Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ets-related | 0.0216 | 0.1386 | 0.1348 |
Giardia lamblia | Prenyltransferase | 0.076 | 0.6228 | 1 |
Mycobacterium ulcerans | beta lactamase-like protein | 0.0066 | 0.0044 | 0.5 |
Loa Loa (eye worm) | hydroxyacylglutathione hydrolase | 0.0066 | 0.0044 | 0.0044 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.076 | 0.6228 | 1 |
Echinococcus multilocularis | protein prenyltransferase alpha subunit | 0.0327 | 0.2368 | 0.2334 |
Echinococcus multilocularis | peptidyl glycine alpha amidating monooxygenase | 0.1183 | 1 | 1 |
Schistosoma mansoni | peptidyl-glycine monooxygenase | 0.1183 | 1 | 1 |
Mycobacterium tuberculosis | Halimadienyl diphosphate synthase | 0.0874 | 0.7244 | 1 |
Brugia malayi | Ets-domain containing protein | 0.0071 | 0.0092 | 0.0049 |
Trypanosoma cruzi | geranylgeranyl transferase type II beta subunit, putative | 0.0238 | 0.1582 | 0.2136 |
Schistosoma mansoni | dopamine-beta-monooxygenase | 0.0628 | 0.5056 | 0.5035 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0327 | 0.2368 | 0.3758 |
Entamoeba histolytica | protein farnesyltransferase alpha subunit, putative | 0.0443 | 0.3407 | 0.5438 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.0486 | 0.3789 | 0.3762 |
Trypanosoma brucei | protein farnesyltransferase beta subunit | 0.076 | 0.6228 | 0.8589 |
Echinococcus multilocularis | Rab geranylgeranyltransferase, beta subunit | 0.0238 | 0.1582 | 0.1545 |
Loa Loa (eye worm) | hypothetical protein | 0.1183 | 1 | 1 |
Leishmania major | geranylgeranyltransferase, putative | 0.0238 | 0.1582 | 0.2487 |
Trypanosoma brucei | lanosterol synthase | 0.0874 | 0.7244 | 1 |
Echinococcus multilocularis | geranylgeranyl transferase type I beta subunit | 0.0486 | 0.3789 | 0.3762 |
Plasmodium vivax | prenyltransferase alpha subunit, putative | 0.0443 | 0.3407 | 0.5438 |
Echinococcus granulosus | geranylgeranyl transferase type 2 subunit alpha | 0.0327 | 0.2368 | 0.2334 |
Brugia malayi | Probable protein farnesyltransferase beta subunit, putative | 0.0238 | 0.1582 | 0.1545 |
Leishmania major | farnesyltransferase beta subunit | 0.076 | 0.6228 | 1 |
Schistosoma mansoni | protein farnesyltransferase subunit beta | 0.076 | 0.6228 | 0.6211 |
Mycobacterium leprae | conserved hypothetical protein | 0.0066 | 0.0044 | 0.5 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.076 | 0.6228 | 1 |
Toxoplasma gondii | prenyltransferase and squalene oxidase repeat-containing protein | 0.076 | 0.6228 | 1 |
Plasmodium falciparum | geranylgeranyltransferase, putative | 0.0238 | 0.1582 | 0.2487 |
Loa Loa (eye worm) | metallo-beta-lactamase superfamily protein | 0.0066 | 0.0044 | 0.0044 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0443 | 0.3407 | 0.5438 |
Toxoplasma gondii | hypothetical protein | 0.0327 | 0.2368 | 0.3758 |
Mycobacterium ulcerans | hydrolase | 0.0066 | 0.0044 | 0.5 |
Mycobacterium ulcerans | Zn-dependent glyoxylase | 0.0066 | 0.0044 | 0.5 |
Plasmodium falciparum | protein farnesyltransferase subunit beta | 0.076 | 0.6228 | 1 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0443 | 0.3407 | 0.5438 |
Toxoplasma gondii | prenyltransferase and squalene oxidase repeat-containing protein | 0.0238 | 0.1582 | 0.2487 |
Onchocerca volvulus | 0.0327 | 0.2368 | 1 | |
Mycobacterium ulcerans | hypothetical protein | 0.0066 | 0.0044 | 0.5 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0327 | 0.2368 | 0.2368 |
Echinococcus multilocularis | geranylgeranyl transferase type 2 subunit alpha | 0.0327 | 0.2368 | 0.2334 |
Entamoeba histolytica | Rab geranylgeranyltransferase alpha subunit, putative | 0.0327 | 0.2368 | 0.3758 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0874 | 0.7244 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0066 | 0.0044 | 0.5 |
Mycobacterium leprae | POSSIBLE HYDROLASE | 0.0066 | 0.0044 | 0.5 |
Treponema pallidum | ribonuclease Z | 0.0066 | 0.0044 | 0.5 |
Echinococcus granulosus | peptidyl glycine alpha amidating monooxygenase | 0.1183 | 1 | 1 |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.0327 | 0.2368 | 0.3228 |
Trichomonas vaginalis | geranylgeranyl transferase type I beta subunit, putative | 0.076 | 0.6228 | 1 |
Plasmodium vivax | farnesyltransferase beta subunit, putative | 0.076 | 0.6228 | 1 |
Entamoeba histolytica | geranylgeranyl transferase beta subunit | 0.0486 | 0.3789 | 0.6057 |
Plasmodium falciparum | geranylgeranyl transferase type-2 subunit alpha, putative | 0.0327 | 0.2368 | 0.3758 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.0486 | 0.3789 | 0.3762 |
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.0327 | 0.2368 | 0.3228 |
Entamoeba histolytica | protein farnesyltransferase beta subunit, putative | 0.076 | 0.6228 | 1 |
Plasmodium falciparum | protein farnesyltransferase subunit alpha | 0.0443 | 0.3407 | 0.5438 |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.0327 | 0.2368 | 0.3228 |
Echinococcus granulosus | protein farnesyltransferase alpha subunit | 0.0443 | 0.3407 | 0.3378 |
Trichomonas vaginalis | geranylgeranyl transferase type beta subunit, putative | 0.076 | 0.6228 | 1 |
Schistosoma mansoni | protein farnesyltransferase alpha subunit | 0.0443 | 0.3407 | 0.3378 |
Trypanosoma brucei | protein farnesyltransferase alpha subunit, putative | 0.0327 | 0.2368 | 0.3228 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0238 | 0.1582 | 0.2487 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0071 | 0.0092 | 0.0049 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.1582 | 0.1582 |
Loa Loa (eye worm) | hypothetical protein | 0.0628 | 0.5056 | 0.5056 |
Brugia malayi | Ets-domain containing protein | 0.0071 | 0.0092 | 0.0049 |
Mycobacterium ulcerans | hypothetical protein | 0.0066 | 0.0044 | 0.5 |
Loa Loa (eye worm) | fli-1 protein | 0.0216 | 0.1386 | 0.1386 |
Plasmodium vivax | conserved Plasmodium protein, unknown function | 0.0521 | 0.4103 | 0.6564 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0044 | 0.0044 |
Trypanosoma cruzi | Protein prenyltransferase alpha subunit repeat, putative | 0.0327 | 0.2368 | 0.3228 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0327 | 0.2368 | 0.2334 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0044 | 0.0044 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.076 | 0.6228 | 0.6211 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0044 | 0.0044 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0443 | 0.3407 | 0.3407 |
Schistosoma mansoni | gabp alpha | 0.0071 | 0.0092 | 0.0049 |
Leishmania major | lanosterol synthase, putative | 0.0635 | 0.5119 | 0.8206 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0148 | 0.0772 | 0.0732 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0443 | 0.3407 | 0.3378 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0327 | 0.2368 | 0.3228 |
Loa Loa (eye worm) | hydroxyacylglutathione hydrolase cytoplasmic | 0.0066 | 0.0044 | 0.0044 |
Chlamydia trachomatis | ribonuclease Z | 0.0066 | 0.0044 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0327 | 0.2368 | 0.3228 |
Mycobacterium leprae | conserved hypothetical protein | 0.0066 | 0.0044 | 0.5 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0148 | 0.0772 | 0.0732 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0327 | 0.2368 | 0.3228 |
Trichomonas vaginalis | protein farnesyltransferase beta subunit, putative | 0.0238 | 0.1582 | 0.2487 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.0486 | 0.3789 | 0.3789 |
Trichomonas vaginalis | protein farnesyltransferase beta subunit, putative | 0.0238 | 0.1582 | 0.2487 |
Brugia malayi | Fli-1 protein | 0.0216 | 0.1386 | 0.1348 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein | 0.0319 | 0.2298 | 0.2264 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.0486 | 0.3789 | 0.3762 |
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.0327 | 0.2368 | 0.3228 |
Mycobacterium ulcerans | hypothetical protein | 0.0066 | 0.0044 | 0.5 |
Loa Loa (eye worm) | acetyltransferase | 0.0148 | 0.0772 | 0.0772 |
Mycobacterium ulcerans | glyoxalase II, GloB | 0.0066 | 0.0044 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.1582 | 0.1582 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0628 | 0.5056 | 0.5035 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0443 | 0.3407 | 0.5438 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0443 | 0.3407 | 0.5438 |
Leishmania major | protein farnesyltransferase alpha subunit, putative | 0.0327 | 0.2368 | 0.3758 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0874 | 0.7244 | 1 |
Plasmodium falciparum | geranylgeranyl transferase type2 beta subunit, putative | 0.0238 | 0.1582 | 0.2487 |
Schistosoma mansoni | geranylgeranyl transferase type II beta subunit | 0.0238 | 0.1582 | 0.1545 |
Echinococcus granulosus | protein farnesyltransferase subunit beta | 0.076 | 0.6228 | 0.6211 |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 0.3407 | 0.3407 |
Trypanosoma cruzi | protein farnesyltransferase, putative | 0.076 | 0.6228 | 0.8589 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0044 | 0.0044 |
Echinococcus granulosus | geranylgeranyl transferase type I beta subunit | 0.0486 | 0.3789 | 0.3762 |
Plasmodium vivax | geranylgeranyl transferase type2 beta subunit, putative | 0.0238 | 0.1582 | 0.2487 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0238 | 0.1582 | 0.2136 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0071 | 0.0092 | 0.0049 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0143 | 0.0735 | 0.0695 |
Trichomonas vaginalis | geranylgeranyl transferase type I beta subunit, putative | 0.0486 | 0.3789 | 0.6057 |
Wolbachia endosymbiont of Brugia malayi | metallo-beta-lactamase superfamily hydrolase | 0.0066 | 0.0044 | 0.5 |
Echinococcus multilocularis | protein farnesyltransferase subunit beta | 0.076 | 0.6228 | 0.6211 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0327 | 0.2368 | 0.2334 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0238 | 0.1582 | 0.2136 |
Echinococcus multilocularis | protein farnesyltransferase alpha subunit | 0.0443 | 0.3407 | 0.3378 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0071 | 0.0092 | 0.0092 |
Mycobacterium ulcerans | hydrolase | 0.0066 | 0.0044 | 0.5 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0148 | 0.0772 | 0.0732 |
Mycobacterium leprae | Beta-lactamase-like protein | 0.0066 | 0.0044 | 0.5 |
Trypanosoma cruzi | protein farnesyltransferase, putative | 0.076 | 0.6228 | 0.8589 |
Plasmodium vivax | protein prenyltransferase alpha subunit, putative | 0.0327 | 0.2368 | 0.3758 |
Echinococcus granulosus | protein prenyltransferase alpha subunit | 0.0327 | 0.2368 | 0.2334 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0117 | 0.0495 | 0.073 |
Entamoeba histolytica | Rab geranylgeranyltransferase beta subunit, putative | 0.0238 | 0.1582 | 0.2487 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.076 | 0.6228 | 1 |
Trypanosoma brucei | geranylgeranyl transferase type II beta subunit, putative | 0.0238 | 0.1582 | 0.2136 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0309 | 0.2215 | 0.2181 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0327 | 0.2368 | 0.3758 |
Toxoplasma gondii | hypothetical protein | 0.0117 | 0.0495 | 0.073 |
Schistosoma mansoni | peptidylglycine monooxygenase | 0.0628 | 0.5056 | 0.5035 |
Toxoplasma gondii | Rab geranylgeranyl transferase type II beta subunit, putative | 0.0238 | 0.1582 | 0.2487 |
Mycobacterium ulcerans | hydrolase | 0.0066 | 0.0044 | 0.5 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.076 | 0.6228 | 0.6228 |
Trichomonas vaginalis | type I geranylgeranyltransferase beta subunit, putative | 0.076 | 0.6228 | 1 |
Plasmodium vivax | geranylgeranyltransferase, putative | 0.0238 | 0.1582 | 0.2487 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LC50 (ADMET) | = 2.3 uM | Cytotoxicity against mouse 3LL cells after 5 days | ChEMBL. | 17035024 |
LC50 (ADMET) | = 2.8 uM | Cytotoxicity against rat H-ras transformed NRK H/1.2 cells after 5 days | ChEMBL. | 17035024 |
LC50 (ADMET) | = 3.2 uM | Cytotoxicity against rat NRK 52E cells after 5 days | ChEMBL. | 17035024 |
LC50 (ADMET) | = 3.4 uM | Cytotoxicity against rat N-ras transformed NRK N/4.2 cells after 5 days | ChEMBL. | 17035024 |
LC50 (ADMET) | = 6.6 uM | Cytotoxicity against rat K-ras transformed NRK K/1 cells after 5 days | ChEMBL. | 17035024 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.