Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Hepatitis C virus | Hepatitis C virus NS5B RNA-dependent RNA polymerase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0808 | 0.0794 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.0546 | 0.062 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.0546 | 0.062 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0808 | 0.0916 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0032 | 0.0861 | 0.0066 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0032 | 0.0861 | 0.0977 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0032 | 0.0861 | 0.0847 |
Schistosoma mansoni | nuclear hormone receptor | 0.0032 | 0.0861 | 0.0847 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0086 | 0.0097 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 1 | 1 |
Onchocerca volvulus | 0.0076 | 0.3322 | 0.314 | |
Echinococcus multilocularis | musashi | 0.0031 | 0.0808 | 0.0794 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.0694 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0861 | 0.0977 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0808 | 0.0916 |
Entamoeba histolytica | DNA repair and recombination protein, putative | 0.0034 | 0.0952 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0808 | 0.0916 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0086 | 0.007 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0032 | 0.0861 | 0.0847 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.8817 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0032 | 0.0861 | 0.0977 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0032 | 0.0861 | 0.0977 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0032 | 0.0861 | 0.0847 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.2284 | 0.2591 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0808 | 0.0794 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0034 | 0.0952 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0015 | 0.0017 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0032 | 0.0861 | 0.0977 |
Giardia lamblia | Rrm3p helicase | 0.0034 | 0.0952 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0032 | 0.0861 | 0.0847 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0032 | 0.0861 | 0.0977 |
Brugia malayi | Cytochrome P450 family protein | 0.0038 | 0.1212 | 0.1375 |
Brugia malayi | bZIP transcription factor family protein | 0.0097 | 0.4486 | 0.5088 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0032 | 0.0861 | 0.0977 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0118 | 0.0134 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0017 | 0.0015 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0086 | 0.0097 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0694 | 0.0787 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0032 | 0.0861 | 0.0977 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0086 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0861 | 0.0977 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF7 | 0.0034 | 0.0952 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0861 | 0.0977 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0032 | 0.0861 | 0.0977 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0015 | 0.0017 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0032 | 0.0861 | 0.0847 |
Onchocerca volvulus | 0.0174 | 0.8817 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.3471 | 0.3461 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0694 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.0808 | 0.0794 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0137 | 0.677 | 0.7679 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0032 | 0.0861 | 0.0847 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0032 | 0.0861 | 0.0847 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0032 | 0.0861 | 0.0847 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0097 | 0.4486 | 0.4477 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0032 | 0.0861 | 0.0847 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0032 | 0.0861 | 0.0977 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0032 | 0.0861 | 0.0847 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0015 | 0.0017 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.1267 | 0.1437 |
Brugia malayi | steroid hormone receptor | 0.0032 | 0.0861 | 0.0977 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF6 | 0.0034 | 0.0952 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0015 | 0.0017 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF6, putative | 0.0034 | 0.0952 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0032 | 0.0861 | 0.0847 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0032 | 0.0861 | 0.0847 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0017 | 0.0015 | 0.0017 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0026 | 0.0546 | 0.062 |
Brugia malayi | hypothetical protein | 0.0174 | 0.8817 | 1 |
Schistosoma mansoni | jun-related protein | 0.0078 | 0.3471 | 0.3461 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0032 | 0.0861 | 0.0847 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0032 | 0.0861 | 0.0977 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0032 | 0.0861 | 0.0977 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0032 | 0.0861 | 0.0977 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0034 | 0.0952 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0032 | 0.0861 | 0.0847 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0032 | 0.0861 | 0.0066 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0808 | 0.0794 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0032 | 0.0861 | 0.0847 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0808 | 0.0916 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0038 | 0.1212 | 0.1375 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0694 | 0.0787 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0034 | 0.0952 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0032 | 0.0861 | 0.0977 |
Brugia malayi | nuclear receptor NHR-88 | 0.0032 | 0.0861 | 0.0977 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.2284 | 0.2591 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0032 | 0.0861 | 0.0847 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0032 | 0.0861 | 0.0847 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0808 | 0.0794 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0032 | 0.0861 | 0.0847 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0017 | 0.0015 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.4337 | 0.4919 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0861 | 0.0977 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0086 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0015 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1267 | 0.1437 |
Brugia malayi | nuclear receptor RXR | 0.0017 | 0.0015 | 0.0017 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0032 | 0.0861 | 0.0847 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0776 | 0.088 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0086 | 0.007 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.2284 | 0.2591 |
Echinococcus granulosus | ATP dependent DNA helicase PIF1 | 0.0034 | 0.0952 | 0.0938 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.0952 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0032 | 0.0861 | 0.0847 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0032 | 0.0861 | 0.0977 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0034 | 0.0952 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0861 | 0.0977 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0808 | 0.0916 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0694 | 0.3643 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0032 | 0.0861 | 0.0977 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0032 | 0.0861 | 0.0977 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0032 | 0.0861 | 0.0847 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0032 | 0.0861 | 0.0847 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0694 | 0.3643 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0032 | 0.0861 | 0.0977 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0032 | 0.0861 | 0.0847 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0861 | 0.0977 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0032 | 0.0861 | 0.0847 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.0546 | 0.062 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0034 | 0.0952 | 0.5 |
Schistosoma mansoni | lamin | 0.0031 | 0.0808 | 0.0794 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.0546 | 0.062 |
Schistosoma mansoni | coup transcription factor | 0.0032 | 0.0861 | 0.0847 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0032 | 0.0861 | 0.0847 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0015 | 0.0017 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0032 | 0.0861 | 0.0977 |
Brugia malayi | hypothetical protein | 0.0076 | 0.3322 | 0.3768 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0032 | 0.0861 | 0.0977 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.2284 | 0.2591 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0032 | 0.0861 | 0.0977 |
Schistosoma mansoni | lamin | 0.0031 | 0.0808 | 0.0794 |
Echinococcus multilocularis | geminin | 0.0195 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0032 | 0.0861 | 0.0977 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0032 | 0.0861 | 0.0977 |
Brugia malayi | ecdysteroid receptor | 0.0032 | 0.0861 | 0.0977 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0861 | 0.0977 |
Echinococcus multilocularis | ATP dependent DNA helicase PIF1 | 0.0034 | 0.0952 | 0.0938 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0086 | 0.0097 |
Brugia malayi | nuclear hormone receptor | 0.0032 | 0.0861 | 0.0977 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0952 | 0.0938 |
Echinococcus granulosus | lamin | 0.0031 | 0.0808 | 0.0794 |
Echinococcus multilocularis | jun protein | 0.0097 | 0.4486 | 0.4477 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0026 | 0.0546 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0032 | 0.0861 | 0.0847 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0032 | 0.0861 | 0.0847 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0086 | 0.007 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0032 | 0.0861 | 0.0066 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0086 | 0.007 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0694 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0137 | 0.677 | 0.7679 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0015 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0861 | 0.0977 |
Onchocerca volvulus | 0.0032 | 0.0861 | 0.0066 | |
Echinococcus granulosus | jun protein | 0.0097 | 0.4486 | 0.4477 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.1267 | 0.1253 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0086 | 0.0097 |
Brugia malayi | MH2 domain containing protein | 0.0137 | 0.677 | 0.7679 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.0694 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.0694 | 0.3643 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0086 | 0.007 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0694 | 0.3643 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0086 | 0.007 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0032 | 0.0861 | 0.0847 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0032 | 0.0861 | 0.0977 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0032 | 0.0861 | 0.0847 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0086 | 0.007 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0097 | 0.4486 | 0.4477 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0032 | 0.0861 | 0.0977 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0086 | 0.007 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.