Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.1711 | 0.5682 | 0.5682 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0032 | 0.0057 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0032 | 0.0032 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.1711 | 0.5682 | 0.5 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.1711 | 0.5682 | 1 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.1711 | 0.5682 | 1 |
Echinococcus granulosus | geminin | 0.0166 | 0.0443 | 0.0779 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0046 | 0.0046 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1166 | 0.3835 | 0.3835 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.1711 | 0.5682 | 1 |
Onchocerca volvulus | 0.1711 | 0.5682 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.1711 | 0.5682 | 0.5682 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.1166 | 0.3835 | 0.3835 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0032 | 0.0032 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0046 | 0.0046 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.1711 | 0.5682 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0032 | 0.0057 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0 | 0.5 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.2985 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.2985 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.2985 | 1 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.1711 | 0.5682 | 0.5682 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0032 | 0.0057 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.2985 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.2985 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1711 | 0.5682 | 0.5682 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.1711 | 0.5682 | 0.5682 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.1711 | 0.5682 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0596 | 0.1902 | 0.1902 |
Mycobacterium ulcerans | hypothetical protein | 0.2985 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0032 | 0.0057 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1166 | 0.3835 | 0.3835 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0225 | 0.0644 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.2985 | 1 | 1 |
Brugia malayi | Synaptic glycoprotein SC2 | 0.1711 | 0.5682 | 0.5682 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.1711 | 0.5682 | 0.5682 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.2985 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0166 | 0.0443 | 0.0779 |
Loa Loa (eye worm) | hypothetical protein | 0.2985 | 1 | 1 |
Plasmodium falciparum | polyprenol reductase, putative | 0.1711 | 0.5682 | 0.5 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.1711 | 0.5682 | 0.5682 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0046 | 0.0046 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0032 | 0.0057 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0794 | 0.2571 | 0.4525 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.0443 | 0.0779 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.2985 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0046 | 0.0046 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.1711 | 0.5682 | 0.5682 |
Leishmania major | C-8 sterol isomerase-like protein | 0.1166 | 0.3835 | 0.3835 |
Loa Loa (eye worm) | hypothetical protein | 0.1711 | 0.5682 | 0.5682 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.0443 | 0.0779 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0032 | 0.0057 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.1711 | 0.5682 | 0.5682 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.2985 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1166 | 0.3835 | 0.3835 |
Plasmodium vivax | polyprenol reductase, putative | 0.1711 | 0.5682 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1711 | 0.5682 | 0.5682 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0032 | 0.0057 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.1711 | 0.5682 | 0.5 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.1711 | 0.5682 | 0.5682 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.1711 | 0.5682 | 1 |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.1711 | 0.5682 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 100 uM | Effective concentration against US28-mediated inositol phosphate production in COS-7 cells | ChEMBL. | 16190772 |
EC50 (functional) | > 100 uM | Effective concentration against US28-mediated inositol phosphate production in COS-7 cells | ChEMBL. | 16190772 |
IC50 (binding) | > 100 uM | Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 | ChEMBL. | 16190772 |
IC50 (binding) | > 100 uM | Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 | ChEMBL. | 16190772 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.