TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 274.294 | Formula: C10H14N2O5S
H donors: 3 H acceptors: 4 LogP: -2.59 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1N)S(=O)(=O)CC(C(=O)O)N
InChi: 1S/C10H14N2O5S/c1-17-7-3-2-4-8(9(7)12)18(15,16)5-6(11)10(13)14/h2-4,6H,5,11-12H2,1H3,(H,13,14)
InChiKey: HLMSHWRCFFGBKU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0134	0.2345
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0251	0.0624	1
Trypanosoma cruzi	hexose transporter	0.0064	0.0134	0.1795
Giardia lamblia	Hexose transporter	0.0029	0.0043	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0153	0.0768
Plasmodium vivax	thrombospondin-related anonymous protein	0.0071	0.0153	0.1139
Echinococcus multilocularis	calcium dependent protein kinase	0.003	0.0045	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0027	0.0138
Toxoplasma gondii	protein kinase, putative	0.0295	0.0739	1
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0062	0.058
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0169	0.0408	0.3464
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0043	0.0464
Brugia malayi	von Willebrand Factor	0.0071	0.0153	0.0639
Trichomonas vaginalis	glucose transporter, putative	0.0064	0.0134	0.2345
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0134	0.2345
Brugia malayi	von Willebrand factor type A domain containing protein	0.0071	0.0153	0.0639
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0032	0.005	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0153	0.0768
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0043	0.0464
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Onchocerca volvulus		0.0071	0.0153	0.0472
Loa Loa (eye worm)	von Willebrand factor type A domain-containing protein	0.0071	0.0153	0.0768
Giardia lamblia	Prolyl-tRNA synthetase	0.0031	0.0048	0.0352
Schistosoma mansoni	sugar transporter	0.0029	0.0043	0.0035
Plasmodium vivax	von Willebrand factor A domain-related protein, putative	0.0071	0.0153	0.1139
Echinococcus multilocularis	voltage dependent calcium channel subunit	0.1742	0.453	0.4515
Schistosoma mansoni	hypothetical protein	0.09	0.2323	0.5319
Brugia malayi	hypothetical protein	0.0071	0.0153	0.0639
Schistosoma mansoni	sugar transporter	0.0029	0.0043	0.0035
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0048	0.0021
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0043	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0043	0.0214
Schistosoma mansoni	protein kinase	0.0032	0.005	0.0053
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0043	0.0077
Plasmodium falciparum	protein kinase 7	0.0295	0.0739	0.6471
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0032	0.005	0.0207
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0071	0.0153	0.0639
Brugia malayi	Zona pellucida-like domain containing protein	0.0071	0.0153	0.0639
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0134	0.1795
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0064	0.0134	0.1795
Onchocerca volvulus		0.0071	0.0153	0.0472
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0043	0.0077
Brugia malayi	Telomerase reverse transcriptase	0.0668	0.1716	0.8621
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0207	0.0509	0.0482
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0169	0.0408	0.5352
Brugia malayi	von Willebrand factor type A domain containing protein	0.0071	0.0153	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0043	0.0214
Echinococcus multilocularis	collagen alpha 1(VII) chain	0.0071	0.0153	0.0126
Brugia malayi	Zona pellucida-like domain containing protein	0.0071	0.0153	0.0639
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0029	0.0043	1
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0029	0.0043	0.0214
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0043	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0043	0.0214
Brugia malayi	von Willebrand factor type A domain containing protein	0.0071	0.0153	0.0639
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Toxoplasma gondii	facilitative glucose transporter GT1	0.0207	0.0509	0.6758
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Plasmodium vivax	hypothetical protein, conserved	0.0071	0.0153	0.1139
Loa Loa (eye worm)	sugar transporter	0.0029	0.0043	0.0214
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Echinococcus granulosus	voltage dependent calcium channel subunit	0.1742	0.453	0.4515
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0043	0.0214
Loa Loa (eye worm)	sugar transporter	0.0207	0.0509	0.256
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0153	0.0768
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0029	0.0043	0.0015
Leishmania major	glucose transporter, lmgt3	0.0064	0.0134	0.1795
Plasmodium falciparum	von Willebrand factor A domain-related protein	0.0071	0.0153	0.1139
Trypanosoma cruzi	glucose transporter, putative	0.0029	0.0043	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0043	0.0214
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Leishmania major	hypothetical protein, conserved	0.0029	0.0043	0.0254
Toxoplasma gondii	sugar transporter ST1	0.0029	0.0043	0.0213
Echinococcus granulosus	solute carrier family 22	0.0029	0.0043	0.0015
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Schistosoma mansoni	dihydropyridine-sensitive l-type calcium channel	0.0842	0.2173	0.4971
Echinococcus multilocularis	General substrate transporter	0.0178	0.0432	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0153	0.0768
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0029	0.0043	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0207	0.0509	0.0482
Toxoplasma gondii	sugar transporter ST2	0.0029	0.0043	0.0213
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0062	0.058
Entamoeba histolytica	hypothetical protein, conserved	0.0071	0.0153	1
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0134	0.1795
Trypanosoma cruzi	hexose transporter, putative	0.0064	0.0134	0.1795
Echinococcus granulosus	calcium dependent protein kinase	0.003	0.0045	0.0018
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0031	0.0048	0.0107
Toxoplasma gondii	von Willebrand factor type A domain-containing protein	0.0071	0.0153	0.1759
Echinococcus multilocularis	voltage dependent calcium channel subunit	0.383	1	1
Toxoplasma gondii	transporter, major facilitator family protein	0.0029	0.0043	0.0213
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0032	0.005	0.0207
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0043	0.0015
Toxoplasma gondii	microneme protein MIC2	0.0071	0.0153	0.1759
Plasmodium falciparum	thrombospondin-related anonymous protein	0.0071	0.0153	0.1139
Trypanosoma cruzi	hexose transporter, putative	0.0064	0.0134	0.1795
Echinococcus granulosus	solute carrier family 22	0.0029	0.0043	0.0015
Trichomonas vaginalis	conserved hypothetical protein	0.0207	0.0509	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0134	0.2345
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0043	0.0214
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0032	0.005	0.0381
Mycobacterium ulcerans	sugar transporter	0.0029	0.0043	1
Echinococcus granulosus	solute carrier family 22	0.0029	0.0043	0.0015
Brugia malayi	hypothetical protein	0.0029	0.0043	0.0077
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0062	0.058
Brugia malayi	von Willebrand factor type A domain containing protein	0.0071	0.0153	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0153	0.0768
Toxoplasma gondii	RNA-directed DNA polymerase	0.0251	0.0624	0.838
Brugia malayi	Cache domain containing protein	0.0771	0.1987	1
Brugia malayi	von Willebrand factor type A domain containing protein	0.0071	0.0153	0.0639
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0032	0.005	0.032
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0043	0.0214
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.005	0.0053
Entamoeba histolytica	hypothetical protein, conserved	0.0071	0.0153	1
Plasmodium vivax	hexose transporter	0.0207	0.0509	0.4373
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0029	0.0043	1
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0029	0.0043	0.0254
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0043	0.0464
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0048	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0043	0.0214
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0134	0.1795
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0031	0.0048	0.0584
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0031	0.0048	0.0107
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0207	0.0509	0.0482
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0134	0.2345
Trypanosoma brucei	telomerase reverse transcriptase	0.0251	0.0624	1
Plasmodium vivax	proline--tRNA ligase, putative	0.0037	0.0062	0.0315
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0032	0.005	0.032
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0032	0.005	0.0116
Brugia malayi	major facilitator superfamily protein	0.0029	0.0043	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0043	0.0214
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0064	0.0134	0.1795
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0031	0.0048	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0153	0.0768
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0043	0.0464
Brugia malayi	Sugar transporter family protein	0.0207	0.0509	0.2456
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0037	0.0062	0.0486
Onchocerca volvulus		0.0071	0.0153	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0153	0.0768
Plasmodium falciparum	telomerase reverse transcriptase	0.0251	0.0624	0.5423
Brugia malayi	Cam kinase protein 1	0.0032	0.005	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0043	0.0214
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0048	0.0244
Schistosoma mansoni	sugar transporter	0.0029	0.0043	0.0035
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0029	0.0043	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Trichomonas vaginalis	CAMK family protein kinase	0.0032	0.005	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0153	0.0768
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0027	0.0154
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0032	0.005	0.0252
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0048	0.0021
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0048	0.0049
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Echinococcus granulosus	solute carrier family 22	0.0029	0.0043	0.0015
Leishmania major	myo-inositol/proton symporter (MIT)	0.0029	0.0043	0.0254
Plasmodium vivax	sugar transporter, putative	0.0029	0.0043	0.0138
Trypanosoma brucei	glucose transporter 1E	0.0064	0.0134	0.1795
Brugia malayi	major facilitator superfamily protein	0.0029	0.0043	0.0077
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0064	0.0134	0.1795
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0032	0.005	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0153	0.0768
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0029	0.0043	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Schistosoma mansoni	sugar transporter	0.0029	0.0043	0.0035
Schistosoma mansoni	protein kinase	0.0032	0.005	0.0053
Plasmodium falciparum	circumsporozoite- and TRAP-related protein	0.0071	0.0153	0.1139
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0048	0.0244
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0064	0.0134	0.1795
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0443	0.1128	1
Plasmodium falciparum	hexose transporter	0.0207	0.0509	0.4373
Plasmodium vivax	circumsporozoite- and TRAP-related protein, putative	0.0071	0.0153	0.1139
Entamoeba histolytica	hypothetical protein	0.0071	0.0153	1
Treponema pallidum	hypothetical protein	0.0071	0.0153	0.5
Treponema pallidum	76K protein	0.0071	0.0153	0.5
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0071	0.0153	0.0639
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0207	0.0509	0.0482
Trichomonas vaginalis	glucose transporter, putative	0.0029	0.0043	0.0464
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0134	0.1795
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Giardia lamblia	Telomerase catalytic subunit	0.0251	0.0624	1
Trypanosoma cruzi	hexose transporter, putative	0.0064	0.0134	0.1795
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0153	0.0768
Loa Loa (eye worm)	CUTiclin-Like family member	0.0071	0.0153	0.0768
Echinococcus granulosus	General substrate transporter	0.0178	0.0432	0.0406
Loa Loa (eye worm)	von Willebrand factor domain-containing protein	0.0071	0.0153	0.0768
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Echinococcus granulosus	synaptic vesicle 2 protein	0.0029	0.0043	0.0015
Mycobacterium ulcerans	integral membrane transport protein	0.0029	0.0043	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Trypanosoma brucei	glucose transporter 2A	0.0064	0.0134	0.1795
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0043	0.0214
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0134	0.1795
Schistosoma mansoni	hypothetical protein	0.0071	0.0153	0.029
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Entamoeba histolytica	protein kinase, putative	0.0032	0.005	0.1813
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0153	0.0768
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0043	0.0077
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0032	0.005	0.032
Schistosoma mansoni	protein kinase	0.0032	0.005	0.0053
Brugia malayi	von Willebrand factor type A domain containing protein	0.0071	0.0153	0.0639
Loa Loa (eye worm)	CUTiclin family member	0.0071	0.0153	0.0768
Echinococcus granulosus	collagen alpha 1VII chain	0.0071	0.0153	0.0126
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0032	0.005	0.0207
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0134	0.1795
Loa Loa (eye worm)	hypothetical protein	0.0032	0.005	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0043	0.0214
Brugia malayi	von Willebrand factor type A domain containing protein	0.0071	0.0153	0.0639
Schistosoma mansoni	glucose transport protein	0.0207	0.0509	0.1115
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0032	0.005	0.0207
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.005	0.0023
Brugia malayi	Sugar transporter family protein	0.0029	0.0043	0.0077
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.005	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0043	0.0214
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.005	0.0023
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0032	0.005	0.0207
Schistosoma mansoni	hypothetical protein	0.0207	0.0509	0.1115
Onchocerca volvulus	Telomerase reverse transcriptase homolog	0.0919	0.2374	1
Trichomonas vaginalis	ubiquitin-conjugating enzyme E2, putative	0.0071	0.0153	0.2717
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0032	0.005	0.0207
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0134	0.1795
Giardia lamblia	Sugar-proton symporter	0.0029	0.0043	0.0254
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0029	0.0043	0.0035
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Trypanosoma cruzi	hexose transporter, putative	0.0029	0.0043	0.0254
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0062	0.058
Plasmodium falciparum	protein kinase 6	0.0443	0.1128	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0033	0.0166
Trichomonas vaginalis	myo-inositol transporter, putative	0.0029	0.0043	0.0464
Plasmodium vivax	telomerase reverse transcriptase, putative	0.0251	0.0624	0.5423
Brugia malayi	von Willebrand factor type A domain containing protein	0.0071	0.0153	0.0639
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0153	0.0768
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0043	0.0214
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0207	0.0509	0.0482
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.005	0.0023
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0062	0.058
Onchocerca volvulus		0.0071	0.0153	0.0472
Trypanosoma cruzi	sugar transporter, putative	0.0029	0.0043	0.0254
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0251	0.0624	1
Trypanosoma brucei	sugar transporter, putative	0.0029	0.0043	0.0254
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0134	0.2345
Trichomonas vaginalis	glucose transporter, putative	0.0064	0.0134	0.2345
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0031	0.0048	0.1677
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0032	0.005	0.0207
Brugia malayi	hypothetical protein	0.0029	0.0043	0.0077
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0027	0.3046
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0207	0.0509	0.0482
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0027	0.5
Leishmania major	glucose transporter, lmgt2	0.0064	0.0134	0.1795
Leishmania major	glucose transporter, lmgt1	0.0064	0.0134	0.1795
Loa Loa (eye worm)	hypothetical protein	0.0771	0.1987	1
Schistosoma mansoni	dihydropyridine-sensitive l-type calcium channel	0.1671	0.4343	1
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0029	0.0043	0.0138
Toxoplasma gondii	sugar transporter ST3	0.0029	0.0043	0.0213
Schistosoma mansoni	serine-rich repeat protein	0.09	0.2323	0.5319
Trichomonas vaginalis	sugar transport protein, putative	0.0029	0.0043	0.0464
Schistosoma mansoni	glucose transport protein	0.0207	0.0509	0.1115
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.005	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0153	0.0768
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0134	0.1795
Schistosoma mansoni	hypothetical protein	0.0071	0.0153	0.029
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0029	0.0043	0.0015
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.005	0.0023
Plasmodium vivax	dynein-related AAA-type ATPase, putative	0.0071	0.0153	0.1139
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0169	0.0408	0.3464
Brugia malayi	hypothetical protein	0.0029	0.0043	0.0077
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0058	0.0517
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0207	0.0509	0.0482
Entamoeba histolytica	protein kinase, putative	0.0032	0.005	0.1813
Brugia malayi	Sugar transporter family protein	0.0029	0.0043	0.0077
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0029	0.0043	0.0015
Onchocerca volvulus		0.0071	0.0153	0.0472
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0043	0.0015
Schistosoma mansoni	glucose transporter	0.0029	0.0043	0.0035
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0043	0.0464
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0032	0.005	0.0207
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.005	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0153	0.0768
Entamoeba histolytica	elongation factor-2 kinase, putative	0.0071	0.0153	1
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0032	0.005	0.0252
Leishmania major	telomerase reverse transcriptase, putative	0.0251	0.0624	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0043	0.0214
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0207	0.0509	0.0482
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0029	0.0043	0.0214
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Onchocerca volvulus		0.0071	0.0153	0.0472
Schistosoma mansoni	glucose transport protein	0.0207	0.0509	0.1115
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0043	0.0464
Plasmodium falciparum	proline--tRNA ligase	0.0037	0.0062	0.0315
Leishmania major	protein kinase, putative	0.0032	0.005	0.0381
Onchocerca volvulus		0.0071	0.0153	0.0472

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 29 uM	Compound was tested for the inhibition of mammalian kynureninase in rat liver	ChEMBL.	9871640
IC50 (binding)	= 29 uM	Compound was tested for the inhibition of mammalian kynureninase in rat liver	ChEMBL.	9871640

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 38295