Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0024 | 0.0074 | 0.0074 |
Entamoeba histolytica | bifunctional short chain isoprenyl diphosphate synthase, putative | 0.0517 | 0.2702 | 0.5 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.0517 | 0.2702 | 0.2648 |
Leishmania major | polyprenyl synthase, putative | 0.0686 | 0.3604 | 0.1235 |
Plasmodium falciparum | geranylgeranyl pyrophosphate synthase, putative | 0.1885 | 1 | 1 |
Plasmodium vivax | octaprenyl pyrophosphate synthase, putative | 0.0517 | 0.2702 | 0.2648 |
Schistosoma mansoni | P2X receptor subunit | 0.0117 | 0.0571 | 0.0501 |
Onchocerca volvulus | 0.0189 | 0.0956 | 1 | |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.0686 | 0.3604 | 0.1235 |
Schistosoma mansoni | glutathione synthetase | 0.0517 | 0.2702 | 0.2648 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0196 | 0.0994 | 0.0994 |
Echinococcus granulosus | prenyl decaprenyl diphosphate synthase | 0.0517 | 0.2702 | 0.2702 |
Chlamydia trachomatis | geranylgeranyl pyrophosphate synthase | 0.0517 | 0.2702 | 0.5 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.1885 | 1 | 1 |
Plasmodium vivax | geranylgeranyl pyrophosphate synthase | 0.1885 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0196 | 0.0994 | 0.0927 |
Echinococcus granulosus | decaprenyl diphosphate synthase subunit 1 | 0.0517 | 0.2702 | 0.2702 |
Wolbachia endosymbiont of Brugia malayi | geranylgeranyl pyrophosphate synthase | 0.0517 | 0.2702 | 0.5 |
Schistosoma mansoni | geranylgeranyl pyrophosphate synthase | 0.0686 | 0.3604 | 0.3557 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0074 | 0.0074 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0023 | 0.0069 | 0.0069 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthetase, putative | 0.0517 | 0.2702 | 0.5 |
Schistosoma mansoni | farnesyl pyrophosphate synthase | 0.1885 | 1 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0196 | 0.0994 | 0.0994 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0024 | 0.0074 | 0.0074 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0051 | 0.0218 | 0.0218 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0196 | 0.0994 | 0.0994 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0196 | 0.0994 | 0.0994 |
Echinococcus multilocularis | decaprenyl diphosphate synthase subunit 1 | 0.0517 | 0.2702 | 0.2702 |
Mycobacterium leprae | PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) | 0.0517 | 0.2702 | 0.5 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase, putative | 0.1885 | 1 | 1 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.1885 | 1 | 1 |
Echinococcus multilocularis | farnesyl pyrophosphate synthase | 0.1885 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | geranylgeranyl pyrophosphate synthase | 0.0517 | 0.2702 | 0.5 |
Echinococcus multilocularis | prenyl (decaprenyl) diphosphate synthase | 0.0517 | 0.2702 | 0.2702 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.0686 | 0.3604 | 0.1235 |
Loa Loa (eye worm) | geranylgeranyl pyrophosphate synthetase | 0.0686 | 0.3604 | 0.3604 |
Schistosoma mansoni | P2X receptor subunit | 0.0117 | 0.0571 | 0.0501 |
Brugia malayi | Polyprenyl synthetase family protein | 0.0517 | 0.2702 | 0.2648 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0024 | 0.0074 | 0.0074 |
Trichomonas vaginalis | geranylgeranyl diphosphate synthase, putative | 0.1885 | 1 | 1 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.1885 | 1 | 1 |
Schistosoma mansoni | trans-prenyltransferase | 0.0517 | 0.2702 | 0.2648 |
Treponema pallidum | octaprenyl-diphosphate synthase | 0.0686 | 0.3604 | 0.5 |
Leishmania major | farnesyl pyrophosphate synthase | 0.1885 | 1 | 1 |
Echinococcus granulosus | farnesyl pyrophosphate synthase | 0.1885 | 1 | 1 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase | 0.1885 | 1 | 1 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0051 | 0.0218 | 0.0218 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.1885 | 1 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0196 | 0.0994 | 0.0994 |
Brugia malayi | Pre-SET motif family protein | 0.0166 | 0.0833 | 0.0765 |
Schistosoma mansoni | P2X receptor subunit | 0.0196 | 0.0994 | 0.0927 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.1885 | 1 | 1 |
Echinococcus multilocularis | geranylgeranyl pyrophosphate synthase | 0.0686 | 0.3604 | 0.3604 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0166 | 0.0833 | 0.0833 |
Echinococcus granulosus | geranylgeranyl pyrophosphate synthase | 0.0686 | 0.3604 | 0.3604 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.0517 | 0.2702 | 0.2702 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.1885 | 1 | 1 |
Brugia malayi | geranylgeranyl pyrophosphate synthetase | 0.0686 | 0.3604 | 0.3557 |
Giardia lamblia | Farnesyl diphosphate synthase | 0.1885 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) | 0.1885 | 1 | 1 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthase, putative | 0.0517 | 0.2702 | 0.5 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0196 | 0.0994 | 0.0994 |
Trypanosoma brucei | farnesyl pyrophosphate synthase | 0.1885 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Survival (functional) | = 33 % | Average percent survival of C57Bl/6 mice thymocytes from dexamethasone (5 uM) induced apoptosis at 5 uM | ChEMBL. | 16190767 |
Survival (functional) | = 33 % | Average percent survival of C57Bl/6 mice thymocytes from dexamethasone (5 uM) induced apoptosis at 5 uM | ChEMBL. | 16190767 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.