 | 0.5809 | 1 |
Brugia malayi | hypothetical protein | 0.0054 | 0.0029 | 0.005 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0113 | 0.094 | 0.094 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0054 | 0.0029 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0703 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.1648 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0113 | 0.094 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0054 | 0.0029 | 0.0176 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.1648 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0113 | 0.094 | 0.094 |
Mycobacterium ulcerans | thymidylate synthase | 0.0113 | 0.094 | 0.5 |
Brugia malayi | prostaglandin transporter | 0.043 | 0.5809 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0052 | 0 | 0.5 |
Echinococcus granulosus | expressed protein | 0.0361 | 0.4737 | 0.4737 |
Loa Loa (eye worm) | thymidylate synthase | 0.0113 | 0.094 | 0.1617 |
Echinococcus multilocularis | thymidylate synthase | 0.0113 | 0.094 | 0.094 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.1648 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.1648 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0159 | 0.1648 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0113 | 0.094 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.1648 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0113 | 0.094 | 0.1617 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0703 | 1 | 1 |
Echinococcus multilocularis | expressed protein | 0.0361 | 0.4737 | 0.4737 |
Loa Loa (eye worm) | hypothetical protein | 0.043 | 0.5809 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 2.2 uM | Inhibition of [125I]-AII binding to angiotensin II receptor of bovine adrenal cortex | ChEMBL. | No reference |
EC50 (binding) | = 2.2 uM | Inhibition of [125I]-AII binding to angiotensin II receptor of bovine adrenal cortex | ChEMBL. | No reference |
ID50 (functional) | = 2.5 mg kg-1 | In vivo potency determined as dose of the compound given iv to produce reduction in angiotensin II pressor response in normotensive rats | ChEMBL. | No reference |
pKB (functional) | = 7.4 | In vitro functional antagonistic affinity measured against angiotensin II receptor in paired rings of rabbit aorta | ChEMBL. | No reference |
pKB (functional) | = 7.4 | In vitro functional antagonistic affinity measured against angiotensin II receptor in paired rings of rabbit aorta | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.