Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0128 | 0.0363 | 0.1694 |
Plasmodium vivax | glutamine-dependent NAD(+) synthetase, putative | 0.0084 | 0 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0805 | 0.599 | 1 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0779 | 0.5773 | 1 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.0779 | 0.5773 | 0.5773 |
Schistosoma mansoni | dihydrofolate reductase | 0.0176 | 0.0762 | 0.132 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0135 | 0.0428 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0135 | 0.0428 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0176 | 0.0762 | 0.1257 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0342 | 0.2141 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0085 | 0.001 | 0.0047 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0085 | 0.001 | 0.0047 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0176 | 0.0762 | 0.0762 |
Echinococcus granulosus | dihydrofolate reductase | 0.0176 | 0.0762 | 0.0709 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0085 | 0.001 | 0.0236 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0135 | 0.0428 | 0.1997 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0135 | 0.0428 | 0.1997 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0085 | 0.001 | 0.0047 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.0779 | 0.5773 | 0.9638 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0176 | 0.0762 | 0.0762 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0779 | 0.5773 | 0.9638 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0135 | 0.0428 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0135 | 0.0428 | 0.1997 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0805 | 0.599 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0135 | 0.0428 | 0.0698 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0135 | 0.0428 | 0.0698 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0085 | 0.001 | 0.0236 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0085 | 0.001 | 0.0047 |
Echinococcus granulosus | fucosidase alpha L 1 tissue | 0.0779 | 0.5773 | 0.9615 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0135 | 0.0428 | 0.1997 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.0666 | 0.1153 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0176 | 0.0762 | 0.1257 |
Schistosoma mansoni | alpha-glucosidase | 0.0755 | 0.5572 | 0.9652 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0135 | 0.0428 | 0.1997 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0135 | 0.0428 | 1 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0128 | 0.0363 | 0.1694 |
Brugia malayi | dihydrofolate reductase family protein | 0.0176 | 0.0762 | 0.1257 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0176 | 0.0762 | 0.0709 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0085 | 0.001 | 0.0236 |
Schistosoma mansoni | alpha glucosidase | 0.0135 | 0.0428 | 0.0741 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0135 | 0.0428 | 1 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0342 | 0.2141 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0805 | 0.599 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0085 | 0.001 | 0.0047 |
Plasmodium falciparum | glutamine-dependent NAD(+) synthetase, putative | 0.0084 | 0 | 0.5 |
Onchocerca volvulus | 0.0596 | 0.4253 | 1 | |
Entamoeba histolytica | glycogen debranching enzyme, putative | 0.0128 | 0.0363 | 0.8485 |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0085 | 0.001 | 0.0236 |
Giardia lamblia | 4-alpha-glucanotransferase, amylo-alpha-1,6-glucosidase | 0.0128 | 0.0363 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0085 | 0.001 | 0.0047 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0135 | 0.0428 | 0.1997 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0135 | 0.0428 | 0.0115 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0135 | 0.0428 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0135 | 0.0428 | 0.1997 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0085 | 0.001 | 0.0047 |
Leishmania major | glycosyl hydrolase-like protein | 0.0085 | 0.001 | 0.0236 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0085 | 0.001 | 0.0047 |
Toxoplasma gondii | Amylo-alpha-1,6-glucosidase | 0.0128 | 0.0363 | 0.8485 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0135 | 0.0428 | 0.0115 |
Schistosoma mansoni | alpha-glucosidase | 0.0755 | 0.5572 | 0.9652 |
Mycobacterium ulcerans | arylamine N-acetyltransferase Nat | 0.1287 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0092 | 0.0068 | 0.0119 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0135 | 0.0428 | 0.1997 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.0779 | 0.5773 | 0.9615 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0363 | 0.059 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0176 | 0.0762 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0176 | 0.0762 | 0.5 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0135 | 0.0428 | 0.1997 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0805 | 0.599 | 1 |
Treponema pallidum | NAD synthetase | 0.0084 | 0 | 0.5 |
Brugia malayi | Amylo-alpha-1,6-glucosidase family protein | 0.0128 | 0.0363 | 0.059 |
Trypanosoma brucei | glucosidase, putative | 0.0135 | 0.0428 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0805 | 0.599 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | > 100 uM | Cytotoxic concentration required to reduce the rRNA level of hepatitis C virus | ChEMBL. | 16134952 |
EC90 (functional) | > 100 uM | Effective concentration required to reduce Hepatitis C virus | ChEMBL. | 16134952 |
IC50 (functional) | 0 uM | In vitro inhibitory concentration against mouse leukemia L1210 cell line; n.a. is not active | ChEMBL. | 16134952 |
IC50 (functional) | 0 uM | In vitro inhibitory concentration against human promyelocytic leukemia HL60 cell line; n.a. is not active | ChEMBL. | 16134952 |
IC50 (functional) | 0 uM | In vitro inhibitory concentration against human cervix carcinoma HeLaS3 cell line; n.a. is not active | ChEMBL. | 16134952 |
IC50 (functional) | NA 0 uM | In vitro inhibitory concentration against human T lymphoblastoid CCRF-CEM cell line | ChEMBL. | 16134952 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.