Detailed information for compound 336988

Basic information

Technical information
  • TDR Targets ID: 336988
  • Name: 3-[[(1S)-2-(4,5-diphenyl-1,3-oxazol-2-yl)cycl ohex-2-en-1-yl]methyl]-N-phenylmethoxybenzami de
  • MW: 540.651 | Formula: C36H32N2O3
  • H donors: 1 H acceptors: 2 LogP: 7.98 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(c1cccc(c1)C[C@@H]1CCCC=C1c1nc(c(o1)c1ccccc1)c1ccccc1)NOCc1ccccc1
  • InChi: 1S/C36H32N2O3/c39-35(38-40-25-26-13-4-1-5-14-26)31-21-12-15-27(24-31)23-30-20-10-11-22-32(30)36-37-33(28-16-6-2-7-17-28)34(41-36)29-18-8-3-9-19-29/h1-9,12-19,21-22,24,30H,10-11,20,23,25H2,(H,38,39)/t30-/m0/s1
  • InChiKey: ZCWNNMZVVGSKSY-PMERELPUSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-benzyloxy-3-[[(1S)-2-(4,5-diphenyloxazol-2-yl)cyclohex-2-en-1-yl]methyl]benzamide
  • N-benzyloxy-3-[[(1S)-2-(4,5-diphenyl-2-oxazolyl)-1-cyclohex-2-enyl]methyl]benzamide
  • 3-[[(1S)-2-(4,5-diphenyl-1,3-oxazol-2-yl)cyclohex-2-en-1-yl]methyl]-N-phenylmethoxy-benzamide
  • N-benzoxy-3-[[(1S)-2-(4,5-diphenyloxazol-2-yl)cyclohex-2-en-1-yl]methyl]benzamide
  • 3-[[(1S)-2-[4,5-di(phenyl)-1,3-oxazol-2-yl]-1-cyclohex-2-enyl]methyl]-N-(phenylmethoxy)benzamide
  • 3-[[(1S)-2-[4,5-di(phenyl)oxazol-2-yl]-1-cyclohex-2-enyl]methyl]-N-(phenylmethoxy)benzamide
  • 3-[[(1S)-2-[4,5-di(phenyl)-2-oxazolyl]-1-cyclohex-2-enyl]methyl]-N-(phenylmethoxy)benzamide
  • N-(benzyloxy)-3-[[(1S)-2-[4,5-di(phenyl)oxazol-2-yl]-1-cyclohex-2-enyl]methyl]benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens prostaglandin D2 receptor (DP) Starlite/ChEMBL References
Homo sapiens prostaglandin F receptor (FP) Starlite/ChEMBL References
Homo sapiens prostaglandin E receptor 4 (subtype EP4) Starlite/ChEMBL References
Homo sapiens thromboxane A2 receptor Starlite/ChEMBL References
Homo sapiens prostaglandin I2 (prostacyclin) receptor (IP) Starlite/ChEMBL References
Homo sapiens prostaglandin E receptor 3 (subtype EP3) Starlite/ChEMBL References
Homo sapiens prostaglandin E receptor 2 (subtype EP2), 53kDa Starlite/ChEMBL References
Homo sapiens prostaglandin E receptor 1 (subtype EP1), 42kDa Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis rhodopsin orphan GPCR prostaglandin D2 receptor (DP) 359 aa 312 aa 23.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0053 0.0673 0.1017
Schistosoma mansoni amine GPCR 0.0053 0.0673 0.1017
Toxoplasma gondii hypothetical protein 0.0054 0.0697 1
Brugia malayi GnHR receptor homolog 0.0053 0.0673 0.0673
Schistosoma mansoni hypothetical protein 0.0035 0.0276 0.0417
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Echinococcus multilocularis somatostatin receptor 0.0053 0.0673 0.1017
Echinococcus granulosus neuropeptide FF receptor 2 0.0053 0.0673 0.1017
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0053 0.0673 0.1017
Plasmodium falciparum transporter, putative 0.0054 0.0697 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0054 0.0697 0.1053
Brugia malayi hypothetical protein 0.0053 0.0673 0.0673
Echinococcus multilocularis fmrfamide receptor 0.0053 0.0673 0.1017
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0053 0.0673 0.1017
Echinococcus multilocularis sodium and chloride dependent glycine 0.0054 0.0697 0.1053
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0673 0.1017
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0054 0.0697 0.1053
Schistosoma mansoni histamine h1 receptor 0.0053 0.0673 0.1017
Loa Loa (eye worm) hypothetical protein 0.0467 1 1
Echinococcus granulosus g-protein coupled receptor 0.0053 0.0673 0.1017
Brugia malayi AKH receptor 0.0053 0.0673 0.0673
Brugia malayi Tachykinin-like peptides receptor 99D 0.0053 0.0673 0.0673
Schistosoma mansoni biogenic amine (5HT) receptor 0.0053 0.0673 0.1017
Loa Loa (eye worm) TYRA-2 protein 0.0053 0.0673 0.0593
Schistosoma mansoni alpha-1 adrenergic receptor 0.0053 0.0673 0.1017
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0673 0.1017
Echinococcus multilocularis neuropeptide s receptor 0.0053 0.0673 0.1017
Echinococcus multilocularis g protein coupled receptor 0.0053 0.0673 0.1017
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0053 0.0673 0.1017
Echinococcus multilocularis g protein coupled receptor 0.0053 0.0673 0.1017
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Echinococcus granulosus hypothetical protein 0.0053 0.0673 0.1017
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0673 0.1017
Loa Loa (eye worm) serotonin transporter b 0.0317 0.6619 0.659
Echinococcus granulosus alpha 1A adrenergic receptor 0.0053 0.0673 0.1017
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0673 0.1017
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0053 0.0673 0.1017
Schistosoma mansoni neuropeptide F-like receptor 0.0053 0.0673 0.1017
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Echinococcus multilocularis neuropeptide Y receptor 0.0053 0.0673 0.1017
Echinococcus granulosus biogenic amine 5HT receptor 0.0053 0.0673 0.1017
Schistosoma mansoni opsin-like receptor 0.0053 0.0673 0.1017
Echinococcus granulosus serotonin receptor 0.0053 0.0673 0.1017
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0673 0.1017
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0054 0.0697 0.1053
Loa Loa (eye worm) hypothetical protein 0.0054 0.0697 0.0617
Echinococcus granulosus peptide allatostatin:somatostatin 0.0053 0.0673 0.1017
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0023 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Giardia lamblia DNA repair protein RAD52 0.0367 0.7756 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0673 0.1017
Schistosoma mansoni sodium/chloride dependent transporter 0.0054 0.0697 0.1053
Brugia malayi hypothetical protein 0.0053 0.0673 0.0673
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0053 0.0673 0.1017
Echinococcus granulosus serotonin transporter 0.0317 0.6619 1
Brugia malayi hypothetical protein 0.0053 0.0673 0.0673
Echinococcus multilocularis sodium and chloride dependent glycine 0.0054 0.0697 0.1053
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0673 0.1017
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0053 0.0673 0.1017
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0673 0.1017
Echinococcus multilocularis neuropeptides capa receptor 0.0053 0.0673 0.1017
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Schistosoma mansoni neuropeptide receptor 0.0053 0.0673 0.1017
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0054 0.0697 0.1053
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0054 0.0697 0.1053
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0053 0.0673 0.1017
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0673 0.1017
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0054 0.0697 0.0697
Brugia malayi follicle stimulating hormone receptor 0.0053 0.0673 0.0673
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0276 0.0417
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0673 0.1017
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0053 0.0673 0.1017
Echinococcus multilocularis G protein coupled receptor 139 0.0053 0.0673 0.1017
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0053 0.0673 0.1017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0673 0.1017
Schistosoma mansoni adenoreceptor 0.0053 0.0673 0.1017
Schistosoma mansoni amine GPCR 0.0053 0.0673 0.1017
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0054 0.0697 0.1053
Echinococcus granulosus tachykinin peptides receptor 99D 0.0053 0.0673 0.1017
Brugia malayi larval opioid receptor 0.0053 0.0673 0.0673
Echinococcus granulosus neuropeptide s receptor 0.0053 0.0673 0.1017
Loa Loa (eye worm) norepinephrine transporter 0.0317 0.6619 0.659
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0276 0.0276
Brugia malayi G-protein coupled receptor 0.0053 0.0673 0.0673
Brugia malayi putative neuropeptide receptor NPR1 0.0053 0.0673 0.0673
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0054 0.0697 0.1053
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0054 0.0697 0.1053
Schistosoma mansoni hypothetical protein 0.0035 0.0276 0.0417
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0054 0.0697 0.1053
Onchocerca volvulus 0.0054 0.0697 0.004
Schistosoma mansoni neuropeptide receptor 0.0053 0.0673 0.1017
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0053 0.0673 0.1017
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0053 0.0673 0.1017
Echinococcus granulosus orexin receptor type 2 0.0053 0.0673 0.1017
Onchocerca volvulus 0.0054 0.0697 0.004
Brugia malayi G-protein coupled receptor 0.0053 0.0673 0.0673
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0053 0.0673 0.1017
Loa Loa (eye worm) hypothetical protein 0.0054 0.0697 0.0617
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0053 0.0673 0.0593
Loa Loa (eye worm) G-protein coupled receptor 0.0053 0.0673 0.0593
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0276 0.0417
Echinococcus multilocularis G-protein coupled receptor, putative 0.0053 0.0673 0.1017
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0053 0.0673 0.1017
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Echinococcus multilocularis neuropeptide FF receptor 2 0.0053 0.0673 0.1017
Schistosoma mansoni opsin-like receptor 0.0053 0.0673 0.1017
Loa Loa (eye worm) hypothetical protein 0.0054 0.0697 0.0617
Brugia malayi neuropeptide F receptor 0.0053 0.0673 0.0673
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0053 0.0673 0.1017
Echinococcus granulosus biogenic amine 5HT receptor 0.0053 0.0673 0.1017
Echinococcus multilocularis neuropeptide receptor 0.0053 0.0673 0.1017
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0053 0.0673 0.1017
Brugia malayi G protein-coupled receptor 0.0053 0.0673 0.0673
Brugia malayi Dopamine receptor 0.0053 0.0673 0.0673
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0673 0.1017
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Schistosoma mansoni biogenic amine receptor 0.0053 0.0673 0.1017
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0673 0.1017
Schistosoma mansoni biogenic amine (5HT) receptor 0.0053 0.0673 0.1017
Echinococcus granulosus dro:myosuppressin receptor 0.0053 0.0673 0.1017
Echinococcus multilocularis neuropeptides capa receptor 0.0053 0.0673 0.1017
Echinococcus granulosus GPCR family 2 0.0035 0.0276 0.0417
Echinococcus granulosus neuropeptide receptor A26 0.0053 0.0673 0.1017
Echinococcus multilocularis neuropeptide Y receptor 0.0053 0.0673 0.1017
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0053 0.0673 0.1017
Echinococcus granulosus sodium and chloride dependent glycine 0.0054 0.0697 0.1053
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0054 0.0697 0.0697
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0053 0.0673 0.1017
Brugia malayi sulfakinin receptor protein 0.0053 0.0673 0.0673
Echinococcus granulosus fmrfamide receptor 0.0053 0.0673 0.1017
Schistosoma mansoni neuropeptide receptor 0.0053 0.0673 0.1017
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0053 0.0673 0.1017
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0053 0.0673 0.1017
Plasmodium vivax amine transporter, putative 0.0054 0.0697 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0673 0.1017
Echinococcus granulosus 7tm_1 domain containing protein 0.0053 0.0673 0.1017
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0053 0.0673 0.1017
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0053 0.0673 0.1017
Loa Loa (eye worm) hypothetical protein 0.0169 0.3282 0.3224
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0054 0.0697 0.0697
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0053 0.0673 0.1017
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0673 0.1017
Brugia malayi Calcitonin receptor-like protein seb-1 0.0111 0.1983 0.1983
Echinococcus granulosus allatostatin A receptor 0.0053 0.0673 0.1017
Brugia malayi Dopamine receptor protein 2 0.0053 0.0673 0.0673
Echinococcus multilocularis dro:myosuppressin receptor 0.0053 0.0673 0.1017
Loa Loa (eye worm) hypothetical protein 0.0054 0.0697 0.0617
Schistosoma mansoni neuropeptide f receptor 76f 0.0053 0.0673 0.1017
Loa Loa (eye worm) hypothetical protein 0.0054 0.0697 0.0617
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0086 0.1227
Echinococcus granulosus neuropeptide Y receptor 0.0053 0.0673 0.1017
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0673 0.1017
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0086 0.1227
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0111 0.1983 0.1983
Loa Loa (eye worm) G-protein coupled receptor 0.0053 0.0673 0.0593
Brugia malayi hypothetical protein 0.0053 0.0673 0.0673
Plasmodium vivax hypothetical protein, conserved 0.0054 0.0697 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.1193 0.1117
Echinococcus granulosus neuropeptide Y receptor 0.0053 0.0673 0.1017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0673 0.1017
Schistosoma mansoni amine GPCR 0.0053 0.0673 0.1017
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0053 0.0673 0.0673
Echinococcus granulosus tm gpcr rhodopsin 0.0053 0.0673 0.1017
Schistosoma mansoni growth hormone secretagogue receptor 0.0053 0.0673 0.1017
Echinococcus multilocularis serotonin receptor 0.0053 0.0673 0.1017
Treponema pallidum sodium- and chloride- dependent transporter 0.0317 0.6619 0.5
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0054 0.0697 0.0617
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0086 0.5
Schistosoma mansoni amine GPCR 0.0053 0.0673 0.1017
Schistosoma mansoni sodium/chloride dependent transporter 0.0054 0.0697 0.1053
Schistosoma mansoni neuropeptide F-like receptor 0.0053 0.0673 0.1017
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Schistosoma mansoni sodium-dependent amino acid transporter 0.0054 0.0697 0.1053
Echinococcus granulosus sodium and chloride dependent glycine 0.0054 0.0697 0.1053
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0053 0.0673 0.1017
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0053 0.0673 0.0593
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0161 0.3102 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0053 0.0673 0.1017
Brugia malayi ORL1-like opioid receptor 0.0053 0.0673 0.0673
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0317 0.6619 0.6619
Loa Loa (eye worm) hypothetical protein 0.0111 0.1983 0.1914
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0161 0.3102 0.5
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Echinococcus granulosus neuropeptide receptor 0.0053 0.0673 0.1017
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0673 0.1017
Brugia malayi neuropeptide F receptor 0.0053 0.0673 0.0673
Loa Loa (eye worm) neuropeptide F receptor 0.0053 0.0673 0.0593
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0054 0.0697 1
Brugia malayi hypothetical protein 0.0027 0.0086 0.0086
Onchocerca volvulus 0.0054 0.0697 0.004
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0054 0.0697 0.1053
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0053 0.0673 0.0673
Mycobacterium tuberculosis Probable aminotransferase 0.0161 0.3102 1
Schistosoma mansoni hypothetical protein 0.0076 0.1193 0.1802
Loa Loa (eye worm) hypothetical protein 0.0317 0.6619 0.659
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0054 0.0697 0.1053
Schistosoma mansoni hypothetical protein 0.0053 0.0673 0.1017
Toxoplasma gondii hypothetical protein 0.0054 0.0697 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Schistosoma mansoni sodium/chloride dependent transporter 0.0317 0.6619 1
Schistosoma mansoni biogenic amine receptor 0.0053 0.0673 0.1017
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0053 0.0673 0.1017
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.1193 0.1193
Echinococcus granulosus tm gpcr rhodopsin 0.0053 0.0673 0.1017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0673 0.1017
Brugia malayi hypothetical protein 0.0053 0.0673 0.0673
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0086 0.5
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0054 0.0697 0.1053
Schistosoma mansoni amine GPCR 0.0053 0.0673 0.1017
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0086 0.5
Brugia malayi hypothetical protein 0.0053 0.0673 0.0673
Schistosoma mansoni hypothetical protein 0.0035 0.0276 0.0417
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0673 0.1017
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0276 0.0192
Echinococcus multilocularis orexin receptor type 2 0.0053 0.0673 0.1017
Brugia malayi hypothetical protein 0.0053 0.0673 0.0673
Loa Loa (eye worm) hypothetical protein 0.0317 0.6619 0.659
Loa Loa (eye worm) hypothetical protein 0.0054 0.0697 0.0617
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0053 0.0673 0.0673
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0053 0.0673 0.0593
Onchocerca volvulus 0.0317 0.6619 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0053 0.0673 0.1017
Loa Loa (eye worm) hypothetical protein 0.0035 0.0276 0.0192
Echinococcus multilocularis g protein coupled receptor 0.0053 0.0673 0.1017
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Loa Loa (eye worm) melatonin receptor type 1A 0.0053 0.0673 0.0593
Echinococcus multilocularis g-protein coupled receptor 0.0053 0.0673 0.1017
Loa Loa (eye worm) neuropeptide F receptor 0.0053 0.0673 0.0593
Echinococcus granulosus somatostatin receptor 0.0053 0.0673 0.1017
Echinococcus granulosus neuropeptides capa receptor 0.0053 0.0673 0.1017
Echinococcus granulosus g protein coupled receptor 0.0053 0.0673 0.1017
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0054 0.0697 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0054 0.0697 0.0697
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0367 0.7756 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Mycobacterium ulcerans hypothetical protein 0.0161 0.3102 1
Plasmodium falciparum amino acid transporter, putative 0.0054 0.0697 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Schistosoma mansoni opsin-like receptor 0.0053 0.0673 0.1017
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0111 0.1983 0.1914
Schistosoma mansoni hypothetical protein 0.0035 0.0276 0.0417
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0053 0.0673 0.1017
Schistosoma mansoni hypothetical protein 0.0053 0.0673 0.1017
Schistosoma mansoni hypothetical protein 0.0053 0.0673 0.1017
Brugia malayi hypothetical protein 0.0169 0.3282 0.3282
Schistosoma mansoni neuropeptide receptor 0.0053 0.0673 0.1017
Echinococcus granulosus G protein coupled receptor 139 0.0053 0.0673 0.1017
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0054 0.0697 1
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0086 0.1227
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0053 0.0673 0.1017
Echinococcus granulosus tm gpcr rhodopsin 0.0053 0.0673 0.1017
Echinococcus granulosus g protein coupled receptor 0.0053 0.0673 0.1017
Onchocerca volvulus 0.0169 0.3282 0.4388
Echinococcus multilocularis neuropeptide receptor 0.0053 0.0673 0.1017
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0673 0.1017
Brugia malayi Melatonin receptor type 1A 0.0053 0.0673 0.0673
Schistosoma mansoni hypothetical protein 0.0053 0.0673 0.1017
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0276 0.0417
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0673 0.1017
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0053 0.0673 0.0593
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0053 0.0673 0.1017
Echinococcus granulosus sex peptide receptor 0.0053 0.0673 0.1017
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Echinococcus multilocularis GPCR, family 2 0.0035 0.0276 0.0417
Brugia malayi hypothetical protein 0.0053 0.0673 0.0673
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Echinococcus multilocularis sex peptide receptor 0.0053 0.0673 0.1017
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0053 0.0673 0.0593
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Echinococcus granulosus 7TM GPCR rhodopsin 0.0053 0.0673 0.1017
Echinococcus multilocularis fmrfamide receptor 0.0053 0.0673 0.1017
Schistosoma mansoni biogenic amine receptor 0.0053 0.0673 0.1017
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Brugia malayi Serotonin receptor 0.0053 0.0673 0.0673
Loa Loa (eye worm) solute carrier family 6 member 4 0.0317 0.6619 0.659
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0053 0.0673 0.0673
Echinococcus multilocularis serotonin transporter 0.0317 0.6619 1
Echinococcus granulosus neuropeptides capa receptor 0.0053 0.0673 0.1017
Echinococcus multilocularis neuropeptide receptor A26 0.0053 0.0673 0.1017
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0054 0.0697 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0054 0.0697 0.0617
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0317 0.6619 1
Loa Loa (eye worm) hypothetical protein 0.0317 0.6619 0.659
Schistosoma mansoni myosin xvIII 0.0053 0.0673 0.1017
Echinococcus granulosus g protein coupled receptor 0.0053 0.0673 0.1017
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0086 0.1227
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0053 0.0673 0.1017
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0054 0.0697 0.1053
Brugia malayi hypothetical protein 0.0054 0.0697 0.0697
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0673 0.1017
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0053 0.0673 0.1017
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0161 0.3102 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0053 0.0673 0.1017
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0161 0.3102 1
Echinococcus granulosus neuropeptide receptor 0.0053 0.0673 0.1017
Brugia malayi Serotonin receptor 0.0053 0.0673 0.0673
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0276 0.0276
Brugia malayi G protein-coupled receptor F59B2.13 0.0053 0.0673 0.0673
Brugia malayi RE15519p 0.0053 0.0673 0.0673
Brugia malayi hypothetical protein 0.0053 0.0673 0.0673
Loa Loa (eye worm) hypothetical protein 0.0054 0.0697 0.0617
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0053 0.0673 0.0673
Leishmania major hypothetical protein, conserved 0.0027 0.0086 0.5
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Echinococcus multilocularis allatostatin A receptor 0.0053 0.0673 0.1017
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0054 0.0697 0.1053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0673 0.1017
Loa Loa (eye worm) hypothetical protein 0.0053 0.0673 0.0593
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0276 0.0417
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0054 0.0697 0.1053
Brugia malayi hypothetical protein 0.0053 0.0673 0.0673
Echinococcus multilocularis serotonin receptor 0.0053 0.0673 0.1017
Brugia malayi putative neuropeptide receptor 0.0053 0.0673 0.0673

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.68 nM Inhibition of [3H]-PGE-2 binding to human prostanoid EP4 receptor ChEMBL. 15857112
Ki (binding) = 0.68 nM Inhibition of [3H]-PGE-2 binding to human prostanoid EP4 receptor ChEMBL. 15857112
Ki (binding) > 1000 nM Inhibtion of [3H]-PGD-2 binding to human prostanoid DP receptor ChEMBL. 15857112
Ki (binding) > 1000 nM Inhibition of [3H]-PGF-2 binding to human prostanoid FP receptor ChEMBL. 15857112
Ki (binding) > 1000 nM Inhibition of [3H]-SQ-29,548 binding to human prostanoid TP receptor ChEMBL. 15857112
Ki (binding) > 1000 nM Inhibtion of [3H]-PGD-2 binding to human prostanoid DP receptor ChEMBL. 15857112
Ki (binding) > 1000 nM Inhibition of [3H]-PGF-2 binding to human prostanoid FP receptor ChEMBL. 15857112
Ki (binding) > 1000 nM Inhibition of [3H]-SQ-29,548 binding to human prostanoid TP receptor ChEMBL. 15857112
Ki (binding) > 3000 nM Inhibition of [3H]-Iloprost binding to human prostanoid IP receptor ChEMBL. 15857112
Ki (binding) > 3000 nM Inhibition of [3H]-PGE-2 binding to human prostanoid EP1 receptor ChEMBL. 15857112
Ki (binding) > 3000 nM Inhibition of [3H]-PGE-2 binding to human prostanoid EP2 receptor ChEMBL. 15857112
Ki (binding) > 3000 nM Inhibition of [3H]-PGE-2 binding to human prostanoid EP3 receptor ChEMBL. 15857112
Ki (binding) > 3000 nM Inhibition of [3H]-Iloprost binding to human prostanoid IP receptor ChEMBL. 15857112
Ki (binding) > 3000 nM Inhibition of [3H]-PGE-2 binding to human prostanoid EP1 receptor ChEMBL. 15857112
Ki (binding) > 3000 nM Inhibition of [3H]-PGE-2 binding to human prostanoid EP2 receptor ChEMBL. 15857112
Ki (binding) > 3000 nM Inhibition of [3H]-PGE-2 binding to human prostanoid EP3 receptor ChEMBL. 15857112

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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