Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0617 | 0.1501 | 0.1418 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.3637 | 1 | 1 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0617 | 0.1501 | 0.1501 |
Loa Loa (eye worm) | hypothetical protein | 0.0617 | 0.1501 | 0.1418 |
Brugia malayi | NNMT/PNMT/TEMT family protein | 0.0272 | 0.0528 | 0.0436 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0617 | 0.1501 | 0.1501 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0617 | 0.1501 | 0.1413 |
Onchocerca volvulus | 0.0617 | 0.1501 | 0.0952 | |
Echinococcus multilocularis | expressed protein | 0.0381 | 0.0837 | 0.0742 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.0236 | 0.0236 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0617 | 0.1501 | 0.1418 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0617 | 0.1501 | 0.1413 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0617 | 0.1501 | 0.1501 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0617 | 0.1501 | 0.1413 |
Plasmodium vivax | hypothetical protein, conserved | 0.0617 | 0.1501 | 1 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0376 | 0.0822 | 0.0733 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0617 | 0.1501 | 0.1413 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0617 | 0.1501 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.3637 | 1 | 1 |
Echinococcus granulosus | kinesin family 1 | 0.1557 | 0.4147 | 0.4086 |
Echinococcus granulosus | expressed protein | 0.0381 | 0.0837 | 0.0742 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0617 | 0.1501 | 0.1418 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0617 | 0.1501 | 0.1501 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0617 | 0.1501 | 0.1501 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0617 | 0.1501 | 0.1501 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.0304 | 0.021 |
Loa Loa (eye worm) | serotonin transporter b | 0.3637 | 1 | 1 |
Onchocerca volvulus | 0.3637 | 1 | 1 | |
Echinococcus multilocularis | geminin | 0.0168 | 0.0236 | 0.0135 |
Brugia malayi | Kinesin motor domain containing protein | 0.0202 | 0.0332 | 0.0239 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0617 | 0.1501 | 0.1501 |
Loa Loa (eye worm) | hypothetical protein | 0.0617 | 0.1501 | 0.1418 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.0528 | 0.0436 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0617 | 0.1501 | 0.1413 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0376 | 0.0822 | 0.5 |
Onchocerca volvulus | 0.0617 | 0.1501 | 0.0952 | |
Echinococcus multilocularis | kinesin family 1 | 0.1557 | 0.4147 | 0.4086 |
Brugia malayi | hypothetical protein | 0.03 | 0.0606 | 0.0515 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0617 | 0.1501 | 0.1501 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0272 | 0.0528 | 0.0436 |
Plasmodium falciparum | transporter, putative | 0.0617 | 0.1501 | 1 |
Entamoeba histolytica | kinesin, putative | 0.0202 | 0.0332 | 0.5 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0617 | 0.1501 | 0.1413 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.0236 | 0.0236 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0617 | 0.1501 | 0.1413 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0617 | 0.1501 | 0.1501 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0376 | 0.0822 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.0528 | 0.0436 |
Plasmodium falciparum | amino acid transporter, putative | 0.0617 | 0.1501 | 1 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0617 | 0.1501 | 0.1418 |
Loa Loa (eye worm) | hypothetical protein | 0.0617 | 0.1501 | 0.1418 |
Schistosoma mansoni | lipoxygenase | 0.0121 | 0.0102 | 0.0102 |
Loa Loa (eye worm) | norepinephrine transporter | 0.3637 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0168 | 0.0236 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.0617 | 0.1501 | 0.1418 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.3637 | 1 | 0.5 |
Plasmodium vivax | amine transporter, putative | 0.0617 | 0.1501 | 1 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0617 | 0.1501 | 0.1501 |
Loa Loa (eye worm) | hypothetical protein | 0.0617 | 0.1501 | 0.1418 |
Loa Loa (eye worm) | hypothetical protein | 0.3637 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1355 | 0.3577 | 0.3577 |
Toxoplasma gondii | hypothetical protein | 0.0617 | 0.1501 | 1 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0617 | 0.1501 | 0.1413 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0804 | 0.2026 | 0.1943 |
Loa Loa (eye worm) | hypothetical protein | 0.3637 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0617 | 0.1501 | 0.1501 |
Loa Loa (eye worm) | hypothetical protein | 0.3637 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0617 | 0.1501 | 0.1418 |
Echinococcus multilocularis | serotonin transporter | 0.3637 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0376 | 0.0822 | 0.0733 |
Giardia lamblia | Kinesin-5 | 0.0202 | 0.0332 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0617 | 0.1501 | 0.1418 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0617 | 0.1501 | 1 |
Brugia malayi | hypothetical protein | 0.0617 | 0.1501 | 0.1418 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0376 | 0.0822 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.3637 | 1 | 1 |
Onchocerca volvulus | 0.0617 | 0.1501 | 0.0952 | |
Loa Loa (eye worm) | hypothetical protein | 0.0617 | 0.1501 | 0.1418 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0617 | 0.1501 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0617 | 0.1501 | 0.1418 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0617 | 0.1501 | 0.1413 |
Echinococcus granulosus | serotonin transporter | 0.3637 | 1 | 1 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0617 | 0.1501 | 0.1413 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0202 | 0.0332 | 0.0239 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0617 | 0.1501 | 0.1413 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0617 | 0.1501 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.0606 | 0.0515 |
Schistosoma mansoni | kinesin eg-5 | 0.0202 | 0.0332 | 0.0332 |
Toxoplasma gondii | hypothetical protein | 0.0617 | 0.1501 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Solubility | = 9.68 ng/ml | Aqueous solubility by radiotracer analysis method | ChEMBL. | 17256924 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.