TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 385.318 | Formula: C15H10F3N3O4S
H donors: 4 H acceptors: 4 LogP: 3.75 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccc(cc1O)O)Nc1nc2c(s1)cc(cc2)OC(F)(F)F
InChi: 1S/C15H10F3N3O4S/c16-15(17,18)25-8-2-4-10-12(6-8)26-14(20-10)21-13(24)19-9-3-1-7(22)5-11(9)23/h1-6,22-23H,(H2,19,20,21,24)
InChiKey: GFBUWOJBXLRDMO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	histone deacetylase, putative	0.0267	0.4508	0.5899
Trypanosoma cruzi	metallo-peptidase, Clan MC, Family M14, putative	0.0065	0.0576	0.0445
Schistosoma mansoni	hypothetical protein	0.0065	0.0576	0.0857
Toxoplasma gondii	histone deacetylase HDAC5	0.0115	0.1541	0.2409
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.0479	0.0714
Brugia malayi	Zinc carboxypeptidase family protein	0.0065	0.0576	0.0788
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0068	0.0635	0.0868
Giardia lamblia	Histone deacetylase	0.0267	0.4508	1
Trypanosoma brucei	histone deacetylase, putative	0.0286	0.4885	0.6401
Schistosoma mansoni	metallocarboxypeptidase D peptidase unit 2 (M14 family)	0.0065	0.0576	0.0857
Trypanosoma cruzi	zinc carboxypeptidase, putative	0.0065	0.0576	0.0445
Loa Loa (eye worm)	hypothetical protein	0.0172	0.2648	0.3501
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0497	0.074
Brugia malayi	Histone deacetylase family protein	0.0286	0.4885	0.6685
Brugia malayi	Zinc carboxypeptidase family protein	0.0065	0.0576	0.0788
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0065	0.0576	0.0739
Loa Loa (eye worm)	histone deacetylase 11	0.0115	0.1541	0.1957
Trichomonas vaginalis	Inorganic phosphate transporter, putative	0.0089	0.1031	0.1811
Trypanosoma brucei	histone deacetylase 4	0.0286	0.4885	0.6401
Echinococcus granulosus	geminin	0.0358	0.6279	0.9351
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0068	0.0635	0.0163
Loa Loa (eye worm)	histone deacetylase 1	0.0267	0.4508	0.6095
Brugia malayi	Carboxypeptidase A2 precursor	0.0065	0.0576	0.0788
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0576	0.0611
Schistosoma mansoni	histone deacetylase	0.0267	0.4508	0.6714
Echinococcus multilocularis	tar DNA binding protein	0.0061	0.0497	0.074
Entamoeba histolytica	histone deacetylase, putative	0.0267	0.4508	1
Schistosoma mansoni	histone deacetylase	0.0267	0.4508	0.6714
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0065	0.0576	0.0739
Leishmania major	histone deacetylase, putative	0.0286	0.4885	0.6452
Loa Loa (eye worm)	zinc carboxypeptidase	0.0065	0.0576	0.0611
Brugia malayi	histone deacetylase 11	0.0115	0.1541	0.2108
Echinococcus granulosus	histone deacetylase	0.0286	0.4885	0.7276
Echinococcus multilocularis		0.0065	0.0576	0.0857
Trypanosoma cruzi	histone deacetylase 1, putative	0.0267	0.4508	0.6026
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0053	0.0339	0.0282
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0479	0.0714
Toxoplasma gondii	zinc carboxypeptidase superfamily protein	0.0065	0.0576	0.0219
Echinococcus multilocularis	histone deacetylase	0.0286	0.4885	0.7276
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0189	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0576	0.0611
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0189	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1541	0.1957
Echinococcus granulosus	tar DNA binding protein	0.0061	0.0497	0.074
Onchocerca volvulus	Subfamily M14A unassigned peptidase homolog	0.038	0.6714	1
Echinococcus multilocularis	geminin	0.0358	0.6279	0.9351
Echinococcus multilocularis	histone deacetylase 8	0.0115	0.1541	0.2294
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0189	0.0282
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0497	0.074
Loa Loa (eye worm)	hypothetical protein	0.0147	0.2166	0.2829
Loa Loa (eye worm)	zinc carboxypeptidase	0.0065	0.0576	0.0611
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0576	0.0611
Plasmodium vivax	histone deacetylase 1, putative	0.0267	0.4508	0.9124
Trypanosoma brucei	histone deacetylase 2	0.0115	0.1541	0.1433
Trypanosoma cruzi	metallo-peptidase, Clan MC, Family M14	0.0065	0.0576	0.0445
Echinococcus multilocularis	histone deacetylase 6	0.0286	0.4885	0.7276
Echinococcus granulosus	histone deacetylase 3	0.0267	0.4508	0.6714
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0065	0.0576	0.0739
Echinococcus granulosus	histone deacetylase 6	0.0286	0.4885	0.7276
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0576	0.0611
Brugia malayi	histone deacetylase 1 (HD1)	0.0267	0.4508	0.6168
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0576	0.0611
Echinococcus multilocularis	survival motor neuron protein 1	0.0264	0.4444	0.6619
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0061	0.0497	0.0501
Trypanosoma cruzi	histone deacetylase, putative	0.0286	0.4885	0.6561
Echinococcus multilocularis	solute carrier family 13	0.0089	0.1031	0.1535
Onchocerca volvulus		0.0065	0.0576	0.0352
Trichomonas vaginalis	sodium-dependent high-affinity dicarboxylate transporter, putative	0.0089	0.1031	0.1811
Schistosoma mansoni	histone deacetylase 4 5	0.0286	0.4885	0.7276
Leishmania major	zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14	0.0065	0.0576	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0576	0.0611
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1031	0.1246
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0068	0.0635	0.0945
Echinococcus multilocularis	subfamily M14A unassigned peptidase	0.038	0.6714	1
Onchocerca volvulus	Histone deacetylase 10 homolog	0.0115	0.1541	0.1868
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0065	0.0576	0.0739
Schistosoma mansoni	peptidase	0.0065	0.0576	0.0857
Trichomonas vaginalis	conserved hypothetical protein	0.0089	0.1031	0.1811
Schistosoma mansoni	histone deacetylase 1 2 3	0.0115	0.1541	0.2294
Trypanosoma cruzi	histone deacetylase, putative	0.0286	0.4885	0.6561
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0065	0.0576	0.0739
Brugia malayi	RNA, U transporter 1	0.008	0.0857	0.1172
Onchocerca volvulus		0.038	0.6714	1
Echinococcus granulosus	Zinc carboxypeptidase family protein	0.0065	0.0576	0.0857
Brugia malayi	Cytochrome P450 family protein	0.0043	0.0137	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0576	0.0611
Trypanosoma brucei	histone deacetylase 1	0.0267	0.4508	0.5841
Echinococcus granulosus	solute carrier family 13	0.0089	0.1031	0.1535
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0267	0.4508	1
Loa Loa (eye worm)	hypothetical protein	0.0264	0.4444	0.6006
Brugia malayi	hypothetical protein	0.0147	0.2166	0.2963
Schistosoma mansoni	subfamily M14A unassigned peptidase (M14 family)	0.038	0.6714	1
Echinococcus granulosus	cytosolic carboxypeptidase 1	0.0065	0.0576	0.0857
Brugia malayi	Zinc carboxypeptidase family protein	0.0065	0.0576	0.0788
Trypanosoma cruzi	histone deacetylase 1, putative	0.0267	0.4508	0.6026
Trypanosoma cruzi	histone deacetylase, putative	0.0115	0.1541	0.1815
Schistosoma mansoni	sodium/dicarboxylate cotransporter-related	0.0089	0.1031	0.1535
Onchocerca volvulus		0.038	0.6714	1
Echinococcus granulosus	histone deacetylase 8	0.0115	0.1541	0.2294
Echinococcus multilocularis	histone deacetylase 6	0.0293	0.502	0.7476
Brugia malayi	RNA recognition motif domain containing protein	0.0061	0.0497	0.068
Echinococcus granulosus	histone deacetylase 6	0.0286	0.4885	0.7276
Trichomonas vaginalis	conserved hypothetical protein	0.0089	0.1031	0.1811
Echinococcus multilocularis	histone deacetylase 3	0.0267	0.4508	0.6714
Toxoplasma gondii	flagellar/basal body protein	0.0065	0.0576	0.0219
Schistosoma mansoni	family M14 non-peptidase homologue (M14 family)	0.0065	0.0576	0.0857
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0497	0.074
Onchocerca volvulus		0.0065	0.0576	0.0352
Toxoplasma gondii	histone deacetylase HDAC3	0.0267	0.4508	0.9143
Brugia malayi	Zinc carboxypeptidase family protein	0.0065	0.0576	0.0788
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0497	0.074
Brugia malayi	Zinc carboxypeptidase family protein	0.0065	0.0576	0.0788
Echinococcus granulosus	solute carrier family 13	0.0089	0.1031	0.1535
Onchocerca volvulus	Carboxypeptidase D homolog	0.0065	0.0576	0.0352
Loa Loa (eye worm)	histone deacetylase	0.0286	0.4885	0.6621
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.041	0.7309	1
Echinococcus granulosus	histone deacetylase 6	0.0293	0.502	0.7476
Plasmodium vivax	histone deacetylase 2, putative	0.0286	0.4885	1
Loa Loa (eye worm)	hypothetical protein	0.021	0.3395	0.4543
Toxoplasma gondii	histone deacetylase HDAC1	0.0286	0.4885	1
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0065	0.0576	0.0739
Brugia malayi	hypothetical protein	0.0264	0.4444	0.6081
Echinococcus granulosus	histone deacetylase 1	0.0267	0.4508	0.6714
Onchocerca volvulus	Cytosolic carboxypeptidase 1 homolog	0.0065	0.0576	0.0352
Toxoplasma gondii	histone deacetylase HDAC4	0.0115	0.1541	0.2409
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0189	0.0259
Trichomonas vaginalis	histone deacetylase, putative	0.0267	0.4508	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0576	0.0611
Echinococcus granulosus	survival motor neuron protein 1	0.0264	0.4444	0.6619
Leishmania major	C-8 sterol isomerase-like protein	0.041	0.7309	1
Plasmodium vivax	histone deacetylase, putative	0.0286	0.4885	1
Echinococcus multilocularis	histone deacetylase 6	0.0286	0.4885	0.7276
Leishmania major	zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14	0.0065	0.0576	0.0141
Schistosoma mansoni	hypothetical protein	0.0358	0.6279	0.9351
Schistosoma mansoni	survival motor neuron protein	0.0054	0.0352	0.0524
Echinococcus granulosus	subfamily M14A unassigned peptidase	0.038	0.6714	1
Schistosoma mansoni	histone deacetylase hda2	0.0115	0.1541	0.2294
Echinococcus granulosus	solute carrier family 13	0.0089	0.1031	0.1535
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0068	0.0635	0.0945
Trichomonas vaginalis	conserved hypothetical protein	0.0089	0.1031	0.1811
Leishmania major	zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14	0.0065	0.0576	0.0141
Loa Loa (eye worm)	RNA binding protein	0.0061	0.0497	0.0501
Brugia malayi	Zinc carboxypeptidase family protein	0.0065	0.0576	0.0788
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.041	0.7309	1
Trichomonas vaginalis	histone deacetylase, putative	0.0267	0.4508	1
Brugia malayi	TAR-binding protein	0.0061	0.0497	0.068
Onchocerca volvulus		0.038	0.6714	1
Loa Loa (eye worm)	hypothetical protein	0.041	0.7309	1
Schistosoma mansoni	hypothetical protein	0.0054	0.0352	0.0524
Toxoplasma gondii	zinc carboxypeptidase, putative	0.0065	0.0576	0.0219
Toxoplasma gondii	zinc carboxypeptidase superfamily protein	0.0065	0.0576	0.0219
Trichomonas vaginalis	Inorganic phosphate transporter, putative	0.0089	0.1031	0.1811
Trichomonas vaginalis	conserved hypothetical protein	0.0089	0.1031	0.1811
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0065	0.0576	0.0739
Loa Loa (eye worm)	TAR-binding protein	0.0061	0.0497	0.0501
Schistosoma mansoni	carboxypeptidase N (M14 family)	0.0065	0.0576	0.0857
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0065	0.0576	0.0739
Chlamydia trachomatis	dicarboxylate translocator	0.0039	0.0072	0.5
Onchocerca volvulus		0.0147	0.2166	0.2851
Brugia malayi	Zinc carboxypeptidase family protein	0.0065	0.0576	0.0788
Schistosoma mansoni	histone deacetylase hda2	0.0293	0.502	0.7476
Leishmania major	histone deacetylase, putative	0.0286	0.4885	0.6452
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0479	0.0714
Echinococcus multilocularis	cytosolic carboxypeptidase protein 5	0.0065	0.0576	0.0857
Echinococcus multilocularis	Zinc carboxypeptidase family protein	0.0065	0.0576	0.0857
Schistosoma mansoni	hypothetical protein	0.0358	0.6279	0.9351
Echinococcus granulosus	cytosolic carboxypeptidase protein 5	0.0065	0.0576	0.0857
Onchocerca volvulus		0.038	0.6714	1
Plasmodium falciparum	histone deacetylase, putative	0.0286	0.4885	1
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0068	0.0635	0.0228
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0497	0.074
Brugia malayi	Histone deacetylase 1	0.0267	0.4508	0.6168
Plasmodium falciparum	histone deacetylase 2	0.0286	0.4885	1
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0068	0.0635	0.0945
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0576	0.0611
Loa Loa (eye worm)	hypothetical protein	0.0178	0.2782	0.3688
Echinococcus multilocularis	snurportin 1	0.0299	0.5135	0.7647
Schistosoma mansoni	hypothetical protein	0.0299	0.5135	0.7647
Trypanosoma brucei	histone deacetylase 3	0.0286	0.4885	0.6401
Echinococcus granulosus	snurportin 1	0.0299	0.5135	0.7647
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.0479	0.0714
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0065	0.0576	0.0739
Schistosoma mansoni	hypothetical protein	0.0049	0.0262	0.039
Loa Loa (eye worm)	histone deacetylase 7A	0.0286	0.4885	0.6621
Trichomonas vaginalis	histone deacetylase, putative	0.0267	0.4508	1
Loa Loa (eye worm)	zinc carboxypeptidase	0.0065	0.0576	0.0611
Mycobacterium ulcerans	short chain dehydrogenase	0.0548	1	1
Loa Loa (eye worm)	histone deacetylase 3	0.0267	0.4508	0.6095
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0065	0.0576	0.0739
Trypanosoma cruzi	histone deacetylase, putative	0.0286	0.4885	0.6561
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0054	0.0352	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0315	0.5442	0.7398
Trypanosoma cruzi	metallo-peptidase, Clan MC, Family M14, putative	0.0065	0.0576	0.0445
Echinococcus multilocularis	histone deacetylase 7	0.0286	0.4885	0.7276
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0299	0.5135	0.6969
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0267	0.4508	1
Trichomonas vaginalis	histone deacetylase, putative	0.0267	0.4508	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0189	0.0282
Echinococcus multilocularis	histone deacetylase 1	0.0267	0.4508	0.6714
Trichomonas vaginalis	histone deacetylase, putative	0.0267	0.4508	1
Trichomonas vaginalis	histone deacetylase, putative	0.0267	0.4508	1
Brugia malayi	RNA binding protein	0.0061	0.0497	0.068
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0267	0.4508	1
Leishmania major	sodium/sulphate symporter, putative	0.0089	0.1031	0.0808
Schistosoma mansoni	protease m14 carboxypeptidase	0.0065	0.0576	0.0857
Loa Loa (eye worm)	zinc carboxypeptidase	0.0065	0.0576	0.0611
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0576	0.0611
Trypanosoma brucei	C-8 sterol isomerase, putative	0.041	0.7309	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0068	0.0635	0.0163
Echinococcus multilocularis	solute carrier family 13	0.0089	0.1031	0.1535
Schistosoma mansoni	histone deacetylase 4 5	0.0286	0.4885	0.7276
Brugia malayi	NaDC-2	0.0089	0.1031	0.141
Plasmodium vivax	histone deacetylase, putative	0.0115	0.1541	0.2239
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0189	0.0282
Schistosoma mansoni	peptidase	0.0065	0.0576	0.0857
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0068	0.0635	0.0163
Echinococcus multilocularis	solute carrier family 13	0.0089	0.1031	0.1535
Trypanosoma cruzi	Carboxypeptidase-like protein	0.0065	0.0576	0.0445
Loa Loa (eye worm)	hypothetical protein	0.0267	0.4508	0.6095
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0189	0.0072
Brugia malayi	histone deacetylase 3 (HD3)	0.0267	0.4508	0.6168
Toxoplasma gondii	histone deacetylase HDAC2	0.0267	0.4508	0.9143
Trichomonas vaginalis	Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase	0.0065	0.0576	0.0739
Schistosoma mansoni	peptidase	0.0065	0.0576	0.0857
Trypanosoma cruzi	histone deacetylase, putative	0.0115	0.1541	0.1815
Brugia malayi	Histone deacetylase family protein	0.0286	0.4885	0.6685
Leishmania major	histone deacetylase, putative	0.0267	0.4508	0.5899
Brugia malayi	Zinc carboxypeptidase family protein	0.0065	0.0576	0.0788
Trichomonas vaginalis	conserved hypothetical protein	0.0089	0.1031	0.1811
Echinococcus granulosus	histone deacetylase 7	0.0286	0.4885	0.7276
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0189	0.0282
Trichomonas vaginalis	conserved hypothetical protein	0.0089	0.1031	0.1811
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0189	0.0282

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	0	Inhibition of beta amyloid-ABAD interaction by ELISA at 1 mM	ChEMBL.	16781151
IC50 (binding)	= 53.8 uM	Inhibition of beta amyloid-ABAD interaction by ELISA	ChEMBL.	16781151

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 371082