Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0139 | 0.473 | 0.6337 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0056 | 0.0736 | 0.5 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0196 | 0.7465 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0107 | 0.3185 | 0.4267 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0196 | 0.7465 | 1 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0196 | 0.7465 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0139 | 0.473 | 0.6337 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0087 | 0.2195 | 0.2941 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0056 | 0.0736 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0056 | 0.0736 | 0.0986 |
Onchocerca volvulus | 0.0228 | 0.9021 | 0.9285 | |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0196 | 0.7465 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0105 | 0.3102 | 0.4155 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0109 | 0.3283 | 0.4398 |
Mycobacterium ulcerans | polyketide synthase | 0.0131 | 0.4337 | 0.581 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1557 | 0.0823 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.8637 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0131 | 0.4337 | 0.581 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0139 | 0.473 | 1 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0122 | 0.3922 | 0.5254 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0056 | 0.0736 | 0.0986 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0087 | 0.2195 | 0.2941 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0045 | 0.0188 | 0.0251 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0139 | 0.473 | 0.6337 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0093 | 0.2515 | 0.3708 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0085 | 0.2116 | 0.2574 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0122 | 0.3922 | 0.3889 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0139 | 0.473 | 0.6337 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0131 | 0.4337 | 0.0684 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0139 | 0.473 | 0.6337 |
Mycobacterium ulcerans | polyketide synthase | 0.0139 | 0.473 | 0.6337 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0236 | 0.9413 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0139 | 0.473 | 0.6337 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0131 | 0.4337 | 0.581 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0109 | 0.3283 | 0.4398 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0105 | 0.3102 | 0.4155 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0053 | 0.0571 | 0.0765 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0105 | 0.3102 | 0.4155 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0131 | 0.4337 | 0.581 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0087 | 0.2195 | 0.2941 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0131 | 0.4337 | 0.581 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0131 | 0.4337 | 0.581 |
Mycobacterium ulcerans | thioesterase | 0.0109 | 0.3283 | 0.4398 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0131 | 0.4337 | 0.581 |
Chlamydia trachomatis | glutamine binding protein | 0.0056 | 0.0736 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0074 | 0.1609 | 0.2155 |
Loa Loa (eye worm) | fatty acid synthase | 0.0129 | 0.4253 | 0.4318 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0056 | 0.0736 | 0.5 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0139 | 0.473 | 0.6337 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0131 | 0.4337 | 0.581 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0078 | 0.1798 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0131 | 0.4337 | 0.581 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0078 | 0.1798 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0094 | 0.2556 | 0.3424 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0078 | 0.1798 | 0.5 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0131 | 0.4337 | 0.581 |
Mycobacterium ulcerans | thioesterase TesA | 0.0109 | 0.3283 | 0.4398 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0139 | 0.473 | 0.6337 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0127 | 0.4144 | 0.5551 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0127 | 0.4144 | 0.5551 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 36 uM | Displacement of [3H]BTX-B from voltage gated sodium channel in rat cerebral cortex synaptoneurosomes | ChEMBL. | 15588087 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.