TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 437.919 | Formula: C24H24ClN3O3
H donors: 1 H acceptors: 3 LogP: 3.65 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: ClC1CCN(CC1)C(=O)c1coc(n1)c1ccc(cc1)CNC(=O)Cc1ccccc1
InChi: 1S/C24H24ClN3O3/c25-20-10-12-28(13-11-20)24(30)21-16-31-23(27-21)19-8-6-18(7-9-19)15-26-22(29)14-17-4-2-1-3-5-17/h1-9,16,20H,10-15H2,(H,26,29)
InChiKey: ZTSIZVQYCRBJBF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	rhodopsin orphan GPCR	0.0031	0.0071	0.0068
Echinococcus multilocularis	sex peptide receptor	0.0031	0.0071	0.0068
Onchocerca volvulus		0.0031	0.0071	0.0315
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0011	0.0018
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0112	0.0109
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0031	0.0071	0.0068
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.0071	0.0068
Schistosoma mansoni	neuropeptide receptor	0.0031	0.0071	0.0068
Plasmodium vivax	sulfate transporter, putative	0.0032	0.0077	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0031	0.0071	0.0072
Schistosoma mansoni	adenoreceptor	0.0031	0.0071	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Onchocerca volvulus		0.0029	0.0062	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Brugia malayi	sulfakinin receptor protein	0.0031	0.0071	0.0072
Loa Loa (eye worm)	hypothetical protein	0.1013	0.4631	0.4631
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.0071	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Schistosoma mansoni	neuropeptide f receptor 76f	0.0031	0.0071	0.0068
Plasmodium vivax	acyl-CoA synthetase, putative	0.0019	0.0016	0.1726
Loa Loa (eye worm)	RNA binding protein	0.0132	0.054	0.054
Onchocerca volvulus		0.0031	0.0071	0.0315
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0046	0.0046
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0031	0.0071	0.0068
Echinococcus granulosus	neuropeptide Y receptor	0.0031	0.0071	0.0068
Echinococcus multilocularis	neuropeptide receptor A26	0.0518	0.2336	0.2351
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0031	0.0071	0.0072
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0081	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0062	0.0062
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0031	0.0071	0.0068
Echinococcus granulosus	allatostatin A receptor	0.0031	0.0071	0.0068
Schistosoma mansoni	hypothetical protein	0.0033	0.0081	0.0078
Echinococcus granulosus	neuropeptide Y receptor	0.0031	0.0071	0.0068
Echinococcus multilocularis	carbonic anhydrase	0.1013	0.4631	0.4663
Schistosoma mansoni	amine GPCR	0.0031	0.0071	0.0068
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0046	0.0048
Echinococcus granulosus	rhodopsin orphan GPCR	0.0031	0.0071	0.0068
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0031	0.0071	0.0068
Trichomonas vaginalis	glucosylceramidase, putative	0.018	0.0763	0.1103
Echinococcus granulosus	GPCR family 2	0.0033	0.0081	0.0078
Mycobacterium leprae	CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE)	0.1415	0.6501	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0081	0.0081
Echinococcus granulosus	dro:myosuppressin receptor	0.0031	0.0071	0.0068
Schistosoma mansoni	opsin-like receptor	0.0031	0.0071	0.0068
Mycobacterium leprae	Probable transmembrane transport protein	0.0231	0.1	0.1478
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0099	0.0096
Echinococcus multilocularis	g protein coupled receptor	0.0031	0.0071	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Onchocerca volvulus		0.0029	0.0062	0.0198
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0046	0.0048
Schistosoma mansoni	hypothetical protein	0.0031	0.0071	0.0068
Onchocerca volvulus		0.0031	0.0071	0.0315
Trichomonas vaginalis	glucosylceramidase, putative	0.0189	0.0808	0.1169
Mycobacterium leprae	PROBABLE TRANSFERASE	0.0066	0.0236	0.0295
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0031	0.0071	0.0071
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0081	0.0078
Schistosoma mansoni	hypothetical protein	0.0071	0.0258	0.0256
Echinococcus granulosus	lamin dm0	0.0029	0.0062	0.0059
Brugia malayi	Serotonin receptor	0.0031	0.0071	0.0072
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0046	0.0046
Echinococcus granulosus	dynactin 5 p25	0.0069	0.0248	0.0246
Brugia malayi	RNA recognition motif domain containing protein	0.0132	0.054	0.0544
Schistosoma mansoni	biogenic amine receptor	0.0031	0.0071	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.0071	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Schistosoma mansoni	tar DNA-binding protein	0.0132	0.054	0.0541
Mycobacterium tuberculosis	Beta-carbonic anhydrase	0.0951	0.4344	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0046	0.0046
Schistosoma mansoni	neuropeptide receptor	0.0031	0.0071	0.0068
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0031	0.0071	0.0068
Echinococcus multilocularis	carbonic anhydrase	0.1013	0.4631	0.4663
Brugia malayi	G-protein coupled receptor	0.0031	0.0071	0.0072
Mycobacterium ulcerans	carbonic anhydrase	0.1415	0.6501	0.9552
Brugia malayi	hypothetical protein	0.0031	0.0071	0.0072
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0081	0.0082
Schistosoma mansoni	opsin-like receptor	0.0031	0.0071	0.0068
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0031	0.0071	0.0068
Echinococcus granulosus	g protein coupled receptor	0.0031	0.0071	0.0068
Brugia malayi	Serotonin receptor	0.0031	0.0071	0.0072
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0062	0.0062
Trichomonas vaginalis	glucosylceramidase, putative	0.0274	0.12	0.1747
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.0071	0.0068
Trichomonas vaginalis	glucosylceramidase, putative	0.0274	0.12	0.1747
Echinococcus granulosus	carbonic anhydrase	0.1013	0.4631	0.4663
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0104	0.041	0.041
Brugia malayi	AKH receptor	0.0031	0.0071	0.0072
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0231	0.1	0.2295
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0031	0.0071	0.0068
Trypanosoma cruzi	Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative	0.0032	0.0077	0.0074
Echinococcus multilocularis	serotonin receptor	0.0031	0.0071	0.0068
Mycobacterium ulcerans	transferase	0.0066	0.0236	0.0326
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0016	0.0016
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0031	0.0071	0.0068
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0274	0.12	0.12
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0062	0.0062
Schistosoma mansoni	hypothetical protein	0.0033	0.0081	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0046	0.0046
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0031	0.0071	0.0068
Schistosoma mansoni	hypothetical protein	0.0031	0.0071	0.0068
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.0071	0.0068
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0046	0.0046
Echinococcus multilocularis	somatostatin receptor	0.0031	0.0071	0.0068
Echinococcus multilocularis	dro:myosuppressin receptor	0.0031	0.0071	0.0068
Schistosoma mansoni	amine GPCR	0.0031	0.0071	0.0068
Wolbachia endosymbiont of Brugia malayi	N-acetylglucosamine-1-phosphate uridyltransferase	0.0069	0.0248	1
Trypanosoma cruzi	Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative	0.0032	0.0077	0.0074
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0031	0.0071	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0011	0.0018
Onchocerca volvulus		0.0031	0.0071	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Echinococcus granulosus	rhodopsin orphan GPCR	0.0031	0.0071	0.0068
Echinococcus multilocularis	neuropeptide Y receptor	0.0031	0.0071	0.0068
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.0071	0.0068
Brugia malayi	hypothetical protein	0.0031	0.0071	0.0072
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0014	0.0011
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0031	0.0071	0.0071
Chlamydia trachomatis	sulfate transporter	0.0032	0.0077	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0031	0.0071	0.0068
Mycobacterium tuberculosis	Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase)	0.0761	0.3461	0.7964
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0236	0.0326
Echinococcus multilocularis	fmrfamide receptor	0.0031	0.0071	0.0068
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0031	0.0071	0.0068
Schistosoma mansoni	carbonic anhydrase	0.1013	0.4631	0.4663
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.0016	0.0027
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0031	0.0071	0.0068
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0031	0.0071	0.0068
Echinococcus multilocularis	serotonin receptor	0.0031	0.0071	0.0068
Schistosoma mansoni	ap endonuclease	0.0018	0.0014	0.0011
Echinococcus granulosus	rhodopsin orphan GPCR	0.0031	0.0071	0.0068
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.2153	0.9926	1
Echinococcus granulosus	orexin receptor type 2	0.0031	0.0071	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0031	0.0071	0.0068
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.2153	0.9926	1
Entamoeba histolytica	bacterial transferase hexapeptide family protein	0.0039	0.0112	0.0151
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0274	0.12	0.1209
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0031	0.0071	0.0071
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0011	0.0018
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0046	0.0046
Trichomonas vaginalis	glucosylceramidase, putative	0.018	0.0763	0.1103
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0031	0.0071	0.0071
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0014	0.0011
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0031	0.0071	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Loa Loa (eye worm)	neuropeptide F receptor	0.0031	0.0071	0.0071
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.0071	0.0068
Echinococcus granulosus	intermediate filament protein	0.0029	0.0062	0.0059
Schistosoma mansoni	histamine h1 receptor	0.0031	0.0071	0.0068
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0031	0.0071	0.0068
Echinococcus granulosus	tm gpcr rhodopsin	0.0031	0.0071	0.0068
Wolbachia endosymbiont of Brugia malayi	carbonic anhydrase	0.0039	0.0112	0.418
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Trichomonas vaginalis	glucosylceramidase, putative	0.018	0.0763	0.1103
Echinococcus granulosus	g-protein coupled receptor	0.0031	0.0071	0.0068
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0046	0.0046
Mycobacterium tuberculosis	Beta-carbonic anhydrase CanB	0.0885	0.404	0.9298
Plasmodium falciparum	carbonic anhydrase	0.1013	0.4631	1
Echinococcus multilocularis	g-protein coupled receptor	0.0031	0.0071	0.0068
Toxoplasma gondii	inorganic anion transporter, sulfate permease (SulP) family protein	0.0032	0.0077	0.0158
Schistosoma mansoni	ap endonuclease	0.0018	0.0014	0.0011
Schistosoma mansoni	myosin xvIII	0.0031	0.0071	0.0068
Brugia malayi	G protein-coupled receptor F59B2.13	0.0031	0.0071	0.0072
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0031	0.0071	0.0068
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0019	0.0016	0.0003
Schistosoma mansoni	tar DNA-binding protein	0.0132	0.054	0.0541
Schistosoma mansoni	amine GPCR	0.0031	0.0071	0.0068
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0062	0.0059
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0014	0.0014
Schistosoma mansoni	hypothetical protein	0.0031	0.0071	0.0068
Echinococcus multilocularis	musashi	0.0029	0.0062	0.0059
Onchocerca volvulus		0.0031	0.0071	0.0315
Echinococcus granulosus	neuropeptide receptor A26	0.0518	0.2336	0.2351
Echinococcus multilocularis	neuropeptide Y receptor	0.0031	0.0071	0.0068
Brugia malayi	Dopamine receptor protein 1	0.0031	0.0071	0.0072
Onchocerca volvulus		0.0066	0.0236	0.2348
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Schistosoma mansoni	tar DNA-binding protein	0.0132	0.054	0.0541
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0059	0.0059
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0031	0.0071	0.0068
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0014	0.0011
Trichomonas vaginalis	glucosylceramidase, putative	0.018	0.0763	0.1103
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.2153	0.9926	1
Brugia malayi	hypothetical protein	0.0031	0.0071	0.0072
Echinococcus multilocularis	carbonic anhydrase	0.1013	0.4631	0.4663
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0031	0.0071	0.0068
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0014	0.0025
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.0071	0.0068
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0046	0.0046
Schistosoma mansoni	neuropeptide receptor	0.0031	0.0071	0.0068
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0014	0.0014
Brugia malayi	RE15519p	0.0031	0.0071	0.0072
Loa Loa (eye worm)	neuropeptide F receptor	0.0031	0.0071	0.0071
Echinococcus granulosus	G protein coupled receptor 139	0.0031	0.0071	0.0068
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0046	0.0046
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0031	0.0071	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Echinococcus multilocularis	neuropeptide receptor	0.0031	0.0071	0.0068
Schistosoma mansoni	neuropeptide receptor	0.0031	0.0071	0.0068
Brugia malayi	neuropeptide F receptor	0.0031	0.0071	0.0072
Schistosoma mansoni	hypothetical protein	0.0033	0.0081	0.0078
Echinococcus granulosus	somatostatin receptor	0.0031	0.0071	0.0068
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0031	0.0071	0.0071
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0081	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0081	0.0078
Echinococcus multilocularis	orexin receptor type 2	0.0031	0.0071	0.0068
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.0071	0.0068
Schistosoma mansoni	growth hormone secretagogue receptor	0.0031	0.0071	0.0068
Echinococcus multilocularis	carbonic anhydrase II	0.2153	0.9926	1
Entamoeba histolytica	hypothetical protein	0.0037	0.0099	0.013
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.2153	0.9926	0.9926
Schistosoma mansoni	biogenic amine receptor	0.0031	0.0071	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0258	0.0258
Mycobacterium ulcerans	integral membrane transporter	0.0032	0.0077	0.0092
Brugia malayi	TAR-binding protein	0.0132	0.054	0.0544
Loa Loa (eye worm)	TYRA-2 protein	0.0031	0.0071	0.0071
Leishmania major	carbonic anhydrase-like protein	0.2153	0.9926	1
Onchocerca volvulus		0.0031	0.0071	0.0315
Schistosoma mansoni	neuropeptide F-like receptor	0.0031	0.0071	0.0068
Schistosoma mansoni	amine GPCR	0.0031	0.0071	0.0068
Trichomonas vaginalis	glucosylceramidase, putative	0.0274	0.12	0.1747
Trichomonas vaginalis	conserved hypothetical protein	0.1481	0.6805	1
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0081	0.0082
Schistosoma mansoni	hypothetical protein	0.0037	0.0099	0.0096
Brugia malayi	hypothetical protein	0.0031	0.0071	0.0072
Schistosoma mansoni	hypothetical protein	0.0033	0.0081	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.1013	0.4631	0.4665
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0031	0.0071	0.0068
Onchocerca volvulus	Glucosylceramidase homolog	0.018	0.0763	0.8856
Toxoplasma gondii	hypothetical protein	0.1013	0.4631	1
Echinococcus granulosus	sex peptide receptor	0.0031	0.0071	0.0068
Brugia malayi	intermediate filament protein	0.0029	0.0062	0.0062
Echinococcus granulosus	g protein coupled receptor	0.0031	0.0071	0.0068
Onchocerca volvulus		0.0031	0.0071	0.0315
Echinococcus granulosus	tar DNA binding protein	0.0132	0.054	0.0541
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.1013	0.4631	0.4631
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0031	0.0071	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Echinococcus granulosus	tm gpcr rhodopsin	0.0031	0.0071	0.0068
Brugia malayi	hypothetical protein	0.0031	0.0071	0.0072
Schistosoma mansoni	lamin	0.0029	0.0062	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.0071	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Echinococcus multilocularis	g protein coupled receptor	0.0031	0.0071	0.0068
Onchocerca volvulus		0.02	0.0856	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0031	0.0071	0.0068
Schistosoma mansoni	carbonic anhydrase-related	0.1013	0.4631	0.4663
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0014	0.1471
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Brugia malayi	Dopamine receptor	0.0031	0.0071	0.0072
Brugia malayi	G-protein coupled receptor	0.0031	0.0071	0.0072
Trichomonas vaginalis	glucosylceramidase, putative	0.018	0.0763	0.1103
Echinococcus granulosus	fmrfamide receptor	0.0031	0.0071	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0031	0.0071	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Schistosoma mansoni	neuropeptide F-like receptor	0.0031	0.0071	0.0068
Schistosoma mansoni	hypothetical protein	0.1013	0.4631	0.4663
Brugia malayi	hypothetical protein	0.0031	0.0071	0.0072
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0031	0.0071	0.0068
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.1013	0.4631	0.4665
Echinococcus multilocularis	lamin	0.0029	0.0062	0.0059
Schistosoma mansoni	tar DNA-binding protein	0.0132	0.054	0.0541
Mycobacterium tuberculosis	Probable serine acetyltransferase CysE (sat)	0.0069	0.0248	0.0563
Echinococcus granulosus	lamin	0.0029	0.0062	0.0059
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.0112	0.0109
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0014	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0046	0.0046
Onchocerca volvulus		0.0031	0.0071	0.0315
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.0071	0.0068
Onchocerca volvulus		0.0031	0.0071	0.0315
Leishmania major	carbonic anhydrase family protein, putative	0.1415	0.6501	0.6548
Echinococcus granulosus	neuropeptide FF receptor 2	0.0031	0.0071	0.0068
Brugia malayi	larval opioid receptor	0.0031	0.0071	0.0072
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0031	0.0071	0.0315
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0046	0.0042
Echinococcus granulosus	g protein coupled receptor	0.0031	0.0071	0.0068
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0046	0.0042
Trichomonas vaginalis	glucosylceramidase, putative	0.018	0.0763	0.1103
Plasmodium falciparum	inorganic anion exchanger, inorganic anion antiporter	0.0032	0.0077	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0031	0.0071	0.0068
Brugia malayi	G protein-coupled receptor	0.0031	0.0071	0.0072
Echinococcus multilocularis	allatostatin A receptor	0.0031	0.0071	0.0068
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0031	0.0071	0.0072
Schistosoma mansoni	carbonic anhydrase	0.1415	0.6501	0.6548
Mycobacterium ulcerans	transmembrane carbonic anhydrase, SulP	0.0032	0.0077	0.0092
Brugia malayi	Melatonin receptor type 1A	0.0031	0.0071	0.0072
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0031	0.0071	0.0068
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0046	0.0046
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0031	0.0071	0.0068
Schistosoma mansoni	biogenic amine receptor	0.0031	0.0071	0.0068
Echinococcus granulosus	neuropeptides capa receptor	0.0031	0.0071	0.0068
Onchocerca volvulus		0.0031	0.0071	0.0315
Brugia malayi	hypothetical protein	0.0031	0.0071	0.0072
Entamoeba histolytica	ankyrin, putative	0.0069	0.0248	0.036
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0003	0.0004
Loa Loa (eye worm)	G-protein coupled receptor	0.0031	0.0071	0.0071
Brugia malayi	hypothetical protein	0.0037	0.0099	0.01
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0014	0.0023
Echinococcus multilocularis	lamin dm0	0.0029	0.0062	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Entamoeba histolytica	hypothetical protein	0.0037	0.0099	0.013
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0014	0.0011
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0031	0.0071	0.0068
Leishmania major	hypothetical protein, conserved	0.0039	0.0112	0.0109
Wolbachia endosymbiont of Brugia malayi	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase	0.0069	0.0248	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0081	0.0081
Onchocerca volvulus		0.0031	0.0071	0.0315
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.2153	0.9926	1
Echinococcus granulosus	hypothetical protein	0.0031	0.0071	0.0068
Entamoeba histolytica	hypothetical protein	0.0037	0.0099	0.013
Echinococcus multilocularis	neuropeptides capa receptor	0.0031	0.0071	0.0068
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0031	0.0071	0.0068
Echinococcus multilocularis	neuropeptide receptor	0.0031	0.0071	0.0068
Echinococcus granulosus	biogenic amine 5HT receptor	0.0031	0.0071	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0046	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0104	0.041	0.041
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.1013	0.4631	0.4665
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Trichomonas vaginalis	conserved hypothetical protein	0.1481	0.6805	1
Echinococcus granulosus	carbonic anhydrase	0.1013	0.4631	0.4663
Loa Loa (eye worm)	TAR-binding protein	0.0132	0.054	0.054
Brugia malayi	ORL1-like opioid receptor	0.0031	0.0071	0.0072
Trichomonas vaginalis	glucosylceramidase, putative	0.0274	0.12	0.1747
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.0071	0.0068
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0031	0.0071	0.0068
Onchocerca volvulus		0.0031	0.0071	0.0315
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0031	0.0071	0.0068
Loa Loa (eye worm)	carbonic anhydrase 3	0.2153	0.9926	0.9926
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0014	0.0011
Onchocerca volvulus		0.0031	0.0071	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Schistosoma mansoni	carbonic anhydrase-related	0.1013	0.4631	0.4663
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0031	0.0071	0.0068
Brugia malayi	GnHR receptor homolog	0.0031	0.0071	0.0072
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0011	0.0018
Brugia malayi	hypothetical protein	0.0031	0.0071	0.0072
Echinococcus granulosus	carbonic anhydrase	0.1013	0.4631	0.4663
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0014	0.5
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0031	0.0071	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0016	0.0016
Brugia malayi	follicle stimulating hormone receptor	0.0031	0.0071	0.0072
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0014	0.5
Echinococcus granulosus	neuropeptide receptor	0.0031	0.0071	0.0068
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0062	0.0062
Echinococcus granulosus	neuropeptides capa receptor	0.0031	0.0071	0.0068
Brugia malayi	putative neuropeptide receptor NPR1	0.0031	0.0071	0.0072
Onchocerca volvulus		0.0031	0.0071	0.0315
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0016	0.0029
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0003	0.0004
Echinococcus multilocularis	fmrfamide receptor	0.0031	0.0071	0.0068
Trypanosoma brucei	carbonic anhydrase-like protein	0.2153	0.9926	1
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0046	0.0046
Trichomonas vaginalis	glucosylceramidase, putative	0.018	0.0763	0.1103
Echinococcus granulosus	biogenic amine 5HT receptor	0.0031	0.0071	0.0068
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0031	0.0071	0.0072
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0046	0.0046
Mycobacterium ulcerans	transmembrane carbonic anhydrase, SulP	0.0032	0.0077	0.0092
Brugia malayi	latrophilin 2 splice variant baaae	0.0071	0.0258	0.026
Brugia malayi	hypothetical protein	0.0031	0.0071	0.0072
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0081	0.0078
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.0071	0.0068
Mycobacterium ulcerans	carbonic anhydrase	0.1481	0.6805	1
Schistosoma mansoni	lamin	0.0029	0.0062	0.0059
Entamoeba histolytica	hypothetical protein	0.0037	0.0099	0.013
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0112	0.0144
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0031	0.0071	0.0068
Echinococcus granulosus	rhodopsin orphan GPCR	0.0031	0.0071	0.0068
Brugia malayi	hypothetical protein	0.0031	0.0071	0.0072
Schistosoma mansoni	hypothetical protein	0.0031	0.0071	0.0068
Mycobacterium tuberculosis	Possible siderophore-binding protein	0.0039	0.0112	0.025
Loa Loa (eye worm)	melatonin receptor type 1A	0.0031	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.0071	0.0068
Echinococcus granulosus	7tm_1 domain containing protein	0.0031	0.0071	0.0068
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0046	0.0097
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.2153	0.9926	1
Entamoeba histolytica	acetyltransferase, putative	0.0069	0.0248	0.036
Echinococcus granulosus	rhodopsin orphan GPCR	0.0031	0.0071	0.0068
Echinococcus granulosus	rhodopsin orphan GPCR	0.0031	0.0071	0.0068
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0104	0.041	0.0413
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0132	0.054	0.054
Echinococcus multilocularis	tar DNA binding protein	0.0132	0.054	0.0541
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0031	0.0071	0.0068
Schistosoma mansoni	amine GPCR	0.0031	0.0071	0.0068
Brugia malayi	Dopamine receptor protein 2	0.0031	0.0071	0.0072
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.1013	0.4631	0.4665
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0016	0.0016
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0003	0.0003
Entamoeba histolytica	acyl-coA synthetase, putative	0.0025	0.0046	0.0048
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0099	0.0096
Schistosoma mansoni	opsin-like receptor	0.0031	0.0071	0.0068
Echinococcus multilocularis	neuropeptide s receptor	0.0518	0.2336	0.2351
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.1013	0.4631	0.4665
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0031	0.0071	0.0068
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0031	0.0071	0.0068
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0104	0.041	0.0413
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0031	0.0071	0.0068
Echinococcus granulosus	7TM GPCR rhodopsin	0.0031	0.0071	0.0068
Echinococcus multilocularis	neuropeptides capa receptor	0.0031	0.0071	0.0068
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0046	0.0097
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.2153	0.9926	1
Onchocerca volvulus		0.0031	0.0071	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.0071	0.0068
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0031	0.0071	0.0068
Trypanosoma brucei	Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative	0.0032	0.0077	0.0074
Echinococcus multilocularis	g protein coupled receptor	0.0031	0.0071	0.0068
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0099	0.0096
Trichomonas vaginalis	glucosylceramidase, putative	0.0274	0.12	0.1747
Brugia malayi	RNA binding protein	0.0132	0.054	0.0544
Echinococcus granulosus	tm gpcr rhodopsin	0.0031	0.0071	0.0068
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0031	0.0071	0.0072
Onchocerca volvulus		0.0031	0.0071	0.0315
Echinococcus granulosus	neuropeptide s receptor	0.0518	0.2336	0.2351
Loa Loa (eye worm)	G-protein coupled receptor	0.0031	0.0071	0.0071
Trichomonas vaginalis	glucosylceramidase, putative	0.0189	0.0808	0.1169
Entamoeba histolytica	carbonic anhydrase, putative	0.1415	0.6501	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0031	0.0071	0.0068
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0112	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0016	0.0016
Onchocerca volvulus		0.0031	0.0071	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Brugia malayi	putative neuropeptide receptor	0.0031	0.0071	0.0072
Loa Loa (eye worm)	hypothetical protein	0.1013	0.4631	0.4631
Toxoplasma gondii	exonuclease III APE	0.0018	0.0014	0.0023
Echinococcus granulosus	carbonic anhydrase II	0.2153	0.9926	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.0071	0.0068
Schistosoma mansoni	tar DNA-binding protein	0.0132	0.054	0.0541
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0071
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.0071	0.0068
Schistosoma mansoni	carbonic anhydrase-related	0.1013	0.4631	0.4663
Trichomonas vaginalis	maltose O-acetyltransferase, putative	0.0066	0.0236	0.0326
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0031	0.0071	0.0068
Brugia malayi	neuropeptide F receptor	0.0031	0.0071	0.0072
Onchocerca volvulus	Putative sulfate transporter	0.02	0.0856	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0274	0.12	0.1747
Echinococcus granulosus	neuropeptide receptor	0.0031	0.0071	0.0068
Echinococcus granulosus	serotonin receptor	0.0031	0.0071	0.0068
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0031	0.0071	0.0068

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 492 nM	Induction of apoptosis in human DLD1 cells assessed as activation of caspases by HTS assay	ChEMBL.	16784854
EC50 (functional)	= 492 nM	Induction of apoptosis in human DLD1 cells assessed as activation of caspases by HTS assay	ChEMBL.	16784854

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	16784854

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 370807