Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Enterococcus faecalis (strain ATCC 700802 / V583) | Beta-ketoacyl-ACP synthase III | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | ko:K01641 hydroxymethylglutaryl-CoA synthase [EC2.3.3.10], putative | Beta-ketoacyl-ACP synthase III | 321 aa | 271 aa | 22.1 % |
Mycobacterium tuberculosis | Conserved hypothetical protein | Beta-ketoacyl-ACP synthase III | 321 aa | 310 aa | 21.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.1014 | 0.1495 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.1337 | 0.0722 |
Onchocerca volvulus | 0.0054 | 0.101 | 0.5 | |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0892 | 0.1315 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.1337 | 0.0722 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0.089 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0066 | 0.1337 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0.089 | 1 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0383 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0892 | 0.1315 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0892 | 0.1315 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0663 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0054 | 0.101 | 0.7551 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0545 | 0.0803 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0041 | 0.0663 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0066 | 0.1337 | 0.1972 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0.089 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0066 | 0.1337 | 1 |
Brugia malayi | Inositol-1 | 0.0041 | 0.0663 | 0.0978 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1014 | 0.1495 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0892 | 0.1315 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0892 | 0.6668 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0041 | 0.0663 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.1337 | 0.0722 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0383 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0265 | 0.6783 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0.089 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0545 | 0.4073 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0383 | 1 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0892 | 0.6668 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0037 | 0.0545 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0383 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0066 | 0.1337 | 0.1972 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0054 | 0.101 | 0.1489 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.6783 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.101 | 0.7551 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0.089 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.1014 | 0.1495 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0041 | 0.0663 | 0.0978 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0663 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.1014 | 0.1495 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0041 | 0.0663 | 0.0978 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0383 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0383 | 1 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0041 | 0.0663 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0265 | 0.6783 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.0663 | 0.496 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.0663 | 0.496 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0892 | 0.1315 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0545 | 0.0803 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0383 | 1 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.1337 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.1337 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0041 | 0.0663 | 0.0978 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0265 | 0.6783 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0663 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0892 | 0.1315 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0892 | 0.6668 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0066 | 0.1337 | 0.0838 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.432 | Inhibition of Enterococcus faecalis FabH by FabD/FabH coupled assay | ChEMBL. | 17707951 |
IC50 (binding) | = 3.7 uM | Inhibitory concentration against Enterococcus faecalis beta-Ketoacyl-acyl carrier protein synthase III | ChEMBL. | 15743201 |
IC50 (binding) | = 3.7 uM | Inhibitory concentration against Enterococcus faecalis beta-Ketoacyl-acyl carrier protein synthase III | ChEMBL. | 15743201 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.