Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Pyruvate kinase | 0.0033 | 0.033 | 1 |
Plasmodium falciparum | pyruvate kinase | 0.0033 | 0.033 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0367 | 0.0728 |
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.033 | 0.0653 |
Echinococcus granulosus | dnaJ subfamily B | 0.0404 | 0.4947 | 1 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0033 | 0.033 | 0.4354 |
Schistosoma mansoni | peptidylglycine monooxygenase | 0.0133 | 0.1578 | 0.3179 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.1578 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0482 | 0.3027 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0033 | 0.033 | 0.1544 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0344 | 0.2146 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0367 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0404 | 0.4947 | 1 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0293 | 0.0578 |
Mycobacterium ulcerans | DNA-3-methyladenine glycosylase I TagA | 0.0178 | 0.2137 | 1 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein | 0.0068 | 0.0761 | 0.4804 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0482 | 0.0475 |
Schistosoma mansoni | dopamine-beta-monooxygenase | 0.0252 | 0.3059 | 0.6178 |
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.033 | 0.0653 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0033 | 0.033 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0017 | 0.013 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0116 | 0.0698 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0482 | 0.0475 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0029 | 0.0044 |
Brugia malayi | DOMON domain containing protein | 0.0026 | 0.0237 | 0.147 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0116 | 0.0698 |
Trichomonas vaginalis | DNA-3-methyladenine glycosylase, putative | 0.0178 | 0.2137 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.0273 | 0.1696 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0293 | 0.0286 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0367 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0116 | 0.0108 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0066 | 0.0737 | 0.4646 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.0273 | 0.1696 |
Leishmania major | pyruvate kinase | 0.0033 | 0.033 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0116 | 0.0219 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0133 | 0.1578 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0029 | 0.0022 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.033 | 0.0779 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.033 | 0.0323 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.033 | 0.2059 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0033 | 0.033 | 0.1544 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.1426 | 0.9031 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0116 | 0.0108 |
Echinococcus granulosus | pyruvate kinase | 0.0017 | 0.013 | 0.0249 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0116 | 0.0219 |
Onchocerca volvulus | Huntingtin homolog | 0.0121 | 0.1426 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.033 | 0.2059 |
Echinococcus granulosus | pyruvate kinase | 0.0017 | 0.013 | 0.0249 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0116 | 0.0698 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0116 | 0.0219 |
Mycobacterium tuberculosis | Probable DNA-3-methyladenine glycosylase I TagA (tag I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine g | 0.0088 | 0.102 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0367 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.1578 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.006 | 0.0669 | 0.1338 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0116 | 0.0219 |
Echinococcus granulosus | peptidyl glycine alpha amidating monooxygenase | 0.0133 | 0.1578 | 0.3179 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0116 | 0.0219 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0367 | 0.0728 |
Echinococcus granulosus | pyruvate kinase | 0.0017 | 0.013 | 0.0249 |
Onchocerca volvulus | 0.0028 | 0.0273 | 0.0299 | |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0028 | 0.0136 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.054 | 0.3394 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0116 | 0.0219 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0482 | 0.0961 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0293 | 0.0578 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0033 | 0.033 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0482 | 0.0961 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0023 | 0.0206 | 0.127 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0033 | 0.033 | 0.2059 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0116 | 0.0698 |
Loa Loa (eye worm) | DOMON domain-containing protein | 0.0026 | 0.0237 | 0.147 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0293 | 0.0578 |
Onchocerca volvulus | Huntingtin homolog | 0.0121 | 0.1426 | 1 |
Trichomonas vaginalis | DNA-3-methyladenine glycosylase, putative | 0.0178 | 0.2137 | 1 |
Brugia malayi | Pyruvate kinase, alpha/beta domain containing protein | 0.001 | 0.0044 | 0.024 |
Echinococcus granulosus | pyruvate kinase | 0.0033 | 0.033 | 0.0653 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0367 | 0.2296 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.054 | 0.3394 |
Chlamydia trachomatis | pyruvate kinase | 0.0033 | 0.033 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0054 | 0.0589 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0344 | 0.2146 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0482 | 0.0961 |
Echinococcus granulosus | pyruvate kinase | 0.0033 | 0.033 | 0.0653 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.033 | 0.0323 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0033 | 0.033 | 0.5 |
Loa Loa (eye worm) | DOMON domain-containing protein | 0.0026 | 0.0237 | 0.147 |
Echinococcus multilocularis | peptidyl glycine alpha amidating monooxygenase | 0.0133 | 0.1578 | 0.1571 |
Mycobacterium leprae | PROBABLE DNA-3-METHYLADENINE GLYCOSYLASE I TAGA (TAG I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine g | 0.0088 | 0.102 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.033 | 0.0779 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0482 | 0.0961 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0404 | 0.4947 | 0.4943 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0367 | 0.0728 |
Echinococcus multilocularis | pyruvate kinase | 0.0017 | 0.013 | 0.0123 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.054 | 0.3394 |
Echinococcus multilocularis | pyruvate kinase | 0.0026 | 0.0244 | 0.0236 |
Brugia malayi | DOMON domain containing protein | 0.0026 | 0.0237 | 0.147 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0344 | 0.068 |
Brugia malayi | hypothetical protein | 0.0121 | 0.1426 | 0.9031 |
Schistosoma mansoni | peptidyl-glycine monooxygenase | 0.0133 | 0.1578 | 0.3179 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0116 | 0.0108 |
Brugia malayi | DOMON domain containing protein | 0.0026 | 0.0237 | 0.147 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.0273 | 0.0537 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0033 | 0.033 | 0.5 |
Plasmodium vivax | pyruvate kinase, putative | 0.0033 | 0.033 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0482 | 0.3027 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0133 | 0.1578 | 1 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0033 | 0.033 | 0.2059 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0367 | 0.036 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.033 | 0.0779 |
Leishmania major | pyruvate kinase | 0.0033 | 0.033 | 0.5 |
Schistosoma mansoni | pyruvate kinase | 0.0017 | 0.013 | 0.0249 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.033 | 0.2059 |
Echinococcus multilocularis | pyruvate kinase | 0.0017 | 0.013 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0206 | 0.127 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0029 | 0.0145 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0367 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.033 | 0.2059 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.1426 | 0.9031 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0116 | 0.0219 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0482 | 0.0961 |
Loa Loa (eye worm) | DOMON domain-containing protein | 0.0026 | 0.0237 | 0.147 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.054 | 0.3394 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 30 % | Displacement of [3H]ZM241385 from recombinant human adenosine A2A receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 30 % | Displacement of [3H]ZM241385 from recombinant human adenosine A2A receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 45 % | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HeLa cells at 0.01 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 45 % | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HeLa cells at 0.01 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 85 % | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 85 % | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.