TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 393.349 | Formula: C14H20NO8PS
H donors: 4 H acceptors: 8 LogP: -0.53 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CC(P(=O)(CC(C(=O)O)CCC(=O)O)O)NS(=O)(=O)c1ccccc1
InChi: 1S/C14H20NO8PS/c1-10(15-25(22,23)12-5-3-2-4-6-12)24(20,21)9-11(14(18)19)7-8-13(16)17/h2-6,10-11,15H,7-9H2,1H3,(H,16,17)(H,18,19)(H,20,21)
InChiKey: NRWDFZNLPXYUAH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0084	0.3378	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0555	0.3952
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Onchocerca volvulus		0.0047	0.1759	0.1724
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0069	0.0031
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0047	0.1759	0.6468
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.1759	0.5147
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0047	0.1759	0.5147
Schistosoma mansoni	hypothetical protein	0.0068	0.2696	1
Onchocerca volvulus		0.0008	0.0069	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0047	0.1759	0.6468
Echinococcus granulosus	tm gpcr rhodopsin	0.0047	0.1759	0.5147
Echinococcus granulosus	FTZ F1 alpha	0.0008	0.0069	0.008
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0047	0.1759	0.6468
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0555	0.4733
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.134	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Brugia malayi	nuclear hormone receptor	0.0008	0.0069	0.0031
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0767	0.6544
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.1033	0.3735
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.1033	0.3735
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0008	0.0069	0.0031
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0047	0.1759	0.6468
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.134	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0047	0.1759	0.6468
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0555	0.0589
Loa Loa (eye worm)	neuropeptide F receptor	0.0047	0.1759	0.197
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.1759	0.5147
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0047	0.1759	0.6468
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0767	0.0833
Schistosoma mansoni	lamin	0.0027	0.0908	0.3265
Schistosoma mansoni	inositol monophosphatase	0.0037	0.134	0.4891
Onchocerca volvulus		0.0047	0.1759	0.1724
Echinococcus granulosus	G protein coupled receptor 139	0.0047	0.1759	0.5147
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0767	0.0833
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.1759	0.6468
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0047	0.1759	0.197
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0037	0.134	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0047	0.1759	0.6468
Echinococcus granulosus	neuropeptide receptor	0.0047	0.1759	0.5147
Echinococcus multilocularis	neuropeptides capa receptor	0.0047	0.1759	0.5147
Echinococcus granulosus	neuropeptide Y receptor	0.0047	0.1759	0.5147
Echinococcus multilocularis	neuropeptide Y receptor	0.0047	0.1759	0.5147
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0767	0.5587
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0047	0.1759	0.5147
Brugia malayi	hypothetical protein	0.0047	0.1759	0.197
Echinococcus multilocularis	g protein coupled receptor	0.0047	0.1759	0.5147
Brugia malayi	Dopamine receptor protein 1	0.0047	0.1759	0.197
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0008	0.0069	0.008
Echinococcus granulosus	biogenic amine 5HT receptor	0.0047	0.1759	0.5147
Echinococcus multilocularis	inositol monophosphatase 1	0.0037	0.134	0.3892
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0008	0.0069	0.008
Echinococcus granulosus	neuropeptide receptor A26	0.0047	0.1759	0.5147
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0508	0.0535
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0037	0.134	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.1759	0.5147
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0008	0.0069	0.0031
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0555	0.5175
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0767	0.5587
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Brugia malayi	Dopamine receptor	0.0047	0.1759	0.197
Onchocerca volvulus		0.0047	0.1759	0.1724
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0007	0.0042	0.0357
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0767	0.5587
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0908	0.0995
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Onchocerca volvulus		0.0047	0.1759	0.1724
Echinococcus granulosus	tm gpcr rhodopsin	0.0047	0.1759	0.5147
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.1759	0.5147
Brugia malayi	intermediate filament protein	0.0027	0.0908	0.0995
Schistosoma mansoni	hypothetical protein	0.0047	0.1759	0.6468
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0007	0.0042	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0069	0.0031
Echinococcus granulosus	g protein coupled receptor	0.0047	0.1759	0.5147
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0555	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Schistosoma mansoni	retinoic acid receptor RXR	0.0008	0.0069	0.0101
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0047	0.1759	0.5147
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0047	0.1759	0.6468
Echinococcus granulosus	neuropeptide FF receptor 2	0.0047	0.1759	0.5147
Echinococcus multilocularis	lamin dm0	0.0027	0.0908	0.2598
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0047	0.1759	0.197
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0767	0.5587
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0555	0.3952
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0767	0.0833
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0008	0.0069	0.0031
Brugia malayi	hypothetical protein	0.0047	0.1759	0.197
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0008	0.0069	0.0031
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0033	0.1173	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.1759	0.5147
Echinococcus granulosus	orexin receptor type 2	0.0047	0.1759	0.5147
Echinococcus granulosus	neuropeptide s receptor	0.0047	0.1759	0.5147
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0304	0.0786
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0007	0.0042	0.0357
Onchocerca volvulus	Protein ultraspiracle homolog	0.0008	0.0069	0.0027
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0767	0.6416
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0008	0.0069	0.0031
Echinococcus multilocularis	neuropeptide receptor	0.0047	0.1759	0.5147
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0767	0.6416
Brugia malayi	nuclear receptor NHR-88	0.0008	0.0069	0.0031
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0047	0.1759	0.5147
Schistosoma mansoni	neuropeptide receptor	0.0047	0.1759	0.6468
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0767	0.5587
Echinococcus granulosus	7TM GPCR rhodopsin	0.0047	0.1759	0.5147
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0037	0.134	1
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0555	0.3952
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0508	0.5
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0047	0.1759	0.197
Loa Loa (eye worm)	neuropeptide F receptor	0.0047	0.1759	0.197
Schistosoma mansoni	growth hormone secretagogue receptor	0.0047	0.1759	0.6468
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0508	0.0535
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.1759	0.6468
Onchocerca volvulus		0.0047	0.1759	0.1724
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.1033	0.3735
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0767	0.5587
Onchocerca volvulus		0.0047	0.1759	0.1724
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0767	0.5587
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0008	0.0069	0.0101
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0767	0.6544
Schistosoma mansoni	amine GPCR	0.0047	0.1759	0.6468
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0047	0.1759	0.1724
Schistosoma mansoni	nuclear hormone receptor	0.0008	0.0069	0.0101
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.1033	0.2972
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0008	0.0069	0.008
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0767	0.5587
Schistosoma mansoni	hypothetical protein	0.0047	0.1759	0.6468
Schistosoma mansoni	opsin-like receptor	0.0047	0.1759	0.6468
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0047	0.1759	0.5147
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0047	0.1759	0.5147
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0047	0.1759	0.5147
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0008	0.0069	0.008
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0047	0.1759	0.197
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0042	0.0357
Schistosoma mansoni	opsin-like receptor	0.0047	0.1759	0.6468
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0008	0.0069	0.008
Echinococcus granulosus	jun protein	0.0084	0.3378	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Brugia malayi	neuropeptide F receptor	0.0047	0.1759	0.197
Echinococcus granulosus	g protein coupled receptor	0.0047	0.1759	0.5147
Echinococcus granulosus	7tm_1 domain containing protein	0.0047	0.1759	0.5147
Schistosoma mansoni	lamin	0.0027	0.0908	0.3265
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0508	0.9078
Brugia malayi	G protein-coupled receptor	0.0047	0.1759	0.197
Echinococcus granulosus	serotonin receptor	0.0047	0.1759	0.5147
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0007	0.0042	0.0357
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.1759	0.6468
Brugia malayi	hypothetical protein	0.0047	0.1759	0.197
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0767	0.0833
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.1759	0.5147
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0047	0.1759	0.5147
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Schistosoma mansoni	neuropeptide F-like receptor	0.0047	0.1759	0.6468
Schistosoma mansoni	biogenic amine receptor	0.0047	0.1759	0.6468
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0008	0.0069	0.008
Echinococcus granulosus	intermediate filament protein	0.0027	0.0908	0.2598
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0508	0.0535
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0047	0.1759	0.197
Brugia malayi	Nuclear hormone receptor-like 1	0.0008	0.0069	0.0031
Schistosoma mansoni	RAR-like nuclear receptor	0.0008	0.0069	0.0101
Brugia malayi	larval opioid receptor	0.0047	0.1759	0.197
Echinococcus granulosus	tm gpcr rhodopsin	0.0047	0.1759	0.5147
Schistosoma mansoni	ap endonuclease	0.0019	0.0555	0.1933
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0047	0.1759	0.6468
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0908	0.0995
Brugia malayi	Inositol-1	0.0037	0.134	0.149
Echinococcus granulosus	ecdysone induced protein 78C	0.0008	0.0069	0.008
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0069	0.0031
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0008	0.0069	0.0027
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0008	0.0069	0.008
Toxoplasma gondii	exonuclease III APE	0.0019	0.0555	0.3952
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0018	0.0508	0.3588
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0008	0.0069	0.0031
Brugia malayi	bZIP transcription factor family protein	0.0084	0.3378	0.3829
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0008	0.0069	0.0031
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.1759	0.6468
Brugia malayi	follicle stimulating hormone receptor	0.0047	0.1759	0.197
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0466	0.3972
Brugia malayi	Dopamine receptor protein 2	0.0047	0.1759	0.197
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0047	0.1759	0.5147
Echinococcus granulosus	sex peptide receptor	0.0047	0.1759	0.5147
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0008	0.0069	0.0031
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0047	0.1759	0.197
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0047	0.1759	0.1724
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0069	0.0031
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0047	0.1759	0.5147
Loa Loa (eye worm)	TYRA-2 protein	0.0047	0.1759	0.197
Onchocerca volvulus		0.0047	0.1759	0.1724
Brugia malayi	sulfakinin receptor protein	0.0047	0.1759	0.197
Echinococcus multilocularis	G protein coupled receptor 139	0.0047	0.1759	0.5147
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.1759	0.5147
Echinococcus multilocularis	g-protein coupled receptor	0.0047	0.1759	0.5147
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0508	0.4698
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.1759	0.6468
Schistosoma mansoni	coup transcription factor	0.0008	0.0069	0.0101
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0008	0.0069	0.0031
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0047	0.1759	0.197
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0008	0.0069	0.008
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.1033	0.2972
Brugia malayi	steroid hormone receptor	0.0008	0.0069	0.0031
Echinococcus granulosus	somatostatin receptor	0.0047	0.1759	0.5147
Brugia malayi	hypothetical protein	0.0047	0.1759	0.197
Echinococcus multilocularis	g protein coupled receptor	0.0047	0.1759	0.5147
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0007	0.0042	0.0357
Echinococcus multilocularis	serotonin receptor	0.0047	0.1759	0.5147
Brugia malayi	G-protein coupled receptor	0.0047	0.1759	0.197
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0555	0.3952
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0047	0.1759	0.6468
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0084	0.3378	1
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0042	0.0357
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0767	0.5587
Brugia malayi	Serotonin receptor	0.0047	0.1759	0.197
Onchocerca volvulus	Bile acid receptor homolog	0.0008	0.0069	0.0027
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0008	0.0069	0.0031
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0555	0.5
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0037	0.134	1
Echinococcus granulosus	lamin	0.0027	0.0908	0.2598
Schistosoma mansoni	neuropeptide receptor	0.0047	0.1759	0.6468
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0047	0.1759	0.197
Brugia malayi	G protein-coupled receptor F59B2.13	0.0047	0.1759	0.197
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Schistosoma mansoni	neuropeptide receptor	0.0047	0.1759	0.6468
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Onchocerca volvulus		0.0047	0.1759	0.1724
Brugia malayi	hypothetical protein	0.0047	0.1759	0.197
Plasmodium vivax	SET domain protein, putative	0.003	0.1033	1
Loa Loa (eye worm)	inositol-1	0.0037	0.134	0.149
Echinococcus granulosus	dro:myosuppressin receptor	0.0047	0.1759	0.5147
Echinococcus granulosus	biogenic amine 5HT receptor	0.0047	0.1759	0.5147
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Onchocerca volvulus		0.0047	0.1759	0.1724
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0908	0.0995
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0555	0.3952
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0508	0.433
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Onchocerca volvulus		0.0047	0.1759	0.1724
Brugia malayi	neuropeptide F receptor	0.0047	0.1759	0.197
Echinococcus multilocularis	fmrfamide receptor	0.0047	0.1759	0.5147
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.134	0.1304
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0047	0.1759	0.5147
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0008	0.0069	0.008
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0366	0.0372
Echinococcus granulosus	g protein coupled receptor	0.0047	0.1759	0.5147
Brugia malayi	hypothetical protein	0.0066	0.2597	0.2932
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0887	0.097
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0555	0.0589
Schistosoma mansoni	amine GPCR	0.0047	0.1759	0.6468
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.1033	0.7637
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0466	0.3972
Echinococcus multilocularis	dro:myosuppressin receptor	0.0047	0.1759	0.5147
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0047	0.1759	0.6468
Schistosoma mansoni	amine GPCR	0.0047	0.1759	0.6468
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0555	0.5
Echinococcus granulosus	lamin dm0	0.0027	0.0908	0.2598
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0008	0.0069	0.008
Echinococcus multilocularis	fmrfamide receptor	0.0047	0.1759	0.5147
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.1759	0.5147
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0008	0.0069	0.0101
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0008	0.0069	0.0101
Echinococcus multilocularis	jun protein	0.0084	0.3378	1
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0767	0.0833
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.1759	0.5147
Onchocerca volvulus		0.0066	0.2597	0.2565
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0047	0.1759	0.5147
Brugia malayi	ecdysteroid receptor	0.0008	0.0069	0.0031
Brugia malayi	ORL1-like opioid receptor	0.0047	0.1759	0.197
Schistosoma mansoni	inositol monophosphatase	0.0037	0.134	0.4891
Schistosoma mansoni	myosin xvIII	0.0047	0.1759	0.6468
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0209	0.8755	1
Echinococcus granulosus	hypothetical protein	0.0047	0.1759	0.5147
Brugia malayi	hypothetical protein	0.0047	0.1759	0.197
Onchocerca volvulus		0.0027	0.0908	0.087
Echinococcus granulosus	fmrfamide receptor	0.0047	0.1759	0.5147
Brugia malayi	putative neuropeptide receptor NPR1	0.0047	0.1759	0.197
Echinococcus multilocularis	neuropeptide Y receptor	0.0047	0.1759	0.5147
Brugia malayi	G-protein coupled receptor	0.0047	0.1759	0.197
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Brugia malayi	putative neuropeptide receptor	0.0047	0.1759	0.197
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0008	0.0069	0.008
Loa Loa (eye worm)	steroid hormone receptor	0.0008	0.0069	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0283	0.0276
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0047	0.1759	0.5147
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0033	0.1173	1
Echinococcus multilocularis	FTZ F1 alpha	0.0008	0.0069	0.008
Schistosoma mansoni	amine GPCR	0.0047	0.1759	0.6468
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0008	0.0069	0.0101
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0466	0.3972
Brugia malayi	RE15519p	0.0047	0.1759	0.197
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0008	0.0069	0.0031
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0008	0.0069	0.0031
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.134	0.1304
Loa Loa (eye worm)	hypothetical protein	0.003	0.1033	0.1138
Echinococcus multilocularis	ecdysone induced protein 78C	0.0008	0.0069	0.008
Brugia malayi	hypothetical protein	0.0047	0.1759	0.197
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0042	0.0357
Schistosoma mansoni	neuropeptide receptor	0.0047	0.1759	0.6468
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.1759	0.6468
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0008	0.0069	0.0031
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0555	0.1538
Schistosoma mansoni	hypothetical protein	0.0047	0.1759	0.6468
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0047	0.1759	0.5147
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.1759	0.5147
Brugia malayi	GnHR receptor homolog	0.0047	0.1759	0.197
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.1033	0.2972
Schistosoma mansoni	biogenic amine receptor	0.0047	0.1759	0.6468
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0042	0.0357
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0767	0.5587
Echinococcus multilocularis	allatostatin A receptor	0.0047	0.1759	0.5147
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Echinococcus multilocularis	neuropeptide receptor A26	0.0047	0.1759	0.5147
Brugia malayi	photoreceptor-specific nuclear receptor	0.0008	0.0069	0.0031
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0047	0.1759	0.5147
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0047	0.1759	0.5147
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0555	0.0515
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0047	0.1759	0.5147
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0069	0.0031
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0047	0.1759	0.5147
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Schistosoma mansoni	adenoreceptor	0.0047	0.1759	0.6468
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0304	0.0786
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0555	0.3952
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.1759	0.5147
Schistosoma mansoni	hypothetical protein	0.0047	0.1759	0.6468
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0466	0.3972
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.1759	0.5147
Loa Loa (eye worm)	G-protein coupled receptor	0.0047	0.1759	0.197
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0047	0.1759	0.5147
Echinococcus granulosus	neuropeptides capa receptor	0.0047	0.1759	0.5147
Brugia malayi	Steroid receptor seven-up type 2	0.0008	0.0069	0.0031
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0047	0.1759	0.5147
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0047	0.1759	0.6468
Brugia malayi	Serotonin receptor	0.0047	0.1759	0.197
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0047	0.1759	0.6468
Brugia malayi	Pre-SET motif family protein	0.003	0.1033	0.1138
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0008	0.0069	0.008
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Onchocerca volvulus		0.0047	0.1759	0.1724
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0555	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0908	0.3265
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0047	0.1759	0.197
Echinococcus granulosus	inositol monophosphatase 1	0.0037	0.134	0.3892
Onchocerca volvulus		0.0027	0.0908	0.087
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0008	0.0069	0.0031
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0008	0.0069	0.0101
Trichomonas vaginalis	inositol monophosphatase, putative	0.0037	0.134	0.1304
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0008	0.0069	0.0031
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0366	0.0372
Schistosoma mansoni	biogenic amine receptor	0.0047	0.1759	0.6468
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0069	0.0031
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.134	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0986	0.283
Echinococcus granulosus	neuropeptide receptor	0.0047	0.1759	0.5147
Echinococcus multilocularis	orexin receptor type 2	0.0047	0.1759	0.5147
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0767	0.0833
Echinococcus multilocularis	lamin	0.0027	0.0908	0.2598
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0304	0.0301
Echinococcus multilocularis	neuropeptide receptor	0.0047	0.1759	0.5147
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.134	1
Echinococcus granulosus	neuropeptide Y receptor	0.0047	0.1759	0.5147
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0767	0.5587
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0008	0.0069	0.008
Brugia malayi	AKH receptor	0.0047	0.1759	0.197
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.1759	0.6468
Echinococcus multilocularis	serotonin receptor	0.0047	0.1759	0.5147
Onchocerca volvulus		0.0024	0.0767	0.0728
Echinococcus multilocularis	somatostatin receptor	0.0047	0.1759	0.5147
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.1759	0.5147
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0069	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.1759	0.5147
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.1759	0.6468
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0047	0.1759	0.6468
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0008	0.0069	0.0031
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0047	0.1759	0.6468
Schistosoma mansoni	jun-related protein	0.0068	0.2696	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0008	0.0069	0.0031
Onchocerca volvulus		0.0047	0.1759	0.1724
Onchocerca volvulus		0.0047	0.1759	0.1724
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0908	0.0995
Brugia malayi	Pre-SET motif family protein	0.0209	0.8755	1
Brugia malayi	hypothetical protein	0.0047	0.1759	0.197
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3278	0.3714
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0047	0.1759	0.5147
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0008	0.0069	0.0101
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0047	0.1759	0.6468
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0007	0.0042	0.0357
Onchocerca volvulus		0.003	0.1033	0.0996
Echinococcus granulosus	g-protein coupled receptor	0.0047	0.1759	0.5147
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0008	0.0069	0.0101
Loa Loa (eye worm)	G-protein coupled receptor	0.0047	0.1759	0.197
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0047	0.1759	0.5147
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Schistosoma mansoni	amine GPCR	0.0047	0.1759	0.6468
Brugia malayi	hypothetical protein	0.0047	0.1759	0.197
Echinococcus multilocularis	neuropeptides capa receptor	0.0047	0.1759	0.5147
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0508	0.0535
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0008	0.0069	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0283	0.0276
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0008	0.0069	0.0031
Echinococcus granulosus	neuropeptides capa receptor	0.0047	0.1759	0.5147
Brugia malayi	hypothetical protein	0.0047	0.1759	0.197
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0008	0.0069	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0508	0.0535
Brugia malayi	Melatonin receptor type 1A	0.0047	0.1759	0.197
Schistosoma mansoni	thyroid hormone receptor	0.0008	0.0069	0.0101
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0008	0.0069	0.008
Echinococcus multilocularis	musashi	0.0027	0.0908	0.2598
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0069	0.0031
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0767	0.5587
Echinococcus multilocularis	g protein coupled receptor	0.0047	0.1759	0.5147
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0047	0.1759	0.5147
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0007	0.0042	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Schistosoma mansoni	opsin-like receptor	0.0047	0.1759	0.6468
Loa Loa (eye worm)	melatonin receptor type 1A	0.0047	0.1759	0.197
Onchocerca volvulus		0.0047	0.1759	0.1724
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0767	0.5587
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0555	0.1538
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0047	0.1759	0.5147
Schistosoma mansoni	ap endonuclease	0.0019	0.0555	0.1933
Echinococcus multilocularis	sex peptide receptor	0.0047	0.1759	0.5147
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0047	0.1759	0.5147
Schistosoma mansoni	histamine h1 receptor	0.0047	0.1759	0.6468
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0047	0.1759	0.6468
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.1759	0.5147
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0767	0.5587
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.1033	0.3735
Onchocerca volvulus		0.0047	0.1759	0.1724
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1759	0.197
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0047	0.1759	0.197
Onchocerca volvulus		0.0047	0.1759	0.1724
Schistosoma mansoni	thyroid hormone receptor	0.0008	0.0069	0.0101
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.1759	0.6468
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0047	0.1759	0.6468
Echinococcus multilocularis	neuropeptide s receptor	0.0047	0.1759	0.5147
Echinococcus granulosus	allatostatin A receptor	0.0047	0.1759	0.5147
Trichomonas vaginalis	set domain proteins, putative	0.0237	1	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0047	0.1759	0.197
Onchocerca volvulus		0.0047	0.1759	0.1724

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	= 54 %	Residual activity of MurD from Escherichia coli at 1 mM	ChEMBL.	16271472
Activity (binding)	= 54 %	Residual activity of MurD from Escherichia coli at 1 mM	ChEMBL.	16271472

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 347355