Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.319 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0541 | 0.1564 | 0.1564 |
Loa Loa (eye worm) | hypothetical protein | 0.0541 | 0.1564 | 0.1564 |
Mycobacterium ulcerans | histidinol dehydrogenase | 0.0876 | 0.2631 | 0.5 |
Mycobacterium tuberculosis | Probable histidinol dehydrogenase HisD (HDH) | 0.0876 | 0.2631 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.319 | 1 | 1 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0541 | 0.1564 | 0.0689 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0706 | 0.2087 | 0.1266 |
Loa Loa (eye worm) | hypothetical protein | 0.0541 | 0.1564 | 0.1564 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0541 | 0.1564 | 0.1564 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0541 | 0.1564 | 0.1541 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0541 | 0.1564 | 0.1541 |
Plasmodium falciparum | transporter, putative | 0.0541 | 0.1564 | 0.5 |
Onchocerca volvulus | 0.319 | 1 | 1 | |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0541 | 0.1564 | 0.1564 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0541 | 0.1564 | 0.0689 |
Brugia malayi | GnHR receptor homolog | 0.0905 | 0.2721 | 0.2701 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0541 | 0.1564 | 0.1564 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0541 | 0.1564 | 0.0689 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0541 | 0.1564 | 0.1564 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0541 | 0.1564 | 0.1564 |
Loa Loa (eye worm) | hypothetical protein | 0.0541 | 0.1564 | 0.1564 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0541 | 0.1564 | 0.1564 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0541 | 0.1564 | 0.1564 |
Echinococcus granulosus | serotonin transporter | 0.319 | 1 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0706 | 0.2087 | 0.2087 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0541 | 0.1564 | 0.1564 |
Loa Loa (eye worm) | norepinephrine transporter | 0.319 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0541 | 0.1564 | 0.1541 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0541 | 0.1564 | 0.1564 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0059 | 0.0027 | 0.0027 |
Plasmodium vivax | hypothetical protein, conserved | 0.0541 | 0.1564 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0541 | 0.1564 | 0.1564 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0541 | 0.1564 | 0.0689 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0541 | 0.1564 | 0.0689 |
Plasmodium falciparum | amino acid transporter, putative | 0.0541 | 0.1564 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.319 | 1 | 1 |
Onchocerca volvulus | 0.0541 | 0.1564 | 0.1564 | |
Toxoplasma gondii | hypothetical protein | 0.0541 | 0.1564 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.319 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.319 | 1 | 1 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0541 | 0.1564 | 0.0689 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0541 | 0.1564 | 0.0689 |
Mycobacterium leprae | Probable histidinol dehydrogenase HisD (HDH) | 0.0876 | 0.2631 | 0.5 |
Onchocerca volvulus | 0.0541 | 0.1564 | 0.1564 | |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0541 | 0.1564 | 0.5 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0541 | 0.1564 | 0.0689 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0541 | 0.1564 | 0.5 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0541 | 0.1564 | 0.0689 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0541 | 0.1564 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.319 | 1 | 0.5 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0541 | 0.1564 | 0.1564 |
Loa Loa (eye worm) | hypothetical protein | 0.319 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0541 | 0.1564 | 0.1541 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0541 | 0.1564 | 0.1564 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0541 | 0.1564 | 0.1564 |
Loa Loa (eye worm) | hypothetical protein | 0.319 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0541 | 0.1564 | 0.1564 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0706 | 0.2087 | 0.1266 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0541 | 0.1564 | 0.1541 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0541 | 0.1564 | 0.5 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0541 | 0.1564 | 0.1564 |
Onchocerca volvulus | 0.0541 | 0.1564 | 0.1564 | |
Echinococcus multilocularis | serotonin transporter | 0.319 | 1 | 1 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0541 | 0.1564 | 0.0689 |
Toxoplasma gondii | hypothetical protein | 0.0541 | 0.1564 | 0.5 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0541 | 0.1564 | 0.0689 |
Plasmodium vivax | amine transporter, putative | 0.0541 | 0.1564 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0541 | 0.1564 | 0.1564 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 16 nM | Inhibition of Brucella suis histidinol dehydrogenase | ChEMBL. | 17481905 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.