TDR Targets

Basic information

Technical information

TDR Targets ID: 369223
Name: 1-[1-(4-bromophenyl)-6,7-dimethoxy-3,4-dihydr o-1H-isoquinolin-2-yl]-2-morpholin-4-ylethano ne
MW: 475.375 | Formula: C23H27BrN2O4
H donors: 0 H acceptors: 1 LogP: 3.28 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc2c(cc1OC)CCN(C2c1ccc(cc1)Br)C(=O)CN1CCOCC1
InChi: 1S/C23H27BrN2O4/c1-28-20-13-17-7-8-26(22(27)15-25-9-11-30-12-10-25)23(19(17)14-21(20)29-2)16-3-5-18(24)6-4-16/h3-6,13-14,23H,7-12,15H2,1-2H3
InChiKey: CKINBMAZZYXVMY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[1-(4-bromophenyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-2-morpholino-ethanone
1-[1-(4-bromophenyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-2-morpholinoethanone
1-[1-(4-bromophenyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-2-morpholin-4-yl-ethanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0545	0.4683	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0545	0.4683	0.4619
Toxoplasma gondii	cathepsin B	0.0431	0.3625	0.7713
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.017	0.1186	0.1101
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0125	0.0771	0.0681
Trypanosoma cruzi	cysteine protease, putative	0.0295	0.2357	0.2357
Brugia malayi	Cathepsin L-like precursor	0.0375	0.3097	0.303
Echinococcus granulosus	cathepsin L	0.0125	0.0771	0.066
Schistosoma mansoni	cathepsin s	0.017	0.1186	0.1101
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0545	0.4683	0.4619
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0545	0.4683	1
Leishmania major	cathepsin L-like protease	0.0545	0.4683	1
Loa Loa (eye worm)	fibroinase	0.0545	0.4683	0.4662
Onchocerca volvulus		0.0545	0.4683	1
Onchocerca volvulus		0.0545	0.4683	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0545	0.4683	0.4662
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0431	0.3625	0.7296
Entamoeba histolytica	cysteine protease, putative	0.0295	0.2357	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0771	0.0734
Plasmodium vivax	unspecified product	0.0295	0.2357	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0771	0.0734
Entamoeba histolytica	cysteine proteinase, putative	0.0295	0.2357	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0545	0.4683	1
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0125	0.0771	0.154
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0125	0.0771	0.0681
Onchocerca volvulus	Cathepsin L homolog	0.0545	0.4683	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0545	0.4683	1
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0771	0.0734
Brugia malayi	Papain family cysteine protease containing protein	0.0125	0.0771	0.0681
Echinococcus granulosus	cathepsin l1	0.0375	0.3097	0.3014
Loa Loa (eye worm)	ctsf protein	0.0545	0.4683	0.4662
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0771	0.0734
Onchocerca volvulus	Cathepsin F homolog	0.0545	0.4683	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0545	0.4683	0.4619
Brugia malayi	Cathepsin L-like precursor	0.0545	0.4683	0.4631
Schistosoma mansoni	cathepsin C	0.0125	0.0771	0.0681
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0305	0.2445	0.5221
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0545	0.4683	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0545	0.4683	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0545	0.4683	1
Brugia malayi	cathepsin L precursor	0.0125	0.0771	0.0681
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0125	0.0771	0.0681
Leishmania major	cathepsin L-like protease	0.0545	0.4683	1
Brugia malayi	Cathepsin L-like precursor	0.0545	0.4683	0.4631
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0545	0.4683	0.4619
Leishmania major	cathepsin L-like protease	0.0545	0.4683	1
Entamoeba histolytica	cysteine proteinase 2	0.0295	0.2357	0.4054
Leishmania major	cathepsin L-like protease	0.0545	0.4683	1
Echinococcus granulosus	cathepsin l1	0.0545	0.4683	0.4619
Leishmania major	cathepsin L-like protease	0.0545	0.4683	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0125	0.0771	0.0734
Brugia malayi	cathepsin L-like precursor	0.0375	0.3097	0.303
Loa Loa (eye worm)	hypothetical protein	0.0375	0.3097	0.3069
Brugia malayi	cathepsin L-like cysteine proteinase	0.0125	0.0771	0.0681
Loa Loa (eye worm)	hypothetical protein	0.017	0.1186	0.1151
Schistosoma mansoni	cathepsin F (C01 family)	0.0545	0.4683	0.4631
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0771	0.0734
Loa Loa (eye worm)	cysteine protease	0.0545	0.4683	0.4662
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0375	0.3097	0.5946
Plasmodium vivax	vivapain-2	0.0545	0.4683	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0295	0.2357	0.2265
Entamoeba histolytica	cysteine protease, putative	0.0295	0.2357	0.4054
Plasmodium vivax	vivapain-2	0.0545	0.4683	1
Entamoeba histolytica	cysteine protease, putative	0.0295	0.2357	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0545	0.4683	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0125	0.0771	0.0681
Giardia lamblia	Cathepsin B precursor	0.0431	0.3625	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0545	0.4683	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0545	0.4683	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0125	0.0771	0.0681
Trypanosoma cruzi	cysteine peptidase, putative	0.0545	0.4683	0.4683
Echinococcus multilocularis	cathepsin L	0.0125	0.0771	0.066
Entamoeba histolytica	cysteine protease, putative	0.0295	0.2357	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0295	0.2357	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0545	0.4683	0.4631
Plasmodium vivax	vivapain-3	0.0295	0.2357	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.0375	0.3097	0.303
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0545	0.4683	1
Onchocerca volvulus		0.0545	0.4683	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0545	0.4683	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0375	0.3097	0.303
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0161	0.1099	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0545	0.4683	1
Mycobacterium ulcerans	hypothetical protein	0.0161	0.1099	0.5
Brugia malayi	Cathepsin L-like precursor	0.017	0.1186	0.1101
Loa Loa (eye worm)	hypothetical protein	0.0375	0.3097	0.3069
Echinococcus multilocularis	cathepsin L cysteine protease	0.0545	0.4683	0.4619
Toxoplasma gondii	cathepsin CPL	0.0545	0.4683	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0295	0.2357	0.2283
Leishmania major	cathepsin L-like protease	0.0545	0.4683	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0545	0.4683	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0305	0.2445	0.2445
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0295	0.2357	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0295	0.2357	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0545	0.4683	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0431	0.3625	0.3625
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0295	0.2357	0.2357
Echinococcus granulosus	cathepsin b	0.1114	1	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1114	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0295	0.2357	0.2357
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0545	0.4683	1
Echinococcus multilocularis	cathepsin b	0.1114	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0545	0.4683	0.4683
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0125	0.0771	0.0734
Plasmodium vivax	vivapain-1	0.0295	0.2357	0.4054
Brugia malayi	fibroinase precursor	0.0125	0.0771	0.0681
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0056	0.0118	0.0023
Toxoplasma gondii	cathepsin CPC1	0.0125	0.0771	0.154
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1114	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0545	0.4683	0.4631
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0545	0.4683	1
Trypanosoma cruzi	cysteine peptidase, putative	0.017	0.1186	0.1186
Brugia malayi	Cathepsin L-like precursor	0.0375	0.3097	0.303
Entamoeba histolytica	cysteine proteinase 1, putative	0.0295	0.2357	0.4054
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0125	0.0771	0.0681
Onchocerca volvulus		0.0545	0.4683	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0545	0.4683	1
Entamoeba histolytica	cysteine protease, putative	0.0295	0.2357	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0545	0.4683	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0545	0.4683	0.4683
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0545	0.4683	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0545	0.4683	1
Toxoplasma gondii	cathepsin CPC2	0.0125	0.0771	0.154
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0545	0.4683	1
Brugia malayi	Papain family cysteine protease containing protein	0.0125	0.0771	0.0681
Entamoeba histolytica	cysteine protease, putative	0.0545	0.4683	1
Entamoeba histolytica	cysteine proteinase, putative	0.0545	0.4683	1
Brugia malayi	Papain family cysteine protease containing protein	0.0295	0.2357	0.2283
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0295	0.2357	0.4054
Loa Loa (eye worm)	hypothetical protein	0.1114	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0545	0.4683	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0305	0.2445	0.2445
Entamoeba histolytica	cysteine proteinase, putative	0.0545	0.4683	1
Entamoeba histolytica	cysteine proteinase, putative	0.0295	0.2357	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0545	0.4683	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0125	0.0771	0.0681
Schistosoma mansoni	cathepsin S (C01 family)	0.0125	0.0771	0.0681
Echinococcus granulosus	cysteine protease	0.0295	0.2357	0.2265
Onchocerca volvulus		0.0375	0.3097	0.5946
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0375	0.3097	0.3097
Brugia malayi	Cathepsin L-like precursor	0.0545	0.4683	0.4631
Brugia malayi	Cathepsin L-like precursor	0.0545	0.4683	0.4631
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0545	0.4683	1
Entamoeba histolytica	cysteine protease, putative	0.0295	0.2357	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0431	0.3625	0.3563
Onchocerca volvulus		0.0545	0.4683	1
Echinococcus multilocularis	cysteine protease	0.0545	0.4683	0.4619
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0545	0.4683	1
Echinococcus multilocularis	cathepsin L	0.0295	0.2357	0.2265
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0295	0.2357	0.2283
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0431	0.3625	0.7741
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0545	0.4683	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0056	0.0118	0.0023
Schistosoma mansoni	cathepsin B (C01 family)	0.0125	0.0771	0.0681
Leishmania major	mitochondrial DNA polymerase beta	0.0305	0.2445	0.4011
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0545	0.4683	1
Loa Loa (eye worm)	hypothetical protein	0.0375	0.3097	0.3069
Giardia lamblia	Cathepsin B precursor	0.0431	0.3625	1
Loa Loa (eye worm)	hypothetical protein	0.017	0.1186	0.1151
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0125	0.0771	0.0734
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0545	0.4683	0.4662
Brugia malayi	cathepsin F-like cysteine proteinase	0.017	0.1186	0.1101
Plasmodium vivax	unspecified product	0.017	0.1186	0.1061
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0545	0.4683	1
Leishmania major	cathepsin L-like protease	0.0545	0.4683	1
Echinococcus granulosus	cathepsin L	0.0295	0.2357	0.2265
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0125	0.0771	0.0681
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0144	0.0946	0.2021
Brugia malayi	cathepsin F-like cysteine proteinase	0.0125	0.0771	0.0681
Trypanosoma cruzi	cysteine peptidase, putative	0.0545	0.4683	0.4683
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0545	0.4683	1
Onchocerca volvulus		0.0545	0.4683	1
Entamoeba histolytica	cysteine protease, putative	0.0295	0.2357	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0295	0.2357	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.017	0.1186	0.1151
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0375	0.3097	0.5946
Entamoeba histolytica	cysteine protease, putative	0.0295	0.2357	0.4054
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0125	0.0771	0.0681
Loa Loa (eye worm)	hypothetical protein	0.0545	0.4683	0.4662
Giardia lamblia	Cathepsin B precursor	0.0431	0.3625	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0545	0.4683	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1114	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0125	0.0771	0.0681
Schistosoma mansoni	cathepsin F (C01 family)	0.0545	0.4683	0.4631
Entamoeba histolytica	cysteine protease, putative	0.0295	0.2357	0.4054
Leishmania major	cathepsin L-like protease	0.0545	0.4683	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0125	0.0771	0.0771
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0545	0.4683	1
Onchocerca volvulus		0.0545	0.4683	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0545	0.4683	0.4683
Onchocerca volvulus	Cathepsin L homolog	0.0545	0.4683	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0125	0.0771	0.0681
Brugia malayi	Papain family cysteine protease containing protein	0.0295	0.2357	0.2283
Loa Loa (eye worm)	cathepsin B	0.0431	0.3625	0.36
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0545	0.4683	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0125	0.0771	0.0681
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0295	0.2357	0.5033
Brugia malayi	Cathepsin L-like precursor	0.0545	0.4683	0.4631
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0431	0.3625	0.7169
Trypanosoma cruzi	cysteine proteinase, putative	0.0295	0.2357	0.2357
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0144	0.0946	0.0946
Echinococcus multilocularis	cysteine protease	0.0545	0.4683	0.4619
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0096	0.0056
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0125	0.0771	0.0681
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0545	0.4683	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0545	0.4683	1
Entamoeba histolytica	cysteine protease, putative	0.0295	0.2357	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0295	0.2357	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0771	0.0734
Leishmania major	cysteine peptidase A (CPA)	0.0545	0.4683	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0125	0.0771	0.0771
Trypanosoma cruzi	cruzipain precursor, putative	0.017	0.1186	0.1186
Echinococcus granulosus	cathepsin b	0.1114	1	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0545	0.4683	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0295	0.2357	0.2283
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1114	1	1
Echinococcus multilocularis	cathepsin b	0.1114	1	1
Entamoeba histolytica	cysteine protease, putative	0.0295	0.2357	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0295	0.2357	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0295	0.2357	0.2357
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0545	0.4683	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1114	1	1
Loa Loa (eye worm)	calpain family protein 1	0.0053	0.0096	0.0056
Loa Loa (eye worm)	hypothetical protein	0.017	0.1186	0.1151
Entamoeba histolytica	cysteine proteinase, putative	0.0375	0.3097	0.5946
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0052	0.0088	0.0088
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0545	0.4683	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0545	0.4683	0.4619
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0545	0.4683	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0295	0.2357	0.5033

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	= 83.8 umol/Kg	Anticonvulsant activity against tonic phase of audiogenic seizures in ip dosed DBA/2 mouse	ChEMBL.	16942035
ED50 (functional)	= 83.8 umol/Kg	Anticonvulsant activity against tonic phase of audiogenic seizures in ip dosed DBA/2 mouse	ChEMBL.	16942035
ED50 (functional)	> 100 umol/Kg	Anticonvulsant activity against clonic phase of audiogenic seizures in ip dosed DBA/2 mouse	ChEMBL.	16942035
ED50 (functional)	> 100 umol/Kg	Anticonvulsant activity against clonic phase of audiogenic seizures in ip dosed DBA/2 mouse	ChEMBL.	16942035

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL213630
PubChem: 16083004

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 369223