Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0617 | 0.1501 | 0.1501 |
Plasmodium vivax | hypothetical protein, conserved | 0.0617 | 0.1501 | 1 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0617 | 0.1501 | 0.1413 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0617 | 0.1501 | 1 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0617 | 0.1501 | 0.1413 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.3637 | 1 | 1 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0376 | 0.0822 | 0.0733 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.3637 | 1 | 1 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0617 | 0.1501 | 0.1418 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0617 | 0.1501 | 0.1501 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0617 | 0.1501 | 0.1501 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0617 | 0.1501 | 0.1413 |
Brugia malayi | NNMT/PNMT/TEMT family protein | 0.0272 | 0.0528 | 0.0436 |
Onchocerca volvulus | 0.0617 | 0.1501 | 0.0952 | |
Loa Loa (eye worm) | hypothetical protein | 0.0617 | 0.1501 | 0.1418 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0617 | 0.1501 | 0.1413 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0617 | 0.1501 | 0.1418 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.0236 | 0.0236 |
Echinococcus multilocularis | expressed protein | 0.0381 | 0.0837 | 0.0742 |
Loa Loa (eye worm) | serotonin transporter b | 0.3637 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.0304 | 0.021 |
Echinococcus granulosus | kinesin family 1 | 0.1557 | 0.4147 | 0.4086 |
Echinococcus granulosus | expressed protein | 0.0381 | 0.0837 | 0.0742 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0617 | 0.1501 | 0.1501 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0617 | 0.1501 | 0.1418 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0617 | 0.1501 | 0.1501 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0617 | 0.1501 | 0.1501 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0617 | 0.1501 | 0.1413 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0376 | 0.0822 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.0528 | 0.0436 |
Echinococcus multilocularis | kinesin family 1 | 0.1557 | 0.4147 | 0.4086 |
Onchocerca volvulus | 0.0617 | 0.1501 | 0.0952 | |
Echinococcus multilocularis | geminin | 0.0168 | 0.0236 | 0.0135 |
Onchocerca volvulus | 0.3637 | 1 | 1 | |
Brugia malayi | Kinesin motor domain containing protein | 0.0202 | 0.0332 | 0.0239 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0617 | 0.1501 | 0.1501 |
Loa Loa (eye worm) | hypothetical protein | 0.0617 | 0.1501 | 0.1418 |
Entamoeba histolytica | kinesin, putative | 0.0202 | 0.0332 | 0.5 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0617 | 0.1501 | 0.1413 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0617 | 0.1501 | 0.1501 |
Brugia malayi | hypothetical protein | 0.03 | 0.0606 | 0.0515 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0272 | 0.0528 | 0.0436 |
Plasmodium falciparum | transporter, putative | 0.0617 | 0.1501 | 1 |
Echinococcus granulosus | geminin | 0.0168 | 0.0236 | 0.0135 |
Plasmodium vivax | amine transporter, putative | 0.0617 | 0.1501 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.3637 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0617 | 0.1501 | 0.1418 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0617 | 0.1501 | 0.1501 |
Loa Loa (eye worm) | hypothetical protein | 0.0617 | 0.1501 | 0.1418 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0617 | 0.1501 | 0.1413 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.0236 | 0.0236 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0376 | 0.0822 | 0.5 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0617 | 0.1501 | 0.1501 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.0528 | 0.0436 |
Plasmodium falciparum | amino acid transporter, putative | 0.0617 | 0.1501 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.3637 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0121 | 0.0102 | 0.0102 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0617 | 0.1501 | 0.1418 |
Loa Loa (eye worm) | hypothetical protein | 0.0617 | 0.1501 | 0.1418 |
Loa Loa (eye worm) | hypothetical protein | 0.3637 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0617 | 0.1501 | 0.1501 |
Echinococcus multilocularis | serotonin transporter | 0.3637 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0617 | 0.1501 | 0.1418 |
Loa Loa (eye worm) | hypothetical protein | 0.3637 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0376 | 0.0822 | 0.0733 |
Toxoplasma gondii | hypothetical protein | 0.0617 | 0.1501 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1355 | 0.3577 | 0.3577 |
Loa Loa (eye worm) | hypothetical protein | 0.3637 | 1 | 1 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0617 | 0.1501 | 0.1413 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0804 | 0.2026 | 0.1943 |
Onchocerca volvulus | 0.0617 | 0.1501 | 0.0952 | |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.3637 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0617 | 0.1501 | 0.1418 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0617 | 0.1501 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0617 | 0.1501 | 0.1418 |
Loa Loa (eye worm) | hypothetical protein | 0.0617 | 0.1501 | 0.1418 |
Giardia lamblia | Kinesin-5 | 0.0202 | 0.0332 | 0.5 |
Brugia malayi | hypothetical protein | 0.0617 | 0.1501 | 0.1418 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0376 | 0.0822 | 0.5 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0617 | 0.1501 | 1 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0617 | 0.1501 | 0.1413 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.0606 | 0.0515 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0617 | 0.1501 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0617 | 0.1501 | 1 |
Schistosoma mansoni | kinesin eg-5 | 0.0202 | 0.0332 | 0.0332 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0617 | 0.1501 | 0.1413 |
Echinococcus granulosus | serotonin transporter | 0.3637 | 1 | 1 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0617 | 0.1501 | 0.1413 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0202 | 0.0332 | 0.0239 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.