TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 377.827 | Formula: C20H16ClN5O
H donors: 3 H acceptors: 3 LogP: 2.96 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cccc(c1)c1cn[nH]c1c1c[nH]c(c1)C(=O)NCc1cccnc1
InChi: 1S/C20H16ClN5O/c21-16-5-1-4-14(7-16)17-12-25-26-19(17)15-8-18(23-11-15)20(27)24-10-13-3-2-6-22-9-13/h1-9,11-12,23H,10H2,(H,24,27)(H,25,26)
InChiKey: IKSOSHYRFLZPCI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania mexicana	mitogen-activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	ko:K04371 extracellular signal-regulated kinase 1/2, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania braziliensis	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Cryptosporidium hominis	MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Brugia malayi	MAP kinase sur-1	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase implicated in PKC1-controlled signalling pathway	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Cryptosporidium parvum	MAPK, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma congolense	tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Giardia lamblia	Kinase, CMGC MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania donovani	mitogen activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania infantum	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania infantum	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania mexicana	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania donovani	mitogen-activated protein kinase 4	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei gambiense	mitogen-activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania braziliensis	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei gambiense	protein kinase, putative,tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 1	360 aa	361 aa	33.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1473	1	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0248	0.0248
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.02	0.1211	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0248	0.0248
Brugia malayi	hypothetical protein	0.0061	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0248	0.0248
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0061	0.0248	0.0248
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1473	1	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0061	0.0248	0.0248
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0061	0.0248	0.0248
Leishmania major	tyrosine specific protein phosphatase, putative	0.0061	0.0248	0.9688
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0061	0.0248	0.0248
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0061	0.0248	0.0248
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0061	0.0248	0.0248
Loa Loa (eye worm)	glycogen phosphorylase	0.0463	0.3024	0.3024
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0034	0.0062	0.0062
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0061	0.0248	0.0248
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0061	0.0248	0.3623
Entamoeba histolytica	glycogen phosphorylase, putative	0.0463	0.3024	1
Onchocerca volvulus		0.0061	0.0248	0.0821
Onchocerca volvulus		0.0061	0.0248	0.0821
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0061	0.0248	0.0248
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0061	0.0248	0.0248
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0061	0.0248	0.0248
Entamoeba histolytica	glycogen phosphorylase, putative	0.02	0.1211	0.389
Brugia malayi	Carboxylesterase family protein	0.0146	0.0838	0.0838
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0248	0.0248
Echinococcus granulosus	acetylcholinesterase	0.0146	0.0838	0.0838
Brugia malayi	carbohydrate phosphorylase	0.0463	0.3024	0.3024
Onchocerca volvulus		0.0061	0.0248	0.0821
Onchocerca volvulus		0.0061	0.0248	0.0821
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1473	1	1
Chlamydia trachomatis	glycogen phosphorylase	0.0463	0.3024	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0061	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0248	0.0248
Brugia malayi	Protein-tyrosine phosphatase	0.0061	0.0248	0.0248
Onchocerca volvulus		0.0061	0.0248	0.0821
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0061	0.0248	0.0248
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0061	0.0248	0.0248
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0061	0.0248	0.0248
Brugia malayi	hypothetical protein	0.0061	0.0248	0.0248
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.0254	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0061	0.0248	0.0248
Brugia malayi	Carboxylesterase family protein	0.0146	0.0838	0.0838
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0248	0.0248
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0061	0.0248	0.0248
Loa Loa (eye worm)	acetylcholinesterase 1	0.0146	0.0838	0.0838
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0248	0.0248
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0061	0.0248	0.0248
Schistosoma mansoni	protein tyrosine phosphatase	0.0061	0.0248	0.0248
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.017	0.1007	0.1007
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0061	0.0248	0.0248
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0061	0.0248	0.0248
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0062	0.0254	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0061	0.0248	0.0248
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0061	0.0248	0.0248
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0061	0.0248	0.0248
Schistosoma mansoni	rotamase	0.0034	0.0062	0.0062
Echinococcus multilocularis		0.0061	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0248	0.0248
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0061	0.0248	0.0248
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0061	0.0248	0.0248
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.017	0.1007	0.1007
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0061	0.0248	0.0248
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0062	0.0204
Schistosoma mansoni	serine/threonine protein kinase	0.0062	0.0254	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0248	0.0248
Schistosoma mansoni	glycogen phosphorylase	0.02	0.1211	0.1211
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0061	0.0248	0.0248
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.017	0.1007	0.1007
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0061	0.0248	0.0248
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0061	0.0248	0.0248
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0061	0.0248	0.0248
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0061	0.0248	0.0647
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0062	0.0254	1
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0061	0.0248	0.0248
Echinococcus granulosus	carboxylesterase 5A	0.0146	0.0838	0.0838
Echinococcus granulosus	acetylcholinesterase	0.0146	0.0838	0.0838
Echinococcus multilocularis	acetylcholinesterase	0.0146	0.0838	0.0838
Onchocerca volvulus		0.0061	0.0248	0.0821
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0248	0.0248
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0061	0.0248	0.0248
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0061	0.0248	0.0248
Onchocerca volvulus		0.0061	0.0248	0.0821
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0248	0.0248
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0062	0.0254	0.0254
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0061	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0248	0.0248
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0061	0.0248	0.0248
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0061	0.0248	0.0248
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0061	0.0248	0.0248
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0061	0.0248	0.0248
Schistosoma mansoni	protein tyrosine phosphatase	0.0061	0.0248	0.0248
Echinococcus granulosus	mitogen activated protein kinase	0.0062	0.0254	0.0254
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0463	0.3024	1
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0061	0.0248	0.9688
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0061	0.0248	0.0248
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0061	0.0248	0.0248
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0061	0.0248	0.0248
Schistosoma mansoni	protein tyrosine phosphatase	0.0061	0.0248	0.0248
Onchocerca volvulus		0.0061	0.0248	0.0821
Onchocerca volvulus		0.0061	0.0248	0.0821
Brugia malayi	hypothetical protein	0.0061	0.0248	0.0248
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0061	0.0248	0.0248
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0254	0.0842
Onchocerca volvulus		0.0061	0.0248	0.0821
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0146	0.0838	0.0838
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0061	0.0248	0.0248
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0061	0.0248	0.0248
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0061	0.0248	0.0647
Trypanosoma brucei	protein kinase, putative	0.0062	0.0254	0.374
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.017	0.1007	0.1007
Echinococcus granulosus	mitogen activated protein kinase 3	0.0062	0.0254	0.0254
Onchocerca volvulus		0.0061	0.0248	0.0821
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.017	0.1007	0.1007
Echinococcus granulosus	glycogen phosphorylase	0.0463	0.3024	0.3024
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0061	0.0248	0.0248
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0062	0.0254	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0061	0.0248	0.0248
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0061	0.0248	0.0248
Schistosoma mansoni	glycogen phosphorylase	0.0463	0.3024	0.3024
Brugia malayi	Protein-tyrosine phosphatase	0.0061	0.0248	0.0248
Echinococcus multilocularis	hypothetical protein	0.0061	0.0248	0.0248
Giardia lamblia	Kinase, CMGC MAPK	0.0062	0.0254	0.0022
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.02	0.1211	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.017	0.1007	0.1007
Brugia malayi	MAP kinase sur-1	0.0062	0.0254	0.0254
Onchocerca volvulus		0.0061	0.0248	0.0821
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0061	0.0248	0.0248
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0061	0.0248	0.0248
Trichomonas vaginalis	rotamase, putative	0.0033	0.0056	0.0186
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0061	0.0248	0.0248
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0061	0.0248	0.0248
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0061	0.0248	0.0248
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0061	0.0248	0.0248
Echinococcus multilocularis	glycogen phosphorylase	0.0463	0.3024	0.3024
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0061	0.0248	0.9688
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0254	0.0842
Trichomonas vaginalis	rotamase, putative	0.0034	0.0062	0.0204
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0061	0.0248	0.0248
Schistosoma mansoni	pcd6 interacting protein-related	0.0061	0.0248	0.0248
Onchocerca volvulus		0.0061	0.0248	0.0821
Echinococcus multilocularis	Glycosyl transferase, family 35	0.0463	0.3024	0.3024
Onchocerca volvulus		0.0061	0.0248	0.0821
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.1473	1	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.0254	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0061	0.0248	0.0248
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0061	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0838	0.0838
Onchocerca volvulus		0.0061	0.0248	0.0821
Echinococcus multilocularis	carboxylesterase 5A	0.0146	0.0838	0.0838
Onchocerca volvulus		0.0061	0.0248	0.0821
Brugia malayi	hypothetical protein	0.0061	0.0248	0.0248
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0061	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0248	0.0248
Giardia lamblia	Glycogen phosphorylase	0.0463	0.3024	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0061	0.0248	0.0248
Echinococcus multilocularis	mitogen activated protein kinase	0.0062	0.0254	0.0254
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0061	0.0248	0.0647
Onchocerca volvulus		0.0061	0.0248	0.0821
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0061	0.0248	0.0248
Echinococcus granulosus	expressed protein	0.0034	0.0062	0.0062
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0061	0.0248	0.0248
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0061	0.0248	0.0248
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0061	0.0248	0.0248
Echinococcus multilocularis	glycogen phosphorylase	0.0463	0.3024	0.3024
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0061	0.0248	0.0248
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0062	0.0254	1
Onchocerca volvulus		0.0061	0.0248	0.0821
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0061	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0248	0.0248
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.017	0.1007	0.1007
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0061	0.0248	0.0248
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0061	0.0248	0.0248
Trichomonas vaginalis	pten, drome, putative	0.0061	0.0248	0.0821
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0248	0.0248
Echinococcus granulosus	Glycosyl transferase family 35	0.0463	0.3024	0.3024
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0061	0.0248	0.0248
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0463	0.3024	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0248	0.0248
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0061	0.0248	0.0248
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0061	0.0248	0.0248
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0061	0.0248	0.0248
Trypanosoma brucei	RNA helicase, putative	0.011	0.0586	1
Brugia malayi	Protein-tyrosine phosphatase 1	0.0061	0.0248	0.0248
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0061	0.0248	0.9688
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0061	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0248	0.0248
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0061	0.0248	0.0248
Onchocerca volvulus		0.0061	0.0248	0.0821
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0061	0.0248	0.0248
Onchocerca volvulus		0.0061	0.0248	0.0821
Onchocerca volvulus		0.0061	0.0248	0.0821
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0061	0.0248	0.0248
Schistosoma mansoni	glycogen phosphorylase	0.0463	0.3024	0.3024
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0061	0.0248	0.0248
Onchocerca volvulus	4.1 G protein, putative homolog	0.0061	0.0248	0.0821
Echinococcus multilocularis	expressed protein	0.0034	0.0062	0.0062
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0061	0.0248	0.9688
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0061	0.0248	0.0248
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0061	0.0248	0.0248
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0061	0.0248	0.0248
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0061	0.0248	0.0248
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0062	0.0254	0.0254
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0061	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0248	0.0248
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0061	0.0248	0.0248
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0061	0.0248	0.0248
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0254	0.0842
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0061	0.0248	0.0248
Entamoeba histolytica	glycogenphosphorylase, putative	0.02	0.1211	0.389
Entamoeba histolytica	glycogen phosphorylase, putative	0.0463	0.3024	1
Brugia malayi	hypothetical protein	0.0061	0.0248	0.0248
Onchocerca volvulus		0.0061	0.0248	0.0821
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0254	0.0842
Echinococcus multilocularis	acetylcholinesterase	0.0146	0.0838	0.0838
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0061	0.0248	0.0248
Onchocerca volvulus		0.0061	0.0248	0.0821
Entamoeba histolytica	glycogen phosphorylase, putative	0.02	0.1211	0.389
Echinococcus granulosus	glycogen phosphorylase	0.0463	0.3024	0.3024
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0248	0.0248
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0061	0.0248	0.0248
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0062	0.0254	0.374
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0061	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0248	0.0248
Schistosoma mansoni	hypothetical protein	0.011	0.0586	0.0586
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0248	0.0248
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0034	0.0062	0.0062
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0061	0.0248	0.0248
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0062	0.0254	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0061	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0248	0.0248
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0061	0.0248	0.0248
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0061	0.0248	0.0248
Onchocerca volvulus	Glycogen phosphorylase homolog	0.0463	0.3024	1
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0838	0.0838
Loa Loa (eye worm)	carboxylesterase	0.0146	0.0838	0.0838

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)		Inhibition of JNK3 at 10 nM by spectophotometric coupled-enzyme assay	ChEMBL.	17300186
Ki (binding)	0	Inhibition of JNK3 at 10 nM by spectophotometric coupled-enzyme assay	ChEMBL.	17300186
Ki (binding)	= 0.23 uM	Inhibition of ERK2 by spectophotometric coupled-enzyme assay	ChEMBL.	17300186
Ki (binding)	= 0.23 uM	Inhibition of ERK2 by spectophotometric coupled-enzyme assay	ChEMBL.	17300186

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL220343

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 414103