Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.1711 | 0.5682 | 0.5682 |
Loa Loa (eye worm) | hypothetical protein | 0.1166 | 0.3835 | 0.3835 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0032 | 0.0057 |
Onchocerca volvulus | 0.1711 | 0.5682 | 1 | |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.2985 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0046 | 0.0046 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.1711 | 0.5682 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1711 | 0.5682 | 0.5682 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.1711 | 0.5682 | 1 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.2985 | 1 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0225 | 0.0644 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0032 | 0.0032 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.1711 | 0.5682 | 0.5682 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.2985 | 1 | 1 |
Plasmodium vivax | polyprenol reductase, putative | 0.1711 | 0.5682 | 1 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.1711 | 0.5682 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.1711 | 0.5682 | 0.5682 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.1711 | 0.5682 | 1 |
Echinococcus granulosus | geminin | 0.0166 | 0.0443 | 0.0779 |
Loa Loa (eye worm) | hypothetical protein | 0.2985 | 1 | 1 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.1711 | 0.5682 | 0.5682 |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.1711 | 0.5682 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0046 | 0.0046 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0032 | 0.0057 |
Plasmodium falciparum | polyprenol reductase, putative | 0.1711 | 0.5682 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.1166 | 0.3835 | 0.3835 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.1711 | 0.5682 | 0.5682 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.1711 | 0.5682 | 0.5682 |
Brugia malayi | Synaptic glycoprotein SC2 | 0.1711 | 0.5682 | 0.5682 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0032 | 0.0032 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0032 | 0.0057 |
Echinococcus multilocularis | geminin | 0.0166 | 0.0443 | 0.0779 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0032 | 0.0057 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0794 | 0.2571 | 0.4525 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1166 | 0.3835 | 0.3835 |
Mycobacterium ulcerans | hypothetical protein | 0.2985 | 1 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.2985 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0032 | 0.0057 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.2985 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1711 | 0.5682 | 0.5682 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0046 | 0.0046 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.2985 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.2985 | 1 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.1711 | 0.5682 | 0.5682 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1711 | 0.5682 | 0.5682 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.2985 | 1 | 1 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.1711 | 0.5682 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.1711 | 0.5682 | 0.5682 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.1711 | 0.5682 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0046 | 0.0046 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.1711 | 0.5682 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0032 | 0.0057 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1711 | 0.5682 | 0.5682 |
Loa Loa (eye worm) | hypothetical protein | 0.0596 | 0.1902 | 0.1902 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.1166 | 0.3835 | 0.3835 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.1711 | 0.5682 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.0443 | 0.0779 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0032 | 0.0057 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.2985 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.0443 | 0.0779 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1166 | 0.3835 | 0.3835 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 100 uM | Effective concentration against US28-mediated inositol phosphate production in COS-7 cells | ChEMBL. | 16190772 |
EC50 (functional) | > 100 uM | Effective concentration against US28-mediated inositol phosphate production in COS-7 cells | ChEMBL. | 16190772 |
IC50 (binding) | > 100 uM | Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 | ChEMBL. | 16190772 |
IC50 (binding) | > 100 uM | Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 | ChEMBL. | 16190772 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.