Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma cruzi | trypanothione reductase, putative | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | trypanothione reductase, putative | 492 aa | 548 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | trypanothione reductase | 0.0076 | 0.0183 | 0.0183 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.1622 | 0.5875 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0076 | 0.0183 | 0.0183 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1622 | 0.5875 | 0.5875 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.1622 | 0.5875 | 1 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.1622 | 0.5875 | 1 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.2743 | 1 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0076 | 0.0183 | 0.0312 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0026 | 0 | 0.5 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.1622 | 0.5875 | 1 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.1622 | 0.5875 | 1 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.1622 | 0.5875 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.2743 | 1 | 1 |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.1622 | 0.5875 | 1 |
Plasmodium vivax | polyprenol reductase, putative | 0.1622 | 0.5875 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0026 | 0 | 0.5 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.1622 | 0.5875 | 0.5875 |
Brugia malayi | Thioredoxin reductase | 0.0076 | 0.0183 | 0.0183 |
Onchocerca volvulus | 0.1622 | 0.5875 | 0.5 | |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.1622 | 0.5875 | 0.5875 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.2743 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.2743 | 1 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.2743 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.2743 | 1 | 1 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.1622 | 0.5875 | 0.5875 |
Plasmodium falciparum | glutathione reductase | 0.0076 | 0.0183 | 0.0312 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.1622 | 0.5875 | 0.5875 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.1622 | 0.5875 | 0.5875 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0 | 0.5 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.2743 | 1 | 1 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.1622 | 0.5875 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0076 | 0.0183 | 0.0183 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1622 | 0.5875 | 0.5875 |
Toxoplasma gondii | thioredoxin reductase | 0.0076 | 0.0183 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.2743 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1622 | 0.5875 | 0.5798 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0076 | 0.0183 | 0.0312 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.2743 | 1 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0076 | 0.0183 | 0.0312 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.1622 | 0.5875 | 0.5875 |
Plasmodium falciparum | polyprenol reductase, putative | 0.1622 | 0.5875 | 1 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.1622 | 0.5875 | 0.5875 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.1622 | 0.5875 | 1 |
Brugia malayi | glutathione reductase | 0.0076 | 0.0183 | 0.0183 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0076 | 0.0183 | 0.0312 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.2743 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0076 | 0.0183 | 0.0312 |
Loa Loa (eye worm) | hypothetical protein | 0.1622 | 0.5875 | 0.5798 |
Treponema pallidum | NADH oxidase | 0.0026 | 0 | 0.5 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.1622 | 0.5875 | 0.5875 |
Brugia malayi | Synaptic glycoprotein SC2 | 0.1622 | 0.5875 | 0.5875 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0076 | 0.0183 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.2743 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5.3 uM | Linear competitive inhibition of trypanothione reductase from Trypanosoma cruzi using (ZCG.dmapa)2 substrate | ChEMBL. | 16335933 |
Ki (binding) | = 5.3 uM | Linear competitive inhibition of trypanothione reductase from Trypanosoma cruzi using (ZCG.dmapa)2 substrate | ChEMBL. | 16335933 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.