TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 386.438 | Formula: C22H26O6
H donors: 4 H acceptors: 5 LogP: 2.06 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: O[C@@H](COc1ccccc1)/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1/C=C/C=C/C=C/C(=O)O)O
InChi: 1S/C22H26O6/c23-16(15-28-17-8-4-3-5-9-17)12-13-19-18(20(24)14-21(19)25)10-6-1-2-7-11-22(26)27/h1-13,16,18-21,23-25H,14-15H2,(H,26,27)/b2-1+,10-6+,11-7+,13-12+/t16-,18-,19-,20+,21-/m1/s1
InChiKey: YFCWDLPFGIWSIR-PCXSKMRESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cathepsin C	0.0053	0.0493	0.0493
Entamoeba histolytica	cysteine protease, putative	0.01	0.1027	0.5392
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0053	0.0493	0.225
Leishmania major	cathepsin L-like protease	0.017	0.181	0.5115
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0493	0.0493
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.181	0.5115
Brugia malayi	Cathepsin L-like precursor	0.0122	0.1276	0.1276
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0314	0.3433	0.3433
Entamoeba histolytica	cysteine proteinase 1, putative	0.01	0.1027	0.5392
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0053	0.0493	0.1151
Echinococcus granulosus	cathepsin b	0.0897	1	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0053	0.0493	0.225
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.181	0.5115
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.181	0.5115
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.017	0.181	0.181
Trypanosoma cruzi	major cysteine proteinase, putative	0.0053	0.0493	0.0387
Giardia lamblia	Cathepsin L precursor	0.0053	0.0493	0.1151
Trypanosoma cruzi	cruzipain precursor, putative	0.017	0.181	0.1718
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.017	0.181	0.5115
Giardia lamblia	Cysteine protease	0.0053	0.0493	0.1151
Entamoeba histolytica	cysteine protease, putative	0.01	0.1027	0.5392
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.017	0.181	0.5115
Onchocerca volvulus		0.017	0.181	0.9461
Plasmodium vivax	vivapain-2	0.017	0.181	1
Entamoeba histolytica	hypothetical protein	0.0053	0.0493	0.225
Brugia malayi	cathepsin L-like cysteine proteinase	0.0053	0.0493	0.0493
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0053	0.0493	0.1151
Loa Loa (eye worm)	hypothetical protein	0.0179	0.1913	0.1913
Onchocerca volvulus	Cathepsin F homolog	0.017	0.181	0.9461
Brugia malayi	Papain family cysteine protease containing protein	0.0053	0.0493	0.0493
Onchocerca volvulus		0.017	0.181	0.9461
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0314	0.3433	1
Entamoeba histolytica	cysteine proteinase 2	0.01	0.1027	0.5392
Giardia lamblia	Cathepsin L precursor	0.0053	0.0493	0.1151
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0435	0.0435
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0493	0.1151
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.017	0.181	0.181
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.017	0.181	0.5115
Giardia lamblia	Cathepsin L precursor	0.0053	0.0493	0.1151
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0053	0.0493	0.225
Leishmania major	cathepsin L-like protease	0.017	0.181	0.5115
Plasmodium falciparum	serine repeat antigen 1	0.0053	0.0493	0.225
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0435	0.0435
Entamoeba histolytica	cysteine protease, putative	0.01	0.1027	0.5392
Giardia lamblia	Cysteine protease	0.0053	0.0493	0.1151
Leishmania major	cathepsin L-like protease	0.017	0.181	0.5115
Schistosoma mansoni	cathepsin B (C01 family)	0.0053	0.0493	0.0493
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0493	0.1151
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0314	0.3433	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0053	0.0493	0.0493
Schistosoma mansoni	ap endonuclease	0.0019	0.0111	0.0111
Plasmodium falciparum	cysteine proteinase falcipain 3	0.017	0.181	1
Giardia lamblia	Cathepsin B precursor	0.0053	0.0493	0.1151
Brugia malayi	Papain family cysteine protease containing protein	0.01	0.1027	0.1027
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0053	0.0493	0.0493
Trypanosoma cruzi	cysteine proteinase, putative	0.01	0.1027	0.0927
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.017	0.181	0.5115
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0053	0.0493	0.0493
Leishmania major	cathepsin L-like protease	0.017	0.181	0.5115
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.017	0.181	1
Trypanosoma cruzi	cysteine peptidase, putative	0.017	0.181	0.1718
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0053	0.0493	0.1151
Plasmodium vivax	vivapain-3	0.01	0.1027	0.5392
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.017	0.181	0.5115
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.017	0.181	0.5115
Loa Loa (eye worm)	cysteine protease	0.017	0.181	0.181
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0897	1	1
Giardia lamblia	Cysteine protease	0.0053	0.0493	0.1151
Entamoeba histolytica	cysteine protease, putative	0.017	0.181	1
Brugia malayi	N-terminal motif family protein	0.0179	0.1913	0.1913
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0053	0.0493	0.1436
Brugia malayi	Papain family cysteine protease containing protein	0.01	0.1027	0.1027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.181	0.5115
Loa Loa (eye worm)	hypothetical protein	0.0122	0.1276	0.1276
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0047	0.0435	0.0435
Entamoeba histolytica	cysteine protease, putative	0.0053	0.0493	0.225
Echinococcus granulosus	cathepsin b	0.0897	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0053	0.0493	0.0493
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0053	0.0493	0.1151
Entamoeba histolytica	cysteine proteinase, putative	0.01	0.1027	0.5392
Echinococcus granulosus	cathepsin l cysteine peptidase	0.017	0.181	0.181
Entamoeba histolytica	cysteine protease, putative	0.01	0.1027	0.5392
Toxoplasma gondii	exonuclease III APE	0.0019	0.0111	0.0322
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0493	0.1151
Echinococcus granulosus	cysteine protease	0.01	0.1027	0.1027
Entamoeba histolytica	cysteine protease, putative	0.01	0.1027	0.5392
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0897	1	1
Brugia malayi	Cathepsin L-like precursor	0.017	0.181	0.181
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0111	0.5
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.01	0.1027	0.0927
Toxoplasma gondii	cathepsin CPC1	0.0053	0.0493	0.1436
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0053	0.0493	0.225
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0897	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0053	0.0493	0.1151
Schistosoma mansoni	cathepsin S (C01 family)	0.0053	0.0493	0.0493
Giardia lamblia	Hypothetical protein	0.0053	0.0493	0.1151
Schistosoma mansoni	cathepsin F (C01 family)	0.017	0.181	0.181
Plasmodium falciparum	serine repeat antigen 8	0.0053	0.0493	0.225
Echinococcus multilocularis	cathepsin L	0.0053	0.0493	0.0493
Brugia malayi	cathepsin F-like cysteine proteinase	0.0053	0.0493	0.0493
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.01	0.1027	0.1027
Echinococcus multilocularis	cathepsin L	0.01	0.1027	0.1027
Leishmania major	cathepsin L-like protease	0.017	0.181	0.5115
Trypanosoma cruzi	cysteine peptidase, putative	0.017	0.181	0.1718
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.017	0.181	0.5115
Giardia lamblia	Cathepsin B precursor	0.0314	0.3433	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.017	0.181	0.5115
Plasmodium vivax	vivapain-2	0.017	0.181	1
Brugia malayi	Cathepsin L-like precursor	0.0122	0.1276	0.1276
Entamoeba histolytica	cysteine protease, putative	0.01	0.1027	0.5392
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0493	0.1151
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0053	0.0493	0.0493
Plasmodium falciparum	serine repeat antigen 5	0.0053	0.0493	0.225
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.017	0.181	0.181
Schistosoma mansoni	cathepsin F (C01 family)	0.017	0.181	0.181
Giardia lamblia	Cathepsin L-like protease	0.0053	0.0493	0.1151
Brugia malayi	Papain family cysteine protease containing protein	0.0053	0.0493	0.0493
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.0435	0.0328
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0053	0.0493	0.0493
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.017	0.181	0.5115
Plasmodium falciparum	serine repeat antigen 6	0.0053	0.0493	0.225
Entamoeba histolytica	cysteine proteinase, putative	0.017	0.181	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0111	0.0111
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0053	0.0493	0.225
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0493	0.1151
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0493	0.0493
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0053	0.0493	0.0493
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0122	0.1276	0.3508
Loa Loa (eye worm)	hypothetical protein	0.0122	0.1276	0.1276
Schistosoma mansoni	cathepsin s	0.0047	0.0435	0.0435
Giardia lamblia	Hypothetical protein	0.0053	0.0493	0.1151
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.017	0.181	0.5115
Brugia malayi	Cathepsin L-like precursor	0.017	0.181	0.181
Entamoeba histolytica	cysteine protease, putative	0.0053	0.0493	0.225
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.181	0.5115
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.017	0.181	0.5115
Loa Loa (eye worm)	fibroinase	0.017	0.181	0.181
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.017	0.181	0.5115
Loa Loa (eye worm)	hypothetical protein	0.017	0.181	0.181
Entamoeba histolytica	cysteine protease, putative	0.0053	0.0493	0.225
Giardia lamblia	Cysteine protease	0.0053	0.0493	0.1151
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.017	0.181	0.181
Plasmodium falciparum	serine repeat antigen 9	0.0053	0.0493	0.225
Leishmania major	cysteine peptidase A (CPA)	0.017	0.181	0.5115
Giardia lamblia	Cathepsin L-like protease	0.0053	0.0493	0.1151
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.181	0.5115
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0053	0.0493	0.0493
Entamoeba histolytica	cysteine proteinase, putative	0.017	0.181	1
Echinococcus granulosus	cathepsin l1	0.017	0.181	0.181
Schistosoma mansoni	cathepsin F (C01 family)	0.0122	0.1276	0.1276
Loa Loa (eye worm)	cathepsin B	0.0314	0.3433	0.3433
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0053	0.0493	0.1151
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.01	0.1027	0.2758
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.01	0.1027	0.2758
Plasmodium falciparum	serine repeat antigen 2	0.0053	0.0493	0.225
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.181	0.5115
Onchocerca volvulus		0.017	0.181	0.9461
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0053	0.0493	0.225
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.017	0.181	0.5115
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0111	0.5
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0053	0.0493	0.225
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0053	0.0493	0.0493
Giardia lamblia	Cathepsin B precursor	0.0053	0.0493	0.1151
Echinococcus multilocularis	cathepsin b	0.0897	1	1
Plasmodium vivax	unspecified product	0.0047	0.0435	0.1908
Onchocerca volvulus	Cathepsin L homolog	0.017	0.181	0.9461
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0897	1	1
Leishmania major	cathepsin L-like protease	0.017	0.181	0.5115
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0493	0.0493
Giardia lamblia	Cathepsin B precursor	0.0053	0.0493	0.1151
Entamoeba histolytica	cysteine protease, putative	0.01	0.1027	0.5392
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.01	0.1027	0.2758
Echinococcus granulosus	cathepsin L cysteine protease	0.01	0.1027	0.1027
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0053	0.0493	0.0493
Giardia lamblia	Cathepsin L precursor	0.0053	0.0493	0.1151
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0053	0.0493	0.225
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0122	0.1276	0.1276
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.01	0.1027	0.2758
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.181	0.5115
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.017	0.181	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.181	0.5115
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.017	0.181	0.5115
Plasmodium vivax	unspecified product	0.0053	0.0493	0.225
Plasmodium vivax	serine-repeat antigen (SERA)	0.0053	0.0493	0.225
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0122	0.1276	0.1179
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0314	0.3433	0.336
Onchocerca volvulus		0.017	0.181	0.9461
Plasmodium falciparum	serine repeat antigen 3	0.0053	0.0493	0.225
Entamoeba histolytica	cysteine protease, putative	0.01	0.1027	0.5392
Giardia lamblia	Cathepsin L precursor	0.0053	0.0493	0.1151
Brugia malayi	cathepsin F-like cysteine proteinase	0.0047	0.0435	0.0435
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0179	0.1913	1
Entamoeba histolytica	cysteine protease, putative	0.01	0.1027	0.5392
Trypanosoma cruzi	cysteine peptidase, putative	0.01	0.1027	0.0927
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0493	0.0493
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.017	0.181	0.5115
Onchocerca volvulus		0.017	0.181	0.9461
Echinococcus granulosus	cathepsin L	0.01	0.1027	0.1027
Onchocerca volvulus		0.0122	0.1276	0.667
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0053	0.0493	0.1151
Plasmodium vivax	vivapain-1	0.01	0.1027	0.5392
Trypanosoma cruzi	cysteine proteinase, putative	0.01	0.1027	0.0927
Toxoplasma gondii	cathepsin CPC2	0.0053	0.0493	0.1436
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0053	0.0493	0.1151
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0053	0.0493	0.225
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0493	0.1151
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0493	0.1151
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.01	0.1027	0.1027
Entamoeba histolytica	cysteine protease, putative	0.0053	0.0493	0.225
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.017	0.181	0.5115
Echinococcus multilocularis	cathepsin L cysteine protease	0.017	0.181	0.181
Giardia lamblia	Cathepsin B precursor	0.0314	0.3433	1
Entamoeba histolytica	cysteine proteinase, putative	0.01	0.1027	0.5392
Trypanosoma cruzi	cysteine protease, putative	0.01	0.1027	0.0927
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.017	0.181	0.5115
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0111	0.0111
Echinococcus multilocularis	cathepsin L cysteine protease	0.017	0.181	0.181
Echinococcus multilocularis	cysteine protease	0.017	0.181	0.181
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.017	0.181	0.5115
Brugia malayi	fibroinase precursor	0.0053	0.0493	0.0493
Plasmodium falciparum	serine repeat antigen 4	0.0053	0.0493	0.225
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0053	0.0493	0.1151
Giardia lamblia	Encystation-specific protease	0.0053	0.0493	0.1151
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.181	0.5115
Schistosoma mansoni	ap endonuclease	0.0019	0.0111	0.0111
Trypanosoma cruzi	cruzipain precursor, putative	0.0047	0.0435	0.0328
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0053	0.0493	0.225
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0111	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0493	0.1151
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0053	0.0493	0.0493
Giardia lamblia	Cathepsin B precursor	0.0053	0.0493	0.1151
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0053	0.0493	0.0493
Onchocerca volvulus		0.0053	0.0493	0.2577
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.181	0.5115
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0053	0.0493	0.0493
Echinococcus multilocularis	cathepsin b	0.0897	1	1
Brugia malayi	Cathepsin L-like precursor	0.017	0.181	0.181
Entamoeba histolytica	cysteine proteinase, putative	0.01	0.1027	0.5392
Toxoplasma gondii	cathepsin B	0.0314	0.3433	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0053	0.0493	0.1151
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.181	0.5115
Onchocerca volvulus	Cathepsin L homolog	0.0053	0.0493	0.2577
Echinococcus granulosus	cathepsin l1	0.0122	0.1276	0.1276
Brugia malayi	Papain family cysteine protease containing protein	0.0053	0.0493	0.0493
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0053	0.0493	0.225
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.01	0.1027	0.1027
Echinococcus granulosus	cathepsin L	0.0053	0.0493	0.0493
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.017	0.181	0.5115
Brugia malayi	Cathepsin L-like precursor	0.017	0.181	0.181
Onchocerca volvulus		0.017	0.181	0.9461
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0053	0.0493	0.225
Toxoplasma gondii	cathepsin CPL	0.017	0.181	0.5272
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0047	0.0435	0.0435
Plasmodium falciparum	serine repeat antigen 7	0.0053	0.0493	0.225
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0053	0.0493	0.1151
Echinococcus granulosus	cathepsin L cysteine proteinase	0.017	0.181	0.181
Entamoeba histolytica	cysteine proteinase, putative	0.0122	0.1276	0.6858
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0493	0.0493
Giardia lamblia	Cathepsin L precursor	0.0053	0.0493	0.1151
Giardia lamblia	Cathepsin B precursor	0.0053	0.0493	0.1151
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0053	0.0493	0.0493
Brugia malayi	Papain family cysteine protease containing protein	0.017	0.181	0.181
Loa Loa (eye worm)	ctsf protein	0.017	0.181	0.181
Plasmodium falciparum	cysteine proteinase falcipain 1	0.01	0.1027	0.5392
Brugia malayi	cathepsin L-like precursor	0.0122	0.1276	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0493	0.0493
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0111	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0493	0.1151
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0053	0.0493	0.225
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.017	0.181	0.5115
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.017	0.181	0.5115
Leishmania major	cathepsin L-like protease	0.017	0.181	0.5115
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0493	0.1151
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0122	0.1276	0.3508
Entamoeba histolytica	cysteine protease, putative	0.01	0.1027	0.5392
Onchocerca volvulus		0.017	0.181	0.9461
Onchocerca volvulus	Cathepsin L homolog	0.017	0.181	0.9461
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0053	0.0493	0.0493
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0435	0.0435
Echinococcus multilocularis	cysteine protease	0.017	0.181	0.181
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0111	0.0111
Entamoeba histolytica	cysteine protease, putative	0.01	0.1027	0.5392
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0493	0.1151
Brugia malayi	Cathepsin L-like precursor	0.017	0.181	0.181
Entamoeba histolytica	cysteine protease, putative	0.01	0.1027	0.5392
Plasmodium vivax	unspecified product	0.01	0.1027	0.5392
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0053	0.0493	0.1151
Loa Loa (eye worm)	hypothetical protein	0.0122	0.1276	0.1276
Giardia lamblia	Cathepsin B precursor	0.0314	0.3433	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0053	0.0493	0.0387
Brugia malayi	Cathepsin L-like precursor	0.017	0.181	0.181
Entamoeba histolytica	cysteine proteinase, putative	0.01	0.1027	0.5392
Plasmodium vivax	serine-repeat antigen (SERA)	0.0053	0.0493	0.225
Brugia malayi	cathepsin L precursor	0.0053	0.0493	0.0493
Entamoeba histolytica	cysteine protease, putative	0.0053	0.0493	0.225
Loa Loa (eye worm)	hypothetical protein	0.0897	1	1
Entamoeba histolytica	cysteine protease, putative	0.0053	0.0493	0.225
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0897	1	1
Entamoeba histolytica	cysteine protease, putative	0.01	0.1027	0.5392
Trypanosoma cruzi	cysteine peptidase, putative	0.017	0.181	0.1718
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0314	0.3433	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0435	0.0435
Leishmania major	cathepsin L-like protease	0.017	0.181	0.5115
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0053	0.0493	0.225
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.181	0.5115
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.181	0.5115
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.017	0.181	0.5115
Trypanosoma cruzi	cysteine peptidase, putative	0.017	0.181	0.1718
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0053	0.0493	0.225

Activities

Activity type	Activity value	Assay description	Source	Reference
Log ED50 (functional)	= 0.699	Antinidatory effect of the compound was determinec in rat	ChEMBL.	15857130

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 336170