Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Mu opioid receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Delta opioid receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Echinococcus granulosus | tm gpcr rhodopsin | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Mitochondrial inner membrane protein homolog | Mu opioid receptor | 398 aa | 334 aa | 23.1 % |
Onchocerca volvulus | Delta opioid receptor | 372 aa | 349 aa | 22.1 % | |
Loa Loa (eye worm) | neuropeptide F receptor | Delta opioid receptor | 372 aa | 317 aa | 23.3 % |
Onchocerca volvulus | Delta opioid receptor | 372 aa | 353 aa | 21.0 % | |
Brugia malayi | ORL1-like opioid receptor | Delta opioid receptor | 372 aa | 300 aa | 24.7 % |
Onchocerca volvulus | Delta opioid receptor | 372 aa | 316 aa | 26.9 % | |
Echinococcus granulosus | allatostatin A receptor | Delta opioid receptor | 372 aa | 302 aa | 27.8 % |
Schistosoma mansoni | peptide (allatostatin)-like receptor | Delta opioid receptor | 372 aa | 353 aa | 29.2 % |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Mu opioid receptor | 398 aa | 397 aa | 22.7 % |
Onchocerca volvulus | Programmed cell death protein 5 homolog | Mu opioid receptor | 398 aa | 323 aa | 24.1 % |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Delta opioid receptor | 372 aa | 320 aa | 25.6 % |
Onchocerca volvulus | Delta opioid receptor | 372 aa | 386 aa | 22.8 % | |
Echinococcus multilocularis | allatostatin A receptor | Delta opioid receptor | 372 aa | 302 aa | 28.5 % |
Schistosoma mansoni | neuropeptide F-like receptor | Mu opioid receptor | 398 aa | 335 aa | 20.6 % |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Delta opioid receptor | 372 aa | 315 aa | 28.6 % |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | Delta opioid receptor | 372 aa | 330 aa | 24.2 % |
Brugia malayi | GnHR receptor homolog | Delta opioid receptor | 372 aa | 313 aa | 18.5 % |
Echinococcus granulosus | thyrotropin releasing hormone receptor | Delta opioid receptor | 372 aa | 330 aa | 24.5 % |
Onchocerca volvulus | Delta opioid receptor | 372 aa | 344 aa | 22.1 % | |
Schistosoma japonicum | Rhodopsin, putative | Mu opioid receptor | 398 aa | 328 aa | 23.2 % |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | Delta opioid receptor | 372 aa | 366 aa | 22.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dihydrofolate reductase | 0.1451 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.0347 | 0.1 | 0.1 |
Echinococcus multilocularis | thymidylate synthase | 0.0347 | 0.1 | 0.096 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0631 | 0.3314 | 0.3285 |
Onchocerca volvulus | 0.0347 | 0.1 | 1 | |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0989 | 0.6236 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1451 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0989 | 0.6236 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1451 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0347 | 0.1 | 0.0429 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1451 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0347 | 0.1 | 0.096 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0989 | 0.6236 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0989 | 0.6236 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1451 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1451 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.1451 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0347 | 0.1 | 0.1 |
Echinococcus granulosus | dihydrofolate reductase | 0.1451 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0989 | 0.6236 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0989 | 0.6236 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.1451 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0347 | 0.1 | 0.06 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0631 | 0.3314 | 0.3285 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 13 % | Percent inhibition of [3H]-DPDPE binding to Opioid receptor delta 1 of rat brain membrane at 10 uM | ChEMBL. | 15984054 |
Activity (binding) | = 13 % | Percent inhibition of [3H]-DPDPE binding to Opioid receptor delta 1 of rat brain membrane at 10 uM | ChEMBL. | 15984054 |
Activity (binding) | = 34 % | Percent inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 of rat brain membrane at 10 uM | ChEMBL. | 15984054 |
Activity (binding) | = 34 % | Percent inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 of rat brain membrane at 10 uM | ChEMBL. | 15984054 |
Ki (binding) | > 10 uM | Inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 of rat brain membrane | ChEMBL. | 15984054 |
Ki (binding) | > 10 uM | Inhibition of [3H]-DPDPE binding to Opioid receptor delta 1 of rat brain membrane | ChEMBL. | 15984054 |
Ki (binding) | > 10 uM | Inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 of rat brain membrane | ChEMBL. | 15984054 |
Ki (binding) | > 10 uM | Inhibition of [3H]-DPDPE binding to Opioid receptor delta 1 of rat brain membrane | ChEMBL. | 15984054 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.