TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 442.958 | Formula: C23H23ClN2O3S
H donors: 0 H acceptors: 2 LogP: 5.02 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1OCc1csc(n1)c1ccc(cc1)Cl)C(=O)N1CCCCC1
InChi: 1S/C23H23ClN2O3S/c1-28-20-7-5-6-19(23(27)26-12-3-2-4-13-26)21(20)29-14-18-15-30-22(25-18)16-8-10-17(24)11-9-16/h5-11,15H,2-4,12-14H2,1H3
InChiKey: UKAHZXRHPDREGU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	sodium channel, voltage-gated, type IX, alpha subunit	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania infantum	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Echinococcus granulosus	sodium channel protein	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania major	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania donovani	calcium channel protein, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania mexicana	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania braziliensis	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	Get druggable targets OG5_126819	All targets in OG5_126819
Echinococcus multilocularis	sodium channel protein	Get druggable targets OG5_126819	All targets in OG5_126819

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	notch-like transmembrane receptor	0.0017	0.0113	0.0113
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.2357	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0214	0.0174
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0126	0.4364	0.8837
Trypanosoma cruzi	trypanothione reductase, putative	0.0055	0.1605	0.6518
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.2357	1
Leishmania major	cathepsin L-like protease	0.002	0.0214	0.0076
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0043	0.1136	0.2297
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0214	0.0174
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0214	0.0174
Onchocerca volvulus		0.002	0.0214	0.0228
Loa Loa (eye worm)	hypothetical protein	0.002	0.0214	0.0103
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0071	0.2217	1
Echinococcus granulosus	peroxidasin	0.0131	0.4568	1
Echinococcus granulosus	sodium channel protein	0.0045	0.1221	0.2487
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0043	0.1136	0.1648
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0214	0.0228
Toxoplasma gondii	thioredoxin reductase	0.0055	0.1605	0.7092
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0019	0.0198	0.0405
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0071	0.2217	0.4724
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0071	0.2217	1
Onchocerca volvulus		0.002	0.0214	0.0228
Loa Loa (eye worm)	thioredoxin reductase	0.0055	0.1605	0.1509
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0214	0.0174
Brugia malayi	Delta serrate ligand family protein	0.0017	0.0113	0.0113
Toxoplasma gondii	aldehyde dehydrogenase	0.0071	0.2217	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0214	0.0174
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0214	0.0174
Leishmania major	trypanothione reductase	0.0055	0.1605	0.6518
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0019	0.0198	0.0198
Brugia malayi	Calcium binding EGF domain containing protein	0.0017	0.0113	0.0113
Trypanosoma cruzi	cruzipain precursor, putative	0.0074	0.2357	1
Trypanosoma brucei	trypanothione reductase	0.0055	0.1605	0.6518
Loa Loa (eye worm)	hypothetical protein	0.0131	0.4568	0.4506
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.2357	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0071	0.2217	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0214	0.0174
Plasmodium vivax	glutathione reductase, putative	0.0055	0.1605	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0214	0.0174
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0214	0.0174
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0214	0.0174
Onchocerca volvulus	Peroxidasin homolog	0.0131	0.4568	1
Plasmodium vivax	thioredoxin reductase, putative	0.0055	0.1605	1
Brugia malayi	Animal haem peroxidase family protein	0.0131	0.4568	0.4568
Loa Loa (eye worm)	hypothetical protein	0.0131	0.4568	0.4506
Brugia malayi	Cadherin domain containing protein	0.0017	0.0113	0.0113
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.2357	1
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0214	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0131	0.4568	0.4506
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0214	0.0163
Onchocerca volvulus		0.002	0.0214	0.0228
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.014	0.4912	1
Loa Loa (eye worm)	hypothetical protein	0.0131	0.4568	0.4506
Onchocerca volvulus	Cathepsin F homolog	0.002	0.0214	0.0228
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0214	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0131	0.4568	0.4506
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0019	0.0198	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.014	0.4912	1
Loa Loa (eye worm)	hypothetical protein	0.0131	0.4568	0.4506
Leishmania major	cathepsin L-like protease	0.0074	0.2357	1
Echinococcus granulosus	ubiquitin specific protease 41	0.0043	0.1136	0.2297
Trypanosoma cruzi	cysteine peptidase, putative	0.0074	0.2357	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.002	0.0214	0.0116
Loa Loa (eye worm)	glutathione reductase	0.0055	0.1605	0.1509
Brugia malayi	EGF-like domain containing protein	0.0017	0.0113	0.0113
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0067	0.2064	0.2064
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0071	0.2217	0.4724
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0043	0.1136	0.1648
Plasmodium falciparum	cysteine proteinase falcipain 3	0.002	0.0214	0.0116
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0067	0.2064	0.9244
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0067	0.2064	0.8644
Onchocerca volvulus	Dual oxidase homolog	0.0131	0.4568	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0214	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0131	0.4568	0.4506
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0214	0.0174
Brugia malayi	Cadherin domain containing protein	0.0017	0.0113	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1136	0.1035
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0062	0.1889	0.1796
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.002	0.0214	0.0103
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0019	0.0198	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0214	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0131	0.4568	0.4506
Plasmodium falciparum	glutathione reductase	0.0055	0.1605	1
Leishmania major	cysteine peptidase A (CPA)	0.002	0.0214	0.0076
Brugia malayi	Blistered cuticle protein 3	0.0131	0.4568	0.4568
Leishmania major	cathepsin L-like protease	0.002	0.0214	0.0076
Onchocerca volvulus		0.0131	0.4568	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0214	0.0174
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0214	0.0228
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0214	0.0174
Loa Loa (eye worm)	animal heme peroxidase	0.0131	0.4568	0.4506
Brugia malayi	Calcium binding EGF domain containing protein	0.0017	0.0113	0.0113
Brugia malayi	EGF-like domain containing protein	0.0017	0.0113	0.0113
Brugia malayi	Calcium binding EGF domain containing protein	0.0017	0.0113	0.0113
Echinococcus multilocularis	sodium channel protein	0.0045	0.1221	0.2487
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0019	0.0198	0.0137
Loa Loa (eye worm)	blistered cuticle protein 3	0.0131	0.4568	0.4506
Treponema pallidum	NADH oxidase	0.0019	0.0198	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0214	0.0174
Brugia malayi	Cathepsin L-like precursor	0.002	0.0214	0.0214
Trypanosoma cruzi	cysteine peptidase, putative	0.0074	0.2357	1
Trypanosoma cruzi	cysteine peptidase, putative	0.002	0.0214	0.0076
Brugia malayi	EGF-like domain containing protein	0.0017	0.0113	0.0113
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.2357	1
Onchocerca volvulus		0.002	0.0214	0.0228
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0043	0.1136	0.4344
Leishmania major	cathepsin L-like protease	0.002	0.0214	0.0076
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.2357	1
Onchocerca volvulus	Chorion peroxidase homolog	0.0131	0.4568	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0214	0.0174
Brugia malayi	Animal haem peroxidase family protein	0.0131	0.4568	0.4568
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0214	0.0174
Echinococcus multilocularis	cysteine protease	0.002	0.0214	0.0228
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0043	0.1136	1
Loa Loa (eye worm)	hypothetical protein	0.0131	0.4568	0.4506
Loa Loa (eye worm)	cysteine protease	0.002	0.0214	0.0103
Echinococcus granulosus	thioredoxin glutathione reductase	0.0055	0.1605	0.335
Onchocerca volvulus	Peroxidase homolog	0.0131	0.4568	1
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0019	0.0198	0.0832
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0071	0.2217	0.4283
Echinococcus multilocularis	ubiquitin specific protease 41	0.0043	0.1136	0.2297
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0043	0.1136	0.4344
Loa Loa (eye worm)	animal heme peroxidase	0.0131	0.4568	0.4506
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0214	0.0228
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0067	0.2064	0.9244
Plasmodium vivax	vivapain-2	0.002	0.0214	0.0116
Leishmania major	cathepsin L-like protease	0.0074	0.2357	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0126	0.4364	0.8837
Brugia malayi	Animal haem peroxidase family protein	0.0131	0.4568	0.4568
Brugia malayi	Animal haem peroxidase family protein	0.0131	0.4568	0.4568
Echinococcus granulosus	cathepsin l cysteine peptidase	0.002	0.0214	0.0228
Echinococcus multilocularis	peroxidasin	0.0131	0.4568	1
Onchocerca volvulus		0.0131	0.4568	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0058	0.1735	0.712
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0043	0.1136	1
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0043	0.1136	0.4344
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.2357	1
Loa Loa (eye worm)	ctsf protein	0.002	0.0214	0.0103
Onchocerca volvulus		0.002	0.0214	0.0228
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.2357	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0126	0.4364	0.8837
Brugia malayi	hypothetical protein	0.0131	0.4568	0.4568
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0214	0.0174
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0055	0.1605	0.335
Leishmania major	cathepsin L-like protease	0.0074	0.2357	1
Brugia malayi	Cathepsin L-like precursor	0.002	0.0214	0.0214
Leishmania major	cathepsin L-like protease	0.002	0.0214	0.0076
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.1136	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0214	0.0228
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0214	0.0174
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.2357	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0043	0.1136	1
Brugia malayi	Thioredoxin reductase	0.0055	0.1605	0.1605
Loa Loa (eye worm)	hypothetical protein	0.0131	0.4568	0.4506
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0067	0.2064	0.4381
Echinococcus multilocularis	cysteine protease	0.002	0.0214	0.0228
Schistosoma mansoni	aldehyde dehydrogenase	0.0071	0.2217	0.339
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0043	0.1136	0.2297
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.002	0.0214	0.0116
Schistosoma mansoni	peroxidasin	0.0131	0.4568	0.7177
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0043	0.1136	0.1136
Toxoplasma gondii	cathepsin CPL	0.002	0.0214	0.0482
Brugia malayi	glutathione reductase	0.0055	0.1605	0.1605
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0214	0.0174
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0045	0.1221	0.4738
Plasmodium falciparum	thioredoxin reductase	0.0055	0.1605	1
Onchocerca volvulus	Peroxidase homolog	0.0131	0.4568	1
Loa Loa (eye worm)	hypothetical protein	0.0131	0.4568	0.4506
Loa Loa (eye worm)	animal heme peroxidase	0.0131	0.4568	0.4506
Brugia malayi	Cathepsin L-like precursor	0.002	0.0214	0.0214
Echinococcus granulosus	cathepsin l1	0.002	0.0214	0.0228
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0043	0.1136	0.2297
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.2357	1
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0067	0.2064	0.3144
Brugia malayi	Cathepsin L-like precursor	0.002	0.0214	0.0214
Trypanosoma cruzi	cysteine peptidase, putative	0.0074	0.2357	1
Loa Loa (eye worm)	hypothetical protein	0.0131	0.4568	0.4506
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0126	0.4364	0.8837
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0214	0.0163
Brugia malayi	EGF-like domain containing protein	0.0017	0.0113	0.0113
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0045	0.1221	0.2487
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0214	0.0174
Brugia malayi	EGF-like domain containing protein	0.0017	0.0113	0.0113
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0019	0.0198	0.0191
Echinococcus granulosus	cathepsin L cysteine proteinase	0.002	0.0214	0.0228
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0214	0.0174
Onchocerca volvulus	Peroxidasin homolog	0.0131	0.4568	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0214	0.0174
Leishmania major	cathepsin L-like protease	0.002	0.0214	0.0076
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.002	0.0214	0.0103
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0071	0.2217	0.9351
Brugia malayi	EGF-like domain containing protein	0.0017	0.0113	0.0113
Loa Loa (eye worm)	animal heme peroxidase	0.0131	0.4568	0.4506
Brugia malayi	Cathepsin L-like precursor	0.002	0.0214	0.0214
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0067	0.2064	0.3959
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0019	0.0198	0.0191
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0043	0.1136	1
Mycobacterium tuberculosis	Probable reductase	0.0126	0.4364	0.8837
Plasmodium vivax	vivapain-2	0.002	0.0214	0.0116
Brugia malayi	EGF-like domain containing protein	0.0017	0.0113	0.0113
Mycobacterium tuberculosis	Probable dehydrogenase	0.0126	0.4364	0.8837
Schistosoma mansoni	aldehyde dehydrogenase	0.0071	0.2217	0.339
Toxoplasma gondii	NADPH-glutathione reductase	0.0019	0.0198	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0131	0.4568	0.4506
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0019	0.0198	0.5
Brugia malayi	Muscle positioning protein 4	0.0017	0.0113	0.0113
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0043	0.1136	0.4344
Brugia malayi	Cathepsin L-like precursor	0.002	0.0214	0.0214
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.014	0.4912	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0214	0.0228
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0067	0.2064	0.4381
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.014	0.4912	1
Onchocerca volvulus		0.002	0.0214	0.0228
Brugia malayi	Peroxidasin	0.0131	0.4568	0.4568
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0043	0.1136	0.2297
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.2357	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.027	1	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0055	0.1605	0.2985
Loa Loa (eye worm)	fibroinase	0.002	0.0214	0.0103
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0017	0.0113	0.0113
Onchocerca volvulus		0.0131	0.4568	1
Schistosoma mansoni	peroxidasin	0.0131	0.4568	0.7177
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0068	0.2105	0.8832
Brugia malayi	Animal haem peroxidase family protein	0.0131	0.4568	0.4568
Brugia malayi	GCC2 and GCC3 family protein	0.0017	0.0113	0.0113
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0214	0.0174
Onchocerca volvulus		0.002	0.0214	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0131	0.4568	0.4506

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 3.7 uM	In vitro inhibitory concentration against Na v1.7 channel expressed in HEK293 cells using Voltage/Ion Probe Reader (VIPR) assay	ChEMBL.	15878274
IC50 (binding)	= 3.7 uM	In vitro inhibitory concentration against Na v1.7 channel expressed in HEK293 cells using Voltage/Ion Probe Reader (VIPR) assay	ChEMBL.	15878274
Inhibition (binding)	= 63 %	Percent inhibition against diplacement of 35[S] MK-499 binding to hERG channel expressed in HEK293 cells at a concentration of 10 uM	ChEMBL.	15878274
Inhibition (binding)	= 63 %	Percent inhibition against diplacement of 35[S] MK-499 binding to hERG channel expressed in HEK293 cells at a concentration of 10 uM	ChEMBL.	15878274

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL196345

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 341766