Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | septate junction protein | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0322 | 1 | 0.5 |
Onchocerca volvulus | Slit protein homolog | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0214 | 0.0421 | 0.2452 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0214 | 0.0421 | 0.2452 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0214 | 0.0421 | 0.2452 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0214 | 0.0421 | 0.2452 |
Giardia lamblia | High cysteine protein | 0.0214 | 0.0421 | 0.5 |
Echinococcus granulosus | protein jagged 2 | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Echinococcus granulosus | notch | 0.0214 | 0.0421 | 0.2452 |
Onchocerca volvulus | 0.0214 | 0.0421 | 0.2452 | |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Brugia malayi | EGF-like domain containing protein | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Mycobacterium ulcerans | thymidylate synthase | 0.0229 | 0.1716 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0322 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0322 | 1 | 0.5 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | notch | 0.0214 | 0.0421 | 0.2452 |
Echinococcus granulosus | neural cadherin | 0.0214 | 0.0421 | 0.2452 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0214 | 0.0421 | 0.0421 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0214 | 0.0421 | 0.2452 |
Onchocerca volvulus | 0.0214 | 0.0421 | 0.2452 | |
Brugia malayi | Muscle positioning protein 4 | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | thymidylate synthase | 0.0229 | 0.1716 | 1 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Brugia malayi | notch-like transmembrane receptor | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Echinococcus multilocularis | fibropellin Ia | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0229 | 0.1716 | 1 |
Brugia malayi | Cadherin domain containing protein | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | notch | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Brugia malayi | thymidylate synthase | 0.0229 | 0.1716 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0214 | 0.0421 | 0.2452 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0214 | 0.0421 | 0.2452 |
Echinococcus granulosus | protein jagged 1 | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | notch | 0.0214 | 0.0421 | 0.2452 |
Echinococcus granulosus | fibropellin Ia | 0.0214 | 0.0421 | 0.2452 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0214 | 0.0421 | 0.2452 |
Onchocerca volvulus | Putative cubilin | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | notch | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | slit | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Brugia malayi | EGF-like domain containing protein | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | Notch2 | 0.0214 | 0.0421 | 0.2452 |
Brugia malayi | EGF-like domain containing protein | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Echinococcus multilocularis | slit 2 protein | 0.0214 | 0.0421 | 0.2452 |
Onchocerca volvulus | 0.0214 | 0.0421 | 0.2452 | |
Echinococcus granulosus | delta-like protein 1 | 0.0214 | 0.0421 | 0.2452 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0229 | 0.1716 | 0.5 |
Onchocerca volvulus | 0.0214 | 0.0421 | 0.2452 | |
Schistosoma mansoni | cell polarity protein | 0.0214 | 0.0421 | 0.2452 |
Brugia malayi | Cadherin domain containing protein | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0322 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Echinococcus granulosus | thymidylate synthase | 0.0229 | 0.1716 | 1 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0214 | 0.0421 | 0.2452 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0214 | 0.0421 | 0.2452 |
Echinococcus granulosus | slit 2 protein | 0.0214 | 0.0421 | 0.2452 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0214 | 0.0421 | 0.2452 |
Echinococcus multilocularis | protein jagged 2 | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Onchocerca volvulus | 0.0229 | 0.1716 | 1 | |
Schistosoma mansoni | notch | 0.0214 | 0.0421 | 0.2452 |
Onchocerca volvulus | 0.0214 | 0.0421 | 0.2452 | |
Brugia malayi | EGF-like domain containing protein | 0.0214 | 0.0421 | 0.2452 |
Echinococcus multilocularis | protein jagged 1 | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0214 | 0.0421 | 0.2452 |
Echinococcus multilocularis | thymidylate synthase | 0.0229 | 0.1716 | 1 |
Brugia malayi | Delta serrate ligand family protein | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Brugia malayi | EGF-like domain containing protein | 0.0214 | 0.0421 | 0.2452 |
Echinococcus multilocularis | neural cadherin | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | notch | 0.0214 | 0.0421 | 0.2452 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0322 | 1 | 0.5 |
Brugia malayi | EGF-like domain containing protein | 0.0214 | 0.0421 | 0.2452 |
Echinococcus granulosus | protein jagged 2 | 0.0214 | 0.0421 | 0.2452 |
Echinococcus multilocularis | notch | 0.0214 | 0.0421 | 0.2452 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0229 | 0.1716 | 0.5 |
Echinococcus multilocularis | protein jagged 1 | 0.0214 | 0.0421 | 0.2452 |
Echinococcus granulosus | protein jagged 1 | 0.0214 | 0.0421 | 0.2452 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0214 | 0.0421 | 0.2452 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0214 | 0.0421 | 0.2452 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | notch protein | 0.0214 | 0.0421 | 0.2452 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Counts (functional) | = 22.9 min-1 | Ability to cause loss of righting reflex in mice represented as no. of counts for each animal for a total of 90 min when 100 mg/kg dose was administered intraperitoneally | ChEMBL. | 4032437 |
Counts (functional) | = 22.9 min-1 | Ability to cause loss of righting reflex in mice represented as no. of counts for each animal for a total of 90 min when 100 mg/kg dose was administered intraperitoneally | ChEMBL. | 4032437 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.