TDR Targets

Basic information

Technical information

TDR Targets ID: 421382
Name: 2-(3-methylphenyl)-4,5-diphenyl-1H-imidazole
MW: 310.392 | Formula: C22H18N2
H donors: 1 H acceptors: 1 LogP: 5.41 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cccc(c1)c1nc(c([nH]1)c1ccccc1)c1ccccc1
InChi: 1S/C22H18N2/c1-16-9-8-14-19(15-16)22-23-20(17-10-4-2-5-11-17)21(24-22)18-12-6-3-7-13-18/h2-15H,1H3,(H,23,24)
InChiKey: XBOYWANAMONMRV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(m-tolyl)-4,5-diphenyl-1H-imidazole
2-(3-methylphenyl)-4,5-di(phenyl)-1H-imidazole

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0146	0.1413	0.1413
Toxoplasma gondii	hypothetical protein	0.0115	0.0957	0.1225
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	0.0578	0.7809	1
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0244	0.2865	0.3332
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0578	0.7809	0.9082
Loa Loa (eye worm)	acetyltransferase	0.0146	0.1413	0.1413
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.0244	0.2865	0.2865
Mycobacterium ulcerans	glyoxalase II, GloB	0.0051	0	0.5
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0578	0.7809	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0178	0.1887	0.2195
Leishmania major	farnesyltransferase beta subunit	0.0578	0.7809	1
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0359	0.4575	0.4575
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1887	0.1887
Trypanosoma cruzi	lanosterol synthase, putative	0.0631	0.8598	1
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0359	0.4575	0.5859
Trypanosoma cruzi	lanosterol synthase, putative	0.0631	0.8598	1
Loa Loa (eye worm)	hypothetical protein	0.0359	0.4575	0.4575
Echinococcus granulosus	peptidyl glycine alpha amidating monooxygenase	0.0725	1	1
Echinococcus multilocularis	peptidyl glycine alpha amidating monooxygenase	0.0725	1	1
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0343	0.4327	0.5542
Mycobacterium ulcerans	hypothetical protein	0.0051	0	0.5
Echinococcus multilocularis	protein farnesyltransferase subunit beta	0.0578	0.7809	0.7809
Mycobacterium ulcerans	hypothetical protein	0.0051	0	0.5
Mycobacterium ulcerans	hydrolase	0.0051	0	0.5
Toxoplasma gondii	hypothetical protein	0.0244	0.2865	0.3669
Mycobacterium leprae	Beta-lactamase-like protein	0.0051	0	0.5
Brugia malayi	Ets-domain containing protein	0.0071	0.0292	0.0292
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.0244	0.2865	0.3332
Echinococcus granulosus	GA binding protein alpha chain	0.0071	0.0292	0.0292
Schistosoma mansoni	peptidylglycine monooxygenase	0.0385	0.4958	0.4958
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0578	0.7809	1
Mycobacterium ulcerans	hypothetical protein	0.0051	0	0.5
Toxoplasma gondii	Rab geranylgeranyl transferase type II beta subunit, putative	0.0178	0.1887	0.2417
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.0244	0.2865	0.3669
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0399	0.5167	0.6618
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0359	0.4575	0.4575
Plasmodium falciparum	geranylgeranyl transferase type2 beta subunit, putative	0.0178	0.1887	0.2417
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0578	0.7809	0.7809
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	0.0578	0.7809	1
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.0178	0.1887	0.2417
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0343	0.4327	0.4327
Brugia malayi	Probable protein farnesyltransferase beta subunit, putative	0.0178	0.1887	0.1887
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0343	0.4327	0.4327
Treponema pallidum	ribonuclease Z	0.0051	0	0.5
Echinococcus multilocularis	Rab geranylgeranyltransferase, beta subunit	0.0178	0.1887	0.1887
Echinococcus granulosus	protein farnesyltransferase subunit beta	0.0578	0.7809	0.7809
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0146	0.1413	0.1413
Giardia lamblia	Rab geranylgeranyltransferase	0.0359	0.4575	0.5859
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.0244	0.2865	0.2865
Mycobacterium ulcerans	Zn-dependent glyoxylase	0.0051	0	0.5
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0359	0.4575	0.5859
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0071	0.0292	0.0292
Plasmodium vivax	farnesyltransferase beta subunit, putative	0.0578	0.7809	1
Onchocerca volvulus		0.0244	0.2865	1
Plasmodium falciparum	geranylgeranyltransferase, putative	0.0178	0.1887	0.2417
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0244	0.2865	0.3332
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0578	0.7809	1
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.0244	0.2865	0.3332
Trypanosoma brucei	protein farnesyltransferase beta subunit	0.0578	0.7809	0.9082
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0359	0.4575	0.5859
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0244	0.2865	0.3332
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0244	0.2865	0.2865
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0244	0.2865	0.2865
Plasmodium falciparum	protein farnesyltransferase subunit beta	0.0578	0.7809	1
Entamoeba histolytica	Rab geranylgeranyltransferase beta subunit, putative	0.0178	0.1887	0.2417
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0359	0.4575	0.4575
Giardia lamblia	Prenyltransferase	0.0578	0.7809	1
Entamoeba histolytica	geranylgeranyl transferase beta subunit	0.0343	0.4327	0.5542
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0244	0.2865	0.3669
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0142	0.1352	0.1352
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0578	0.7809	1
Brugia malayi	Ets-domain containing protein	0.0071	0.0292	0.0292
Brugia malayi	acetyltransferase, GNAT family protein	0.0146	0.1413	0.1413
Trypanosoma cruzi	hypothetical protein, conserved	0.0244	0.2865	0.3332
Brugia malayi	Fli-1 protein	0.0214	0.2421	0.2421
Mycobacterium leprae	conserved hypothetical protein	0.0051	0	0.5
Giardia lamblia	Rab geranylgeranyltransferase	0.0178	0.1887	0.2417
Schistosoma mansoni	gabp alpha	0.0071	0.0292	0.0292
Mycobacterium ulcerans	hypothetical protein	0.0051	0	0.5
Mycobacterium ulcerans	hydrolase	0.0051	0	0.5
Schistosoma mansoni	peptidyl-glycine monooxygenase	0.0725	1	1
Schistosoma mansoni	ets-related	0.0214	0.2421	0.2421
Mycobacterium leprae	conserved hypothetical protein	0.0051	0	0.5
Schistosoma mansoni	protein farnesyltransferase subunit beta	0.0578	0.7809	0.7809
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0343	0.4327	0.4327
Echinococcus multilocularis	GA binding protein alpha chain	0.0071	0.0292	0.0292
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0244	0.2865	0.3332
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0359	0.4575	0.4575
Trypanosoma brucei	hypothetical protein, conserved	0.0244	0.2865	0.3332
Leishmania major	geranylgeranyltransferase, putative	0.0178	0.1887	0.2417
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0244	0.2865	0.2865
Trypanosoma cruzi	hypothetical protein, conserved	0.0244	0.2865	0.3332
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.0244	0.2865	0.3669
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0578	0.7809	0.9082
Echinococcus multilocularis	geranylgeranyl transferase type I beta subunit	0.0343	0.4327	0.4327
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0359	0.4575	0.5859
Mycobacterium ulcerans	hydrolase	0.0051	0	0.5
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	0.0578	0.7809	1
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1887	0.1887
Echinococcus granulosus	geranylgeranyl transferase type I beta subunit	0.0343	0.4327	0.4327
Mycobacterium ulcerans	beta lactamase-like protein	0.0051	0	0.5
Wolbachia endosymbiont of Brugia malayi	metallo-beta-lactamase superfamily hydrolase	0.0051	0	0.5
Plasmodium vivax	geranylgeranyl transferase type2 beta subunit, putative	0.0178	0.1887	0.2417
Mycobacterium tuberculosis	Halimadienyl diphosphate synthase	0.0631	0.8598	1
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.019	0.2059	0.2059
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein	0.0195	0.2145	0.2145
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0359	0.4575	0.4575
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.0244	0.2865	0.2865
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0359	0.4575	0.5859
Schistosoma mansoni	dopamine-beta-monooxygenase	0.0385	0.4958	0.4958
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0578	0.7809	1
Trypanosoma cruzi	geranylgeranyl transferase type II beta subunit, putative	0.0178	0.1887	0.2195
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.0244	0.2865	0.3669
Giardia lamblia	Rab geranylgeranyltransferase	0.0244	0.2865	0.3669
Chlamydia trachomatis	ribonuclease Z	0.0051	0	0.5
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0115	0.0957	0.1225
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0178	0.1887	0.2417
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.0178	0.1887	0.2417
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.0244	0.2865	0.3669
Leishmania major	lanosterol synthase, putative	0.0453	0.5957	0.7629
Trypanosoma cruzi	hypothetical protein, conserved	0.0178	0.1887	0.2195
Schistosoma mansoni	geranylgeranyl transferase type II beta subunit	0.0178	0.1887	0.1887
Mycobacterium leprae	POSSIBLE HYDROLASE	0.0051	0	0.5
Plasmodium vivax	geranylgeranyltransferase, putative	0.0178	0.1887	0.2417
Loa Loa (eye worm)	hypothetical protein	0.006	0.014	0.014
Loa Loa (eye worm)	fli-1 protein	0.0214	0.2421	0.2421
Trypanosoma brucei	lanosterol synthase	0.0631	0.8598	1
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0385	0.4958	0.4958
Trypanosoma brucei	geranylgeranyl transferase type II beta subunit, putative	0.0178	0.1887	0.2195
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0578	0.7809	0.7809
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.0244	0.2865	0.2865
Loa Loa (eye worm)	hypothetical protein	0.0385	0.4958	0.4958
Loa Loa (eye worm)	hypothetical protein	0.0725	1	1
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0343	0.4327	0.4327
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0359	0.4575	0.5859

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 9.31 %	Antiinflammatory activity assessed as reduction of carrageenan-induced paw volume in intraperitonially dosed Wistar rat after 3 hrs	ChEMBL.	17079151
Activity (functional)	= 4.1 s	Antinociceptive activity in ip dosed Swiss albino mouse assessed as latency time by tail flick method	ChEMBL.	17079151
Activity (functional)	= 4.1 s	Antinociceptive activity in ip dosed Swiss albino mouse assessed as latency time after 15 mins by tail flick method	ChEMBL.	17079151
Activity (functional)	= 4.1 s	Antinociceptive activity in ip dosed Swiss albino mouse assessed as latency time by tail flick method	ChEMBL.	17079151
Activity (functional)	= 4.1 s	Antinociceptive activity in ip dosed Swiss albino mouse assessed as latency time after 15 mins by tail flick method	ChEMBL.	17079151
Activity (functional)	= 4.48 s	Antinociceptive activity in ip dosed Swiss albino mouse assessed as latency time after 30 mins by tail flick method	ChEMBL.	17079151
Activity (functional)	= 4.48 s	Antinociceptive activity in ip dosed Swiss albino mouse assessed as latency time after 30 mins by tail flick method	ChEMBL.	17079151
Activity (functional)	= 4.56 s	Antinociceptive activity in ip dosed Swiss albino mouse assessed as latency time by hot plate method	ChEMBL.	17079151
Activity (functional)	= 4.56 s	Antinociceptive activity in ip dosed Swiss albino mouse assessed as latency time by hot plate method	ChEMBL.	17079151
Activity (functional)	= 4.6 s	Antinociceptive activity in ip dosed Swiss albino mouse assessed as latency time after 15 mins by hot plate method	ChEMBL.	17079151
Activity (functional)	= 4.6 s	Antinociceptive activity in ip dosed Swiss albino mouse assessed as latency time after 15 mins by hot plate method	ChEMBL.	17079151
Activity (functional)	= 4.63 s	Antinociceptive activity in ip dosed Swiss albino mouse assessed as latency time after 30 mins by hot plate method	ChEMBL.	17079151
Activity (functional)	= 4.63 s	Antinociceptive activity in ip dosed Swiss albino mouse assessed as latency time after 30 mins by hot plate method	ChEMBL.	17079151
Activity (functional)	= 4.67 s	Antinociceptive activity in ip dosed Swiss albino mouse assessed as latency time after 60 mins by hot plate method	ChEMBL.	17079151
Activity (functional)	= 4.67 s	Antinociceptive activity in ip dosed Swiss albino mouse assessed as latency time after 60 mins by hot plate method	ChEMBL.	17079151
Activity (functional)	= 5.72 s	Antinociceptive activity in ip dosed Swiss albino mouse assessed as latency time after 120 mins by hot plate method	ChEMBL.	17079151
Activity (functional)	= 5.72 s	Antinociceptive activity in ip dosed Swiss albino mouse assessed as latency time after 120 mins by hot plate method	ChEMBL.	17079151
Activity (functional)	= 5.89 s	Antinociceptive activity in ip dosed Swiss albino mouse assessed as latency time after 60 mins by tail flick method	ChEMBL.	17079151
Activity (functional)	= 5.89 s	Antinociceptive activity in ip dosed Swiss albino mouse assessed as latency time after 60 mins by tail flick method	ChEMBL.	17079151
Activity (functional)	= 5.93 s	Antinociceptive activity in ip dosed Swiss albino mouse assessed as latency time after 120 mins by tail flick method	ChEMBL.	17079151
Activity (functional)	= 5.93 s	Antinociceptive activity in ip dosed Swiss albino mouse assessed as latency time after 120 mins by tail flick method	ChEMBL.	17079151

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL427089
PubChem: 23558482

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 421382