TDR Targets

Basic information

Technical information

TDR Targets ID: 374323
Name: 1-benzyl-N-cycloheptyl-7-methyl-4-oxo-1,8-nap hthyridine-3-carboxamide
MW: 389.49 | Formula: C24H27N3O2
H donors: 1 H acceptors: 3 LogP: 4.69 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc2c(n1)n(Cc1ccccc1)cc(c2=O)C(=O)NC1CCCCCC1
InChi: 1S/C24H27N3O2/c1-17-13-14-20-22(28)21(24(29)26-19-11-7-2-3-8-12-19)16-27(23(20)25-17)15-18-9-5-4-6-10-18/h4-6,9-10,13-14,16,19H,2-3,7-8,11-12,15H2,1H3,(H,26,29)
InChiKey: FYDMSCKJDXXIOE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-cycloheptyl-7-methyl-4-oxo-1-(phenylmethyl)-1,8-naphthyridine-3-carboxamide
1-benzyl-N-cycloheptyl-4-keto-7-methyl-1,8-naphthyridine-3-carboxamide
1-(benzyl)-N-cycloheptyl-4-keto-7-methyl-1,8-naphthyridine-3-carboxamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	cannabinoid receptor 2 (macrophage)	Starlite/ChEMBL	References
Mus musculus	cannabinoid receptor 1 (brain)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	sex peptide receptor	0.0046	0.0084	0.0046
Schistosoma mansoni	glutamate receptor NMDA	0.0665	0.4008	0.4008
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0055	0.0139	0.0102
Echinococcus multilocularis	neuropeptides capa receptor	0.0046	0.0084	0.0046
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0046	0.0084	0.0084
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0055	0.0139	0.1767
Echinococcus multilocularis	glutamate receptor subunit protein glur	0.0055	0.0139	0.0101
Brugia malayi	Dopamine receptor protein 2	0.0046	0.0084	0.1066
Brugia malayi	G protein-coupled receptor F59B2.13	0.0046	0.0084	0.1066
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0157	0.0788	0.0753
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0046	0.0084	0.0084
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0055	0.0139	0.1767
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0046	0.0084	0.0084
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0046	0.0084	0.0084
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0046	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0083	0.0317	0.028
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0055	0.0139	0.0102
Echinococcus multilocularis	nmda type glutamate receptor	0.0778	0.4721	0.4701
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0055	0.0139	0.0102
Echinococcus granulosus	nmda type glutamate receptor	0.0778	0.4721	0.4701
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0055	0.0139	0.0139
Trypanosoma brucei	glycerol uptake protein, putative	0.0157	0.0788	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0055	0.0139	0.0139
Echinococcus granulosus	neuropeptides capa receptor	0.0046	0.0084	0.0046
Leishmania major	hypothetical protein, conserved	0.0157	0.0788	0.5
Brugia malayi	neuropeptide F receptor	0.0046	0.0084	0.1066
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0139	0.0139
Brugia malayi	MBOAT family protein	0.0157	0.0788	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Schistosoma mansoni	neuropeptide receptor	0.0046	0.0084	0.0084
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0055	0.0139	0.0139
Loa Loa (eye worm)	TYRA-2 protein	0.0046	0.0084	0.0084
Echinococcus multilocularis	G protein coupled receptor 139	0.0046	0.0084	0.0046
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0046	0.0084	0.1066
Mycobacterium ulcerans	short chain dehydrogenase	0.1112	0.6839	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.0084	0.0046
Schistosoma mansoni	neuropeptide F-like receptor	0.0046	0.0084	0.0084
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.0084	0.0046
Echinococcus granulosus	tm gpcr rhodopsin	0.0046	0.0084	0.0046
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0157	0.0788	1
Echinococcus multilocularis	glutamate receptor 2	0.0083	0.0317	0.028
Leishmania major	glycerol uptake protein, putative	0.0157	0.0788	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.0084	0.0084
Echinococcus multilocularis	neuropeptide receptor	0.0046	0.0084	0.0046
Brugia malayi	follicle stimulating hormone receptor	0.0046	0.0084	0.1066
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0046	0.0084	0.0046
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0046	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0366	0.0366
Loa Loa (eye worm)	hhat protein	0.0157	0.0788	0.0788
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0055	0.0139	0.0102
Echinococcus granulosus	G protein coupled receptor 139	0.0046	0.0084	0.0046
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.0157	0.0788	0.0753
Brugia malayi	CHE-14 protein	0.0039	0.0038	0.048
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0055	0.0139	0.0139
Brugia malayi	hypothetical protein	0.0046	0.0084	0.1066
Echinococcus granulosus	neuropeptide receptor A26	0.0046	0.0084	0.0046
Leishmania major	glycerol uptake protein, putative	0.0157	0.0788	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.0788	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0097	0.1225
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0157	0.0788	0.0753
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0046	0.0084	0.0046
Schistosoma mansoni	glutamate receptor AMPA	0.0055	0.0139	0.0139
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.0084	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Brugia malayi	Dopamine receptor	0.0046	0.0084	0.1066
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Brugia malayi	MBOAT family protein	0.0157	0.0788	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0046	0.0084	0.0084
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0046	0.0084	0.1066
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0046	0.0084	0.0084
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0097	0.0097
Leishmania major	glycerol uptake protein, putative	0.0157	0.0788	0.5
Echinococcus granulosus	dro:myosuppressin receptor	0.0046	0.0084	0.0046
Schistosoma mansoni	patched 1	0.0039	0.0038	0.0038
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0083	0.0317	0.028
Echinococcus multilocularis	NMDA receptor	0.0055	0.0139	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0046	0.0084	0.0046
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.0084	0.0046
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0046	0.0084	0.0046
Trypanosoma cruzi	GUP1, putative	0.0157	0.0788	0.5
Brugia malayi	hypothetical protein	0.0081	0.0306	0.3875
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.0084	0.0084
Brugia malayi	hypothetical protein	0.0046	0.0084	0.1066
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0055	0.0139	0.1767
Entamoeba histolytica	vacuolar protein sorting 26	0.0157	0.0788	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.0084	0.0046
Loa Loa (eye worm)	MBOAT family protein	0.0157	0.0788	0.0788
Echinococcus multilocularis	g protein coupled receptor	0.0046	0.0084	0.0046
Schistosoma mansoni	hypothetical protein	0.0037	0.0029	0.0029
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0055	0.0139	0.1767
Echinococcus granulosus	Niemann Pick C1 protein	0.013	0.0612	0.0577
Echinococcus granulosus	nmda type glutamate receptor	0.0611	0.3661	0.3636
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0055	0.0139	0.1767
Echinococcus multilocularis	serotonin receptor	0.0046	0.0084	0.0046
Echinococcus granulosus	lysophospholipid acyltransferase 7	0.0157	0.0788	0.0753
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0097	0.1225
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0083	0.0317	0.028
Brugia malayi	diacylglycerol acyltransferase	0.0157	0.0788	1
Schistosoma mansoni	adenoreceptor	0.0046	0.0084	0.0084
Loa Loa (eye worm)	MBOAT family protein	0.0157	0.0788	0.0788
Loa Loa (eye worm)	neuropeptide F receptor	0.0046	0.0084	0.0084
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.0788	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0091	0.0366	0.0329
Brugia malayi	hypothetical protein	0.0046	0.0084	0.1066
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0055	0.0139	0.0102
Echinococcus multilocularis	neuropeptide Y receptor	0.0046	0.0084	0.0046
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0747	0.4523	0.4502
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0046	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Schistosoma mansoni	leukocyte receptor cluster (lrc) member 4 protein	0.0157	0.0788	0.0788
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0788	0.0788
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.0084	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0097	0.0097
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0055	0.0139	0.1767
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0157	0.0788	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0139	0.0139
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.0157	0.0788	0.0753
Echinococcus granulosus	neuropeptide receptor	0.0046	0.0084	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0055	0.0139	0.0102
Loa Loa (eye worm)	G-protein coupled receptor	0.0046	0.0084	0.0084
Schistosoma mansoni	coup transcription factor	0.0055	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Echinococcus multilocularis	neuropeptides capa receptor	0.0046	0.0084	0.0046
Schistosoma mansoni	glutamate receptor NMDA	0.0055	0.0139	0.0139
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0055	0.0139	0.0139
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.0084	0.0046
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0055	0.0139	0.0139
Echinococcus granulosus	glutamate receptor ionotropic kainate	0.0055	0.0139	0.0101
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0046	0.0084	0.0084
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0046	0.0084	0.0046
Echinococcus granulosus	neuropeptide Y receptor	0.0046	0.0084	0.0046
Echinococcus granulosus	7TM GPCR rhodopsin	0.0046	0.0084	0.0046
Echinococcus granulosus	ecdysone induced protein 78C	0.0055	0.0139	0.0102
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0046	0.0084	0.0046
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.0084	0.0084
Echinococcus multilocularis	neuropeptide s receptor	0.0046	0.0084	0.0046
Loa Loa (eye worm)	hypothetical protein	0.1611	1	1
Echinococcus granulosus	orexin receptor type 2	0.0046	0.0084	0.0046
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0046	0.0084	0.0084
Loa Loa (eye worm)	G-protein coupled receptor	0.0046	0.0084	0.0084
Entamoeba histolytica	hypothetical protein	0.0157	0.0788	1
Leishmania major	glycerol uptake protein, putative	0.0157	0.0788	0.5
Schistosoma mansoni	sterol O-acyltransferase 1	0.1611	1	1
Echinococcus granulosus	neuropeptides capa receptor	0.0046	0.0084	0.0046
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0055	0.0139	0.1767
Brugia malayi	Steroid receptor seven-up type 2	0.0055	0.0139	0.1767
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Echinococcus multilocularis	ecdysone induced protein 78C	0.0055	0.0139	0.0102
Schistosoma mansoni	amine GPCR	0.0046	0.0084	0.0084
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.0157	0.0788	0.0753
Schistosoma mansoni	neuropeptide receptor	0.0046	0.0084	0.0084
Echinococcus granulosus	neuropeptide FF receptor 2	0.0046	0.0084	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.0788	1
Schistosoma mansoni	histamine h1 receptor	0.0046	0.0084	0.0084
Brugia malayi	MBOAT family protein	0.0157	0.0788	1
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	0.0157	0.0788	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0055	0.0139	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0139	0.0139
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0055	0.0139	0.1767
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0139	0.0139
Echinococcus multilocularis	Niemann Pick C1 protein	0.013	0.0612	0.0577
Brugia malayi	ecdysteroid receptor	0.0055	0.0139	0.1767
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0157	0.0788	0.0753
Brugia malayi	MBOAT family protein	0.0157	0.0788	1
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0157	0.0788	0.0788
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0055	0.0139	0.0784
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0046	0.0084	0.0046
Echinococcus multilocularis	Membrane bound O acyl transferase, MBOAT	0.0157	0.0788	0.0753
Echinococcus multilocularis	expressed conserved protein	0.0085	0.0331	0.0294
Leishmania major	glycerol uptake protein, putative	0.0157	0.0788	0.5
Loa Loa (eye worm)	hhat protein	0.0157	0.0788	0.0788
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0093	0.0093
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0083	0.0317	0.028
Entamoeba histolytica	hypothetical protein, conserved	0.0157	0.0788	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0055	0.0139	0.0139
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0055	0.0139	0.0139
Echinococcus granulosus	allatostatin A receptor	0.0046	0.0084	0.0046
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.0084	0.0046
Echinococcus granulosus	7tm_1 domain containing protein	0.0046	0.0084	0.0046
Brugia malayi	putative neuropeptide receptor NPR1	0.0046	0.0084	0.1066
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Echinococcus multilocularis	allatostatin A receptor	0.0046	0.0084	0.0046
Brugia malayi	sulfakinin receptor protein	0.0046	0.0084	0.1066
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0083	0.0317	0.028
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0046	0.0084	0.0046
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0157	0.0788	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0046	0.0084	0.1066
Trichomonas vaginalis	transmembrane protein nessy, putative	0.0157	0.0788	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0046	0.0084	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Echinococcus multilocularis	somatostatin receptor	0.0046	0.0084	0.0046
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0046	0.0084	0.1066
Schistosoma mansoni	hypothetical protein	0.0046	0.0084	0.0084
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.0084	0.0046
Toxoplasma gondii	hypothetical protein	0.0157	0.0788	0.5
Brugia malayi	Glutamate receptor 2 precursor	0.0055	0.0139	0.1762
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0055	0.0139	0.1767
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Echinococcus granulosus	glutamate receptor ionotropic kainate 3	0.0055	0.0139	0.0101
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0055	0.0139	0.0139
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.0084	0.0046
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0046	0.0084	0.0046
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0055	0.0139	0.0139
Brugia malayi	GnHR receptor homolog	0.0046	0.0084	0.1066
Echinococcus granulosus	glutamate receptor subunit protein glur	0.0055	0.0139	0.0101
Echinococcus granulosus	membrane bound acyltransferase:hhat	0.0157	0.0788	0.0753
Trypanosoma cruzi	GUP1, putative	0.0157	0.0788	0.5
Echinococcus granulosus	serotonin receptor	0.0046	0.0084	0.0046
Echinococcus granulosus	glutamate receptor 2	0.0083	0.0317	0.028
Trypanosoma cruzi	glycerol uptake protein, putative	0.0157	0.0788	0.5
Schistosoma mansoni	zinc finger protein	0.0157	0.0788	0.0788
Echinococcus multilocularis	glutamate receptor NMDA	0.0582	0.3482	0.3458
Brugia malayi	Niemann-Pick C1 protein precursor	0.0091	0.0366	0.464
Schistosoma mansoni	hypothetical protein	0.0046	0.0084	0.0084
Brugia malayi	nuclear hormone receptor	0.0055	0.0139	0.1767
Echinococcus multilocularis	FTZ F1 alpha	0.0055	0.0139	0.0102
Brugia malayi	hypothetical protein	0.0046	0.0084	0.1066
Echinococcus multilocularis	neuropeptide Y receptor	0.0046	0.0084	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0046	0.0084	0.0046
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0046	0.0084	0.1066
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0083	0.0317	0.028
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0055	0.0139	0.0101
Schistosoma mansoni	hypothetical protein	0.0046	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Schistosoma mansoni	biogenic amine receptor	0.0046	0.0084	0.0084
Brugia malayi	hypothetical protein	0.0046	0.0084	0.1066
Echinococcus granulosus	g protein coupled receptor	0.0046	0.0084	0.0046
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0046	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.1454	0.9003	0.9003
Brugia malayi	Serotonin receptor	0.0046	0.0084	0.1066
Echinococcus granulosus	g protein coupled receptor	0.0046	0.0084	0.0046
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.0084	0.0046
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0157	0.0788	0.0753
Echinococcus granulosus	tm gpcr rhodopsin	0.0046	0.0084	0.0046
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0038	0.0038
Brugia malayi	Dopamine receptor protein 1	0.0046	0.0084	0.1066
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0046	0.0084	0.0046
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0055	0.0139	0.0139
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0046	0.0084	0.0046
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0046	0.0084	0.0084
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.0084	0.0046
Brugia malayi	Glutamate receptor 1 precursor	0.0055	0.0139	0.1762
Loa Loa (eye worm)	neuropeptide F receptor	0.0046	0.0084	0.0084
Schistosoma mansoni	thyroid hormone receptor	0.0055	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0046	0.0084	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Loa Loa (eye worm)	MBOAT family protein	0.0157	0.0788	0.0788
Schistosoma mansoni	neuropeptide receptor	0.0046	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.0084	0.0084
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0157	0.0788	0.0788
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0139	0.0139
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0055	0.0139	0.0139
Trypanosoma cruzi	glycerol uptake protein, putative	0.0157	0.0788	0.5
Schistosoma mansoni	eyes absent homolog	0.0081	0.0306	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0046	0.0084	0.0046
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0083	0.0317	0.028
Schistosoma mansoni	myosin xvIII	0.0046	0.0084	0.0084
Echinococcus granulosus	tm gpcr rhodopsin	0.0046	0.0084	0.0046
Treponema pallidum	alginate O-acetylation protein (algI)	0.0157	0.0788	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0139	0.0139
Schistosoma mansoni	hypothetical protein	0.0037	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0139	0.0139
Echinococcus multilocularis	orexin receptor type 2	0.0046	0.0084	0.0046
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0055	0.0139	0.0102
Echinococcus granulosus	glutamate receptor NMDA	0.0582	0.3482	0.3458
Brugia malayi	hypothetical protein	0.0046	0.0084	0.1066
Onchocerca volvulus	Bile acid receptor homolog	0.0055	0.0139	0.0784
Schistosoma mansoni	growth hormone secretagogue receptor	0.0046	0.0084	0.0084
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.0084	0.0084
Echinococcus granulosus	g-protein coupled receptor	0.0046	0.0084	0.0046
Schistosoma mansoni	hypothetical protein	0.0037	0.0029	0.0029
Echinococcus granulosus	hypothetical protein	0.0046	0.0084	0.0046
Schistosoma mansoni	amine GPCR	0.0046	0.0084	0.0084
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0046	0.0084	0.0046
Schistosoma mansoni	glutamate receptor kainate	0.0055	0.0139	0.0139
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0055	0.0139	0.1767
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0046	0.0084	0.0084
Brugia malayi	larval opioid receptor	0.0046	0.0084	0.1066
Schistosoma mansoni	glutamate receptor kainate	0.0055	0.0139	0.0139
Echinococcus granulosus	FTZ F1 alpha	0.0055	0.0139	0.0102
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0055	0.0139	0.0102
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0055	0.0139	0.0101
Brugia malayi	Nuclear hormone receptor-like 1	0.0055	0.0139	0.1767
Echinococcus multilocularis	g-protein coupled receptor	0.0046	0.0084	0.0046
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0046	0.0084	0.0084
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0055	0.0139	0.0102
Trypanosoma cruzi	glycerol uptake protein, putative	0.0157	0.0788	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.0084	0.0046
Brugia malayi	Serotonin receptor	0.0046	0.0084	0.1066
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.0084	0.0046
Trypanosoma brucei	glycerol uptake protein, putative	0.0157	0.0788	0.5
Brugia malayi	hypothetical protein	0.0046	0.0084	0.1066
Schistosoma mansoni	biogenic amine receptor	0.0046	0.0084	0.0084
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0046	0.0084	0.0046
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0055	0.0139	0.0102
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0055	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0046	0.0084	0.0046
Brugia malayi	G-protein coupled receptor	0.0046	0.0084	0.1066
Echinococcus multilocularis	fmrfamide receptor	0.0046	0.0084	0.0046
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0055	0.0139	0.0139
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0046	0.0084	0.0046
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0046	0.0084	0.0046
Schistosoma mansoni	hypothetical protein	0.0046	0.0084	0.0084
Brugia malayi	Hhat protein	0.0157	0.0788	1
Brugia malayi	Melatonin receptor type 1A	0.0046	0.0084	0.1066
Brugia malayi	putative neuropeptide receptor	0.0046	0.0084	0.1066
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Echinococcus granulosus	neuropeptide Y receptor	0.0046	0.0084	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.0157	0.0788	0.0753
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0157	0.0788	0.0788
Echinococcus multilocularis	nmda type glutamate receptor	0.0611	0.3661	0.3636
Brugia malayi	hypothetical protein	0.0046	0.0084	0.1066
Chlamydia trachomatis	glutamine binding protein	0.0141	0.0682	0.5
Loa Loa (eye worm)	melatonin receptor type 1A	0.0046	0.0084	0.0084
Echinococcus granulosus	fmrfamide receptor	0.0046	0.0084	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Loa Loa (eye worm)	glutamate receptor 2	0.0055	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0788	0.0788
Echinococcus multilocularis	g protein coupled receptor	0.0046	0.0084	0.0046
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	0.0157	0.0788	0.5
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0083	0.0317	0.028
Echinococcus granulosus	biogenic amine 5HT receptor	0.0046	0.0084	0.0046
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0046	0.0084	0.0046
Schistosoma mansoni	opsin-like receptor	0.0046	0.0084	0.0084
Echinococcus multilocularis	serotonin receptor	0.0046	0.0084	0.0046
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0157	0.0788	0.0788
Echinococcus granulosus	Niemann Pick C1 protein	0.0091	0.0366	0.0329
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0157	0.0788	0.0788
Schistosoma mansoni	hypothetical protein	0.0157	0.0788	0.0788
Schistosoma mansoni	ATP-binding cassette transporter	0.0055	0.0139	0.0139
Schistosoma mansoni	thyroid hormone receptor	0.0055	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Echinococcus granulosus	sex peptide receptor	0.0046	0.0084	0.0046
Schistosoma mansoni	neuropeptide F-like receptor	0.0046	0.0084	0.0084
Mycobacterium tuberculosis	Probable oxidoreductase	0.1112	0.6839	1
Echinococcus granulosus	neuropeptide s receptor	0.0046	0.0084	0.0046
Echinococcus granulosus	Ribosomal protein S1 RNA binding domain	0.0055	0.0139	0.0101
Echinococcus multilocularis	dro:myosuppressin receptor	0.0046	0.0084	0.0046
Echinococcus multilocularis	sterol O acyltransferase 1	0.1611	1	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0046	0.0084	0.0084
Brugia malayi	MBOAT family protein	0.0157	0.0788	1
Echinococcus granulosus	g protein coupled receptor	0.0046	0.0084	0.0046
Echinococcus multilocularis	glutamate receptor 2	0.0055	0.0139	0.0101
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0046	0.0084	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Onchocerca volvulus		0.0055	0.0139	0.0784
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0055	0.0139	0.0102
Brugia malayi	G-protein coupled receptor	0.0046	0.0084	0.1066
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0046	0.0084	0.0046
Schistosoma mansoni	glutamate receptor AMPA	0.0055	0.0139	0.0139
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0195	0.103	0.0996
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0788	0.0788
Brugia malayi	ORL1-like opioid receptor	0.0046	0.0084	0.1066
Echinococcus multilocularis	g protein coupled receptor	0.0046	0.0084	0.0046
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0055	0.0139	0.1767
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.0084	0.0084
Echinococcus multilocularis	glutamate receptor ionotropic kainate	0.0055	0.0139	0.0101
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0046	0.0084	0.0084
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0055	0.0139	0.1767
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0046	0.0084	0.0046
Schistosoma mansoni	amine GPCR	0.0046	0.0084	0.0084
Echinococcus multilocularis	neuropeptide receptor	0.0046	0.0084	0.0046
Plasmodium falciparum	diacylglycerol O-acyltransferase	0.0157	0.0788	0.5
Echinococcus granulosus	neuropeptide receptor	0.0046	0.0084	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0306	0.0306
Echinococcus multilocularis	Ribosomal protein S1, RNA binding domain	0.0055	0.0139	0.0101
Schistosoma mansoni	biogenic amine receptor	0.0046	0.0084	0.0084
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.0084	0.0084
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0157	0.0788	0.0753
Schistosoma mansoni	nuclear hormone receptor	0.0055	0.0139	0.0139
Brugia malayi	photoreceptor-specific nuclear receptor	0.0055	0.0139	0.1767
Schistosoma mansoni	hypothetical protein	0.0037	0.0029	0.0029
Trichomonas vaginalis	porcupine, putative	0.0157	0.0788	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0055	0.0139	0.1767
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.0084	0.0084
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0092	0.0375	0.0375
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0157	0.0788	0.0753
Brugia malayi	RE15519p	0.0046	0.0084	0.1066
Echinococcus granulosus	biogenic amine 5HT receptor	0.0046	0.0084	0.0046
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0046	0.0084	0.0084
Schistosoma mansoni	amine GPCR	0.0046	0.0084	0.0084
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.0084	0.0046
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0055	0.0139	0.0102
Brugia malayi	hypothetical protein	0.0046	0.0084	0.1066
Echinococcus granulosus	expressed conserved protein	0.0085	0.0331	0.0294
Schistosoma mansoni	glutamate receptor kainate	0.0055	0.0139	0.0139
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0055	0.0139	0.0102
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0039	0.0038	0.0038
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0046	0.0084	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Brugia malayi	hypothetical protein	0.0046	0.0084	0.1066
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Echinococcus multilocularis	membrane bound acyltransferase:hhat	0.0157	0.0788	0.0753
Schistosoma mansoni	neuropeptide receptor	0.0046	0.0084	0.0084
Echinococcus granulosus	somatostatin receptor	0.0046	0.0084	0.0046
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0046	0.0084	0.0084
Loa Loa (eye worm)	glutamate receptor 1	0.0055	0.0139	0.0139
Echinococcus granulosus	Membrane bound O acyl transferase MBOAT	0.0157	0.0788	0.0753
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0046	0.0084	0.0084
Loa Loa (eye worm)	steroid hormone receptor	0.0055	0.0139	0.0139
Brugia malayi	AKH receptor	0.0046	0.0084	0.1066
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Echinococcus multilocularis	protein dispatched 1	0.0044	0.0073	0.0035
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0046	0.0084	0.1066
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0084	0.0084
Brugia malayi	steroid hormone receptor	0.0055	0.0139	0.1767
Loa Loa (eye worm)	membrane bound O-acyltransferase domain containing 1	0.0157	0.0788	0.0788
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	0.0157	0.0788	0.5
Onchocerca volvulus		0.0157	0.0788	1
Schistosoma mansoni	amine GPCR	0.0046	0.0084	0.0084
Schistosoma mansoni	opsin-like receptor	0.0046	0.0084	0.0084
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.0141	0.0682	0.5
Echinococcus multilocularis	fmrfamide receptor	0.0046	0.0084	0.0046
Brugia malayi	G protein-coupled receptor	0.0046	0.0084	0.1066
Onchocerca volvulus	Protein ultraspiracle homolog	0.0055	0.0139	0.0784
Schistosoma mansoni	RAR-like nuclear receptor	0.0055	0.0139	0.0139
Schistosoma mansoni	opsin-like receptor	0.0046	0.0084	0.0084
Brugia malayi	neuropeptide F receptor	0.0046	0.0084	0.1066
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0046	0.0084	0.0084
Brugia malayi	nuclear receptor NHR-88	0.0055	0.0139	0.1767
Echinococcus multilocularis	neuropeptide receptor A26	0.0046	0.0084	0.0046
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0046	0.0084	0.0084
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0055	0.0139	0.0139
Schistosoma mansoni	membrane-bound acyltransferase/hhat	0.0157	0.0788	0.0788
Schistosoma mansoni	hypothetical protein	0.0055	0.0139	0.0139
Echinococcus multilocularis	lysophospholipid acyltransferase 7	0.0157	0.0788	0.0753

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 5.1 nM	Displacement of [3H]CP 55940 from CB2 receptor in DBA/J2 mouse spleen	ChEMBL.	17004710
Ki (binding)	= 5.1 nM	Displacement of [3H]CP 55940 from CB2 receptor in DBA/J2 mouse spleen	ChEMBL.	17004710
Ki (binding)	= 143.2 nM	Displacement of [3H]CP 55940 from CB1 receptor in DBA/J2 mouse brain	ChEMBL.	17004710
Ki (binding)	= 143.2 nM	Displacement of [3H]CP 55940 from CB1 receptor in DBA/J2 mouse brain	ChEMBL.	17004710
Ratio Ki (binding)	= 28	Selectivity for DBA/J2 mouse CB2 receptor over CB1 receptor	ChEMBL.	17004710
Ratio Ki (binding)	= 28	Selectivity for DBA/J2 mouse CB2 receptor over CB1 receptor	ChEMBL.	17004710

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL217266
PubChem: 16086905

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 374323