Detailed information for compound 338281

Basic information

Technical information
  • TDR Targets ID: 338281
  • Name: ethyl 2-[5-[12-[4-(2-ethoxy-2-oxoethyl)-3-met hyl-1,3-thiazol-3-ium-5-yl]dodecyl]-3-methyl- 1,3-thiazol-3-ium-4-yl]acetate diiodide
  • MW: 792.615 | Formula: C28H46I2N2O4S2
  • H donors: 0 H acceptors: 2 LogP: 9.68 Rotable bonds: 21
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOC(=O)Cc1[n+](C)csc1CCCCCCCCCCCCc1sc[n+](c1CC(=O)OCC)C.[I-].[I-]
  • InChi: 1S/C28H46N2O4S2.2HI/c1-5-33-27(31)19-23-25(35-21-29(23)3)17-15-13-11-9-7-8-10-12-14-16-18-26-24(30(4)22-36-26)20-28(32)34-6-2;;/h21-22H,5-20H2,1-4H3;2*1H/q+2;;/p-2
  • InChiKey: NMRBLXUHBWUBCY-UHFFFAOYSA-L  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • ethyl 2-[5-[12-[4-(2-ethoxy-2-oxo-ethyl)-3-methyl-thiazol-3-ium-5-yl]dodecyl]-3-methyl-thiazol-3-ium-4-yl]acetate diiodide
  • 2-[5-[12-[4-(2-ethoxy-2-oxoethyl)-3-methyl-5-thiazol-3-iumyl]dodecyl]-3-methyl-4-thiazol-3-iumyl]acetic acid ethyl ester diiodide
  • ethyl 2-[5-[12-[4-(2-ethoxy-2-oxo-ethyl)-3-methyl-1,3-thiazol-3-ium-5-yl]dodecyl]-3-methyl-1,3-thiazol-3-ium-4-yl]ethanoate diiodide
  • 2-[5-[12-[4-(2-ethoxy-2-keto-ethyl)-3-methyl-thiazol-3-ium-5-yl]dodecyl]-3-methyl-thiazol-3-ium-4-yl]acetic acid ethyl ester diiodide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) fli-1 protein 0.0216 0.1116 0.1116
Toxoplasma gondii cathepsin CPC1 0.0278 0.1509 0.4179
Trypanosoma cruzi prolyl endopeptidase 0.0141 0.0649 0.0649
Trypanosoma cruzi oligopeptidase b 0.0064 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0071 0.0216 0.0216
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0089 0.0328 0.0328
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0271 0.146 0.3784
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0089 0.0328 0.0328
Entamoeba histolytica cysteine protease, putative 0.0163 0.0787 0.4054
Brugia malayi Cathepsin L-like precursor 0.0271 0.146 0.146
Echinococcus multilocularis prolyl endopeptidase 0.0141 0.0649 0.0649
Brugia malayi cathepsin L-like precursor 0.0197 0.1001 0.1001
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0064 0.0171 0.5
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0097 0.0375 0.0375
Leishmania major oligopeptidase b 0.0064 0.0171 0.0516
Trypanosoma cruzi cysteine peptidase, putative 0.0271 0.146 0.146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0271 0.146 0.3784
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0161 0.0776 0.1498
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0569 0.3319 1
Giardia lamblia Encystation-specific protease 0.0161 0.0776 0.1498
Toxoplasma gondii cathepsin CPC2 0.0161 0.0776 0.1823
Brugia malayi cathepsin F-like cysteine proteinase 0.0089 0.0328 0.0328
Entamoeba histolytica cysteine protease, putative 0.0163 0.0787 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0271 0.146 0.3784
Loa Loa (eye worm) hypothetical protein 0.0271 0.146 0.146
Loa Loa (eye worm) hypothetical protein 0.0043 0.0042 0.0042
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0089 0.0328 0.2173
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0271 0.146 0.146
Echinococcus multilocularis cathepsin L 0.0089 0.0328 0.0328
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.0787 0.1534
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.007 0.0209 0.0209
Echinococcus multilocularis cysteine protease 0.0271 0.146 0.146
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0101 0.0403 0.0403
Brugia malayi Cathepsin L-like precursor 0.0271 0.146 0.146
Giardia lamblia Cathepsin B precursor 0.0569 0.3319 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0278 0.1509 0.1509
Onchocerca volvulus 0.0118 0.0507 0.2736
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0089 0.0328 0.0328
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0182 0.0906 0.0906
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0161 0.0776 0.3794
Loa Loa (eye worm) hypothetical protein 0.0074 0.0232 0.0232
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0052 0.0052
Echinococcus multilocularis cathepsin b 0.164 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.164 1 1
Onchocerca volvulus 0.0197 0.1001 0.6502
Schistosoma mansoni cathepsin S (C01 family) 0.0089 0.0328 0.0328
Toxoplasma gondii cathepsin B 0.0569 0.3319 1
Leishmania major cathepsin L-like protease 0.0271 0.146 0.4398
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0052 0.0052
Echinococcus granulosus cathepsin l1 0.0271 0.146 0.146
Leishmania major cathepsin L-like protease 0.0271 0.146 0.4398
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0278 0.1509 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0074 0.0232 0.0232
Entamoeba histolytica cysteine proteinase, putative 0.0271 0.146 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0271 0.146 0.9585
Plasmodium falciparum cysteine proteinase falcipain 1 0.0163 0.0787 0.3886
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.007 0.0209 0.0629
Onchocerca volvulus 0.0271 0.146 1
Trypanosoma cruzi cysteine proteinase, putative 0.0163 0.0787 0.0787
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0163 0.0787 0.0787
Leishmania major cathepsin L-like protease 0.0271 0.146 0.4398
Loa Loa (eye worm) hypothetical protein 0.0083 0.0291 0.0291
Echinococcus granulosus cathepsin l cysteine peptidase 0.0271 0.146 0.146
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0052 0.0052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0271 0.146 0.4398
Loa Loa (eye worm) hypothetical protein 0.0061 0.0151 0.0151
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0271 0.146 0.3784
Entamoeba histolytica cysteine proteinase, putative 0.0163 0.0787 0.4054
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.007 0.0209 0.0209
Brugia malayi cathepsin L precursor 0.0089 0.0328 0.0328
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0271 0.146 0.3784
Trypanosoma cruzi cysteine peptidase, putative 0.0271 0.146 0.146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0271 0.146 0.3784
Plasmodium vivax unspecified product 0.0089 0.0328 0.2173
Entamoeba histolytica cysteine protease, putative 0.0163 0.0787 0.4054
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0064 0.0171 0.0171
Entamoeba histolytica cysteine protease, putative 0.0163 0.0787 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0163 0.0787 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0271 0.146 0.4398
Entamoeba histolytica cysteine proteinase, putative 0.0163 0.0787 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.0787 0.1534
Entamoeba histolytica cysteine protease, putative 0.0163 0.0787 0.4054
Loa Loa (eye worm) hypothetical protein 0.0074 0.0232 0.0232
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0052 0.0052
Trypanosoma cruzi major cysteine proteinase, putative 0.0089 0.0328 0.0328
Trypanosoma cruzi cysteine proteinase, putative 0.0163 0.0787 0.0787
Toxoplasma gondii prolyl endopeptidase 0.0141 0.0649 0.1416
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0163 0.0787 0.0787
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0163 0.0787 0.0787
Loa Loa (eye worm) hypothetical protein 0.006 0.0148 0.0148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0271 0.146 0.3784
Trypanosoma cruzi cysteine peptidase, putative 0.0271 0.146 0.146
Brugia malayi Papain family cysteine protease containing protein 0.0089 0.0328 0.0328
Entamoeba histolytica cysteine proteinase, putative 0.0197 0.1001 0.5946
Brugia malayi Cathepsin L-like precursor 0.0197 0.1001 0.1001
Loa Loa (eye worm) cathepsin B 0.0569 0.3319 0.3319
Echinococcus granulosus cathepsin L cysteine proteinase 0.0271 0.146 0.146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0271 0.146 0.3784
Brugia malayi Cathepsin L-like precursor 0.0271 0.146 0.146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0271 0.146 0.3784
Giardia lamblia Cathepsin B precursor 0.0569 0.3319 1
Schistosoma mansoni ets-related 0.0216 0.1116 0.1116
Schistosoma mansoni cathepsin B (C01 family) 0.0089 0.0328 0.0328
Plasmodium vivax serine-repeat antigen (SERA) 0.0089 0.0328 0.2173
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0278 0.1509 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0089 0.0328 0.2173
Echinococcus granulosus cathepsin L 0.0163 0.0787 0.0787
Echinococcus multilocularis calpain A 0.0101 0.0403 0.0403
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0278 0.1509 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0052 0.0052
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.007 0.0209 0.0209
Echinococcus granulosus cathepsin l1 0.0197 0.1001 0.1001
Entamoeba histolytica cysteine protease, putative 0.0163 0.0787 0.4054
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0141 0.0649 0.1956
Onchocerca volvulus 0.0271 0.146 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0271 0.146 0.3784
Brugia malayi cathepsin Z-like cysteine proteinase 0.0089 0.0328 0.0328
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0271 0.146 0.3784
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0052 0.0052
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.164 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0271 0.146 0.4398
Entamoeba histolytica cysteine proteinase, putative 0.0163 0.0787 0.4054
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0052 0.0052
Schistosoma mansoni cathepsin F (C01 family) 0.0271 0.146 0.146
Loa Loa (eye worm) hypothetical protein 0.0197 0.1001 0.1001
Onchocerca volvulus Prolyl endopeptidase homolog 0.0141 0.0649 0.3821
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0271 0.146 0.146
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0271 0.146 0.4398
Leishmania major cathepsin L-like protease 0.0271 0.146 0.4398
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0064 0.0171 0.5
Brugia malayi Cathepsin L-like precursor 0.0074 0.0232 0.0232
Echinococcus granulosus prolyl endopeptidase 0.0141 0.0649 0.0649
Echinococcus granulosus cathepsin L 0.0089 0.0328 0.0328
Schistosoma mansoni gabp alpha 0.0071 0.0215 0.0215
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0074 0.0232 0.0232
Schistosoma mansoni cathepsin F (C01 family) 0.0271 0.146 0.146
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.007 0.0209 0.0629
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0089 0.0328 0.0328
Trypanosoma brucei oligopeptidase b 0.0064 0.0171 0.0516
Loa Loa (eye worm) hypothetical protein 0.0141 0.0649 0.0649
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0089 0.0328 0.2173
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0089 0.0328 0.2173
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0141 0.0649 0.0649
Onchocerca volvulus 0.0271 0.146 1
Onchocerca volvulus 0.0089 0.0328 0.1371
Brugia malayi prolyl oligopeptidase family protein 0.007 0.0209 0.0209
Echinococcus granulosus calpain A 0.0101 0.0403 0.0403
Trypanosoma cruzi major cysteine proteinase, putative 0.0089 0.0328 0.0328
Brugia malayi cathepsin F-like cysteine proteinase 0.0074 0.0232 0.0232
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0064 0.0171 0.0171
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0278 0.1509 1
Echinococcus multilocularis cathepsin L 0.0163 0.0787 0.0787
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0271 0.146 0.4398
Echinococcus multilocularis calpain family protein 1, d 0.0071 0.0216 0.0216
Brugia malayi Cathepsin L-like precursor 0.0271 0.146 0.146
Loa Loa (eye worm) calpain family protein 1 0.0097 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.0089 0.0328 0.0328
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0271 0.146 0.4398
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0089 0.0328 0.0328
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0271 0.146 0.3784
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0271 0.146 0.9585
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0271 0.146 0.4398
Loa Loa (eye worm) cysteine protease 0.0271 0.146 0.146
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0232 0.0232
Onchocerca volvulus 0.0271 0.146 1
Brugia malayi Peptidase family M1 containing protein 0.0118 0.0507 0.0507
Brugia malayi Cathepsin L-like precursor 0.0271 0.146 0.146
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0271 0.146 0.3784
Brugia malayi Papain family cysteine protease containing protein 0.0271 0.146 0.146
Trypanosoma brucei prolyl endopeptidase 0.0141 0.0649 0.1956
Plasmodium vivax vivapain-2 0.0271 0.146 0.9675
Loa Loa (eye worm) fibroinase 0.0271 0.146 0.146
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0089 0.0328 0.2173
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0161 0.0776 0.5143
Plasmodium vivax vivapain-2 0.0271 0.146 0.9675
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0089 0.0328 0.0328
Loa Loa (eye worm) hypothetical protein 0.0097 0.0375 0.0375
Loa Loa (eye worm) peptidase family M1 containing protein 0.0095 0.0367 0.0367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0271 0.146 0.4398
Entamoeba histolytica cysteine protease, putative 0.0163 0.0787 0.4054
Entamoeba histolytica cysteine protease, putative 0.0163 0.0787 0.4054
Onchocerca volvulus Cathepsin L homolog 0.0271 0.146 1
Leishmania major cathepsin L-like protease 0.0271 0.146 0.4398
Loa Loa (eye worm) ctsf protein 0.0271 0.146 0.146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0271 0.146 0.3784
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0569 0.3319 0.3319
Brugia malayi Papain family cysteine protease containing protein 0.0163 0.0787 0.0787
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0101 0.0403 0.0403
Brugia malayi Ets-domain containing protein 0.0071 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0197 0.1001 0.1001
Brugia malayi Fli-1 protein 0.0216 0.1116 0.1116
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0089 0.0328 0.2173
Brugia malayi prolyl oligopeptidase family protein 0.0141 0.0649 0.0649
Toxoplasma gondii cathepsin CPL 0.0271 0.146 0.4022
Trypanosoma cruzi cruzipain precursor, putative 0.0271 0.146 0.146
Echinococcus granulosus cysteine protease 0.0163 0.0787 0.0787
Plasmodium vivax vivapain-1 0.0163 0.0787 0.5215
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0089 0.0328 0.0328
Loa Loa (eye worm) calpain family protein 1 0.0071 0.0216 0.0216
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.164 1 1
Brugia malayi calpain family protein 1 0.0097 0.0375 0.0375
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0271 0.146 0.3784
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.164 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0271 0.146 0.3784
Schistosoma mansoni cathepsin F (C01 family) 0.0197 0.1001 0.1001
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0089 0.0328 0.2173
Brugia malayi Papain family cysteine protease containing protein 0.0089 0.0328 0.0328
Schistosoma mansoni cathepsin s 0.0074 0.0232 0.0232
Entamoeba histolytica cysteine protease, putative 0.0163 0.0787 0.4054
Brugia malayi prolyl oligopeptidase family protein 0.0182 0.0906 0.0906
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0182 0.0906 0.0906
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0197 0.1001 0.1001
Trypanosoma cruzi cruzipain precursor, putative 0.0074 0.0232 0.0232
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0207 0.1061 0.245
Giardia lamblia Cathepsin B precursor 0.0569 0.3319 1
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0182 0.0906 0.0906
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0182 0.0906 0.5777
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0161 0.0776 0.1498
Brugia malayi calpain family protein 1 0.0097 0.0375 0.0375
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0271 0.146 0.3784
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0271 0.146 0.146
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0141 0.0649 0.0649
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0064 0.0171 0.0516
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0278 0.1509 0.3948
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0163 0.0787 0.0787
Brugia malayi fibroinase precursor 0.0089 0.0328 0.0328
Entamoeba histolytica cysteine protease, putative 0.0271 0.146 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0101 0.0403 0.0403
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0271 0.146 0.3784
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0307 0.1689 0.1689
Brugia malayi Ets-domain containing protein 0.0071 0.0215 0.0215
Entamoeba histolytica cysteine protease, putative 0.0163 0.0787 0.4054
Onchocerca volvulus 0.0271 0.146 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0569 0.3319 1
Echinococcus granulosus Dipeptidyl peptidase 9 0.007 0.0209 0.0209
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0089 0.0328 0.0328
Loa Loa (eye worm) hypothetical protein 0.0089 0.0328 0.0328
Schistosoma mansoni cathepsin C 0.0089 0.0328 0.0328
Onchocerca volvulus Cathepsin F homolog 0.0271 0.146 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0271 0.146 0.4398
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0052 0.0052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.0787 0.237
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.007 0.0209 0.0629
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0271 0.146 0.3784
Loa Loa (eye worm) hypothetical protein 0.0106 0.0431 0.0431
Leishmania major cysteine peptidase A (CPA) 0.0271 0.146 0.4398
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0197 0.1001 0.225
Plasmodium vivax unspecified product 0.0074 0.0232 0.1534
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0215 0.0215
Entamoeba histolytica cysteine proteinase 1, putative 0.0163 0.0787 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.0089 0.0328 0.0328
Trypanosoma cruzi cysteine peptidase, putative 0.0271 0.146 0.146
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0114 0.0483 1
Brugia malayi Papain family cysteine protease containing protein 0.0163 0.0787 0.0787
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0569 0.3319 0.3319
Onchocerca volvulus 0.0271 0.146 1
Brugia malayi Cathepsin L-like precursor 0.0197 0.1001 0.1001
Echinococcus granulosus cathepsin b 0.164 1 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0307 0.0307
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0271 0.146 0.3784
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0271 0.146 0.3784
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0215 0.0215
Echinococcus multilocularis aminopeptidase N 0.0118 0.0507 0.0507
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0271 0.146 0.4398
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0271 0.146 0.3784
Entamoeba histolytica cysteine proteinase, putative 0.0271 0.146 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0271 0.146 0.146
Brugia malayi cathepsin Z-like cysteine proteinase 0.0089 0.0328 0.0328
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0271 0.146 0.4398
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0089 0.0328 0.0328
Trypanosoma cruzi cysteine protease, putative 0.0163 0.0787 0.0787
Onchocerca volvulus 0.0271 0.146 1
Loa Loa (eye worm) prolyl oligopeptidase 0.0182 0.0906 0.0906
Brugia malayi cathepsin L-like cysteine proteinase 0.0089 0.0328 0.0328
Echinococcus granulosus tachykinin peptides receptor 99D 0.0307 0.1689 0.1689
Loa Loa (eye worm) hypothetical protein 0.0089 0.0328 0.0328
Echinococcus multilocularis Dipeptidyl peptidase 9 0.007 0.0209 0.0209
Plasmodium falciparum cysteine proteinase falcipain 3 0.0271 0.146 0.9585
Echinococcus granulosus cathepsin b 0.164 1 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.0328 0.0328
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.0787 0.237
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0197 0.1001 0.225
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0271 0.146 0.146
Entamoeba histolytica cysteine protease, putative 0.0163 0.0787 0.4054
Entamoeba histolytica cysteine protease, putative 0.0163 0.0787 0.4054
Loa Loa (eye worm) hypothetical protein 0.0074 0.0232 0.0232
Trypanosoma brucei prolyl oligopeptidase, putative 0.0064 0.0171 0.0516
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0064 0.0171 0.0516
Leishmania major cathepsin L-like protease 0.0271 0.146 0.4398
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.164 1 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0197 0.1001 0.1001
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0089 0.0328 0.2173
Plasmodium vivax vivapain-3 0.0163 0.0787 0.5215
Loa Loa (eye worm) hypothetical protein 0.164 1 1
Plasmodium vivax unspecified product 0.0163 0.0787 0.5215
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0089 0.0328 0.0328
Entamoeba histolytica cysteine protease, putative 0.0163 0.0787 0.4054
Echinococcus multilocularis cysteine protease 0.0271 0.146 0.146
Loa Loa (eye worm) hypothetical protein 0.0089 0.0328 0.0328
Echinococcus granulosus aminopeptidase N 0.0118 0.0507 0.0507
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0569 0.3319 1
Trypanosoma cruzi cysteine peptidase, putative 0.0163 0.0787 0.0787
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0089 0.0328 0.0328
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0089 0.0328 0.0328
Loa Loa (eye worm) hypothetical protein 0.0197 0.1001 0.1001
Onchocerca volvulus Cathepsin L homolog 0.0089 0.0328 0.1371
Onchocerca volvulus Cathepsin L homolog 0.0271 0.146 1
Trypanosoma cruzi oligopeptidase b 0.0064 0.0171 0.0171
Brugia malayi Cathepsin L-like precursor 0.0271 0.146 0.146
Entamoeba histolytica cysteine proteinase 2 0.0163 0.0787 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0271 0.146 0.3784
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0271 0.146 0.3784
Loa Loa (eye worm) hypothetical protein 0.0089 0.0328 0.0328
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0101 0.0403 0.0403
Leishmania major cathepsin L-like protease 0.0271 0.146 0.4398
Toxoplasma gondii preprocathepsin c precursor, putative 0.0278 0.1509 0.4179
Echinococcus granulosus cathepsin L cysteine protease 0.0163 0.0787 0.0787
Echinococcus multilocularis cathepsin b 0.164 1 1
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0215 0.0215
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0052 0.0052
Leishmania major cathepsin L-like protease 0.0271 0.146 0.4398
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0271 0.146 0.3784
Echinococcus multilocularis cathepsin L cysteine protease 0.0271 0.146 0.146
Brugia malayi hypothetical protein 0.0043 0.0042 0.0042

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 22 nM In vitro inhibitory concentration of the compound against Plasmodium falciparum ChEMBL. 15887971

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.