Detailed information for compound 422592

Basic information

Technical information
  • TDR Targets ID: 422592
  • Name: (8Z,11Z,14Z,17Z)-2-(hydroxymethyl)tricosa-8,1 1,14,17-tetraene-1,4-diol
  • MW: 378.588 | Formula: C24H42O3
  • H donors: 3 H acceptors: 3 LogP: 5.78 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(CC(CO)CO)O
  • InChi: 1S/C24H42O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(27)20-23(21-25)22-26/h6-7,9-10,12-13,15-16,23-27H,2-5,8,11,14,17-22H2,1H3/b7-6-,10-9-,13-12-,16-15-
  • InChiKey: QLYQFYHEINHPMA-DOFZRALJSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (8Z,11Z,14Z,17Z)-2-methyloltricosa-8,11,14,17-tetraene-1,4-diol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0048 0.0559 0.0559
Brugia malayi hypothetical protein 0.0048 0.0559 0.0542
Echinococcus multilocularis Ankyrin 0.0015 0.002 0.004
Loa Loa (eye worm) hypothetical protein 0.0111 0.1558 0.1558
Loa Loa (eye worm) hypothetical protein 0.0048 0.0559 0.0559
Loa Loa (eye worm) hypothetical protein 0.0074 0.0974 0.0974
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0103 0.1431 0.2852
Loa Loa (eye worm) hypothetical protein 0.002 0.0105 0.0105
Brugia malayi hypothetical protein 0.0504 0.7885 0.7881
Echinococcus granulosus intermediate filament protein 0.0028 0.0235 0.0473
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0048 0.0559 0.1124
Loa Loa (eye worm) hypothetical protein 0.0054 0.0652 0.0652
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0239 0.3616 0.7264
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0463 0.0931
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0103 0.1431 0.1415
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0086 0.1155 0.4107
Loa Loa (eye worm) hypothetical protein 0.0048 0.0559 0.0559
Toxoplasma gondii exonuclease III APE 0.0039 0.0407 0.0032
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0343 0.0326
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0463 0.0155
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0048 0.0559 0.1124
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0407 0.0621
Echinococcus granulosus ecdysone induced protein 78C 0.0103 0.1431 0.2878
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0103 0.1431 0.1431
Schistosoma mansoni hypothetical protein 0.0035 0.0343 0.0657
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0323 0.4971 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0103 0.1431 0.1415
Schistosoma mansoni steroid hormone receptor ad4bp 0.0103 0.1431 0.2852
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.002
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0392 0.0373
Brugia malayi Protein kinase domain containing protein 0.0015 0.0018 0.000000013774
Loa Loa (eye worm) hypothetical protein 0.0048 0.0559 0.0559
Brugia malayi Calcitonin receptor-like protein seb-1 0.0111 0.1558 0.1543
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.2036 0.4096
Brugia malayi Nuclear hormone receptor E75 0.0048 0.0559 0.0542
Brugia malayi hypothetical protein 0.0054 0.0652 0.0636
Schistosoma mansoni nuclear hormone receptor 0.0103 0.1431 0.2852
Brugia malayi hypothetical protein 0.0078 0.1032 0.1016
Brugia malayi NAD-dependent deacetylase SIRT1 0.0086 0.1155 0.1139
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0103 0.1431 0.2878
Schistosoma mansoni zinc finger protein 0.0048 0.0559 0.1093
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0103 0.1431 0.2852
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0048 0.0559 0.1124
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.002 0.0004
Onchocerca volvulus 0.0048 0.0559 0.0688
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0103 0.1431 0.1431
Brugia malayi follicle stimulating hormone receptor 0.0249 0.3786 0.3775
Schistosoma mansoni thyroid hormone receptor 0.0229 0.3466 0.6962
Schistosoma mansoni inositol monophosphatase 0.0038 0.0392 0.0755
Echinococcus granulosus nuclear factor of activated T cells 5 0.0076 0.0995 0.2002
Loa Loa (eye worm) hypothetical protein 0.0256 0.3894 0.3894
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0048 0.0559 0.1124
Brugia malayi conserved hypotetical protein 0.0048 0.0559 0.0542
Mycobacterium ulcerans hypothetical protein 0.0027 0.0214 0.0225
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0103 0.1431 0.1431
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0142 0.2056 0.2042
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0214 0.0197
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0142 0.2056 0.3634
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0048 0.0559 0.1093
Echinococcus granulosus thyroid hormone receptor alpha 0.0048 0.0559 0.1124
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0035 0.0343 0.0343
Brugia malayi hypothetical protein 0.0154 0.225 0.2236
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0407 0.039
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0343 0.0343
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0323 0.4971 1
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0323 0.4971 1
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0018 0.0036
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0018 0.000000027759
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0392 0.0789
Onchocerca volvulus 0.0028 0.0235 0.0276
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.052 0.1015
Brugia malayi nuclear receptor RXR 0.0048 0.0559 0.0542
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0463 0.0382
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0103 0.1431 0.1415
Loa Loa (eye worm) hypothetical protein 0.0054 0.0652 0.0652
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0142 0.2056 0.4115
Echinococcus multilocularis hormone sensitive lipase 0.0239 0.3616 0.7274
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0103 0.1431 0.2878
Loa Loa (eye worm) hypothetical protein 0.0504 0.7885 0.7885
Loa Loa (eye worm) thymidylate synthase 0.0323 0.4971 0.4971
Mycobacterium tuberculosis Hypothetical protein 0.0154 0.225 0.4428
Schistosoma mansoni nuclear receptor 0.0048 0.0559 0.1093
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0127 0.1816 0.3654
Loa Loa (eye worm) acetyltransferase 0.0144 0.2101 0.2101
Schistosoma mansoni nuclear hormone receptor 0.0048 0.0559 0.1093
Brugia malayi ecdysone receptor 0.0048 0.0559 0.0542
Loa Loa (eye worm) hypothetical protein 0.0048 0.0559 0.0559
Loa Loa (eye worm) hypothetical protein 0.0103 0.1431 0.1431
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0018 0.0036
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0328 0.0493
Schistosoma mansoni nuclear hormone receptor 0.0048 0.0559 0.1093
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0142 0.2056 0.3634
Brugia malayi nuclear hormone receptor 0.0103 0.1431 0.1415
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0086 0.1155 0.4107
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0263 0.401 0.8066
Loa Loa (eye worm) hypothetical protein 0.0027 0.0214 0.0214
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0214 0.0225
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0407 0.1045
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0214 0.0225
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.1768 0.3417
Loa Loa (eye worm) hypothetical protein 0.002 0.0105 0.0105
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0018 0.0018
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0263 0.401 0.8066
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0103 0.1431 0.2852
Echinococcus granulosus Nuclear hormone receptor HR96 0.0048 0.0559 0.1124
Echinococcus multilocularis jun protein 0.0263 0.401 0.8066
Loa Loa (eye worm) nuclear receptor NHR-67 0.0048 0.0559 0.0559
Echinococcus granulosus Ankyrin 0.0015 0.002 0.004
Brugia malayi nuclear hormone receptor family member nhr-6 0.0048 0.0559 0.0542
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0103 0.1431 0.2878
Brugia malayi intermediate filament protein 0.0028 0.0235 0.0218
Loa Loa (eye worm) inositol-1 0.0038 0.0392 0.0392
Schistosoma mansoni lamin 0.0028 0.0235 0.0439
Echinococcus multilocularis FTZ F1 alpha 0.0103 0.1431 0.2878
Schistosoma mansoni intermediate filament proteins 0.0028 0.0235 0.0439
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0343 0.069
Loa Loa (eye worm) hypothetical protein 0.0161 0.2374 0.2374
Brugia malayi ecdysteroid receptor 0.0103 0.1431 0.1415
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0239 0.3616 0.7264
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0048 0.0559 0.1124
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0103 0.1431 0.2878
Echinococcus multilocularis lamin 0.0028 0.0235 0.0473
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.052 0.1015
Schistosoma mansoni hypothetical protein 0.0127 0.1816 0.3631
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0103 0.1431 0.1415
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0103 0.1431 0.2878
Trichomonas vaginalis conserved hypothetical protein 0.0154 0.225 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0343 0.069
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0343 0.0326
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0111 0.1558 0.1558
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0054 0.0652 0.1312
Echinococcus granulosus lamin dm0 0.0028 0.0235 0.0473
Brugia malayi nuclear receptor NHR-88 0.0103 0.1431 0.1415
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0214 0.0261
Brugia malayi nuclear hormone receptor 0.0048 0.0559 0.0542
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0103 0.1431 0.2878
Loa Loa (eye worm) hypothetical protein 0.0103 0.1431 0.1431
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.2101 0.4206
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0407 0.008
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0127 0.1816 0.3654
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0214 0.0225
Loa Loa (eye worm) hypothetical protein 0.002 0.0105 0.0105
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0463 0.0736
Loa Loa (eye worm) runx1 0.0063 0.0797 0.0797
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0142 0.2056 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0103 0.1431 0.2852
Echinococcus granulosus hormone sensitive lipase 0.0239 0.3616 0.7274
Brugia malayi Nuclear hormone receptor-like 1 0.0103 0.1431 0.1415
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0103 0.1431 0.1415
Loa Loa (eye worm) DR-78 0.0048 0.0559 0.0559
Schistosoma mansoni lamin 0.0028 0.0235 0.0439
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0406 0.0619
Loa Loa (eye worm) hypothetical protein 0.0048 0.0559 0.0559
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.1768 0.3533
Loa Loa (eye worm) hypothetical protein 0.0103 0.1431 0.1431
Loa Loa (eye worm) hypothetical protein 0.0048 0.0559 0.0559
Echinococcus granulosus muscleblind protein 0.0161 0.2374 0.4776
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0103 0.1431 0.1431
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0103 0.1431 0.2852
Echinococcus granulosus lamin 0.0028 0.0235 0.0473
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0024 0.0006
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0407 0.0621
Loa Loa (eye worm) steroid hormone receptor 0.0103 0.1431 0.1431
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0407 0.0621
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0103 0.1431 0.1431
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0214 0.0225
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0103 0.1431 0.2878
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0018 0.0036
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0124 0.1768 0.3441
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0142 0.2056 0.4136
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.052 0.1047
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0323 0.4971 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0086 0.1155 0.2296
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0214 0.0197
Echinococcus multilocularis thymidylate synthase 0.0323 0.4971 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0103 0.1431 0.2878
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0103 0.1431 0.2878
Brugia malayi nuclear hormone receptor family member odr-7 0.0048 0.0559 0.0542
Loa Loa (eye worm) hypothetical protein 0.002 0.0105 0.0105
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0407 0.0818
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0235 0.0235
Brugia malayi Steroid receptor seven-up type 2 0.0103 0.1431 0.1415
Brugia malayi tailless protein 0.0048 0.0559 0.0542
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.1768 0.3533
Brugia malayi nuclear receptor NHR-88 0.0048 0.0559 0.0542
Brugia malayi Inositol-1 0.0038 0.0392 0.0375
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0407 1
Onchocerca volvulus 0.0048 0.0559 0.0688
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0407 0.0032
Echinococcus multilocularis GPCR, family 2 0.0035 0.0343 0.069
Loa Loa (eye worm) hypothetical protein 0.0028 0.0235 0.0235
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0407 0.0032
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0048 0.0559 0.1093
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0086 0.1155 0.4107
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0018 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0103 0.1431 0.1415
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0323 0.4971 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0103 0.1431 0.1415
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0235 0.0235
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0463 0.0382
Schistosoma mansoni coup transcription factor 0.0103 0.1431 0.2852
Loa Loa (eye worm) hypothetical protein 0.0161 0.2374 0.2374
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.0996 0.098
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0214 0.0197
Loa Loa (eye worm) hypothetical protein 0.0027 0.0214 0.0214
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0103 0.1431 0.1431
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0214 0.0225
Schistosoma mansoni ap endonuclease 0.0039 0.0407 0.0785
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0124 0.1768 0.3556
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0463 0.0155
Loa Loa (eye worm) hypothetical protein 0.0054 0.0652 0.0652
Brugia malayi Nuclear hormone receptor E75 0.0048 0.0559 0.0542
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0103 0.1431 0.2878
Loa Loa (eye worm) hypothetical protein 0.0103 0.1431 0.1431
Loa Loa (eye worm) hypothetical protein 0.0048 0.0559 0.0559
Loa Loa (eye worm) hypothetical protein 0.0103 0.1431 0.1431
Loa Loa (eye worm) hypothetical protein 0.0636 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0103 0.1431 0.1415
Echinococcus multilocularis ecdysone induced protein 78C 0.0103 0.1431 0.2878
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0103 0.1431 0.1796
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0103 0.1431 0.1415
Schistosoma mansoni nuclear receptor 0.0048 0.0559 0.1093
Schistosoma mansoni nuclear receptor nhr-48 0.0048 0.0559 0.1093
Echinococcus multilocularis transcription factor Dp 1 0.0082 0.1098 0.2208
Brugia malayi Uncoordinated protein 44 0.0015 0.0018 0.000000013774
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0103 0.1431 0.2878
Echinococcus granulosus FTZ F1 alpha 0.0103 0.1431 0.2878
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.052 0.1047
Schistosoma mansoni jun-related protein 0.0214 0.3217 0.646
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0124 0.1768 0.3265
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0323 0.4971 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0048 0.0559 0.0688
Echinococcus granulosus death domain containing protein 0.0015 0.0018 0.0036
Echinococcus granulosus Nuclear hormone receptor HR96 0.0048 0.0559 0.1124
Echinococcus granulosus transcription factor Dp 1 0.0082 0.1098 0.2208
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.1768 0.3417
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0239 0.3616 0.7264
Echinococcus multilocularis muscleblind protein 0.0161 0.2374 0.4776
Echinococcus multilocularis lamin dm0 0.0028 0.0235 0.0473
Loa Loa (eye worm) hypothetical protein 0.0028 0.0227 0.0227
Schistosoma mansoni hypothetical protein 0.0078 0.1032 0.2048
Schistosoma mansoni RAR-like nuclear receptor 0.0103 0.1431 0.2852
Schistosoma mansoni thyroid hormone receptor 0.0229 0.3466 0.6962
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.1032 0.2077
Brugia malayi hypothetical protein 0.0207 0.3101 0.3089
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.2101 0.2087
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0214 0.0225
Echinococcus multilocularis nuclear receptor nhr 48 0.0048 0.0559 0.1124
Schistosoma mansoni hypothetical protein 0.0076 0.0996 0.1975
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0048 0.0559 0.0559
Onchocerca volvulus 0.0028 0.0235 0.0276
Mycobacterium ulcerans thymidylate synthase 0.0323 0.4971 1
Echinococcus multilocularis Protein lozenge 0.0063 0.0797 0.1604
Echinococcus granulosus nuclear receptor nhr 48 0.0048 0.0559 0.1124
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.052 0.1047
Onchocerca volvulus 0.0504 0.7885 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0343 0.069
Loa Loa (eye worm) hypothetical protein 0.0048 0.0559 0.0559
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0323 0.4971 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0142 0.2056 0.2056
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0103 0.1431 0.1415
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0103 0.1431 0.1415
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0142 0.2056 0.4136
Brugia malayi hypothetical protein 0.0048 0.0559 0.0542
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0407 0.0407
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0214 0.0261
Brugia malayi steroid hormone receptor 0.0103 0.1431 0.1415
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0154 0.225 0.4057
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0249 0.3786 0.3786
Schistosoma mansoni hypothetical protein 0.0035 0.0343 0.0657
Brugia malayi Nuclear hormone receptor-like 1 0.0054 0.0652 0.0636
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0392 0.0964
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0407 0.0655
Loa Loa (eye worm) hypothetical protein 0.0048 0.0559 0.0559
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0407 0.5
Schistosoma mansoni hypothetical protein 0.0035 0.0343 0.0657
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0407 0.008
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0392 0.0789
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.1768 0.3417
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.052 0.1047
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0086 0.1155 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0406 0.1041
Schistosoma mansoni retinoic acid receptor RXR 0.0103 0.1431 0.2852
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0328 0.0239
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0214 0.0225
Onchocerca volvulus 0.0207 0.3101 0.392
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.1032 0.2077
Entamoeba histolytica hypothetical protein 0.0078 0.1032 0.4442
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0142 0.2056 0.3634
Loa Loa (eye worm) hypothetical protein 0.0027 0.0214 0.0214
Brugia malayi nuclear receptor NHR-67 0.0048 0.0559 0.0542
Onchocerca volvulus Bile acid receptor homolog 0.0103 0.1431 0.1796
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0105 0.5
Entamoeba histolytica hypothetical protein 0.0078 0.1032 0.4442
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.052 0.0503
Entamoeba histolytica hypothetical protein 0.0078 0.1032 0.4442
Onchocerca volvulus 0.0323 0.4971 0.6296
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0142 0.2056 0.3871
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0103 0.1431 0.2852
Loa Loa (eye worm) hypothetical protein 0.0103 0.1431 0.1431
Schistosoma mansoni hypothetical protein 0.0214 0.3217 0.646
Loa Loa (eye worm) hypothetical protein 0.0103 0.1431 0.1431
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.052 0.052
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0048 0.0559 0.1124
Onchocerca volvulus 0.0103 0.1431 0.1796
Loa Loa (eye worm) hypothetical protein 0.0054 0.0652 0.0652
Loa Loa (eye worm) hypothetical protein 0.0048 0.0559 0.0559
Echinococcus multilocularis muscleblind protein 1 0.0161 0.2374 0.4776
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0392 0.059
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0407 0.0404
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0105 0.0036
Brugia malayi nuclear receptor RXR 0.0054 0.0652 0.0636
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0103 0.1431 0.2878
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0103 0.1431 0.1431
Loa Loa (eye worm) nuclear hormone receptor 0.0048 0.0559 0.0559
Brugia malayi orphan nuclear receptor NR2E1 0.0048 0.0559 0.0542
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0235 0.0218
Loa Loa (eye worm) hypothetical protein 0.0239 0.3616 0.3616
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.1032 0.2048
Brugia malayi photoreceptor-specific nuclear receptor 0.0103 0.1431 0.1415
Loa Loa (eye worm) hypothetical protein 0.0048 0.0559 0.0559
Echinococcus multilocularis thyroid hormone receptor alpha 0.0229 0.3466 0.6973
Schistosoma mansoni inositol monophosphatase 0.0038 0.0392 0.0755
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0054 0.0652 0.1312
Loa Loa (eye worm) hypothetical protein 0.0076 0.0996 0.0996
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0048 0.0559 0.0688
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0103 0.1431 0.2878
Echinococcus multilocularis musashi 0.0028 0.0235 0.0473
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0323 0.4971 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0111 0.1558 0.1543
Loa Loa (eye worm) hypothetical protein 0.0054 0.0652 0.0652
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.2101 0.4227
Echinococcus granulosus GPCR family 2 0.0035 0.0343 0.069
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0086 0.1155 0.2324
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0048 0.0559 0.1124
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0054 0.0652 0.0652
Schistosoma mansoni ap endonuclease 0.0039 0.0407 0.0785
Loa Loa (eye worm) hypothetical protein 0.0504 0.7885 0.7885
Schistosoma mansoni lozenge 0.0063 0.0797 0.1574
Brugia malayi bZIP transcription factor family protein 0.0263 0.401 0.3999
Brugia malayi hypothetical protein 0.0054 0.0652 0.0636
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0323 0.4971 1
Entamoeba histolytica hypothetical protein 0.0078 0.1032 0.4442
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0407 0.0008
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0048 0.0559 0.0542
Loa Loa (eye worm) hypothetical protein 0.0103 0.1431 0.1431
Brugia malayi Muscleblind-like protein 0.0161 0.2374 0.2361
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0086 0.1155 0.4107
Brugia malayi Death domain containing protein 0.0015 0.0018 0.000000013774
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.052 0.1015
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0103 0.1431 0.1415
Brugia malayi Nuclear hormone receptor-like 1 0.0054 0.0652 0.0636
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0407 0.0032
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0086 0.1155 0.2324
Onchocerca volvulus Protein ultraspiracle homolog 0.0103 0.1431 0.1796
Brugia malayi thymidylate synthase 0.0323 0.4971 0.4962
Schistosoma mansoni hypothetical protein 0.0035 0.0343 0.0657
Echinococcus granulosus jun protein 0.0263 0.401 0.8066
Toxoplasma gondii aldehyde dehydrogenase 0.0124 0.1768 0.3004
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0343 0.069
Onchocerca volvulus 0.0027 0.0214 0.025
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0054 0.0652 0.1281
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0407 0.0818
Loa Loa (eye worm) hypothetical protein 0.0015 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0086 0.1155 0.1155
Loa Loa (eye worm) hypothetical protein 0.0048 0.0559 0.0559
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0054 0.0652 0.1281
Loa Loa (eye worm) hypothetical protein 0.002 0.0105 0.0105
Echinococcus granulosus thymidylate synthase 0.0323 0.4971 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0103 0.1431 0.1415
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0076 0.0995 0.2002
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0124 0.1768 0.3556

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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