Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0663 | 0.0576 | 0.0576 |
Brugia malayi | purine nucleoside phosphorylase I, inosine and guanosine-specific family protein | 0.0663 | 0.0576 | 0.0576 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0791 | 0.1308 | 0.1308 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0791 | 0.1308 | 0.1308 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.0663 | 0.0576 | 0.0629 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0663 | 0.0576 | 0.0576 |
Onchocerca volvulus | 0.072 | 0.0903 | 0.4473 | |
Mycobacterium ulcerans | 5'-methylthioadenosine phosphorylase | 0.2315 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0663 | 0.0576 | 0.0576 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.2315 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0663 | 0.0576 | 0.0576 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0663 | 0.0576 | 0.0576 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0663 | 0.0576 | 0.0576 |
Loa Loa (eye worm) | hypothetical protein | 0.0791 | 0.1308 | 0.1308 |
Chlamydia trachomatis | AMP nucleosidase | 0.0562 | 0 | 0.5 |
Plasmodium falciparum | purine nucleoside phosphorylase | 0.0562 | 0 | 0.5 |
Giardia lamblia | 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase | 0.2168 | 0.9162 | 1 |
Onchocerca volvulus | 0.0791 | 0.1308 | 1 | |
Loa Loa (eye worm) | S-methyl-5'-thioadenosine phosphorylase MTAP | 0.2315 | 1 | 1 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0663 | 0.0576 | 0.0576 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0663 | 0.0576 | 0.0576 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0663 | 0.0576 | 0.0576 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0663 | 0.0576 | 0.0576 |
Entamoeba histolytica | MTA/SAH nucleosidase, putative | 0.2168 | 0.9162 | 1 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.2315 | 1 | 1 |
Treponema pallidum | pfs protein (pfs) | 0.2168 | 0.9162 | 1 |
Mycobacterium ulcerans | bifunctional Mta/Sah nucleosidase Mtn | 0.2168 | 0.9162 | 0.9111 |
Toxoplasma gondii | phosphorylase family protein | 0.0562 | 0 | 0.5 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.2315 | 1 | 1 |
Echinococcus granulosus | methylthioadenosine phosphorylase | 0.2315 | 1 | 1 |
Echinococcus multilocularis | methylthioadenosine phosphorylase | 0.2315 | 1 | 1 |
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | 0.2315 | 1 | 1 |
Toxoplasma gondii | Purine nucleoside phosphorylase | 0.0562 | 0 | 0.5 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.0663 | 0.0576 | 1 |
Mycobacterium tuberculosis | Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase | 0.2168 | 0.9162 | 1 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.0663 | 0.0576 | 0.0629 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.0663 | 0.0576 | 0.0629 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.2168 | 0.9162 | 1 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.2315 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0663 | 0.0576 | 0.0576 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0663 | 0.0576 | 0.0576 |
Mycobacterium tuberculosis | Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) | 0.1753 | 0.6796 | 0.7418 |
Plasmodium vivax | purine nucleoside phosphorylase, putative | 0.0562 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0791 | 0.1308 | 0.1308 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0663 | 0.0576 | 0.0576 |
Leishmania major | methylthioadenosine phosphorylase, putative | 0.2315 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0663 | 0.0576 | 0.0576 |
Toxoplasma gondii | phosphorylase family protein | 0.0562 | 0 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0663 | 0.0576 | 0.0576 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0663 | 0.0576 | 0.0576 |
Brugia malayi | Trypsin family protein | 0.0791 | 0.1308 | 0.1308 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalis | ChEMBL. | 14980694 |
IC50 (binding) | > 100 uM | Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureus | ChEMBL. | 14980694 |
IC50 (binding) | > 100 uM | Inhibitory activity against human phenylalanyl-tRNA synthetase was determined | ChEMBL. | 14980694 |
IC50 (binding) | > 100 uM | Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalis | ChEMBL. | 14980694 |
IC50 (binding) | > 100 uM | Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureus | ChEMBL. | 14980694 |
IC50 (binding) | > 100 uM | Inhibitory activity against human phenylalanyl-tRNA synthetase was determined | ChEMBL. | 14980694 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.