Detailed information for compound 373739

Basic information

Technical information
  • TDR Targets ID: 373739
  • Name: 2-(2,2-dimethylpropanoylamino)-4-methyl-N-(2, 4,6-trimethylphenyl)-1,3-thiazole-5-carboxami de
  • MW: 359.486 | Formula: C19H25N3O2S
  • H donors: 2 H acceptors: 3 LogP: 4.53 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(C)c(c(c1)C)NC(=O)c1sc(nc1C)NC(=O)C(C)(C)C
  • InChi: 1S/C19H25N3O2S/c1-10-8-11(2)14(12(3)9-10)21-16(23)15-13(4)20-18(25-15)22-17(24)19(5,6)7/h8-9H,1-7H3,(H,21,23)(H,20,22,24)
  • InChiKey: JDOKXJGHJJJMNT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2,2-dimethylpropanoylamino)-4-methyl-N-(2,4,6-trimethylphenyl)thiazole-5-carboxamide
  • 2-[(2,2-dimethyl-1-oxopropyl)amino]-4-methyl-N-(2,4,6-trimethylphenyl)-5-thiazolecarboxamide
  • N-mesityl-4-methyl-2-(pivaloylamino)thiazole-5-carboxamide
  • 4-methyl-2-(pivaloylamino)-N-(2,4,6-trimethylphenyl)thiazole-5-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens LCK proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major heat shock protein 83-1 0.0065 0.0269 0.0269
Schistosoma mansoni hypothetical protein 0.0052 0.018 0.018
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0176 0.0176
Echinococcus multilocularis cyclin dependent kinase 1 0.0415 0.2718 0.2718
Loa Loa (eye worm) hypothetical protein 0.0081 0.038 0.038
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0415 0.2718 0.2718
Trichomonas vaginalis cyclin B3, putative 0.0217 0.1335 0.1335
Echinococcus multilocularis cyclin y 0.0052 0.018 0.018
Entamoeba histolytica cell division protein kinase 2, putative 0.0415 0.2718 0.2718
Trichomonas vaginalis heat shock protein, putative 0.004 0.0093 0.0093
Trypanosoma cruzi cyclin 9, putative 0.0052 0.018 0.018
Leishmania major heat shock protein 83-1 0.0065 0.0269 0.0269
Entamoeba histolytica protein kinase domain containing protein 0.0108 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0081 0.038 0.038
Echinococcus multilocularis dual specificity 0.0108 0.0567 0.0567
Leishmania major cyclin 9, putative 0.0052 0.018 0.018
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.018 0.018
Leishmania major heat shock protein 83-1 0.0065 0.0269 0.0269
Trichomonas vaginalis cyclin B, putative 0.0369 0.24 0.24
Echinococcus multilocularis cyclins 0.0217 0.1335 0.1335
Echinococcus granulosus protein kinase shaggy 0.1455 1 1
Brugia malayi Protein kinase domain containing protein 0.0415 0.2718 0.2718
Trichomonas vaginalis cyclin B, putative 0.0369 0.24 0.24
Echinococcus multilocularis Cyclin L1 0.0052 0.018 0.018
Plasmodium vivax protein kinase Crk2 0.0415 0.2718 0.2718
Echinococcus multilocularis cyclin t1 0.0052 0.018 0.018
Echinococcus granulosus cyclins 0.0217 0.1335 0.1335
Schistosoma mansoni endoplasmin 0.0065 0.0269 0.0269
Toxoplasma gondii hypothetical protein 0.0165 0.0968 0.0968
Echinococcus multilocularis heat shock protein 90 0.0052 0.0176 0.0176
Brugia malayi hypothetical protein 0.0256 0.1603 0.1603
Echinococcus multilocularis cyclins 0.0217 0.1335 0.1335
Giardia lamblia Kinase, CMGC GSK 0.1455 1 1
Trypanosoma cruzi cyclin, putative 0.0369 0.24 0.24
Echinococcus granulosus cyclins 0.0217 0.1335 0.1335
Plasmodium falciparum cyclin 0.0217 0.1335 0.1335
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0176 0.0176
Entamoeba histolytica cyclin family protein 0.0217 0.1335 0.1335
Echinococcus granulosus cyclin y 0.0052 0.018 0.018
Echinococcus multilocularis G1:S specific cyclin D1 0.0052 0.018 0.018
Trypanosoma brucei protein kinase, putative 0.0027 0.0004 0.0004
Onchocerca volvulus 0.1455 1 1
Plasmodium falciparum protein kinase 5 0.0415 0.2718 0.2718
Loa Loa (eye worm) hypothetical protein 0.0081 0.038 0.038
Trichomonas vaginalis cyclin B, putative 0.0052 0.018 0.018
Entamoeba histolytica cyclin, domain containing protein 0.0052 0.018 0.018
Trichomonas vaginalis cyclin B, putative 0.0369 0.24 0.24
Trypanosoma brucei heat shock protein, putative 0.0065 0.0269 0.0269
Trichomonas vaginalis CMGC family protein kinase 0.1455 1 1
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0898 0.6105 0.6105
Trichomonas vaginalis cyclins, putative 0.0217 0.1335 0.1335
Leishmania major heat shock protein 83-1 0.0065 0.0269 0.0269
Trichomonas vaginalis endoplasmin, putative 0.004 0.0093 0.0093
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0108 0.0567 0.0567
Schistosoma mansoni cyclin B 0.0369 0.24 0.24
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0534 0.3552 0.3552
Echinococcus granulosus activin receptor type 0.0027 0.0004 0.0004
Loa Loa (eye worm) cyclin domain-containing protein 0.0898 0.6105 0.6105
Trypanosoma cruzi heat shock protein 85, putative 0.0052 0.0176 0.0176
Echinococcus multilocularis roundabout 2 0.0081 0.038 0.038
Trypanosoma brucei heat shock protein, putative 0.0065 0.0269 0.0269
Echinococcus granulosus cyclin 0.0052 0.018 0.018
Giardia lamblia Cyclin B-like protein 0.0052 0.018 0.0004
Loa Loa (eye worm) hypothetical protein 0.0534 0.3552 0.3552
Schistosoma mansoni protein kinase 0.0027 0.0004 0.0004
Brugia malayi Cyclin, N-terminal domain containing protein 0.0052 0.018 0.018
Trichomonas vaginalis CMGC family protein kinase 0.1455 1 1
Echinococcus granulosus cyclins 0.0217 0.1335 0.1335
Echinococcus granulosus tyrosine protein kinase Lyn 0.0036 0.0067 0.0067
Echinococcus granulosus heat shock protein 90 0.0065 0.0269 0.0269
Entamoeba histolytica protein kinase domain containing protein 0.0027 0.0004 0.0004
Toxoplasma gondii cyclin 4, putative 0.0052 0.018 0.018
Entamoeba histolytica cyclin, putative 0.0369 0.24 0.24
Schistosoma mansoni cell adhesion molecule 0.0081 0.038 0.038
Giardia lamblia Cyclin A 0.0217 0.1335 0.118
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.018 0.018
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0052 0.018 0.018
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0004 0.0004
Brugia malayi Cyclin C 0.0052 0.018 0.018
Leishmania major heat shock protein 83-1 0.0065 0.0269 0.0269
Echinococcus granulosus endoplasmin 0.0052 0.0176 0.0176
Trichomonas vaginalis cyclins, putative 0.0369 0.24 0.24
Loa Loa (eye worm) hypothetical protein 0.0369 0.24 0.24
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0052 0.018 0.018
Leishmania major protein kinase, putative 0.0027 0.0004 0.0004
Echinococcus multilocularis cyclins 0.0217 0.1335 0.1335
Echinococcus granulosus Immunoglobulin 0.0081 0.038 0.038
Schistosoma mansoni serine/threonine protein kinase 0.0415 0.2718 0.2718
Brugia malayi cell division control protein 2 homolog 0.0415 0.2718 0.2718
Echinococcus granulosus cyclin B3 1 0.0217 0.1335 0.1335
Loa Loa (eye worm) cyclin domain-containing protein 0.0052 0.018 0.018
Brugia malayi Protein kinase domain containing protein 0.0108 0.0567 0.0567
Giardia lamblia Cyclin fold protein 1, putative 0.0052 0.018 0.0004
Echinococcus multilocularis endoplasmin 0.0052 0.0176 0.0176
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0052 0.018 0.018
Toxoplasma gondii heat shock protein HSP90 0.0065 0.0269 0.0269
Trichomonas vaginalis cyclin B, putative 0.0217 0.1335 0.1335
Plasmodium vivax cyclin homologue, putative 0.0052 0.018 0.018
Plasmodium falciparum endoplasmin, putative 0.004 0.0093 0.0093
Treponema pallidum heat shock protein 90 0.0052 0.0176 0.5
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0052 0.018 0.018
Schistosoma mansoni cyclin B3 0.0898 0.6105 0.6105
Trypanosoma cruzi mitotic cyclin, putative 0.0052 0.018 0.018
Loa Loa (eye worm) cyclin domain-containing protein 0.0052 0.018 0.018
Loa Loa (eye worm) cyclin domain-containing protein 0.0052 0.018 0.018
Leishmania major heat shock protein 83-1 0.0065 0.0269 0.0269
Schistosoma mansoni nephrin 0.0081 0.038 0.038
Giardia lamblia Heat shock protein HSP 90-alpha 0.0065 0.0269 0.0095
Entamoeba histolytica heat shock protein 90, putative 0.0065 0.0269 0.0269
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0027 0.0004 0.0004
Trypanosoma cruzi heat shock protein 90, putative 0.0065 0.0269 0.0269
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.0269 0.0269
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0415 0.2718 0.2718
Loa Loa (eye worm) TK/KIN16 protein kinase 0.009 0.0441 0.0441
Trypanosoma brucei cdc2-related kinase 1 0.0415 0.2718 0.2718
Plasmodium vivax heat shock protein 86, putative 0.0065 0.0269 0.0269
Trichomonas vaginalis cyclin D, putative 0.0052 0.018 0.018
Schistosoma mansoni Cyclin fold protein 0.0052 0.018 0.018
Schistosoma mansoni cyclin G2 0.0052 0.018 0.018
Schistosoma mansoni endoplasmin 0.0065 0.0269 0.0269
Echinococcus granulosus heat shock protein 90 0.0052 0.0176 0.0176
Entamoeba histolytica hypothetical protein 0.0108 0.0567 0.0567
Trypanosoma cruzi cdc2-related kinase 1 0.0415 0.2718 0.2718
Trypanosoma brucei cdc2-related kinase 3 0.0415 0.2718 0.2718
Schistosoma mansoni protein kinase 0.0027 0.0004 0.0004
Trichomonas vaginalis heat shock protein, putative 0.0065 0.0269 0.0269
Entamoeba histolytica protein kinase, putative 0.0108 0.0567 0.0567
Echinococcus granulosus cyclin dependent kinase 0.0415 0.2718 0.2718
Brugia malayi Fibronectin type III domain containing protein 0.0081 0.038 0.038
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0081 0.038 0.038
Loa Loa (eye worm) hypothetical protein 0.0081 0.038 0.038
Echinococcus multilocularis cyclins 0.0217 0.1335 0.1335
Echinococcus granulosus G1:S specific cyclin D1 0.0052 0.018 0.018
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0415 0.2718 0.2718
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.1455 1 1
Entamoeba histolytica cyclin, putative 0.0217 0.1335 0.1335
Echinococcus granulosus cyclin dependent kinase 5 0.0415 0.2718 0.2718
Trichomonas vaginalis conserved hypothetical protein 0.0217 0.1335 0.1335
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.0269 0.0269
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.018 0.018
Entamoeba histolytica protein kinase domain containing protein 0.1455 1 1
Plasmodium vivax cyclin 4, putative 0.0052 0.018 0.018
Echinococcus multilocularis Immunoglobulin 0.0081 0.038 0.038
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0108 0.0567 0.0567
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0108 0.0567 0.0567
Leishmania major heat shock protein 83-1 0.0065 0.0269 0.0269
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0081 0.038 0.038
Echinococcus multilocularis cyclin dependent kinase 1 0.0415 0.2718 0.2718
Loa Loa (eye worm) hypothetical protein 0.0089 0.0436 0.0436
Echinococcus granulosus neuroglian 0.0081 0.038 0.038
Brugia malayi Immunoglobulin I-set domain containing protein 0.0081 0.038 0.038
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1455 1 1
Entamoeba histolytica cyclin, domain containing protein 0.0052 0.018 0.018
Loa Loa (eye worm) cyclin domain-containing protein 0.0052 0.018 0.018
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0534 0.3552 0.3552
Leishmania major heat shock protein 83-1 0.0065 0.0269 0.0269
Echinococcus multilocularis protein kinase shaggy 0.1455 1 1
Trypanosoma brucei mitotic cyclin 0.0052 0.018 0.018
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0052 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0152 0.0878 0.0878
Echinococcus multilocularis heat shock protein 90 0.0065 0.0269 0.0269
Echinococcus granulosus cyclin k 0.0052 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0052 0.018 0.018
Trypanosoma brucei protein kinase, putative 0.1455 1 1
Trypanosoma brucei heat shock protein, putative 0.0065 0.0269 0.0269
Trichomonas vaginalis CMGC family protein kinase 0.0415 0.2718 0.2718
Brugia malayi heat shock protein 90 0.0065 0.0269 0.0269
Trichomonas vaginalis cyclin A, putative 0.0052 0.018 0.018
Echinococcus granulosus cyclin y 0.0052 0.018 0.018
Onchocerca volvulus Cyclin L homolog 0.0052 0.018 0.018
Trichomonas vaginalis cyclins, putative 0.0204 0.1245 0.1245
Toxoplasma gondii heat shock protein 90, putative 0.0065 0.0269 0.0269
Leishmania major heat shock protein 83-1 0.0065 0.0269 0.0269
Echinococcus granulosus roundabout 2 0.0081 0.038 0.038
Toxoplasma gondii hypothetical protein 0.0052 0.018 0.018
Schistosoma mansoni cyclin l 0.0052 0.018 0.018
Schistosoma mansoni cyclin d 0.0052 0.018 0.018
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0052 0.0176 0.0176
Onchocerca volvulus 0.0369 0.24 0.24
Onchocerca volvulus Cyclin L homolog 0.0052 0.018 0.018
Brugia malayi Cyclin, N-terminal domain containing protein 0.0898 0.6105 0.6105
Loa Loa (eye worm) hypothetical protein 0.0081 0.038 0.038
Brugia malayi Endoplasmin precursor 0.0065 0.0269 0.0269
Echinococcus multilocularis cyclins 0.0217 0.1335 0.1335
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0081 0.038 0.038
Mycobacterium ulcerans heat shock protein 90 0.0052 0.0176 0.5
Trypanosoma cruzi cyclin 6, putative 0.0369 0.24 0.24
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0415 0.2718 0.2718
Schistosoma mansoni vesicular amine transporter 0.0081 0.038 0.038
Brugia malayi cyclin fold protein 1 variant b 0.0052 0.018 0.018
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0567 0.0567
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0415 0.2718 0.2718
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0052 0.0176 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0415 0.2718 0.2718
Echinococcus multilocularis cyclin dependent kinase 0.0415 0.2718 0.2718
Leishmania major heat shock protein 83-1 0.0065 0.0269 0.0269
Trypanosoma brucei Heat shock protein 83, putative 0.0065 0.0269 0.0269
Echinococcus granulosus cyclin G2 0.0052 0.018 0.018
Leishmania major heat shock protein 83-1 0.0065 0.0269 0.0269
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0108 0.0567 0.0567
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0052 0.018 0.018
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.1455 1 1
Loa Loa (eye worm) hypothetical protein 0.0369 0.24 0.24
Echinococcus granulosus heat shock protein 0.0065 0.0269 0.0269
Leishmania major heat shock protein 83-1 0.0065 0.0269 0.0269
Echinococcus granulosus dual specificity 0.0108 0.0567 0.0567
Trichomonas vaginalis cyclin B, putative 0.0369 0.24 0.24
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0415 0.2718 0.2718
Plasmodium falciparum cyclin 1 0.0052 0.018 0.018
Trichomonas vaginalis cyclins, putative 0.0052 0.018 0.018
Brugia malayi Immunoglobulin I-set domain containing protein 0.009 0.0441 0.0441
Schistosoma mansoni protein kinase 0.0027 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.018 0.018
Echinococcus multilocularis cyclin 0.0052 0.018 0.018
Plasmodium vivax hypothetical protein, conserved 0.0052 0.018 0.018
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1455 1 1
Leishmania major heat shock protein 83-1 0.0065 0.0269 0.0269
Brugia malayi Cyclin, N-terminal domain containing protein 0.0052 0.018 0.018
Trypanosoma brucei heat shock protein 90, putative 0.0065 0.0269 0.0269
Trypanosoma brucei cyclin 3 0.0052 0.018 0.018
Loa Loa (eye worm) heat shock protein 90 0.0065 0.0269 0.0269
Leishmania major mitotic cyclin, putative 0.0052 0.018 0.018
Giardia lamblia Hypothetical protein 0.0052 0.018 0.0004
Trypanosoma cruzi Heat shock protein 83, putative 0.0065 0.0269 0.0269
Echinococcus multilocularis cyclin k 0.0052 0.018 0.018
Trypanosoma brucei heat shock protein, putative 0.0065 0.0269 0.0269
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.1455 1 1
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0108 0.0567 0.0567
Leishmania major heat shock protein 83-1 0.0065 0.0269 0.0269
Schistosoma mansoni serine/threonine protein kinase 0.0415 0.2718 0.2718
Trichomonas vaginalis cyclins, putative 0.0052 0.018 0.018
Giardia lamblia Hypothetical protein 0.0052 0.018 0.0004
Echinococcus multilocularis cyclins 0.0217 0.1335 0.1335
Trichomonas vaginalis cyclins, putative 0.0369 0.24 0.24
Giardia lamblia G2/mitotic-specific cyclin B 0.0369 0.24 0.2263
Echinococcus multilocularis heat shock protein 0.0065 0.0269 0.0269
Trypanosoma cruzi hypothetical protein, conserved 0.0052 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0052 0.018 0.018
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0004 0.0004
Trypanosoma cruzi cdc2-related kinase 1 0.0415 0.2718 0.2718
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0052 0.018 0.018
Schistosoma mansoni g1/s-specific cyclin C 0.0052 0.018 0.018
Echinococcus granulosus glycogen synthase kinase 3 beta 0.1455 1 1
Schistosoma mansoni cyclin G 0.0052 0.018 0.018
Trypanosoma cruzi cdc2-related kinase 3 0.0415 0.2718 0.2718
Loa Loa (eye worm) hypothetical protein 0.0081 0.038 0.038
Leishmania major heat shock protein 83-1 0.0065 0.0269 0.0269
Loa Loa (eye worm) cyclin domain-containing protein 0.0052 0.018 0.018
Giardia lamblia Kinase, CMGC CDK 0.0415 0.2718 0.2587
Loa Loa (eye worm) hypothetical protein 0.0089 0.0436 0.0436
Echinococcus granulosus cyclins 0.0052 0.018 0.018
Echinococcus multilocularis neuroglian 0.0081 0.038 0.038
Toxoplasma gondii cyclin dependent kinase binding protein 0.0052 0.018 0.018
Brugia malayi Cyclin, N-terminal domain containing protein 0.0369 0.24 0.24
Trichomonas vaginalis cyclin D, putative 0.0217 0.1335 0.1335
Trypanosoma brucei heat shock protein, putative 0.0065 0.0269 0.0269
Giardia lamblia Kinase, CMGC CDK 0.0415 0.2718 0.2587
Trypanosoma brucei mitotic cyclin 6 0.0369 0.24 0.24
Brugia malayi Cyclin, N-terminal domain containing protein 0.0052 0.018 0.018
Loa Loa (eye worm) cyclin C 0.0052 0.018 0.018
Plasmodium falciparum heat shock protein 90 0.0065 0.0269 0.0269
Echinococcus multilocularis cyclin B 0.0369 0.24 0.24
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0534 0.3552 0.3552
Trypanosoma cruzi mitotic cyclin, putative 0.0052 0.018 0.018
Echinococcus multilocularis cyclins 0.0217 0.1335 0.1335
Entamoeba histolytica protein kinase domain containing protein 0.1455 1 1
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0027 0.0004 0.0004
Trypanosoma cruzi cyclin, putative 0.0369 0.24 0.24
Echinococcus multilocularis cyclin G2 0.0052 0.018 0.018
Echinococcus multilocularis cyclin G2 0.0052 0.018 0.018
Echinococcus granulosus defective proboscis extension response 0.0081 0.038 0.038
Trypanosoma cruzi cdc2-related kinase 3 0.0415 0.2718 0.2718
Onchocerca volvulus 0.0052 0.018 0.018
Trichomonas vaginalis cyclin B3, putative 0.0052 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0396 0.2587 0.2587
Loa Loa (eye worm) endoplasmin 0.0065 0.0269 0.0269
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0052 0.018 0.018
Schistosoma mansoni heat shock protein 0.0065 0.0269 0.0269
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0081 0.038 0.038
Trichomonas vaginalis cyclin A, putative 0.0369 0.24 0.24
Brugia malayi hypothetical protein 0.0052 0.018 0.018
Echinococcus granulosus cyclin A3 4 0.0052 0.018 0.018
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0052 0.018 0.018
Brugia malayi hypothetical protein 0.0081 0.038 0.038
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0052 0.018 0.018
Plasmodium vivax endoplasmin, putative 0.0065 0.0269 0.0269
Entamoeba histolytica heat shock protein 90, putative 0.0065 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0256 0.1603 0.1603
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0027 0.0004 0.0004
Trypanosoma brucei heat shock protein, putative 0.0065 0.0269 0.0269
Brugia malayi Cyclin, N-terminal domain containing protein 0.0052 0.018 0.018
Echinococcus granulosus cyclin dependent kinase 1 0.0415 0.2718 0.2718
Echinococcus granulosus cyclin b3 0.0217 0.1335 0.1335
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0052 0.0176 0.5
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0369 0.24 0.24
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0081 0.038 0.038
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0256 0.1603 0.1603
Leishmania major mitotic cyclin, putative 0.0052 0.018 0.018
Leishmania major heat shock protein 83-1 0.0065 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0081 0.038 0.038
Echinococcus multilocularis activin receptor type 0.0027 0.0004 0.0004
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.1455 1 1
Echinococcus multilocularis cyclin y 0.0052 0.018 0.018
Schistosoma mansoni cyclin k 0.0052 0.018 0.018
Echinococcus granulosus cyclin G2 0.0052 0.018 0.018
Schistosoma mansoni cyclins 0.0217 0.1335 0.1335
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0415 0.2718 0.2718
Echinococcus multilocularis cyclin B3 1 0.0217 0.1335 0.1335
Brugia malayi Cyclin, N-terminal domain containing protein 0.0369 0.24 0.24
Echinococcus granulosus cyclin t1 0.0052 0.018 0.018
Trypanosoma cruzi CYC2-like cyclin, putative 0.0369 0.24 0.24
Entamoeba histolytica hypothetical protein 0.0052 0.018 0.018
Loa Loa (eye worm) CYL-1 protein 0.0052 0.018 0.018
Entamoeba histolytica cyclin family protein 0.0217 0.1335 0.1335
Leishmania major heat shock protein 83-1 0.0065 0.0269 0.0269
Trichomonas vaginalis cyclin D, putative 0.0217 0.1335 0.1335
Trichomonas vaginalis cyclins, putative 0.0369 0.24 0.24
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0052 0.018 0.018
Brugia malayi Cyclin, N-terminal domain containing protein 0.0052 0.018 0.018
Echinococcus multilocularis Immunoglobulin 0.0081 0.038 0.038
Plasmodium falciparum protein kinase, putative 0.0027 0.0004 0.0004
Echinococcus multilocularis cyclin A3 4 0.0052 0.018 0.018
Entamoeba histolytica protein kinase, putative 0.1455 1 1
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0176 0.0176
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0004 0.0004
Plasmodium falciparum glycogen synthase kinase 3 0.1455 1 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0052 0.0176 0.5
Leishmania major cyclin 0.0369 0.24 0.24
Brugia malayi hypothetical protein 0.0052 0.018 0.018
Trichomonas vaginalis cyclins, putative 0.0369 0.24 0.24
Echinococcus granulosus cyclin B 0.0369 0.24 0.24
Trypanosoma brucei cyclin 9 0.0052 0.018 0.018
Trichomonas vaginalis cyclin B3, putative 0.0052 0.018 0.018
Echinococcus granulosus Cyclin L1 0.0052 0.018 0.018
Trypanosoma cruzi heat shock protein 90, putative 0.0052 0.0176 0.0176
Brugia malayi Cyclin, N-terminal domain containing protein 0.0052 0.018 0.018
Trypanosoma brucei heat shock protein, putative 0.0065 0.0269 0.0269
Echinococcus multilocularis cyclin b3 0.0217 0.1335 0.1335
Echinococcus multilocularis cyclin dependent kinase 5 0.0415 0.2718 0.2718
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0052 0.018 0.018
Schistosoma mansoni hypothetical protein 0.0052 0.018 0.018
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0052 0.018 0.018
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0898 0.6105 0.6105
Giardia lamblia Kinase, CMGC GSK 0.1455 1 1
Loa Loa (eye worm) cyclin domain-containing protein 0.0052 0.018 0.018
Trypanosoma brucei heat shock protein 90, putative 0.0065 0.0269 0.0269
Echinococcus granulosus twitchin 0.01 0.0511 0.0511
Schistosoma mansoni heat shock protein 0.0065 0.0269 0.0269
Onchocerca volvulus Protein CNPPD1 homolog 0.0052 0.018 0.018
Echinococcus granulosus cyclins 0.0217 0.1335 0.1335
Brugia malayi Cyclin, N-terminal domain containing protein 0.0052 0.018 0.018
Entamoeba histolytica protein kinase, putative 0.0108 0.0567 0.0567
Echinococcus granulosus cyclins 0.0217 0.1335 0.1335
Trichomonas vaginalis CMGC family protein kinase 0.0415 0.2718 0.2718
Loa Loa (eye worm) hypothetical protein 0.0081 0.038 0.038
Plasmodium vivax glycogen synthase kinase 3, putative 0.1455 1 1
Trichomonas vaginalis cyclin B, putative 0.0052 0.018 0.018
Trypanosoma brucei heat shock protein, putative 0.0065 0.0269 0.0269
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.1455 1 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0415 0.2718 0.2718
Entamoeba histolytica cyclin C, putative 0.0052 0.018 0.018
Giardia lamblia Hypothetical protein 0.0217 0.1335 0.118

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 12.08 uM Inhibition of human Lck in presence of ATP ChEMBL. 17154512
IC50 (binding) = 12.08 uM Inhibition of human Lck in presence of ATP ChEMBL. 17154512

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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