Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 reverse transcriptase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma brucei | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Plasmodium yoelii | integrase-related | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma congolense | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | RNA helicase, putative | 0.01 | 0.1341 | 0.0601 |
Mycobacterium tuberculosis | Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) | 0.0422 | 0.9943 | 1 |
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | 0.0169 | 0.3173 | 0.2587 |
Plasmodium falciparum | octaprenyl pyrophosphate synthase | 0.0169 | 0.3173 | 0.2603 |
Leishmania major | polyprenyl synthase, putative | 0.0424 | 1 | 1 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.0424 | 1 | 1 |
Onchocerca volvulus | 0.0079 | 0.079 | 1 | |
Loa Loa (eye worm) | hexokinase | 0.0079 | 0.079 | 0.079 |
Schistosoma mansoni | glutathione synthetase | 0.0169 | 0.3173 | 0.2587 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0116 | 0.0116 |
Echinococcus multilocularis | geranylgeranyl pyrophosphate synthase | 0.0424 | 1 | 1 |
Echinococcus granulosus | geranylgeranyl pyrophosphate synthase | 0.0424 | 1 | 1 |
Loa Loa (eye worm) | geranylgeranyl pyrophosphate synthetase | 0.0424 | 1 | 1 |
Schistosoma mansoni | geranylgeranyl pyrophosphate synthase | 0.0424 | 1 | 1 |
Leishmania major | solanesyl-diphosphate synthase, putative | 0.0169 | 0.3173 | 0.2587 |
Loa Loa (eye worm) | hexokinase | 0.0079 | 0.079 | 0.079 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.0422 | 0.9943 | 0.5 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.0422 | 0.9943 | 0.5 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase, putative | 0.0422 | 0.9943 | 0.9938 |
Giardia lamblia | Farnesyl diphosphate synthase | 0.0422 | 0.9943 | 0.5 |
Echinococcus granulosus | farnesyl pyrophosphate synthase | 0.0422 | 0.9943 | 0.9938 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthetase, putative | 0.0169 | 0.3173 | 1 |
Mycobacterium leprae | PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) | 0.0169 | 0.3173 | 0.5 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.0422 | 0.9943 | 1 |
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | 0.0169 | 0.3173 | 0.2587 |
Onchocerca volvulus | 0.0079 | 0.079 | 1 | |
Brugia malayi | Polyprenyl synthetase family protein | 0.0169 | 0.3173 | 0.3173 |
Echinococcus multilocularis | prenyl (decaprenyl) diphosphate synthase | 0.0169 | 0.3173 | 0.2587 |
Onchocerca volvulus | 0.0079 | 0.079 | 1 | |
Trichomonas vaginalis | geranylgeranyl diphosphate synthase, putative | 0.0422 | 0.9943 | 0.5 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.0169 | 0.3173 | 0.3173 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.0424 | 1 | 1 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.0169 | 0.3173 | 0.2603 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase | 0.0422 | 0.9943 | 0.9938 |
Brugia malayi | Polyprenyl synthetase family protein | 0.0422 | 0.9943 | 0.9943 |
Brugia malayi | hexokinase | 0.0079 | 0.079 | 0.079 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthase, putative | 0.0169 | 0.3173 | 1 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.0422 | 0.9943 | 0.9943 |
Leishmania major | farnesyl pyrophosphate synthase | 0.0422 | 0.9943 | 0.9938 |
Echinococcus granulosus | prenyl decaprenyl diphosphate synthase | 0.0169 | 0.3173 | 0.2587 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.1341 | 0.0597 |
Plasmodium falciparum | geranylgeranyl pyrophosphate synthase, putative | 0.0422 | 0.9943 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.0079 | 0.079 | 0.079 |
Echinococcus granulosus | decaprenyl diphosphate synthase subunit 1 | 0.0169 | 0.3173 | 0.2587 |
Trypanosoma brucei | solanesyl-diphosphate synthase, putative | 0.0169 | 0.3173 | 0.2603 |
Trypanosoma brucei | farnesyl pyrophosphate synthase | 0.0422 | 0.9943 | 1 |
Brugia malayi | Hexokinase family protein | 0.0079 | 0.079 | 0.079 |
Echinococcus multilocularis | farnesyl pyrophosphate synthase | 0.0422 | 0.9943 | 0.9938 |
Trypanosoma cruzi | solanesyl-diphosphate synthase | 0.0169 | 0.3173 | 0.2587 |
Wolbachia endosymbiont of Brugia malayi | geranylgeranyl pyrophosphate synthase | 0.0169 | 0.3173 | 0.5 |
Schistosoma mansoni | farnesyl pyrophosphate synthase | 0.0422 | 0.9943 | 0.9938 |
Treponema pallidum | octaprenyl-diphosphate synthase | 0.0424 | 1 | 1 |
Echinococcus multilocularis | decaprenyl diphosphate synthase subunit 1 | 0.0169 | 0.3173 | 0.2587 |
Entamoeba histolytica | bifunctional short chain isoprenyl diphosphate synthase, putative | 0.0169 | 0.3173 | 1 |
Plasmodium vivax | geranylgeranyl pyrophosphate synthase | 0.0422 | 0.9943 | 1 |
Chlamydia trachomatis | geranylgeranyl pyrophosphate synthase | 0.0169 | 0.3173 | 0.5 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.0422 | 0.9943 | 1 |
Schistosoma mansoni | trans-prenyltransferase | 0.0169 | 0.3173 | 0.2587 |
Wolbachia endosymbiont of Brugia malayi | geranylgeranyl pyrophosphate synthase | 0.0169 | 0.3173 | 0.5 |
Plasmodium vivax | octaprenyl pyrophosphate synthase, putative | 0.0169 | 0.3173 | 0.2603 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.0422 | 0.9943 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cell death (functional) | = 22.5 % | Toxicity of compound against human MT-2 cell line at the concentration of 50 uM | ChEMBL. | 16137881 |
Cell death (functional) | = 22.5 % | Toxicity of compound against human MT-2 cell line at the concentration of 50 uM | ChEMBL. | 16137881 |
GI50 (functional) | = 0.1 ug ml-1 | Cytotoxicity against human SF268 cells | ChEMBL. | 15787438 |
GI50 (functional) | = 0.2 ug ml-1 | Cytotoxicity against human MCF7 cells | ChEMBL. | 15787438 |
GI50 (functional) | = 0.3 ug ml-1 | Cytotoxicity against human H460 cells | ChEMBL. | 15787438 |
IC50 (binding) | uM | Inhibitory concentration against recombinant human immunodeficiency virus 1 reverse transcriptase; NT= not tested | ChEMBL. | 16137881 |
IC50 (binding) | 0 uM | Inhibitory concentration against recombinant human immunodeficiency virus 1 reverse transcriptase; NT= not tested | ChEMBL. | 16137881 |
IC50 (functional) | = 1.3 uM | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 10 mins prior to LPS-challenge measured after 18 hrs by Griess method | ChEMBL. | 22831798 |
IC50 (binding) | = 2.5 uM | Inhibitory concentration against recombinant human immunodeficiency virus 1 reverse transcriptase | ChEMBL. | 16137881 |
IC50 (binding) | = 2.5 uM | Inhibitory concentration against recombinant human immunodeficiency virus 1 reverse transcriptase | ChEMBL. | 16137881 |
Inhibition (binding) | Inhibition of STAT1 phosphorylation in LPS-induced mouse RAW264.7 cells incubated for 10 mins prior to LPS-challenge measured after 30 mins by Western blot analysis | ChEMBL. | 22831798 | |
Inhibition (functional) | U 0 % | Anti-HIV activity (at 50 uM) against human HeLa cells through a HeLa-Tet-ON assay; U= unspecific | ChEMBL. | 16137881 |
Inhibition (functional) | 0 % | Anti-HIV activity (at 25 uM) against human HeLa-Tat-Luc cells transfected with HIV-1 LTR activated by Tat protein; NT= not tested | ChEMBL. | 16137881 |
Inhibition (functional) | S 0 % | Anti-HIV activity (at 50 uM) against human HeLa cells through a HeLa-Tet-ON assay; U= specific | ChEMBL. | 16137881 |
Inhibition (functional) | = 11.5 % | Anti-HIV activity (at 25 uM) against human HeLa-Tat-Luc cells transfected with HIV-1 LTR activated by Tat protein | ChEMBL. | 16137881 |
Inhibition (functional) | = 11.5 % | Anti-HIV activity (at 25 uM) against human HeLa-Tat-Luc cells transfected with HIV-1 LTR activated by Tat protein | ChEMBL. | 16137881 |
Inhibition (functional) | = 33.7 % | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at 1 uM incubated for 10 mins prior to LPS-challenge measured after 18 hrs by Griess method relative to control | ChEMBL. | 22831798 |
Inhibition (functional) | = 67.1 % | Anti-HIV activity (at 25 uM) against Jurkat-derived 5.1 cell line stably transfected with HIV-LTR activated by TNF alpha | ChEMBL. | 16137881 |
Inhibition (functional) | = 71 % | Anti-HIV activity (at 25 uM) against Jurkat-derived 5.1 cell line stably transfected with HIV-LTR activated by TNF alpha | ChEMBL. | 16137881 |
Inhibition (functional) | = 71.3 % | Anti-HIV activity (at 50 uM) against human HeLa-Tat-Luc cells transfected with HIV-1 LTR activated by Tat protein | ChEMBL. | 16137881 |
Inhibition (functional) | = 71.3 % | Anti-HIV activity (at 50 uM) against human HeLa-Tat-Luc cells transfected with HIV-1 LTR activated by Tat protein | ChEMBL. | 16137881 |
Inhibition (functional) | = 77.9 % | Anti-HIV activity (at 50 uM) against Jurkat-derived 5.1 cell line stably transfected with HIV-LTR activated by TNF alpha | ChEMBL. | 16137881 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 22831798 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.