TDR Targets

Basic information

Technical information

TDR Targets ID: 373794
Name: 6-(dipropylamino)-4-(trifluoromethyl)-1H-quin olin-2-one
MW: 312.33 | Formula: C16H19F3N2O
H donors: 1 H acceptors: 1 LogP: 3.68 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCCN(c1ccc2c(c1)c(cc(=O)[nH]2)C(F)(F)F)CCC
InChi: 1S/C16H19F3N2O/c1-3-7-21(8-4-2)11-5-6-14-12(9-11)13(16(17,18)19)10-15(22)20-14/h5-6,9-10H,3-4,7-8H2,1-2H3,(H,20,22)
InChiKey: HFWOWAKTWKSIBL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-(dipropylamino)-4-(trifluoromethyl)carbostyril

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	androgen receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0006	0.0016	0.0024
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0113	0.2266	1
Schistosoma mansoni	glucose transport protein	0.0113	0.2266	1
Schistosoma mansoni	protein kinase	0.0035	0.0611	0.2648
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0621	0.868
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0074	0.0261
Onchocerca volvulus		0.0016	0.0217	1
Schistosoma mansoni	protein kinase	0.0035	0.0611	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0009	0.0074	0.0261
Mycobacterium ulcerans	integral membrane transport protein	0.0016	0.0217	0.5239
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0217	0.0894
Schistosoma mansoni	thyroid hormone receptor	0.0009	0.0074	0.0261
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0035	0.0612	0.0597
Plasmodium falciparum	protein kinase 7	0.032	0.6617	0.6612
Loa Loa (eye worm)	sugar transporter	0.0113	0.2266	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0009	0.0074	0.0261
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0035	0.0612	0.0597
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0621	0.274
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.0621	0.274
Echinococcus granulosus	calcium dependent protein kinase	0.0033	0.0566	0.2448
Schistosoma mansoni	glucose transport protein	0.0113	0.2266	1
Onchocerca volvulus		0.0016	0.0217	1
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0014	0.0175	0.0709
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0009	0.0074	0.0261
Plasmodium falciparum	proline--tRNA ligase	0.004	0.0715	0.0701
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0009	0.0074	0.0261
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0217	0.0894
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0113	0.2266	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0611	0.2648
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0217	0.0894
Toxoplasma gondii	sugar transporter ST2	0.0016	0.0217	0.0327
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0021	0.0333	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0611	0.2648
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0034	0.0597	0.2583
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0621	0.868
Plasmodium vivax	hexose transporter	0.0113	0.2266	0.2253
Schistosoma mansoni	protein kinase	0.0035	0.0611	0.2648
Schistosoma mansoni	RAR-like nuclear receptor	0.0009	0.0074	0.0261
Entamoeba histolytica	protein kinase, putative	0.0035	0.0611	1
Brugia malayi	nuclear hormone receptor	0.0009	0.0074	0.0261
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Schistosoma mansoni	sugar transporter	0.0016	0.0217	0.0894
Trypanosoma cruzi	hexose transporter, putative	0.0016	0.0217	0.303
Toxoplasma gondii	transporter, major facilitator family protein	0.0016	0.0217	0.0327
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0217	0.0956
Schistosoma mansoni	lysyl-tRNA synthetase	0.0025	0.0414	0.1769
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Onchocerca volvulus		0.0016	0.0217	1
Brugia malayi	steroid hormone receptor	0.0009	0.0074	0.0261
Schistosoma mansoni	serine/threonine protein kinase	0.0035	0.0611	0.2648
Brugia malayi	Sugar transporter family protein	0.0113	0.2266	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0034	0.0597	0.2583
Echinococcus granulosus	solute carrier family 22	0.0016	0.0217	0.0894
Plasmodium falciparum	hexose transporter	0.0113	0.2266	0.2253
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0009	0.0074	0.0261
Brugia malayi	Nuclear hormone receptor-like 1	0.0009	0.0074	0.0261
Echinococcus multilocularis	FTZ F1 alpha	0.0009	0.0074	0.0261
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0113	0.2266	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0009	0.0074	0.0261
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0009	0.0074	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0414	0.1769
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0621	0.868
Echinococcus multilocularis	calcium dependent protein kinase	0.0033	0.0566	0.2448
Chlamydia trachomatis	lysine--tRNA ligase	0.0025	0.0414	1
Onchocerca volvulus		0.0016	0.0217	1
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.0218
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0009	0.0074	0.0261
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0217	0.0956
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.004	0.0715	0.1081
Schistosoma mansoni	sugar transporter	0.0016	0.0217	0.0894
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0006	0.0016	0.0377
Brugia malayi	Steroid receptor seven-up type 2	0.0009	0.0074	0.0261
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0016	0.0217	0.6499
Onchocerca volvulus		0.0016	0.0217	1
Schistosoma mansoni	sugar transporter	0.0016	0.0217	0.0894
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0113	0.2266	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0009	0.0074	0.0261
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0035	0.0612	0.0597
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0035	0.0612	0.0597
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0006	0.0016	0.0377
Leishmania major	glucose transporter, lmgt1	0.0035	0.0621	0.868
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0034	0.0597	0.2634
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0034	0.0597	0.2583
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0597	0.2583
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0035	0.0621	0.868
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0034	0.0597	0.2583
Giardia lamblia	Lysyl-tRNA synthetase	0.0025	0.0414	0.6849
Plasmodium vivax	proline--tRNA ligase, putative	0.004	0.0715	0.0701
Trichomonas vaginalis	CAMK family protein kinase	0.0035	0.0611	0.2699
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0009	0.0074	0.0261
Echinococcus granulosus	ecdysone induced protein 78C	0.0009	0.0074	0.0261
Schistosoma mansoni	lysyl-tRNA synthetase	0.0025	0.0414	0.1769
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0009	0.0074	0.0261
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0009	0.0074	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0074	0.0261
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0025	0.0414	0.5783
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0012	0.0134	0.3243
Echinococcus granulosus	solute carrier family 22	0.0016	0.0217	0.0894
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0035	0.0612	0.0925
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0009	0.0074	0.0261
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0016	0.0217	0.5239
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0217	0.0894
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0035	0.0612	0.0925
Toxoplasma gondii	lysine-tRNA ligase	0.0025	0.0414	0.0625
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Brugia malayi	photoreceptor-specific nuclear receptor	0.0009	0.0074	0.0261
Entamoeba histolytica	hypothetical protein	0.0025	0.0414	0.6679
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0611	0.2648
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0035	0.0611	0.2648
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0217	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Onchocerca volvulus		0.0016	0.0217	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0074	0.0261
Onchocerca volvulus		0.0016	0.0217	1
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0621	0.868
Brugia malayi	hypothetical protein	0.0016	0.0217	0.0894
Trypanosoma cruzi	hexose transporter, putative	0.0019	0.0286	0.3994
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0035	0.0612	0.0925
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0113	0.2266	1
Trichomonas vaginalis	glucose transporter, putative	0.0035	0.0621	0.274
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.0621	0.274
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0025	0.0414	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0009	0.0074	0.0261
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.0621	0.274
Onchocerca volvulus		0.0016	0.0217	1
Schistosoma mansoni	sugar transporter	0.0016	0.0217	0.0894
Echinococcus multilocularis	ecdysone induced protein 78C	0.0009	0.0074	0.0261
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0009	0.0074	0.0261
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0009	0.0074	0.0261
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0022	0.0348	0.1536
Leishmania major	myo-inositol/proton symporter (MIT)	0.0016	0.0217	0.303
Onchocerca volvulus		0.0016	0.0217	1
Schistosoma mansoni	nuclear hormone receptor	0.0009	0.0074	0.0261
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0016	0.0217	0.0894
Echinococcus granulosus	solute carrier family 22	0.0016	0.0217	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0621	0.274
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0074	0.0261
Echinococcus granulosus	lysyl tRNA synthetase	0.0025	0.0414	0.1769
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0021	0.0333	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0074	0.0261
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0009	0.0074	0.0261
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Trypanosoma cruzi	sugar transporter, putative	0.0016	0.0217	0.303
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0034	0.0597	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0025	0.0414	0.6932
Giardia lamblia	Prolyl-tRNA synthetase	0.0034	0.0597	1
Onchocerca volvulus		0.0016	0.0217	1
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0034	0.0597	0.2583
Brugia malayi	nuclear receptor NHR-88	0.0009	0.0074	0.0261
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0009	0.0074	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0597	0.2583
Mycobacterium ulcerans	sugar transporter	0.0016	0.0217	0.5239
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Trichomonas vaginalis	sugar transport protein, putative	0.0016	0.0217	0.0956
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Plasmodium vivax	sugar transporter, putative	0.0016	0.0217	0.0201
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.0621	0.868
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0113	0.2266	1
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0035	0.0612	0.0597
Loa Loa (eye worm)	steroid hormone receptor	0.0009	0.0074	0.0261
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0621	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0217	0.0956
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0009	0.0074	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0074	0.0261
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0217	0.0894
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0035	0.0612	0.0597
Brugia malayi	major facilitator superfamily protein	0.0016	0.0217	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0217	0.0894
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0034	0.0597	0.9752
Treponema pallidum	prolyl-tRNA synthetase	0.0012	0.0134	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0016	0.0217	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0074	0.0261
Echinococcus granulosus	General substrate transporter	0.0097	0.193	0.851
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0113	0.2266	1
Onchocerca volvulus		0.0016	0.0217	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0009	0.0074	0.0261
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.0715	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0611	0.2648
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0183	0.3734	0.3724
Trypanosoma cruzi	hexose transporter	0.0035	0.0621	0.868
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0009	0.0074	0.0261
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0016	0.0217	0.0894
Trichomonas vaginalis	glucose transporter, putative	0.0016	0.0217	0.0956
Loa Loa (eye worm)	sugar transporter	0.0016	0.0217	0.0894
Schistosoma mansoni	hypothetical protein	0.0113	0.2266	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0009	0.0074	0.0261
Echinococcus granulosus	solute carrier family 22	0.0016	0.0217	0.0894
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0025	0.0414	0.1826
Trichomonas vaginalis	myo-inositol transporter, putative	0.0016	0.0217	0.0956
Brugia malayi	ecdysteroid receptor	0.0009	0.0074	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0217	0.0894
Plasmodium falciparum	lysine--tRNA ligase	0.0025	0.0414	0.0399
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0009	0.0074	0.0261
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0217	0.0894
Leishmania major	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.0218
Entamoeba histolytica	protein kinase, putative	0.0035	0.0611	1
Echinococcus granulosus	FTZ F1 alpha	0.0009	0.0074	0.0261
Toxoplasma gondii	protein kinase, putative	0.032	0.6617	1
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.0218
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0006	0.0016	0.0468
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0035	0.0611	0.855
Trypanosoma brucei	glucose transporter 1E	0.0035	0.0621	0.868
Trypanosoma brucei	sugar transporter, putative	0.0016	0.0217	0.303
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0217	0.0894
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0009	0.0074	0.0261
Schistosoma mansoni	retinoic acid receptor RXR	0.0009	0.0074	0.0261
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0009	0.0074	0.0261
Echinococcus granulosus	synaptic vesicle 2 protein	0.0016	0.0217	0.0894
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0611	0.2648
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0113	0.2266	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0009	0.0074	0.0261
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0006	0.0016	0.0262
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0006	0.0016	0.0218
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0183	0.3734	0.3724
Brugia malayi	hypothetical protein	0.0016	0.0217	0.0894
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0035	0.0612	0.0597
Leishmania major	glucose transporter, lmgt2	0.0035	0.0621	0.868
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0621	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0611	0.2648
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0016	0.0217	0.6499
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0621	0.868
Chlamydia trachomatis	proline--tRNA ligase	0.0012	0.0134	0.2978
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0009	0.0074	0.0261
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.004	0.0715	1
Brugia malayi	major facilitator superfamily protein	0.0016	0.0217	0.0894
Onchocerca volvulus		0.0016	0.0217	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0611	0.2648
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0035	0.0611	0.2648
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0009	0.0074	0.0261
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.0621	0.868
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0021	0.0333	0.5587
Echinococcus multilocularis	lysyl tRNA synthetase	0.0025	0.0414	0.1769
Plasmodium vivax	lysine--tRNA ligase, putative	0.0025	0.0414	0.0399
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0009	0.0074	0.0261
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0034	0.0597	0.2583
Brugia malayi	lysyl-tRNA synthetase	0.0025	0.0414	0.1769
Leishmania major	hypothetical protein, conserved	0.0016	0.0217	0.303
Giardia lamblia	Hexose transporter	0.0016	0.0217	0.346
Giardia lamblia	Sugar-proton symporter	0.0016	0.0217	0.346
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0217	0.0894
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0009	0.0074	0.0261
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.0218
Trichomonas vaginalis	conserved hypothetical protein	0.0113	0.2266	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0611	0.2648
Echinococcus multilocularis	General substrate transporter	0.0097	0.193	0.851
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0217	0.0894
Trypanosoma cruzi	glucose transporter, putative	0.0016	0.0217	0.303
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0217	0.0894
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.0715	1
Plasmodium vivax	CDK-related protein kinase 6, putative	0.048	1	1
Onchocerca volvulus	Putative transporter	0.0016	0.0217	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0009	0.0074	0.0261
Schistosoma mansoni	glucose transport protein	0.0113	0.2266	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0217	0.0894
Brugia malayi	Sugar transporter family protein	0.0016	0.0217	0.0894
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0009	0.0074	0.0261
Onchocerca volvulus		0.0016	0.0217	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0009	0.0074	0.0261
Toxoplasma gondii	facilitative glucose transporter GT1	0.0113	0.2266	0.3424
Leishmania major	protein kinase, putative	0.0035	0.0611	0.855
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0621	0.868
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0009	0.0074	0.0261
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0035	0.0611	0.2648
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0217	0.0956
Onchocerca volvulus		0.0016	0.0217	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0009	0.0074	0.0261
Brugia malayi	Cam kinase protein 1	0.0035	0.0611	0.2648
Schistosoma mansoni	coup transcription factor	0.0009	0.0074	0.0261
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0016	0.0217	0.0894
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0183	0.3734	0.5643
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0009	0.0074	0.0261
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0016	0.0217	0.5239
Toxoplasma gondii	sugar transporter ST3	0.0016	0.0217	0.0327
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.0069
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0016	0.0217	1
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.0715	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0074	0.0261
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.004	0.0715	1
Brugia malayi	hypothetical protein	0.0016	0.0217	0.0894
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0621	0.868
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0217	0.0894
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0217	0.0894
Leishmania major	glucose transporter, lmgt3	0.0035	0.0621	0.868
Onchocerca volvulus		0.0016	0.0217	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0009	0.0074	0.0261
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0009	0.0074	0.0261
Onchocerca volvulus		0.0016	0.0217	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0463	0.1987
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0035	0.0612	0.0597
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.0621	0.868
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0035	0.0612	0.0597
Toxoplasma gondii	sugar transporter ST1	0.0016	0.0217	0.0327
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0016	0.0217	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0217	0.0894
Schistosoma mansoni	glucose transporter	0.0016	0.0217	0.0894
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0025	0.0414	0.5783
Trypanosoma brucei	glucose transporter 2A	0.0035	0.0621	0.868
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0025	0.0414	1
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0621	0.868
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0009	0.0074	0.0261
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Schistosoma mansoni	thyroid hormone receptor	0.0009	0.0074	0.0261
Toxoplasma gondii	glycyl-tRNA synthetase	0.0006	0.0016	0.0024
Brugia malayi	Sugar transporter family protein	0.0016	0.0217	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0217	0.0894
Leishmania major	lysyl-tRNA synthetase, putative	0.0025	0.0414	0.5783
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0035	0.0611	0.2648
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0016	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0217	0.0956
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0009	0.0074	0.0261
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0016	0.0217	0.303
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0009	0.0074	0.0261
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0016	0.0217	0.0201
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0621	0.868
Trichomonas vaginalis	glucose transporter, putative	0.0035	0.0621	0.274

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 1.5 nM	Agonist activity at human androgen receptor in CV1 cells measured as stimulation of luciferase reporter gene activity by cotransfection assay	ChEMBL.	17034117
EC50 (functional)	= 1.5 nM	Agonist activity at human AR	ChEMBL.	17267219
EC50 (functional)	= 1.5 nM	Agonist activity at human androgen receptor in CV1 cells measured as stimulation of luciferase reporter gene activity by cotransfection assay	ChEMBL.	17034117
EC50 (functional)	= 1.5 nM	Agonist activity at human AR	ChEMBL.	17267219
Efficacy (functional)	< 20 %	Antagonist activity against human androgen receptor in CV1 cells measured as percent of maximal inhibition of DHT-stimulated luciferase reporter gene activity by cotransfection assay	ChEMBL.	17034117
Efficacy (functional)	< 20 %	Antagonist activity at human AR assessed as inhibition of DHT-induced response	ChEMBL.	17267219
Efficacy (functional)	< 20 %	Antagonist activity against human androgen receptor in CV1 cells measured as percent of maximal inhibition of DHT-stimulated luciferase reporter gene activity by cotransfection assay	ChEMBL.	17034117
Efficacy (functional)	< 20 %	Antagonist activity at human AR assessed as inhibition of DHT-induced response	ChEMBL.	17267219
Efficacy (functional)	= 72 %	Agonist activity at human androgen receptor in CV1 cells measured as stimulation of luciferase reporter gene activity with relative to DHT by cotransfection assay	ChEMBL.	17034117
Efficacy (functional)	= 72 %	Agonist activity at human AR relative to DHT	ChEMBL.	17267219
Efficacy (functional)	= 72 %	Agonist activity at human androgen receptor in CV1 cells measured as stimulation of luciferase reporter gene activity with relative to DHT by cotransfection assay	ChEMBL.	17034117
Efficacy (functional)	= 72 %	Agonist activity at human AR relative to DHT	ChEMBL.	17267219
IC50 (functional)	> 10000 nM	Antagonist activity against human androgen receptor in CV1 cells measured as inhibition of DHT-stimulated luciferase reporter gene activity by cotransfection assay	ChEMBL.	17034117
IC50 (functional)	> 10000 nM	Antagonist activity at human AR	ChEMBL.	17267219
IC50 (functional)	> 10000 nM	Antagonist activity against human androgen receptor in CV1 cells measured as inhibition of DHT-stimulated luciferase reporter gene activity by cotransfection assay	ChEMBL.	17034117
IC50 (functional)	> 10000 nM	Antagonist activity at human AR	ChEMBL.	17267219
Ki (binding)	= 64 nM	Displacement of [3H]DHT from human androgen receptor expressed in MDA-MB-453 cells by whole cell receptor binding assay	ChEMBL.	17034117
Ki (binding)	= 64 nM	Binding affinity to human AR	ChEMBL.	17267219
Ki (binding)	= 64 nM	Displacement of [3H]DHT from human androgen receptor expressed in MDA-MB-453 cells by whole cell receptor binding assay	ChEMBL.	17034117
Ki (binding)	= 64 nM	Binding affinity to human AR	ChEMBL.	17267219

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL442240
PubChem: 16090310

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 373794