Detailed information for compound 400332

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1877.64 | Formula: C88H95Cl2N9O33
  • H donors: 24 H acceptors: 24 LogP: -0.2 Rotable bonds: 21
    Rule of 5 violations (Lipinski): 4
  • SMILES: CCCCC/C=C/CCC(=O)NC1C(OC(C(C1O)O)CO)Oc1c2cc3cc1Oc1ccc(cc1Cl)C[C@H]1C(=O)N[C@@H](C(=O)N[C@@H]3C(=O)N[C@@H]3C(=O)N[C@H]([C@H](c4ccc(O2)c(Cl)c4)OC2OC(CO)C(C(C2NC(=O)C)O)O)C(=O)N[C@H](c2c(c4cc3ccc4O)c(cc(c2)O)OC2OC(CO)C(C(C2O)O)O)C(=O)O)c2cc(O)cc(c2)Oc2cc([C@@H](C(=O)N1)N)ccc2O
  • InChi: 1S/C88H95Cl2N9O33/c1-3-4-5-6-7-8-9-10-60(108)94-68-74(113)71(110)58(32-101)129-87(68)132-78-55-26-40-27-56(78)126-52-18-14-38(24-47(52)90)77(131-86-67(92-34(2)103)73(112)70(109)57(31-100)128-86)69-84(121)98-66(85(122)123)45-29-42(105)30-54(127-88-76(115)75(114)72(111)59(33-102)130-88)61(45)44-23-37(13-15-49(44)106)63(81(118)99-69)96-83(120)65(40)97-82(119)64-39-21-41(104)28-43(22-39)124-53-25-36(12-16-50(53)107)62(91)80(117)93-48(79(116)95-64)20-35-11-17-51(125-55)46(89)19-35/h7-8,11-19,21-30,48,57-59,62-77,86-88,100-102,104-107,109-115H,3-6,9-10,20,31-33,91H2,1-2H3,(H,92,103)(H,93,117)(H,94,108)(H,95,116)(H,96,120)(H,97,119)(H,98,121)(H,99,118)(H,122,123)/b8-7+/t48-,57?,58?,59?,62-,63-,64+,65-,66+,67?,68?,69+,70?,71?,72?,73?,74?,75?,76?,77-,86?,87?,88?/m1/s1
  • InChiKey: YMWQIYMUNZBOOV-MGKYNHEVSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0957 0.2691 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Entamoeba histolytica protein kinase, putative 0.007 0.0144 1
Loa Loa (eye worm) TK/ALK protein kinase 0.007 0.0144 0.5807
Schistosoma mansoni protein kinase 0.007 0.0144 0.3362
Entamoeba histolytica hypothetical protein 0.007 0.0144 1
Plasmodium falciparum tyrosine kinase-like protein 0.007 0.0144 0.0477
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0144 0.5807
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Echinococcus multilocularis c src tyrosine kinase 0.007 0.0144 0.0978
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.007 0.0144 0.0978
Schistosoma mansoni serine/threonine RGC 0.007 0.0144 0.3362
Echinococcus multilocularis tyrosine protein kinase Fgr 0.007 0.0144 0.0978
Echinococcus multilocularis tyrosine protein kinase csk 0.007 0.0144 0.0978
Plasmodium falciparum telomerase reverse transcriptase 0.0957 0.2691 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.007 0.0144 0.0978
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Loa Loa (eye worm) inositol-1 0.0037 0.005 0.1919
Schistosoma mansoni protein tyrosine kinase 0.007 0.0144 0.3362
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0144 0.5807
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Echinococcus granulosus tyrosine protein kinase Blk 0.007 0.0144 0.0978
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Loa Loa (eye worm) TK/CSK protein kinase 0.007 0.0144 0.5807
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.007 0.0144 0.5807
Entamoeba histolytica ankyrin repeat protein 0.007 0.0144 1
Leishmania major hypothetical protein, conserved 0.007 0.0144 0.0477
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Leishmania major telomerase reverse transcriptase, putative 0.0957 0.2691 1
Loa Loa (eye worm) TK protein kinase 0.007 0.0144 0.5807
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Echinococcus multilocularis p2X purinoceptor 4 0.0067 0.0138 0.0937
Entamoeba histolytica protein kinase domain containing protein 0.007 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.017 0.6901
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.007 0.0144 0.0477
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0125 0.292
Entamoeba histolytica tyrosine kinase, putative 0.007 0.0144 1
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.007 0.0144 0.0978
Echinococcus granulosus activated cdc42 kinase 1 0.007 0.0144 0.0978
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0144 0.5807
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0085 0.0187 0.4374
Loa Loa (eye worm) RGC/RGC protein kinase 0.007 0.0144 0.5807
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.007 0.0144 0.0978
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.007 0.0144 0.5807
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.007 0.0144 1
Echinococcus granulosus tyrosine protein kinase csk 0.007 0.0144 0.0978
Echinococcus multilocularis epidermal growth factor receptor 0.007 0.0144 0.0978
Echinococcus granulosus tyrosine protein kinase Srms 0.007 0.0144 0.0978
Loa Loa (eye worm) RGC/RGC protein kinase 0.007 0.0144 0.5807
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.007 0.0144 0.0978
Entamoeba histolytica hypothetical protein 0.007 0.0144 1
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0144 0.5807
Echinococcus granulosus p2X purinoceptor 4 0.0067 0.0138 0.0937
Entamoeba histolytica protein kinase domain containing protein 0.007 0.0144 1
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.007 0.0144 1
Entamoeba histolytica protein kinase domain containing protein 0.007 0.0144 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.007 0.0144 1
Trichomonas vaginalis CAMK family protein kinase 0.007 0.0144 1
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.007 0.0144 0.5807
Schistosoma mansoni src-type protein tyrosine kinase-related 0.007 0.0144 0.3362
Loa Loa (eye worm) hypothetical protein 0.007 0.0144 0.5807
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0125 0.0151
Entamoeba histolytica cysteine surface protein, putative 0.007 0.0144 1
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.007 0.0144 1
Loa Loa (eye worm) TK protein kinase 0.007 0.0144 0.5807
Schistosoma mansoni tyrosine protein kinase 0.007 0.0144 0.3362
Brugia malayi Telomerase reverse transcriptase 0.2546 0.7253 1
Echinococcus multilocularis integrin linked protein kinase 0.007 0.0144 0.0978
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0144 0.3362
Giardia lamblia Telomerase catalytic subunit 0.0957 0.2691 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0047 0.0317
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0144 0.5807
Echinococcus granulosus protein tyrosine kinase 0.007 0.0144 0.0978
Loa Loa (eye worm) TK/KIN6 protein kinase 0.007 0.0144 0.5807
Schistosoma mansoni P2X receptor subunit 0.0067 0.0138 0.3223
Echinococcus multilocularis activated cdc42 kinase 1 0.007 0.0144 0.0978
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Entamoeba histolytica protein kinase, putative 0.007 0.0144 1
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Entamoeba histolytica protein kinase, putative 0.007 0.0144 1
Loa Loa (eye worm) TK/FAK protein kinase 0.007 0.0144 0.5807
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0144 0.5807
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.005 0.0125
Entamoeba histolytica protein kinase domain containing protein 0.007 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.0245 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Echinococcus granulosus fibroblast growth factor receptor 4 0.007 0.0144 0.0978
Loa Loa (eye worm) hypothetical protein 0.0085 0.0187 0.7593
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Entamoeba histolytica tyrosine kinase, putative 0.007 0.0144 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.007 0.0144 0.0978
Entamoeba histolytica serine/threonine kinase, putative 0.007 0.0144 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0125 0.5028
Brugia malayi Raf kinase 0.007 0.0144 0.0178
Entamoeba histolytica hypothetical protein, conserved 0.007 0.0144 1
Loa Loa (eye worm) TK protein kinase 0.007 0.0144 0.5807
Schistosoma mansoni P2X receptor subunit 0.0067 0.0138 0.3223
Loa Loa (eye worm) TK/EPH protein kinase 0.007 0.0144 0.5807
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Schistosoma mansoni P2X receptor subunit 0.0067 0.0138 0.3223
Echinococcus multilocularis epidermal growth factor receptor 0.007 0.0144 0.0978
Entamoeba histolytica protein kinase, putative 0.007 0.0144 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.007 0.0144 0.0978
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Loa Loa (eye worm) TK/DDR protein kinase 0.007 0.0144 0.5807
Echinococcus multilocularis tyrosine protein kinase Fyn 0.007 0.0144 0.0978
Entamoeba histolytica tyrosine kinase, putative 0.007 0.0144 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Entamoeba histolytica protein kinase, putative 0.007 0.0144 1
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0144 0.5807
Entamoeba histolytica protein kinase domain containing protein 0.007 0.0144 1
Echinococcus multilocularis fibroblast growth factor receptor 4 0.007 0.0144 0.0978
Echinococcus multilocularis retinal guanylyl cyclase 2 0.007 0.0144 0.0978
Loa Loa (eye worm) hypothetical protein 0.007 0.0144 0.5807
Brugia malayi Bromodomain containing protein 0.0038 0.0053 0.0053
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Loa Loa (eye worm) TK/Met protein kinase 0.007 0.0144 0.5807
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Entamoeba histolytica protein kinase domain containing protein 0.007 0.0144 1
Brugia malayi C-terminal src kinase protein 1 0.007 0.0144 0.0178
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.007 0.0144 0.0978
Schistosoma mansoni hypothetical protein 0.0168 0.0428 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Entamoeba histolytica tyrosin kinase, putative 0.007 0.0144 1
Entamoeba histolytica protein kinase domain containing protein 0.007 0.0144 1
Entamoeba histolytica protein kinase domain containing protein 0.007 0.0144 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.007 0.0144 0.0978
Echinococcus granulosus activin receptor type 0.007 0.0144 0.0978
Echinococcus granulosus tyrosine protein kinase shark 0.007 0.0144 0.0978
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0008 0.0198
Entamoeba histolytica protein kinase domain containing protein 0.007 0.0144 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0144 0.3362
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.007 0.0144 1
Loa Loa (eye worm) RNA binding protein 0.0063 0.0125 0.5028
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Echinococcus granulosus tyrosine protein kinase HCK 0.007 0.0144 0.0978
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0144 0.5807
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0144 1
Brugia malayi Guanylyl cyclase protein 23 0.007 0.0144 0.0178
Loa Loa (eye worm) RGC/RGC protein kinase 0.007 0.0144 0.5807
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Entamoeba histolytica tyrosine kinase, putative 0.007 0.0144 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.007 0.0144 1
Echinococcus granulosus tar DNA binding protein 0.0063 0.0125 0.0849
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.007 0.0144 0.0978
Brugia malayi SH2 domain containing protein 0.007 0.0144 0.0178
Echinococcus granulosus receptor type guanylyl cyclase 0.007 0.0144 0.0978
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Loa Loa (eye worm) hypothetical protein 0.007 0.0144 0.5807
Schistosoma mansoni tyrosine-protein kinase fps85d 0.007 0.0144 0.3362
Loa Loa (eye worm) hypothetical protein 0.007 0.0144 0.5807
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0144 0.5807
Entamoeba histolytica protein kinase, putative 0.007 0.0144 1
Brugia malayi protein-tyrosine kinase 0.007 0.0144 0.0178
Brugia malayi Furin-like cysteine rich region family protein 0.007 0.0144 0.0178
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.007 0.0144 0.0978
Loa Loa (eye worm) TK protein kinase 0.007 0.0144 0.5807
Echinococcus granulosus tyrosine kinase 0.007 0.0144 0.0978
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Echinococcus multilocularis dual specificity testis specific protein kinase 0.007 0.0144 0.0978
Entamoeba histolytica serine/threonine kinase, putative 0.007 0.0144 1
Echinococcus granulosus natriuretic peptide receptor 1 0.007 0.0144 0.0978
Echinococcus multilocularis tyrosine protein kinase csk 0.007 0.0144 0.0978
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.007 0.0144 0.0978
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Echinococcus granulosus tyrosine kinase 0.007 0.0144 0.0978
Echinococcus granulosus tyrosine protein kinase ABL1 0.007 0.0144 0.0978
Toxoplasma gondii protein kinase domain-containing protein 0.007 0.0144 0.0477
Entamoeba histolytica tyrosine kinase, putative 0.007 0.0144 1
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Onchocerca volvulus 0.0085 0.0187 0.0044
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Echinococcus multilocularis tyrosine protein kinase pr2 0.007 0.0144 0.0978
Loa Loa (eye worm) TK protein kinase 0.007 0.0144 0.5807
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.007 0.0144 0.5807
Entamoeba histolytica protein kinase domain containing protein 0.007 0.0144 1
Echinococcus multilocularis protection of telomeres protein 1 0.0531 0.147 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Entamoeba histolytica protein kinase, putative 0.007 0.0144 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.005 0.0125
Plasmodium falciparum protein kinase, putative 0.007 0.0144 0.0477
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Echinococcus granulosus p2X purinoceptor 4 0.0067 0.0138 0.0937
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.005 0.5
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0066 0.2591
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.007 0.0144 0.0477
Echinococcus granulosus tyrosine protein kinase Src64B 0.007 0.0144 0.0978
Trypanosoma cruzi protein kinase, putative 0.007 0.0144 0.0477
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.007 0.0144 0.5807
Echinococcus multilocularis protein kinase 0.007 0.0144 0.0978
Entamoeba histolytica hypothetical protein 0.007 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0144 0.5807
Echinococcus granulosus epidermal growth factor receptor 0.007 0.0144 0.0978
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.007 0.0144 0.0978
Loa Loa (eye worm) hypothetical protein 0.004 0.006 0.2367
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Entamoeba histolytica protein kinase, putative 0.007 0.0144 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0085 0.0187 0.4374
Leishmania major protein kinase, putative 0.007 0.0144 0.0477
Entamoeba histolytica tyrosine kinase, putative 0.007 0.0144 1
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0957 0.2691 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.007 0.0144 1
Brugia malayi Receptor family ligand binding region containing protein 0.007 0.0144 0.0178
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.007 0.0144 1
Entamoeba histolytica protein kinase domain containing protein 0.007 0.0144 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.007 0.0144 1
Echinococcus granulosus tyrosine protein kinase pr2 0.007 0.0144 0.0978
Echinococcus granulosus insulin receptor 0.007 0.0144 0.0978
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Entamoeba histolytica receptor protein kinase, putative 0.007 0.0144 1
Loa Loa (eye worm) TK/ROR protein kinase 0.007 0.0144 0.5807
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.007 0.0144 0.0477
Entamoeba histolytica hypothetical protein 0.007 0.0144 1
Echinococcus multilocularis tyrosine protein kinase csk 0.007 0.0144 0.0978
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0047 0.0317
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0538
Echinococcus multilocularis heat shock protein 70 0.007 0.0144 0.0978
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.007 0.0144 0.3362
Entamoeba histolytica hypothetical protein 0.007 0.0144 1
Entamoeba histolytica hypothetical protein 0.007 0.0144 1
Entamoeba histolytica tyrosine kinase, putative 0.007 0.0144 1
Echinococcus granulosus tyrosine protein kinase 0.007 0.0144 0.0978
Loa Loa (eye worm) TK protein kinase 0.007 0.0144 0.5807
Loa Loa (eye worm) TK/ACK protein kinase 0.007 0.0144 0.5807
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Brugia malayi Inositol-1 0.0037 0.005 0.0047
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.005 0.0125
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.005 0.0125
Loa Loa (eye worm) hypothetical protein 0.007 0.0146 0.5896
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.005 0.0337
Brugia malayi hypothetical protein 0.007 0.0144 0.0178
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0008 0.0058
Entamoeba histolytica tyrosine kinase, putative 0.007 0.0144 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.007 0.0144 1
Entamoeba histolytica tyrosine kinase, putative 0.007 0.0144 1
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Entamoeba histolytica hypothetical protein 0.007 0.0144 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.007 0.0144 1
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Schistosoma mansoni protein kinase 0.007 0.0144 0.3362
Echinococcus granulosus retinal guanylyl cyclase 2 0.007 0.0144 0.0978
Entamoeba histolytica protein kinase, putative 0.007 0.0144 1
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0125 0.292
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0008 0.0058
Schistosoma mansoni bromodomain containing protein 0.0063 0.0125 0.2916
Echinococcus multilocularis tyrosine protein kinase csk 0.007 0.0144 0.0978
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.007 0.0144 0.0978
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.005 0.0125
Schistosoma mansoni hypothetical protein 0.0105 0.0245 0.5738
Echinococcus multilocularis p2X purinoceptor 4 0.0067 0.0138 0.0937
Plasmodium vivax protein kinase, putative 0.007 0.0144 0.0477
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.007 0.0144 0.0978
Loa Loa (eye worm) TK protein kinase 0.007 0.0144 0.5807
Schistosoma mansoni protein kinase 0.007 0.0144 0.3362
Echinococcus multilocularis p2X purinoceptor 4 0.0067 0.0138 0.0937
Schistosoma mansoni inositol monophosphatase 0.0037 0.005 0.1158
Loa Loa (eye worm) hypothetical protein 0.007 0.0144 0.5807
Toxoplasma gondii protein kinase 0.007 0.0144 0.0477
Entamoeba histolytica hypothetical protein 0.007 0.0144 1
Echinococcus granulosus tyrosine protein kinase csk 0.007 0.0144 0.0978
Entamoeba histolytica tyrosine kinase, putative 0.007 0.0144 1
Trichomonas vaginalis TK family protein kinase 0.007 0.0144 1
Schistosoma mansoni protein kinase 0.007 0.0144 0.3362
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Echinococcus multilocularis receptor type guanylyl cyclase 0.007 0.0144 0.0978
Loa Loa (eye worm) TK/EGFR protein kinase 0.007 0.0144 0.5807
Brugia malayi Cation transporter family protein 0.0085 0.0187 0.0237
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.007 0.0144 0.3362
Loa Loa (eye worm) TK protein kinase 0.007 0.0144 0.5807
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0125 0.292
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.007 0.0144 0.0978
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.007 0.0144 0.0178
Loa Loa (eye worm) TK/INSR protein kinase 0.007 0.0144 0.5807
Echinococcus granulosus protection of telomeres protein 1 0.0531 0.147 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.007 0.0144 0.0978
Entamoeba histolytica protein kinase domain containing protein 0.007 0.0144 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Entamoeba histolytica protein kinase domain containing protein 0.007 0.0144 1
Schistosoma mansoni protein kinase 0.007 0.0144 0.3362
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0144 0.5807
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0144 1
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.007 0.0144 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.007 0.0144 0.0978
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0125 0.0849
Echinococcus granulosus tyrosine protein kinase csk 0.007 0.0144 0.0978
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Entamoeba histolytica protein kinase domain containing protein 0.007 0.0144 1
Loa Loa (eye worm) serine/threonine protein kinase 0.007 0.0144 0.5807
Brugia malayi Tyrosine-protein kinase PR2 0.007 0.0144 0.0178
Echinococcus multilocularis tyrosine protein kinase Src42A 0.007 0.0144 0.0978
Brugia malayi hypothetical protein 0.0105 0.0245 0.0318
Echinococcus multilocularis tyrosine protein kinase Abl 0.007 0.0144 0.0978
Loa Loa (eye worm) hypothetical protein 0.0038 0.0054 0.2088
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.007 0.0144 0.0477
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.007 0.0144 1
Echinococcus granulosus c src tyrosine kinase 0.007 0.0144 0.0978
Echinococcus granulosus tyrosine protein kinase Btk29A 0.007 0.0144 0.0978
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.007 0.0144 1
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.007 0.0144 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.007 0.0144 0.3362
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0125 0.292
Brugia malayi TAR-binding protein 0.0063 0.0125 0.0151
Echinococcus multilocularis raf serine:threonine protein kinase 0.007 0.0144 0.0978
Entamoeba histolytica tyrosine kinase, putative 0.007 0.0144 1
Echinococcus granulosus geminin 0.0168 0.0428 0.2908
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.007 0.0144 0.0978
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Schistosoma mansoni protein kinase 0.007 0.0144 0.3362
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.007 0.0144 0.0978
Echinococcus granulosus integrin linked protein kinase 0.007 0.0144 0.0978
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.007 0.0144 0.0477
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Trichomonas vaginalis protein kinase atn1, putative 0.007 0.0144 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.007 0.0144 0.0978
Loa Loa (eye worm) hypothetical protein 0.007 0.0144 0.5807
Brugia malayi SRC-1 0.007 0.0144 0.0178
Trypanosoma cruzi protein kinase, putative 0.007 0.0144 0.0477
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Echinococcus granulosus kinase suppressor of Ras 1 0.007 0.0144 0.0978
Loa Loa (eye worm) hypothetical protein 0.0105 0.0245 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.007 0.0144 0.0978
Entamoeba histolytica serine/threonine kinase, putative 0.007 0.0144 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.007 0.0144 0.0978
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.007 0.0144 0.0978
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0144 0.5807
Trichomonas vaginalis serine-threonine protein kinase, putative 0.007 0.0144 1
Entamoeba histolytica protein kinase, putative 0.007 0.0144 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.007 0.0144 0.0978
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Entamoeba histolytica protein kinase domain containing protein 0.007 0.0144 1
Echinococcus multilocularis tyrosine protein kinase shark 0.007 0.0144 0.0978
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.007 0.0144 1
Loa Loa (eye worm) TK/RYK protein kinase 0.007 0.0144 0.5807
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.007 0.0144 0.0978
Plasmodium vivax telomerase reverse transcriptase, putative 0.0957 0.2691 1
Entamoeba histolytica protein kinase, putative 0.007 0.0144 1
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0144 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0038 0.5
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.005 0.0337
Leishmania major protein kinase, putative 0.007 0.0144 0.0477
Loa Loa (eye worm) TK protein kinase 0.007 0.0144 0.5807
Entamoeba histolytica tyrosin kinase, putative 0.007 0.0144 1
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0144 0.5807
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0114 0.0779
Brugia malayi hypothetical protein 0.007 0.0144 0.0178
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Entamoeba histolytica protein kinase, putative 0.007 0.0144 1
Entamoeba histolytica serine/threonine kinase, putative 0.007 0.0144 1
Trypanosoma brucei Flagellum attachment zone protein 20 0.007 0.0144 0.0477
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.007 0.0144 0.0978
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.007 0.0144 0.5807
Schistosoma mansoni protein kinase 0.007 0.0144 0.3362
Echinococcus granulosus epidermal growth factor receptor 0.007 0.0144 0.0978
Echinococcus multilocularis tyrosine protein kinase Src64B 0.007 0.0144 0.0978
Entamoeba histolytica receptor protein kinase, putative 0.007 0.0144 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.007 0.0144 0.0178
Entamoeba histolytica protein kinase, putative 0.007 0.0144 1
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0144 0.3362
Echinococcus multilocularis tyrosine protein kinase HCK 0.007 0.0144 0.0978
Trichomonas vaginalis STE family protein kinase 0.007 0.0144 1
Echinococcus granulosus raf serine:threonine protein kinase 0.007 0.0144 0.0978
Echinococcus granulosus tyrosine kinase 0.007 0.0144 0.0978
Echinococcus granulosus protein kinase 0.007 0.0144 0.0978
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.007 0.0144 1
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.007 0.0144 0.0477
Loa Loa (eye worm) hypothetical protein 0.007 0.0144 0.5807
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Entamoeba histolytica tyrosine kinase, putative 0.007 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0144 0.5807
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Echinococcus multilocularis protein kinase 0.007 0.0144 0.0978
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.007 0.0144 0.5807
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0114 0.0779
Entamoeba histolytica serine/threonine kinase, putative 0.007 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0144 0.5807
Brugia malayi Bromodomain containing protein 0.0075 0.0158 0.0197
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Echinococcus granulosus activated cdc42 kinase 1 0.007 0.0144 0.0978
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Schistosoma mansoni hypothetical protein 0.0021 0.0003 0.0071
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.007 0.0144 0.0978
Echinococcus multilocularis activin receptor type 0.007 0.0144 0.0978
Entamoeba histolytica protein kinase, putative 0.007 0.0144 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Echinococcus multilocularis tyrosine protein kinase 0.007 0.0144 0.0978
Loa Loa (eye worm) hypothetical protein 0.007 0.0144 0.5807
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0144 0.3362
Echinococcus multilocularis transfer RNA-Thr 0.007 0.0144 0.0978
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.007 0.0144 0.3362
Entamoeba histolytica hypothetical protein 0.007 0.0144 1
Brugia malayi hypothetical protein 0.0025 0.0016 0.0001
Echinococcus granulosus tyrosine protein kinase Fyn 0.007 0.0144 0.0978
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Entamoeba histolytica protein kinase domain containing protein 0.007 0.0144 1
Echinococcus multilocularis insulin receptor 0.007 0.0144 0.0978
Brugia malayi Tyrosine-protein kinase abl-1 0.007 0.0144 0.0178
Schistosoma mansoni ephrin receptor 0.007 0.0144 0.3362
Loa Loa (eye worm) hypothetical protein 0.007 0.0144 0.5807
Loa Loa (eye worm) hypothetical protein 0.007 0.0144 0.5807
Echinococcus granulosus ephrin type A receptor 4 A 0.007 0.0144 0.0978
Echinococcus granulosus dual specificity testis-specific protein kinase 0.007 0.0144 0.0978
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.005 0.5
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Entamoeba histolytica protein kinase, putative 0.007 0.0144 1
Plasmodium falciparum protein kinase, putative 0.007 0.0144 0.0477
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Schistosoma mansoni protein kinase 0.007 0.0144 0.3362
Schistosoma mansoni hypothetical protein 0.007 0.0144 0.3362
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0144 1
Brugia malayi hypothetical protein 0.007 0.0144 0.0178
Entamoeba histolytica tyrosin kinase, putative 0.007 0.0144 1
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Trypanosoma brucei telomerase reverse transcriptase 0.0957 0.2691 1
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Schistosoma mansoni tyrosine-protein kinase fps85d 0.007 0.0144 0.3362
Echinococcus granulosus p2X purinoceptor 4 0.0067 0.0138 0.0937
Echinococcus multilocularis FL cytokine receptor 0.007 0.0144 0.0978
Loa Loa (eye worm) SRC-1 0.007 0.0144 0.5807
Entamoeba histolytica hypothetical protein 0.007 0.0144 1
Schistosoma mansoni tyrosine kinase 0.007 0.0144 0.3362
Plasmodium falciparum protein kinase, putative 0.007 0.0144 0.0477
Entamoeba histolytica protein kinase domain containing protein 0.007 0.0144 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.007 0.0144 0.0178
Brugia malayi Immunoglobulin I-set domain containing protein 0.007 0.0144 0.0178
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Echinococcus multilocularis tyrosine kinase 0.007 0.0144 0.0978
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Toxoplasma gondii STE kinase 0.007 0.0144 0.0477
Entamoeba histolytica protein kinase domain containing protein 0.007 0.0144 1
Echinococcus multilocularis tyrosine kinase 0.007 0.0144 0.0978
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.007 0.0144 0.0978
Echinococcus multilocularis protein tyrosine kinase 0.007 0.0144 0.0978
Entamoeba histolytica tyrosine kinase, putative 0.007 0.0144 1
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0144 0.5807
Entamoeba histolytica protein kinase, putative 0.007 0.0144 1
Schistosoma mansoni protein kinase 0.007 0.0144 0.3362
Echinococcus multilocularis geminin 0.0168 0.0428 0.2908
Entamoeba histolytica protein kinase, putative 0.007 0.0144 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Trypanosoma brucei Pseudokinase, putative 0.007 0.0144 0.0477
Brugia malayi RNA binding protein 0.0063 0.0125 0.0151
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Entamoeba histolytica ankyrin repeat protein 0.007 0.0144 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.007 0.0144 0.0978
Echinococcus multilocularis natriuretic peptide receptor 1 0.007 0.0144 0.0978
Brugia malayi integrin-linked kinase 0.007 0.0144 0.0178
Plasmodium vivax tyrosine kinase-like protein, putative 0.007 0.0144 0.0477
Brugia malayi Immunoglobulin I-set domain containing protein 0.007 0.0144 0.0178
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.007 0.0144 1
Entamoeba histolytica tyrosin kinase, putative 0.007 0.0144 1
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0144 0.5807
Schistosoma mansoni protein kinase 0.007 0.0144 0.3362
Onchocerca volvulus 0.0085 0.0187 0.0044
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.005 0.1158
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.007 0.0144 0.0178
Echinococcus multilocularis tyrosine protein kinase Fyn 0.007 0.0144 0.0978
Schistosoma mansoni P2X receptor subunit 0.0067 0.0138 0.3223
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.007 0.0144 1
Plasmodium falciparum tyrosine kinase-like protein 0.007 0.0144 0.0477
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0038 0.5
Echinococcus multilocularis protein KINase family member (kin 25) 0.007 0.0144 0.0978
Echinococcus granulosus tyrosine protein kinase Btk29A 0.007 0.0144 0.0978
Onchocerca volvulus 0.0085 0.0187 0.0044
Schistosoma mansoni hypothetical protein 0.0168 0.0428 1
Echinococcus multilocularis ephrin type A receptor 4 A 0.007 0.0144 0.0978
Entamoeba histolytica tyrosine kinase, putative 0.007 0.0144 1
Entamoeba histolytica protein kinase domain containing protein 0.007 0.0144 1
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0144 0.5807
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.007 0.0144 0.5807
Brugia malayi ephrin receptor 1 precursor 0.007 0.0144 0.0178
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.007 0.0144 0.0978
Brugia malayi hypothetical protein 0.0105 0.0245 0.0318
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0144 0.5807
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.007 0.0144 0.0978
Toxoplasma gondii RNA-directed DNA polymerase 0.0957 0.2691 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0125 0.292
Brugia malayi Probable tyrosine-protein kinase kin-31 0.007 0.0144 0.0178
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Entamoeba histolytica protein kinase, putative 0.007 0.0144 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.007 0.0144 0.0477
Brugia malayi SH2 domain containing protein 0.007 0.0144 0.0178
Loa Loa (eye worm) protein kinase domain-containing protein 0.007 0.0144 0.5807
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.007 0.0144 0.0978
Echinococcus granulosus insulin growth factor 1 receptor beta 0.007 0.0144 0.0978
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.007 0.0144 0.0978
Echinococcus granulosus tyrosine protein kinase Fps85D 0.007 0.0144 0.0978
Entamoeba histolytica tyrosine kinase, putative 0.007 0.0144 1
Schistosoma mansoni protein kinase 0.007 0.0144 0.3362
Entamoeba histolytica protein kinase domain containing protein 0.007 0.0144 1
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0144 0.5807
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0125 0.5028
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Entamoeba histolytica serine/threonine kinase, putative 0.007 0.0144 1
Trypanosoma brucei protein kinase, putative 0.007 0.0144 0.0477
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0144 1
Loa Loa (eye worm) TK protein kinase 0.007 0.0144 0.5807
Brugia malayi bone morphogenetic protein type 1 receptor 0.007 0.0144 0.0178
Entamoeba histolytica tyrosine kinase, putative 0.007 0.0144 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.007 0.0144 0.0978
Loa Loa (eye worm) hypothetical protein 0.0085 0.0187 0.7593
Entamoeba histolytica protein kinase domain containing protein 0.007 0.0144 1
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0144 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.007 0.0144 0.0978
Entamoeba histolytica tyrosine kinase, putative 0.007 0.0144 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.007 0.0144 0.0978
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Schistosoma mansoni ephrin receptor 0.007 0.0144 0.3362
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.007 0.0144 0.0477
Entamoeba histolytica hypothetical protein 0.007 0.0144 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.007 0.0144 1
Brugia malayi Protein kinase domain containing protein 0.007 0.0144 0.0178
Echinococcus multilocularis tyrosine protein kinase ABL1 0.007 0.0144 0.0978
Trichomonas vaginalis TKL family protein kinase 0.007 0.0144 1
Entamoeba histolytica protein kinase, putative 0.007 0.0144 1
Echinococcus multilocularis kinase suppressor of Ras 1 0.007 0.0144 0.0978
Trichomonas vaginalis AGC family protein kinase 0.007 0.0144 1
Loa Loa (eye worm) TK/ABL protein kinase 0.007 0.0144 0.5807
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.007 0.0144 0.0978
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.007 0.0144 0.0178
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.007 0.0144 0.0978
Entamoeba histolytica protein kinase domain containing protein 0.007 0.0144 1
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0144 1
Trichomonas vaginalis protein tyrosine kinase, putative 0.007 0.0144 1

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.12 mg kg-1 Subcutaneously administration into mice infected with Streptococcus pyogenes C 203 ChEMBL. 2530352
ED50 (functional) = 170 mg kg-1 In vivo effective dose given perorally to mice infected with Streptococcus pyogenes C 203 ChEMBL. 2530352
Ka (binding) = 0.000021 M-1 Association constant with Ac2-L-Lys-D-Ala-D-Ala ChEMBL. 2530352
logD (ADMET) = -2.7 Partition coefficient (logD6.0) (1-butanol) ChEMBL. 2530352
MIC (functional) = 0.06 ug ml-1 In vitro minimum inhibitory concentration against Streptococcus pyogenes C 203 ChEMBL. 2530352
MIC (functional) = 0.06 ug ml-1 In vitro minimum inhibitory concentration against Streptococcus pneumoniae UC41 ChEMBL. 2530352
MIC (functional) = 0.12 ug ml-1 In vitro minimum inhibitory concentration against Staphylococcus aureus Tour ChEMBL. 2530352
MIC (functional) = 0.12 ug ml-1 In vitro minimum inhibitory concentration against Streptococcus faecalis ATCC 7080 ChEMBL. 2530352
MIC (functional) = 0.25 ug ml-1 In vitro minimum inhibitory concentration against Staphylococcus epidermis ATCC 12228 ChEMBL. 2530352
MIC (functional) = 0.25 ug ml-1 Minimum inhibitory concentration of compound against 12 strains of Staphylococcus epidermidis ChEMBL. 2530352
MIC (functional) = 0.25 ug ml-1 Minimum inhibitory concentration of compound against 16 different strains of staphylococcus species ChEMBL. 2530352
MIC (functional) = 2 ug ml-1 Minimum inhibitory concentration of compound against 8 strains of Staphylococcus hemolyticus ChEMBL. 2530352
MIC (functional) = 4 ug ml-1 In vitro minimum inhibitory concentration against Staphylococcus hemolyticus 602 cell line ChEMBL. 2530352
MIC50 (functional) = 0.5 ug ml-1 50 percent Minimum inhibitory concentration of compound against 12 strains of Staphylococcus epidermidis ChEMBL. 2530352
MIC50 (functional) = 1 ug ml-1 50 percent Minimum inhibitory concentration of compound against 16 different strains of staphylococcus species ChEMBL. 2530352
MIC50 (functional) = 16 ug ml-1 50 percent Minimum inhibitory concentration of compound against 8 strains of Staphylococcus hemolyticus ChEMBL. 2530352
MIC90 (functional) = 2 ug ml-1 90 percent Minimum inhibitory concentration of compound against 12 strains of Staphylococcus epidermidis ChEMBL. 2530352
MIC90 (functional) = 4 ug ml-1 90 percent Minimum inhibitory concentration of compound against 16 different strains of staphylococcus species ChEMBL. 2530352
MIC90 (functional) = 32 ug ml-1 90 percent Minimum inhibitory concentration of compound against 8 strains of Staphylococcus hemolyticus ChEMBL. 2530352

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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