Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | esterase, putative | 0.0072 | 0.0137 | 0.3208 |
Brugia malayi | Carboxylesterase family protein | 0.0555 | 0.3508 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0137 | 0.0137 |
Brugia malayi | Helix-loop-helix DNA-binding domain containing protein | 0.0109 | 0.0396 | 0.0963 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0072 | 0.0137 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Echinococcus multilocularis | acetylcholinesterase | 0.0555 | 0.3508 | 0.3466 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0116 | 0.0116 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0072 | 0.0136 | 0.0072 |
Loa Loa (eye worm) | TWK-28 protein | 0.0062 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | carboxylesterase | 0.0094 | 0.0289 | 0.0289 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0099 | 0.0329 | 0.0769 |
Onchocerca volvulus | 0.0094 | 0.0289 | 1 | |
Loa Loa (eye worm) | TWK-7 protein | 0.0062 | 0.0064 | 0.0064 |
Echinococcus granulosus | neuroligin | 0.0094 | 0.0289 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Plasmodium vivax | hypothetical protein, conserved | 0.0072 | 0.0137 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | large conductance calcium-activated potassium channel alpha subunit ai | 0.0062 | 0.0064 | 0.0064 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0072 | 0.0137 | 0.026 |
Mycobacterium tuberculosis | Conserved protein | 0.0072 | 0.0137 | 0.026 |
Brugia malayi | hypothetical protein | 0.0072 | 0.0136 | 0.0209 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0072 | 0.0137 | 0.0073 |
Mycobacterium ulcerans | hypothetical protein | 0.0072 | 0.0137 | 0.3208 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0072 | 0.0137 | 0.026 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0094 | 0.0289 | 0.0226 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0142 | 0.0627 | 0.0566 |
Brugia malayi | beta-lactamase family protein | 0.0072 | 0.0137 | 0.021 |
Echinococcus multilocularis | neuroligin | 0.0094 | 0.0289 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.1485 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0094 | 0.0289 | 0.0653 |
Brugia malayi | hypothetical protein | 0.0239 | 0.1303 | 0.3595 |
Brugia malayi | beta-lactamase | 0.0072 | 0.0137 | 0.021 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0101 | 0.0338 | 0.0338 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0555 | 0.3508 | 0.3466 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0099 | 0.0329 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.0688 | 0.0688 |
Mycobacterium tuberculosis | Conserved protein | 0.0072 | 0.0137 | 0.026 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0289 | 0.0289 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0289 | 0.0289 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0094 | 0.0289 | 0.0811 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0099 | 0.0329 | 0.0267 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0072 | 0.0137 | 0.026 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Echinococcus multilocularis | acetylcholinesterase | 0.0555 | 0.3508 | 0.3466 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0094 | 0.0289 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.0568 | 0.3598 | 0.3598 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0094 | 0.0289 | 0.0226 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0094 | 0.0289 | 0.0226 |
Loa Loa (eye worm) | helix-loop-helix DNA-binding domain-containing protein | 0.0109 | 0.0393 | 0.0393 |
Loa Loa (eye worm) | uncoordinated protein 58 | 0.0062 | 0.0064 | 0.0064 |
Brugia malayi | hypothetical protein | 0.0094 | 0.0289 | 0.0653 |
Onchocerca volvulus | 0.0072 | 0.0137 | 0.3208 | |
Onchocerca volvulus | 0.0094 | 0.0289 | 1 | |
Mycobacterium ulcerans | lipase LipD | 0.0072 | 0.0137 | 0.3208 |
Onchocerca volvulus | 0.0094 | 0.0289 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0329 | 0.0329 |
Loa Loa (eye worm) | beta-lactamase | 0.0072 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0393 | 0.0393 |
Echinococcus granulosus | muscleblind protein | 0.0151 | 0.0688 | 0.0628 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0555 | 0.3508 | 0.3466 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0094 | 0.0289 | 0.0226 |
Mycobacterium leprae | Probable lipase LipE | 0.0072 | 0.0137 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.0136 | 0.2711 |
Brugia malayi | Carboxylesterase family protein | 0.0094 | 0.0289 | 0.0653 |
Onchocerca volvulus | 0.0072 | 0.0137 | 0.3208 | |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Echinococcus granulosus | geminin | 0.0167 | 0.0801 | 0.0741 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0072 | 0.0137 | 0.3208 |
Plasmodium falciparum | potassium channel | 0.0062 | 0.0064 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Onchocerca volvulus | 0.0094 | 0.0289 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.0116 | 0.0052 |
Brugia malayi | beta-lactamase family protein | 0.0072 | 0.0137 | 0.021 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0094 | 0.0289 | 0.0811 |
Echinococcus granulosus | expressed conserved protein | 0.0093 | 0.0287 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Mycobacterium tuberculosis | Conserved protein | 0.0072 | 0.0137 | 0.026 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0094 | 0.0289 | 0.0226 |
Schistosoma mansoni | calcium-activated potassium channel | 0.1201 | 0.8014 | 0.8001 |
Brugia malayi | Carboxylesterase family protein | 0.0094 | 0.0289 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Schistosoma mansoni | gliotactin | 0.0094 | 0.0289 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.0688 | 0.0688 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0151 | 0.0688 | 0.0628 |
Schistosoma mansoni | calcium-activated potassium channel | 0.1485 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0555 | 0.3508 | 0.3508 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.0136 | 0.2711 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0094 | 0.0289 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0101 | 0.034 | 0.0277 |
Echinococcus multilocularis | muscleblind protein | 0.0151 | 0.0688 | 0.0628 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.0136 | 0.2711 |
Giardia lamblia | Hypothetical protein | 0.0062 | 0.0064 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.1303 | 0.1303 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0072 | 0.0137 | 0.3208 |
Toxoplasma gondii | ABC1 family protein | 0.0072 | 0.0137 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0072 | 0.0137 | 0.021 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0239 | 0.1303 | 0.1246 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0289 | 0.0289 |
Echinococcus granulosus | carboxylesterase 5A | 0.0555 | 0.3508 | 0.3466 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0072 | 0.0137 | 0.3208 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0072 | 0.0137 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0289 | 0.0289 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.0477 | 0.0477 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.0801 | 0.0741 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0072 | 0.0136 | 0.0072 |
Schistosoma mansoni | acetylcholinesterase | 0.0094 | 0.0289 | 0.0226 |
Loa Loa (eye worm) | carboxylesterase | 0.0555 | 0.3508 | 0.3508 |
Echinococcus granulosus | transcription factor eb | 0.0109 | 0.0396 | 0.0334 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0072 | 0.0137 | 0.3208 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.1485 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0633 | 0.4051 | 0.4051 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0338 | 0.0338 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0072 | 0.0137 | 0.026 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Brugia malayi | Carboxylesterase family protein | 0.0555 | 0.3508 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0072 | 0.0137 | 0.026 |
Leishmania major | hypothetical protein, conserved | 0.0072 | 0.0137 | 1 |
Onchocerca volvulus | 0.0094 | 0.0289 | 1 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0072 | 0.0137 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Schistosoma mansoni | hypothetical protein | 0.1485 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0101 | 0.0338 | 0.0795 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0072 | 0.0137 | 0.3208 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0072 | 0.0137 | 0.026 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.0136 | 0.0072 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0289 | 0.0289 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0072 | 0.0137 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0239 | 0.1303 | 0.1246 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0072 | 0.0137 | 0.0073 |
Mycobacterium leprae | conserved hypothetical protein | 0.0072 | 0.0137 | 0.5 |
Brugia malayi | Muscleblind-like protein | 0.0151 | 0.0688 | 0.1812 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0094 | 0.0289 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0555 | 0.3508 | 0.3508 |
Echinococcus granulosus | acetylcholinesterase | 0.0555 | 0.3508 | 0.3466 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0099 | 0.0329 | 0.0267 |
Brugia malayi | Carboxylesterase family protein | 0.0094 | 0.0289 | 0.0653 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0094 | 0.0289 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0137 | 0.0137 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0101 | 0.0338 | 0.0795 |
Echinococcus multilocularis | geminin | 0.0167 | 0.0801 | 0.0741 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0072 | 0.0136 | 0.0072 |
Loa Loa (eye worm) | S-phase kinase-associated protein 1A | 0.0062 | 0.0064 | 0.0064 |
Echinococcus multilocularis | transcription factor eb | 0.0109 | 0.0396 | 0.0334 |
Echinococcus multilocularis | expressed conserved protein | 0.0093 | 0.0287 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Onchocerca volvulus | 0.0072 | 0.0137 | 0.3208 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0094 | 0.0289 | 0.0226 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0072 | 0.0137 | 0.3208 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0072 | 0.0137 | 0.0137 |
Echinococcus granulosus | acetylcholinesterase | 0.0555 | 0.3508 | 0.3466 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0142 | 0.0627 | 0.0566 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0137 | 0.0137 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.0477 | 0.1198 |
Plasmodium falciparum | potassium channel | 0.0062 | 0.0064 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | potassium voltage-gated channel subfamily Q member 5 | 0.0062 | 0.0064 | 0.0064 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0094 | 0.0289 | 0.0226 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0072 | 0.0137 | 0.026 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0069 | 0.0116 | 0.0149 |
Loa Loa (eye worm) | hypothetical protein | 0.0555 | 0.3508 | 0.3508 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Mycobacterium ulcerans | beta-lactamase | 0.0072 | 0.0137 | 0.3208 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0094 | 0.0289 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0094 | 0.0289 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0459 | 0.284 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0064 | 0.0064 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.0136 | 0.2711 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0094 | 0.0289 | 0.0811 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0072 | 0.0137 | 0.3208 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0289 | 0.0289 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0094 | 0.0289 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.1191 | 0.1191 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.0477 | 0.0477 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0072 | 0.0137 | 0.0073 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.0801 | 0.0741 |
Loa Loa (eye worm) | carboxylesterase | 0.0094 | 0.0289 | 0.0289 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0289 | 0.0289 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
BP (functional) | > 20 mmHg | Antihypertensive effect in spontaneously hypertensive rat (SHR), expressed as fall in blood pressure (BP) at 50 mg/kg dose given orally | ChEMBL. | 7452695 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.