TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 361.411 | Formula: C19H24FN3O3
H donors: 1 H acceptors: 3 LogP: 0.89 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCn1cc(C(=O)O)c(=O)c2c1cc(N1CCC(CC1)N(C)C)c(c2)F
InChi: 1S/C19H24FN3O3/c1-4-22-11-14(19(25)26)18(24)13-9-15(20)17(10-16(13)22)23-7-5-12(6-8-23)21(2)3/h9-12H,4-8H2,1-3H3,(H,25,26)
InChiKey: MFHHIVDRXGMGTJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	potassium channel subfamily K	0.0139	0.0379	0.0379
Echinococcus multilocularis	potassium channel subfamily K 8	0.0139	0.0379	0.0379
Echinococcus multilocularis	Polycystic kidney disease protein	0.0022	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 24	0.0139	0.0379	0.2947
Trypanosoma cruzi	cysteine peptidase, putative	0.007	0.0162	0.4275
Onchocerca volvulus		0.0139	0.0379	1
Loa Loa (eye worm)	TWK-7 protein	0.0139	0.0379	0.0379
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0072	0.0169	0.4364
Onchocerca volvulus		0.0022	0.001	0.027
Schistosoma mansoni	rab6-interacting	0.0022	0.001	0.001
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.0162	0.4166
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0139	0.0379	0.2947
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Echinococcus granulosus	twik family of potassium channels	0.0139	0.0379	0.0379
Echinococcus multilocularis	twik family of potassium channels	0.0139	0.0379	0.0379
Leishmania major	cathepsin L-like protease	0.007	0.0162	0.4275
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 12	0.0139	0.0379	0.2947
Echinococcus granulosus	choline:ethanolamine kinase	0.0125	0.0336	0.0336
Loa Loa (eye worm)	large conductance calcium-activated potassium channel alpha subunit ai	0.0139	0.0379	0.0379
Onchocerca volvulus		0.0139	0.0379	1
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0072	0.0169	0.0169
Mycobacterium ulcerans	transmembrane cation transporter	0.0139	0.0379	1
Schistosoma mansoni	lipoxygenase	0.0061	0.0133	0.0133
Leishmania major	calcium/potassium channel (CAKC), putative	0.0139	0.0379	1
Echinococcus multilocularis	RUN	0.0022	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Echinococcus granulosus	potassium channel subfamily K	0.0139	0.0379	0.0379
Onchocerca volvulus		0.0139	0.0379	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0022	0.001	0.001
Brugia malayi	jmjC domain containing protein	0.0064	0.0145	0.1126
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0139	0.0379	1
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0072	0.0169	0.4364
Echinococcus granulosus	lysine specific demethylase 5A	0.0064	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.1283	0.3974	0.3974
Trypanosoma cruzi	cysteine peptidase, putative	0.007	0.0162	0.4275
Schistosoma mansoni	acetylcholinesterase	0.0072	0.0169	0.0169
Echinococcus multilocularis	acetylcholinesterase	0.0428	0.1287	0.1287
Loa Loa (eye worm)	choline/ethanolamine kinase	0.0125	0.0336	0.0336
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0139	0.0379	1
Echinococcus granulosus	twik family of potassium channels	0.0139	0.0379	0.0379
Onchocerca volvulus		0.0139	0.0379	1
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Schistosoma mansoni	ap endonuclease	0.0021	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0169	0.0169
Brugia malayi	Doublecortin family protein	0.0022	0.001	0.008
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 45	0.0139	0.0379	0.2947
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Plasmodium vivax	potassium channel, putative	0.0139	0.0379	1
Echinococcus multilocularis	TWiK family of potassium channels protein 7	0.0139	0.0379	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0169	0.0169
Echinococcus granulosus	acetylcholinesterase	0.0428	0.1287	0.1287
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39A	0.0139	0.0379	0.2947
Brugia malayi	hypothetical protein	0.0022	0.001	0.008
Toxoplasma gondii	ion channel protein	0.0139	0.0379	1
Onchocerca volvulus		0.0139	0.0379	1
Schistosoma mansoni	rab6-interacting	0.0022	0.001	0.001
Loa Loa (eye worm)	jmjC domain-containing protein	0.0064	0.0145	0.0145
Echinococcus multilocularis	para nitrobenzyl esterase	0.0072	0.0169	0.0169
Mycobacterium ulcerans	ion transport protein	0.0139	0.0379	1
Onchocerca volvulus		0.0072	0.0169	0.447
Schistosoma mansoni	twik family of potassium channels-related	0.0139	0.0379	0.0379
Echinococcus multilocularis	lysine specific demethylase 5A	0.0064	0.0145	0.0145
Echinococcus granulosus	acetylcholinesterase	0.0428	0.1287	0.1287
Leishmania major	cathepsin L-like protease	0.007	0.0162	0.4275
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 35	0.0139	0.0379	0.2947
Schistosoma mansoni	twik family of potassium channels-related	0.0139	0.0379	0.0379
Schistosoma mansoni	hypothetical protein	0.0139	0.0379	0.0379
Plasmodium vivax	potassium channel, putative	0.0139	0.0379	1
Echinococcus granulosus	potassium channel subfamily K 8	0.0139	0.0379	0.0379
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0007	0.0007
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.0162	0.4166
Loa Loa (eye worm)	hypothetical protein	0.0428	0.1287	0.1287
Brugia malayi	Choline/ethanolamine kinase family protein	0.0125	0.0336	0.2613
Toxoplasma gondii	ion channel protein	0.0139	0.0379	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0007	0.0187
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0072	0.0169	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0139	0.0379	1
Echinococcus granulosus	calcium activated potassium channel variant	0.0139	0.0379	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Brugia malayi	hypothetical protein	0.0139	0.0379	0.2947
Echinococcus granulosus	lipoxygenase domain containing protein	0.0022	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.143	0.4434	0.4434
Brugia malayi	Cytochrome P450 family protein	0.005	0.0098	0.0763
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.0162	0.4166
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 13	0.0139	0.0379	0.2947
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog	0.0139	0.0379	0.2947
Brugia malayi	hypothetical protein	0.0072	0.0169	0.1317
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0021	0.0007	0.5
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0007	0.0187
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0061	0.0133	0.0133
Echinococcus granulosus	neuroligin	0.0072	0.0169	0.0169
Schistosoma mansoni	BC026374 protein (S09 family)	0.0072	0.0169	0.0169
Echinococcus granulosus	RUN	0.0022	0.001	0.001
Plasmodium falciparum	LCCL domain-containing protein	0.0022	0.001	0.027
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0022	0.001	0.001
Brugia malayi	Carboxylesterase family protein	0.0072	0.0169	0.1317
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Schistosoma mansoni	polycystin 1-related	0.0022	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Echinococcus granulosus	Polycystic kidney disease protein	0.0022	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0246	0.0246
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0139	0.0379	1
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0349	0.104	0.104
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Loa Loa (eye worm)	hypothetical protein	0.3201	1	1
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0246	0.0246
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0064	0.0145	0.0145
Leishmania major	potassium channel subunit-like protein	0.0139	0.0379	1
Schistosoma mansoni	calcium-activated potassium channel	0.2712	0.8466	0.8466
Schistosoma mansoni	twik family of potassium channels-related	0.0139	0.0379	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Echinococcus multilocularis	carboxylesterase 5A	0.0428	0.1287	0.1287
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0169	0.0169
Echinococcus multilocularis	microtubule associated protein 2	0.0757	0.232	0.232
Plasmodium falciparum	potassium channel	0.0139	0.0379	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0022	0.001	0.001
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39B	0.0139	0.0379	0.2947
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0007	0.0187
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.0162	0.4166
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0021	0.0007	0.5
Echinococcus multilocularis	small conductance calcium activated potassium	0.3201	1	1
Echinococcus granulosus	Two pore potassium channel protein sup 9	0.0139	0.0379	0.0379
Schistosoma mansoni	hypothetical protein	0.3201	1	1
Echinococcus granulosus	microtubule associated protein 2	0.0757	0.232	0.232
Schistosoma mansoni	hypothetical protein	0.0022	0.001	0.001
Loa Loa (eye worm)	doublecortin family protein	0.0022	0.001	0.001
Entamoeba histolytica	calcium-gated potassium channel protein, putative	0.0139	0.0379	1
Brugia malayi	Carboxylesterase family protein	0.0428	0.1287	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0072	0.0169	0.0169
Onchocerca volvulus		0.0072	0.0169	0.447
Echinococcus multilocularis	twik family of potassium channels	0.0139	0.0379	0.0379
Loa Loa (eye worm)	S-phase kinase-associated protein 1A	0.0139	0.0379	0.0379
Loa Loa (eye worm)	acetylcholinesterase 1	0.0428	0.1287	0.1287
Trypanosoma cruzi	ion transport protein, putative	0.0139	0.0379	1
Echinococcus multilocularis	potassium channel subfamily K 8	0.0139	0.0379	0.0379
Schistosoma mansoni	twik family of potassium channels-related	0.0139	0.0379	0.0379
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0139	0.0379	1
Trypanosoma cruzi	cruzipain precursor, putative	0.007	0.0162	0.4275
Echinococcus multilocularis	neuroligin	0.0072	0.0169	0.0169
Onchocerca volvulus		0.0072	0.0169	0.447
Plasmodium vivax	multidomain scavenger receptor, putative	0.0022	0.001	0.027
Onchocerca volvulus		0.0072	0.0169	0.447
Echinococcus multilocularis	calcium activated potassium channel variant	0.0139	0.0379	0.0379
Mycobacterium ulcerans	carboxylesterase, LipT	0.0072	0.0169	0.4364
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Mycobacterium tuberculosis	Possible transmembrane cation transporter	0.0139	0.0379	1
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 7	0.0139	0.0379	0.2947
Plasmodium vivax	choline kinase, putative	0.0125	0.0336	0.8866
Onchocerca volvulus		0.0022	0.001	0.027
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0021	0.0007	0.0187
Brugia malayi	hypothetical protein	0.0139	0.0379	0.2947
Loa Loa (eye worm)	carboxylesterase	0.0428	0.1287	0.1287
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0072	0.0169	0.0169
Trypanosoma brucei	calcium/potassium channel (CAKC), putative	0.0139	0.0379	1
Schistosoma mansoni	twik family of potassium channels-related	0.0139	0.0379	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0169	0.0169
Onchocerca volvulus		0.0072	0.0169	0.447
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0428	0.1287	0.1287
Loa Loa (eye worm)	potassium voltage-gated channel subfamily Q member 5	0.0139	0.0379	0.0379
Brugia malayi	Carboxylesterase family protein	0.0072	0.0169	0.1317
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0007	0.0055
Echinococcus multilocularis	Two pore potassium channel protein sup 9	0.0139	0.0379	0.0379
Trypanosoma cruzi	cysteine peptidase, putative	0.007	0.0162	0.4275
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Echinococcus granulosus	BC026374 protein S09 family	0.0072	0.0169	0.0169
Onchocerca volvulus		0.0139	0.0379	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0064	0.0145	0.0145
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.0162	0.4166
Echinococcus multilocularis	choline:ethanolamine kinase	0.0125	0.0336	0.0336
Brugia malayi	Twik (KCNK-like) family of potasium channels, alpha subunit 40	0.0139	0.0379	0.2947
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0021	0.0007	0.0187
Plasmodium falciparum	potassium channel	0.0139	0.0379	1
Leishmania major	ion transport protein-like protein	0.0139	0.0379	1
Brugia malayi	jmjC domain containing protein	0.0064	0.0145	0.1126
Loa Loa (eye worm)	carboxylesterase	0.0072	0.0169	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Trichomonas vaginalis	spcc417.12 protein, putative	0.0072	0.0169	0.447
Schistosoma mansoni	calcium-activated potassium channel	0.0139	0.0379	0.0379
Trypanosoma brucei	calcium-activated potassium channel, putative	0.0139	0.0379	1
Schistosoma mansoni	lipoxygenase	0.0022	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.0162	0.4166
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Toxoplasma gondii	exonuclease III APE	0.0021	0.0007	0.0187
Onchocerca volvulus		0.0097	0.0246	0.6494
Brugia malayi	Carboxylesterase family protein	0.0072	0.0169	0.1317
Schistosoma mansoni	calcium-activated potassium channel	0.0139	0.0379	0.0379
Leishmania major	cathepsin L-like protease	0.007	0.0162	0.4275
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0072	0.0169	0.0169
Onchocerca volvulus		0.0139	0.0379	1
Echinococcus granulosus	TWiK family of potassium channels protein 7	0.0139	0.0379	0.0379
Trypanosoma cruzi	hypothetical protein, conserved	0.0139	0.0379	1
Schistosoma mansoni	twik family of potassium channels-related	0.0139	0.0379	0.0379
Brugia malayi	Carboxylesterase family protein	0.0072	0.0169	0.1317
Brugia malayi	hypothetical protein	0.0022	0.001	0.008
Echinococcus granulosus	potassium channel subfamily K 8	0.0139	0.0379	0.0379
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog	0.0139	0.0379	0.2947
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0072	0.0169	0.0169
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0064	0.0143	0.3772
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0097	0.0246	0.0246
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0139	0.0379	0.2947
Loa Loa (eye worm)	cytochrome P450 family protein	0.005	0.0098	0.0098
Schistosoma mansoni	twik family of potassium channels-related	0.0139	0.0379	0.0379
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0061	0.0133	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0072	0.0169	0.447
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Leishmania major	hypothetical protein, conserved	0.0139	0.0379	1
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0064	0.0145	0.0145
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0139	0.0379	1
Loa Loa (eye worm)	hypothetical protein	0.0428	0.1287	0.1287
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0007	0.0187
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0064	0.0145	0.0145
Schistosoma mansoni	calcium-activated potassium channel	0.3201	1	1
Brugia malayi	Trypsin family protein	0.0097	0.0246	0.1913
Schistosoma mansoni	loxhd1	0.0022	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Brugia malayi	Carboxylesterase family protein	0.0428	0.1287	1
Schistosoma mansoni	twik family of potassium channels-related	0.0139	0.0379	0.0379
Schistosoma mansoni	jumonji domain containing protein	0.0064	0.0145	0.0145
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.0162	0.4166
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0072	0.0169	0.4364
Plasmodium falciparum	choline kinase	0.0125	0.0336	0.8866
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 28	0.0139	0.0379	0.2947
Loa Loa (eye worm)	uncoordinated protein 58	0.0139	0.0379	0.0379
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0072	0.0169	0.0169
Loa Loa (eye worm)	carboxylesterase	0.0072	0.0169	0.0169
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.0162	0.4166
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0139	0.0379	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0169	0.0169
Loa Loa (eye worm)	TWK-28 protein	0.0139	0.0379	0.0379
Onchocerca volvulus		0.0086	0.0212	0.56
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0097	0.0246	0.0246
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0139	0.0379	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.0162	0.4166
Echinococcus multilocularis	acetylcholinesterase	0.0428	0.1287	0.1287
Trypanosoma cruzi	major cysteine proteinase, putative	0.0055	0.0115	0.3035
Schistosoma mansoni	microtubule-associated protein tau	0.0757	0.232	0.232
Echinococcus granulosus	para nitrobenzyl esterase	0.0072	0.0169	0.0169
Trypanosoma cruzi	ion transport protein, putative	0.0139	0.0379	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 17	0.0139	0.0379	0.2947
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0139	0.0379	1
Echinococcus granulosus	carboxylesterase 5A	0.0428	0.1287	0.1287
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0021	0.0007	0.0187
Echinococcus granulosus	lipoxygenase domain containing protein	0.0022	0.001	0.001
Trypanosoma cruzi	hypothetical protein, conserved	0.0139	0.0379	1
Leishmania major	hypothetical protein, conserved	0.0139	0.0379	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0169	0.0169
Giardia lamblia	Hypothetical protein	0.0139	0.0379	1
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0379	0.0379
Onchocerca volvulus		0.0139	0.0379	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0169	0.0169
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0007	0.0187
Schistosoma mansoni	ap endonuclease	0.0021	0.0007	0.0007
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.0162	0.4166
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 5	0.0139	0.0379	0.2947
Toxoplasma gondii	phosphotransferase enzyme family protein	0.0125	0.0336	0.8866
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 21	0.0139	0.0379	0.2947
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.0162	0.4166
Schistosoma mansoni	gliotactin	0.0072	0.0169	0.0169

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	= 0.1 ug ml-1	In vitro for antibacterial activity against Gram-negative Escherichia coli NIJH JC-2.	ChEMBL.	7452690
MIC (functional)	= 0.1 ug ml-1	In vitro for antibacterial activity against Gram-negative Escherichia coli NIJH JC-2.	ChEMBL.	7452690
MIC (functional)	= 0.39 ug ml-1	In vitro antibacterial activity against Gram-positive, Staphylococcus aureus 209 P	ChEMBL.	7452690
MIC (functional)	= 3.13 ug ml-1	In vitro antibacterial activity against Gram-negative Pseudomonas aeruginosa V-1.	ChEMBL.	7452690

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL28748

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 36719