Detailed view for Rv0535

Basic information

TDR Targets ID: 980710
Mycobacterium tuberculosis, Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase)
Source Database / ID:  Tuberculist 

pI: 6.1541 | Length (AA): 264 | MW (Da): 27964 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Cysteine and methionine metabolism (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 258 5tc5 (A) 1 274 34.00 0 1 1.44107 -0.71
3 262 4glj (A) 11 282 38.00 0 1 1.48365 -0.66
8 255 1wta (A) 14 271 43.00 0 1 1.48219 -0.7

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128424)

Species Accession Gene Product
Brugia malayi Bm1_42810   MTAP
Candida albicans CaO19.14200   ADH2 expression
Candida albicans CaO19.6938   ADH2 expression
Caenorhabditis elegans CELE_B0228.7   Protein B0228.7
Drosophila melanogaster Dmel_CG4802   Methylthioadenosine phosphorylase ortholog
Echinococcus granulosus EgrG_000622900   methylthioadenosine phosphorylase
Echinococcus multilocularis EmuJ_000622900   methylthioadenosine phosphorylase
Homo sapiens ENSG00000099810   methylthioadenosine phosphorylase
Leishmania braziliensis LbrM.05.0800   methylthioadenosine phosphorylase, putative
Leishmania donovani LdBPK_050830.1   methylthioadenosine phosphorylase, putative
Leishmania infantum LinJ.05.0830   methylthioadenosine phosphorylase, putative
Leishmania major LmjF.05.0830   methylthioadenosine phosphorylase, putative
Leishmania mexicana LmxM.05.0830   methylthioadenosine phosphorylase, putative
Loa Loa (eye worm) LOAG_01831   S-methyl-5'-thioadenosine phosphorylase MTAP
Mus musculus ENSMUSG00000062937   methylthioadenosine phosphorylase
Mycobacterium tuberculosis Rv0535   Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase)
Mycobacterium ulcerans MUL_0634   5'-methylthioadenosine phosphorylase
Saccharomyces cerevisiae YLR017W   S-methyl-5-thioadenosine phosphorylase
Schistosoma japonicum Sjp_0213000   ko:K00772 5'-methylthioadenosine phosphorylase [EC2.4.2.28], putative
Schistosoma mansoni Smp_102440   methylthioadenosine phosphorylase
Schistosoma mansoni Smp_028190   methylthioadenosine phosphorylase
Schmidtea mediterranea mk4.006248.03   S-methyl-5'-thioadenosine phosphorylase
Trypanosoma brucei gambiense Tbg972.7.8280   methylthioadenosine phosphorylase, putative
Trypanosoma brucei Tb927.7.7040   methylthioadenosine phosphorylase, putative
Trypanosoma congolense TcIL3000_7_5710   methylthioadenosine phosphorylase, putative
Trypanosoma cruzi TcCLB.506789.280   methylthioadenosine phosphorylase, putative
Trypanosoma cruzi TcCLB.508387.20   methylthioadenosine phosphorylase, putative

Essentiality

Rv0535 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.7040 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.7.7040 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.7.7040 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.7.7040 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens methylthioadenosine phosphorylase Compounds References
Mus musculus methylthioadenosine phosphorylase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0856 0.6051 0.9897
0.089 0.5069 0.9142
0.0854 0.6124 1
0.0866 0.5088 0.982
0.1727 0.7699 0.9387
0.0516 0.8001 1
0.014 0.7681 1
0.0828 0.2793 0.9699
0.0987 0.8059 1
0.046 0.325 0.4897
0.188 0.6623 0.7176
0.0777 0.4447 0.8174
0.2009 0.7607 1
0.1501 0.3054 1
0.0813 0.3546 1
0.0457 0.5031 1
0.0823 0.2814 1
0.0837 0.3124 1
0.1597 0.712 0.6956
0.0261 0.3149 0.633
0.1626 0.6508 0.6508
0.0705 0.3836 0.7812
0.0869 0.2789 1
0.2045 0.4362 0.4362
0.0691 0.3881 0.7772
0.0459 0.7934 1
0.0813 0.3546 1
0.0828 0.2789 0.9696
0.0823 0.2802 1
0.086 0.4792 0.968
0.0458 0.2593 0.4831
0.0873 0.4474 0.9488
0.014 0.5408 1
0.07 0.2778 0.7982
0.1756 0.7194 0.7068
0.0902 0.5258 1
0.1626 0.6508 0.6508
0.0249 0.6059 1
0.0796 0.4379 0.8115
0.0694 0.3958 0.757
0.09 0.5 0.9504
0.014 0.7693 0.5
0.0843 0.5879 0.9413
0.0896 0.4939 0.9383
0.0914 0.4941 0.9387
0.0878 0.4926 1
0.176 0.5073 0.7419
0.189 0.6625 0.7192
0.1738 0.7374 0.7339
0.1328 0.4079 0.4079
0.0698 0.3871 0.7795
0.0806 0.3628 0.3583
0.0356 0.645 1
0.014 0.2614 1
0.0492 0.2635 1
0.0694 0.3957 0.7872
0.0851 0.5963 0.9817
0.1753 0.6796 0.7418
0.0866 0.6311 1
0.0799 0.324 1
0.1597 0.712 0.6956
0.0116 0.2588 0
0.0694 0.5048 1
0.087 0.611 1
0.0516 0.8001 1
0.0813 0.3546 1
0.0869 0.2789 1
0.0516 0.8001 1
0.1747 0.7566 0.9722
0.0713 0.386 0.7777
0.0699 0.495 1
0.0861 0.4541 0.9326
0.0843 0.2698 0.9431
0.0356 0.645 1
0.0873 0.5217 0.9349
0.1199 0.317 0.207
0.0869 0.2789 1
0.0701 0.3857 0.7816
0.0707 0.5182 1
0.0813 0.3546 1
0.014 0.326 0.5226
0.1337 0.3755 0.2645
0.0837 0.613 1
0.0823 0.2814 1
0.0853 0.5979 0.9817
0.0896 0.5013 0.9606
0.0707 0.2548 0.2548
0.0706 0.3872 0.7838
0.0766 0.4423 0.8448
0.0848 0.4585 0.9405
0.202 0.6503 1
0.0692 0.3864 1
0.0858 0.6109 1
0.0574 0.4144 1
0.014 0.2815 0.531
0.0458 0.2593 0.4831
0.014 0.4986 1
0.1513 0.6878 0.6907
0.0766 0.4423 0.8448
0.09 0.4943 0.936
0.0825 0.6105 1
0.0937 0.5027 0.4522
0.014 0.4986 1
0.0853 0.4981 0.9275
0.1788 0.7497 0.8016
0.0722 0.8112 1
0.0696 0.3857 0.7815
0.0851 0.5963 0.9817
0.014 0.2614 1
0.0766 0.4423 0.8448
0.0875 0.5147 0.9846
0.07 0.5097 1
0.0725 0.6092 0.7371
0.0945 0.6763 1
0.0571 0.4161 0.6268
0.1394 0.6297 0.6297
0.0232 0.7728 1
0.0823 0.2802 1
0.0699 0.3874 0.7834
0.0817 0.7753 1
0.0813 0.3546 1
0.014 0.2614 1
0.0848 0.4585 0.9405
0.0813 0.3546 1
0.0869 0.2789 1
0.0689 0.7998 1
0.0694 0.5048 1
0.0911 0.5289 1
0.0861 0.6039 0.9863
0.0707 0.3892 0.7817
0.0228 0.3109 0.5
0.0702 0.2993 0.7843
0.1501 0.7763 1
0.0894 0.5071 0.9693
0.0698 0.3946 0.7612
0.0562 0.3211 0.3777
0.046 0.3231 0.4849
0.1753 0.6796 0.7418
0.0479 0.6146 1
0.0828 0.2793 0.9699
0.0456 0.2573 0.4892
0.09 0.4943 0.936
0.0828 0.2789 0.9696
0.086 0.7345 0.9431
0.2045 0.4362 0.4362
0.0849 0.5066 0.9676
0.0261 0.281 0.8607
0.0853 0.6028 0.9919
0.0126 0.7256 0.5
0.0919 0.4931 0.9364
0.0905 0.5229 0.9957
0.2045 0.4362 0.4362
0.0713 0.2658 0.7901
0.202 0.6503 1
0.0698 0.3871 0.7795
0.0339 0.326 1
0.0851 0.5963 0.9817
0.0702 0.2993 0.7843
0.0342 0.806 1
0.0848 0.4585 0.9405
0.0261 0.3149 0.633
0.0828 0.2789 1
0.0772 0.4351 0.7922
0.0869 0.2789 1
0.0875 0.6053 0.9887
0.0873 0.5077 0.9762
0.1325 0.3827 0.269
0.014 0.2707 0.5
0.0843 0.6132 1
0.0849 0.499 0.9297
0.0698 0.3956 0.7571
0.0457 0.3239 0.2997
0.071 0.5134 1
0.0848 0.3743 0.9299
0.0936 0.7485 1
0.0848 0.4585 0.9405
0.014 0.5408 1
0.0834 0.6069 0.9885
0.0458 0.2577 0.4735
0.014 0.3291 1
0.1798 0.733 0.7406
0.014 0.2614 1
0.0879 0.4906 0.9808
0.0894 0.4656 0.9693
0.087 0.6109 0.9756
0.014 0.7681 1
0.1772 0.7462 0.7411
0.0722 0.8112 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Rv0535 (Mycobacterium tuberculosis), Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase)
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